HK1211021A1 - 2-substituted-6-biarylmethylamino-9-cyclopentyl-9h-purine derivatives, use thereof as medicaments, and pharmaceutical compositions - Google Patents

2-substituted-6-biarylmethylamino-9-cyclopentyl-9h-purine derivatives, use thereof as medicaments, and pharmaceutical compositions Download PDF

Info

Publication number
HK1211021A1
HK1211021A1 HK15111650.1A HK15111650A HK1211021A1 HK 1211021 A1 HK1211021 A1 HK 1211021A1 HK 15111650 A HK15111650 A HK 15111650A HK 1211021 A1 HK1211021 A1 HK 1211021A1
Authority
HK
Hong Kong
Prior art keywords
cyclopentyl
amino
ylmethyl
purin
purine
Prior art date
Application number
HK15111650.1A
Other languages
English (en)
Chinese (zh)
Inventor
托馬斯．伽基
托马斯．伽基
拉德克．約爾達
拉德克．约尔达
馬雷克．扎特盧卡爾
马雷克．扎特卢卡尔
弗拉基米爾．克里斯托夫
弗拉基米尔．克里斯托夫
露西．拉羅瓦
露西．拉罗瓦
伊娃．雷茲尼科瓦
伊娃．雷兹尼科瓦
沃爾夫岡．米庫利茨
沃尔夫冈．米库利茨
米羅斯拉夫．斯特爾納德
米罗斯拉夫．斯特尔纳德
Original Assignee
奥洛穆茨帕拉茨基大学
比奥帕特尔斯有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 奥洛穆茨帕拉茨基大学, 比奥帕特尔斯有限公司 filed Critical 奥洛穆茨帕拉茨基大学
Publication of HK1211021A1 publication Critical patent/HK1211021A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15111650.1A 2013-02-08 2014-02-05 2-substituted-6-biarylmethylamino-9-cyclopentyl-9h-purine derivatives, use thereof as medicaments, and pharmaceutical compositions HK1211021A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZPV2013-88 2013-02-08
CZ2013-88A CZ306894B6 (cs) 2013-02-08 2013-02-08 2-Substituované-6-biarylmethylamino-9-cyklopentyl-9H-purinové deriváty, jejich použití jako léčiva a farmaceutické přípravky tyto sloučeniny obsahující
PCT/CZ2014/000014 WO2014121764A2 (en) 2013-02-08 2014-02-05 2-substituted-6-biarylmethylamino-9-cyclopentyl-9h-purine derivatives, use thereof as medicaments, and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
HK1211021A1 true HK1211021A1 (en) 2016-05-13

Family

ID=50289324

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111650.1A HK1211021A1 (en) 2013-02-08 2014-02-05 2-substituted-6-biarylmethylamino-9-cyclopentyl-9h-purine derivatives, use thereof as medicaments, and pharmaceutical compositions

Country Status (12)

Country Link
US (1) US20150368248A1 (cs)
EP (1) EP2953951B1 (cs)
CN (1) CN105026396A (cs)
AU (1) AU2014214355B2 (cs)
CA (1) CA2900292C (cs)
CZ (1) CZ306894B6 (cs)
EA (1) EA028206B1 (cs)
HK (1) HK1211021A1 (cs)
NZ (1) NZ710291A (cs)
SG (1) SG11201505640VA (cs)
WO (1) WO2014121764A2 (cs)
ZA (1) ZA201505318B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105348298B (zh) * 2014-07-04 2019-03-19 沈阳中化农药化工研发有限公司 取代芳基吡啶类化合物及其用途
EP4115882A1 (en) 2015-01-16 2023-01-11 The General Hospital Corporation Compounds for improving mrna splicing
CZ307147B6 (cs) * 2015-05-14 2018-02-07 Ústav experimentální botaniky AV ČR, v. v. i. 5-Substituované 7-[4-(2-pyridyl)fenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako léčiva, a farmaceutické přípravky
CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
CN111217814B (zh) * 2018-11-26 2022-08-26 天津科技大学 一类联哌啶衍生物及其作为抗肿瘤药物的应用
CN113307765A (zh) * 2021-05-24 2021-08-27 上海泰坦科技股份有限公司 吡啶甲胺类化合物及其制备方法
US20250101023A1 (en) * 2022-01-21 2025-03-27 Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University) Heteroaryl derivative and uses thereof
CN117659016A (zh) * 2022-08-26 2024-03-08 嘉兴优博生物技术有限公司 细胞周期蛋白调节剂
CN116217576B (zh) * 2023-03-08 2024-06-14 四川大学 一种基于嘌呤骨架的近红外发射荧光分子及其制备方法和应用
CN116813621A (zh) * 2023-06-08 2023-09-29 江南大学 9h嘌呤类化合物及其药物组合物和用途
WO2025018768A1 (ko) * 2023-07-20 2025-01-23 한양대학교 산학협력단 헤테로아릴 유도체 및 이의 용도

