IL277033A - Thrombin solution and methods of use thereof - Google Patents

Thrombin solution and methods of use thereof

Info

Publication number
IL277033A
IL277033A IL277033A IL27703320A IL277033A IL 277033 A IL277033 A IL 277033A IL 277033 A IL277033 A IL 277033A IL 27703320 A IL27703320 A IL 27703320A IL 277033 A IL277033 A IL 277033A
Authority
IL
Israel
Prior art keywords
methods
thrombin solution
thrombin
solution
Prior art date
Application number
IL277033A
Other languages
Hebrew (he)
Other versions
IL277033B1 (en
IL277033B2 (en
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Priority claimed from PCT/IL2013/000088 external-priority patent/WO2014087394A1/en
Publication of IL277033A publication Critical patent/IL277033A/en
Publication of IL277033B1 publication Critical patent/IL277033B1/en
Publication of IL277033B2 publication Critical patent/IL277033B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4833Thrombin (3.4.21.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6429Thrombin (3.4.21.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21005Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
IL277033A 2012-12-03 2013-11-28 Thrombin solution and methods of use thereof IL277033B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL22339612 2012-12-03
US201361753542P 2013-01-17 2013-01-17
PCT/IL2013/000088 WO2014087394A1 (en) 2012-12-03 2013-11-28 Thrombin solution and methods of use thereof

Publications (3)

Publication Number Publication Date
IL277033A true IL277033A (en) 2020-10-29
IL277033B1 IL277033B1 (en) 2024-01-01
IL277033B2 IL277033B2 (en) 2024-05-01

Family

ID=67068240

Family Applications (1)

Application Number Title Priority Date Filing Date
IL277033A IL277033B2 (en) 2012-12-03 2013-11-28 Thrombin solution and methods of use thereof

Country Status (4)

Country Link
KR (1) KR102223275B1 (en)
ES (1) ES2828498T3 (en)
IL (1) IL277033B2 (en)
NZ (1) NZ708737A (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1927658B1 (en) * 2004-06-22 2012-10-10 Zymogenetics, Inc. Thrombin compositions
ES2226587B1 (en) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. STABLE THROMBINE COMPOSITION.
DK2252335T3 (en) * 2008-03-03 2013-07-08 Omrix Biopharmaceuticals Ltd GELATIN FUNGI, INCLUDING AN ACTIVE INGREDIENT, MANUFACTURING AND USING THEREOF
IL207586A0 (en) * 2010-08-12 2010-12-30 Omrix Biopharmaceuticals Ltd A fibrin based therapeutic preparation and use thereof

Also Published As

Publication number Publication date
KR102223275B1 (en) 2021-03-09
NZ708737A (en) 2019-06-28
IL277033B1 (en) 2024-01-01
KR20200039831A (en) 2020-04-16
IL277033B2 (en) 2024-05-01
ES2828498T3 (en) 2021-05-26

Similar Documents

Publication Publication Date Title
SG10201609940RA (en) Compounds and their methods of use
ZA201502503B (en) Hppd variants and methods of use
IL239353A0 (en) Continuous extraction unit and methods making use of same
IL235436A0 (en) Anti-pcsk9 compositions and use thereof
SI2909204T1 (en) Gsk3 inhibitors and methods of use thereof
ZA201405858B (en) Recombinant microorganisms and methods of use thereof
ZA201404675B (en) Anti-lrp5 antibodies and methods of use
EP2790709A4 (en) Hemostatic agents and methods of use
SG10201707813YA (en) Cd40l-specific tn3-derived scaffolds and methods of use thereof
EP2806811A4 (en) Vertebral construct and methods of use
IL233481A0 (en) Peptides and methods of using same
ZA201406082B (en) Use of ccr3-inhibitors
IL239043B (en) Thrombin solution and methods of use thereof
ZA201405829B (en) Cleaning arrangement and method of use
PL2864417T3 (en) Polymer and method of use
ZA201408128B (en) Etract of greyia radlkoferi and use thereof
ZA201405644B (en) Weatherised minerals and methods of making and using same
EP2859071A4 (en) Chemical compositions and methods of using same
IL277033A (en) Thrombin solution and methods of use thereof
GB201316230D0 (en) Catalysts and methods of making and using catalysts