HK1204797A1 - Novel anti-siglec15 antibody -siglec-15 - Google Patents
Novel anti-siglec15 antibody -siglec-15Info
- Publication number
- HK1204797A1 HK1204797A1 HK15105298.1A HK15105298A HK1204797A1 HK 1204797 A1 HK1204797 A1 HK 1204797A1 HK 15105298 A HK15105298 A HK 15105298A HK 1204797 A1 HK1204797 A1 HK 1204797A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- siglec
- novel anti
- siglec15
- antibody
- siglec15 antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012078841 | 2012-03-30 | ||
PCT/JP2013/059653 WO2013147212A1 (ja) | 2012-03-30 | 2013-03-29 | 新規抗Siglec-15抗体 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1204797A1 true HK1204797A1 (en) | 2015-12-04 |
Family
ID=49260453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15105298.1A HK1204797A1 (en) | 2012-03-30 | 2015-06-03 | Novel anti-siglec15 antibody -siglec-15 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20150125470A1 (xx) |
EP (1) | EP2832855A4 (xx) |
JP (1) | JPWO2013147212A1 (xx) |
KR (1) | KR20140138215A (xx) |
CN (1) | CN104321430A (xx) |
AU (1) | AU2013241002A1 (xx) |
BR (1) | BR112014024267A8 (xx) |
CA (1) | CA2868965A1 (xx) |
HK (1) | HK1204797A1 (xx) |
MX (1) | MX2014011826A (xx) |
RU (1) | RU2014143770A (xx) |
TW (1) | TW201345925A (xx) |
WO (1) | WO2013147212A1 (xx) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009048072A1 (ja) | 2007-10-11 | 2009-04-16 | Daiichi Sankyo Company, Limited | 破骨細胞関連蛋白質Siglec-15を標的とした抗体 |
FI3354729T3 (fi) | 2015-09-24 | 2024-04-23 | Daiichi Sankyo Co Ltd | Anti-garp-vasta-aine |
BR112019005292A2 (pt) | 2016-09-21 | 2019-09-03 | Nextcure Inc | anticorpos para siglec-15 e métodos de uso dos mesmos. |
CN110913905A (zh) | 2017-06-30 | 2020-03-24 | 国立大学法人北海道大学 | 不产生生长障碍的小儿骨质疏松症治疗药 |
CN110218257A (zh) * | 2019-06-24 | 2019-09-10 | 王跃驹 | 植物作为宿主在表达Antis15抗体中的应用 |
KR102651263B1 (ko) * | 2020-03-27 | 2024-03-25 | 바이오션, 인코포레이티드 | Siglec15에 결합하는 항체 및 이의 용도 |
CN113817057B (zh) * | 2020-06-19 | 2024-02-20 | 盛禾(中国)生物制药有限公司 | 一种抗siglec15抗体及其应用 |
US20240092897A1 (en) * | 2020-11-05 | 2024-03-21 | Shanghai Jmt-Bio Technology Co., Ltd. | Anti-siglec-15 antibody and application thereof in preparing drug |
CN112694532B (zh) * | 2021-01-12 | 2023-04-18 | 倍而达药业(苏州)有限公司 | 抗Siglec-15的抗体或其抗原结合片段及应用 |
CN114957468A (zh) * | 2021-02-25 | 2022-08-30 | 石药集团巨石生物制药有限公司 | 一种抗Siglec15抗体及其用途 |
WO2022188871A1 (en) * | 2021-03-12 | 2022-09-15 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric siglec15 |
CN112979761B (zh) * | 2021-03-19 | 2021-12-10 | 江苏元本生物科技有限公司 | 一种靶向Siglec-15的噬菌体多肽 |
WO2022223004A1 (zh) * | 2021-04-22 | 2022-10-27 | 上海医药集团股份有限公司 | 抗Siglec15抗体及其用途 |
WO2022228183A1 (zh) * | 2021-04-30 | 2022-11-03 | 杭州邦顺制药有限公司 | 抗siglec15抗体及其制备方法和用途 |
WO2023030311A1 (zh) * | 2021-08-31 | 2023-03-09 | 上海医药集团股份有限公司 | 靶向Siglec15的抗原结合蛋白及其用途 |
CN116655792B (zh) * | 2022-03-21 | 2024-01-02 | 南京蓬勃生物科技有限公司 | 靶向Siglec-15的单克隆抗体及其应用 |
WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
DK0605522T3 (da) | 1991-09-23 | 2000-01-17 | Medical Res Council | Fremgangsmåde til fremstilling af humaniserede antistoffer |
ES2227512T3 (es) | 1991-12-02 | 2005-04-01 | Medical Research Council | Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago. |
JP3507073B2 (ja) | 1992-03-24 | 2004-03-15 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的結合対の成員の製造方法 |
GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
EP0731842A1 (en) | 1993-12-03 | 1996-09-18 | Medical Research Council | Recombinant binding proteins and peptides |
PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
PT1914244E (pt) | 1999-04-09 | 2013-07-26 | Kyowa Hakko Kirin Co Ltd | Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico |
CA2785941C (en) | 2000-10-06 | 2017-01-10 | Kyowa Hakko Kirin Co., Ltd. | Antibody composition-producing cell |
PT1583830E (pt) | 2003-01-07 | 2006-11-30 | Symphogen As | Método para produzir proteínas policlonais recombinantes |
CA2638823A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
US8168181B2 (en) * | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
WO2009048072A1 (ja) | 2007-10-11 | 2009-04-16 | Daiichi Sankyo Company, Limited | 破骨細胞関連蛋白質Siglec-15を標的とした抗体 |
KR101690340B1 (ko) | 2009-04-09 | 2016-12-27 | 다이이찌 산쿄 가부시키가이샤 | 항 Siglec-15 항체 |
-
2013
- 2013-03-29 CA CA2868965A patent/CA2868965A1/en not_active Abandoned
- 2013-03-29 CN CN201380028016.7A patent/CN104321430A/zh active Pending
- 2013-03-29 KR KR20147026900A patent/KR20140138215A/ko not_active Application Discontinuation
- 2013-03-29 MX MX2014011826A patent/MX2014011826A/es unknown
- 2013-03-29 TW TW102111479A patent/TW201345925A/zh unknown
- 2013-03-29 AU AU2013241002A patent/AU2013241002A1/en not_active Abandoned
- 2013-03-29 BR BR112014024267A patent/BR112014024267A8/pt not_active IP Right Cessation
- 2013-03-29 JP JP2014508116A patent/JPWO2013147212A1/ja active Pending
- 2013-03-29 WO PCT/JP2013/059653 patent/WO2013147212A1/ja active Application Filing
- 2013-03-29 EP EP13767251.5A patent/EP2832855A4/en not_active Withdrawn
- 2013-03-29 RU RU2014143770A patent/RU2014143770A/ru not_active Application Discontinuation
- 2013-03-29 US US14/388,342 patent/US20150125470A1/en not_active Abandoned
-
2015
- 2015-06-03 HK HK15105298.1A patent/HK1204797A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPWO2013147212A1 (ja) | 2015-12-14 |
AU2013241002A1 (en) | 2014-10-09 |
BR112014024267A8 (pt) | 2017-07-25 |
CA2868965A1 (en) | 2013-10-03 |
KR20140138215A (ko) | 2014-12-03 |
CN104321430A (zh) | 2015-01-28 |
US20150125470A1 (en) | 2015-05-07 |
EP2832855A1 (en) | 2015-02-04 |
RU2014143770A (ru) | 2016-05-27 |
EP2832855A4 (en) | 2016-02-24 |
TW201345925A (zh) | 2013-11-16 |
MX2014011826A (es) | 2014-11-21 |
WO2013147212A1 (ja) | 2013-10-03 |
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