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US696970A (en) 1902-01-27 1902-04-08 Michigan Specialty Company Ltd Harness-hook.
CA2361518A1 (en) * 1999-02-01 2000-08-03 Cv Therapeutics, Inc. Purine inhibitors of cyclin dependent kinase 2 and ikb-.alpha.
US6627633B2 (en) * 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6969720B2 (en) * 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
CZ294535B6 (cs) 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
US6812232B2 (en) * 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
CZ294538B6 (cs) 2002-12-30 2005-01-12 Ústav Experimentální Botaniky Akademie Vědčeské Re Substituční deriváty N6-benzyladenosinu, způsob jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
CZ302225B6 (cs) 2007-07-04 2010-12-29 Univerzita Palackého v Olomouci Substituované 6-anilinopurinové deriváty jako inhibitory cytokinin oxidasy a prípravky obsahující tyto slouceniny
CZ300774B6 (cs) 2007-10-05 2009-08-05 Univerzita Palackého Substituované 6-(alkylbenzylamino)purinové deriváty pro použití jako antagonisté cytokininových receptoru a prípravky obsahující tyto slouceniny
CZ302122B6 (cs) * 2009-01-28 2010-10-20 Univerzita Palackého v Olomouci Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující
US20130005747A1 (en) * 2010-12-21 2013-01-03 Cyclacel Limited Method for selecting a cancer therapy

Also Published As

Publication number Publication date
AU2014214355B2 (en) 2016-05-19
NZ710291A (en) 2016-03-31
CZ201388A3 (cs) 2014-08-20
WO2014121764A3 (en) 2014-10-16
CZ306894B6 (cs) 2017-08-30
ZA201505318B (en) 2016-03-30
CA2900292A1 (en) 2014-08-14
WO2014121764A2 (en) 2014-08-14
CA2900292C (en) 2017-01-10
EA028206B1 (ru) 2017-10-31
CN105026396A (zh) 2015-11-04
AU2014214355A1 (en) 2015-08-13
US20150368248A1 (en) 2015-12-24
EP2953951A2 (en) 2015-12-16
EP2953951B1 (en) 2017-05-03
EA201500821A1 (ru) 2016-03-31
SG11201505640VA (en) 2015-08-28

Similar Documents

Publication Publication Date Title
HK1211021A1 (en) 2-substituted-6-biarylmethylamino-9-cyclopentyl-9h-purine derivatives, use thereof as medicaments, and pharmaceutical compositions
JP6869947B2 (ja) 置換キナゾリン化合物ならびにそのｇ１２ｃ変異ｋｒａｓ、ｈｒａｓおよび／またはｎｒａｓタンパク質の阻害剤としての使用
Buckley et al. 6-Substituted hexamethylene amiloride (HMA) derivatives as potent and selective inhibitors of the human urokinase plasminogen activator for use in cancer
CA2754808C (en) Prodrug forms of kinase inhibitors and their use in therapy
CA3214900A1 (en) Carboxamide pyrolopyrazine and pyridine compounds useful as inhibitors of myt1 and use thereof in the treatment of cancer
JP6474068B2 (ja) ２−アミノピリミジン系化合物およびその薬物組成物と使用
CN111386266B (zh) 具有抑制癌细胞生长作用的新型嘧啶衍生物及包含其的药物组合物
JP6139782B2 (ja) 置換ピラゾロピリミジン化合物、及びその薬学的に許容される塩、並びにこれらの溶媒和物、立体異性体、及び互変異性体、並びにこれらを含む医薬組成物
EP4116293A2 (en) Rho kinase inhibitors
BR112015000653A2 (pt) compostos inibidores do receptor de fator de crescimento de fibroblasto, sua composição farmacêutica e seus usos
JP6321821B2 (ja) ２，３，４，６−４置換ベンゼン−１，５−ジアミン誘導体、その製造方法および医薬品における使用
MXPA04011789A (es) Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina.
AU2016331955A1 (en) Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
CN105164116A (zh) 杂芳基取代的吲唑
WO2016026445A1 (zh) 作为fgfr激酶抑制剂的吲唑类化合物及其制备和应用
EP2315761B1 (en) Pharmaceutical compounds
CN104918919A (zh) 取代的反向嘧啶Bmi-1抑制剂
JP6855636B2 (ja) イミダゾリジン化合物
CN105980377B (zh) 作为egfr-t790m激酶抑制剂的取代的嘧啶类化合物
JP2020530833A (ja) ピロロピリミジン及びピロロピリジン誘導体
EP3154547B1 (en) Pyrimidine compounds and methods using the same
CN119546588A (zh) 吡啶检查点激酶1（chk1）抑制剂及其用途
CN116917288A (zh) 一种7,9-二氢嘌呤衍生物及其制药用途
CN111936470B (zh) 用作fgfr不可逆抑制剂的酰胺基吡唑类化合物
US20230293539A1 (en) Mll1-wdr5 protein-protein interaction inhibitor compounds and uses thereof