HK1203932A1 - 作為 受體拮抗劑的雜環酰胺衍生物 - Google Patents
作為 受體拮抗劑的雜環酰胺衍生物Info
- Publication number
- HK1203932A1 HK1203932A1 HK15104330.4A HK15104330A HK1203932A1 HK 1203932 A1 HK1203932 A1 HK 1203932A1 HK 15104330 A HK15104330 A HK 15104330A HK 1203932 A1 HK1203932 A1 HK 1203932A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- receptor antagonists
- amide derivatives
- heterocyclic amide
- heterocyclic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2012050282 | 2012-01-20 | ||
PCT/IB2013/050479 WO2013108227A1 (en) | 2012-01-20 | 2013-01-18 | Heterocyclic amide derivatives as p2x7 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1203932A1 true HK1203932A1 (zh) | 2015-11-06 |
Family
ID=47757670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15104330.4A HK1203932A1 (zh) | 2012-01-20 | 2015-05-07 | 作為 受體拮抗劑的雜環酰胺衍生物 |
Country Status (23)
Country | Link |
---|---|
US (1) | US9409917B2 (zh) |
EP (1) | EP2804865B1 (zh) |
JP (1) | JP6111268B2 (zh) |
KR (1) | KR102033190B1 (zh) |
CN (1) | CN104066737B (zh) |
AR (1) | AR089753A1 (zh) |
AU (1) | AU2013210682B2 (zh) |
BR (1) | BR112014017735B1 (zh) |
CA (1) | CA2863228C (zh) |
CL (1) | CL2014001772A1 (zh) |
EA (1) | EA024204B1 (zh) |
ES (1) | ES2563189T3 (zh) |
HK (1) | HK1203932A1 (zh) |
IL (1) | IL233662A0 (zh) |
MA (1) | MA35893B1 (zh) |
MX (1) | MX336247B (zh) |
NZ (1) | NZ628910A (zh) |
PH (1) | PH12014501415A1 (zh) |
PL (1) | PL2804865T3 (zh) |
SG (1) | SG11201403933UA (zh) |
TW (1) | TWI576347B (zh) |
WO (1) | WO2013108227A1 (zh) |
ZA (1) | ZA201406085B (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2574840T3 (es) | 2011-07-22 | 2016-06-22 | Actelion Pharmaceuticals Ltd. | Derivados de amidas heterocíclicas como antagonistas de receptores p2x7 |
ES2618056T3 (es) | 2012-12-12 | 2017-06-20 | Actelion Pharmaceuticals Ltd. | Derivados de indol carboxamida como antagonistas del receptor P2X7 |
AR094053A1 (es) | 2012-12-18 | 2015-07-08 | Actelion Pharmaceuticals Ltd | Derivados de indol carboxamida como antagonistas del receptor p2x₇ |
WO2014115078A1 (en) | 2013-01-22 | 2014-07-31 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
ES2616114T3 (es) | 2013-01-22 | 2017-06-09 | Actelion Pharmaceuticals Ltd. | Derivados de amida heterocíclica como antagonistas del receptor P2X7 |
CA3044998A1 (en) * | 2014-03-26 | 2015-10-01 | The Children's Medical Center Corporation | Celastrol and derivatives for the treatment of obesity |
LT3609868T (lt) | 2017-03-13 | 2023-12-11 | Raqualia Pharma Inc. | Tetrahidrochinolino dariniai kaip p2x7 receptoriaus antagonistai |
MX2020007532A (es) | 2018-01-19 | 2020-09-09 | Cytokinetics Inc | Inhibidores de sarcomero cardiaco. |
JP7438148B2 (ja) | 2018-06-26 | 2024-02-26 | サイトキネティックス, インコーポレイテッド | 心臓サルコメア阻害剤 |
JP2024508526A (ja) | 2021-03-04 | 2024-02-27 | サイトキネティックス, インコーポレイテッド | 心筋サルコメア阻害剤 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002541249A (ja) | 1999-04-09 | 2002-12-03 | アストラゼネカ・アクチエボラーグ | アダマンタン誘導体 |
SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
SE0103836D0 (sv) | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
SE0200920D0 (sv) | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
EP1581507A1 (en) | 2002-12-31 | 2005-10-05 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
ES2396565T3 (es) | 2003-05-12 | 2013-02-22 | Pah Usa 15 Llc | Inhibidores benzamida del receptor P2X7 |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
SE0302139D0 (sv) | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
JP2007510981A (ja) * | 2003-10-30 | 2007-04-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 入力を予測する方法 |
JP2007535553A (ja) | 2004-04-29 | 2007-12-06 | アボット・ラボラトリーズ | アミノ−テトラゾール類縁体および使用方法 |
SA05260265A (ar) | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
SE0402925D0 (sv) | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
WO2006080884A1 (en) | 2005-01-27 | 2006-08-03 | Astrazeneca Ab | Novel biaromatic compounds, inhibitors of the p2x7-receptor |
ES2319461T3 (es) | 2005-02-10 | 2009-05-07 | Bristol-Myers Squibb Company | Dihidroquinazolinonas como moduladores de 5ht. |
US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
WO2007055374A1 (ja) * | 2005-11-14 | 2007-05-18 | Mitsubishi Tanabe Pharma Corporation | 骨粗鬆症治療剤 |
US20100298285A1 (en) | 2006-03-16 | 2010-11-25 | Kelly Michael G | Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof |
CA2645551C (en) | 2006-03-16 | 2016-06-28 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
DK2001474T3 (en) | 2006-03-16 | 2016-05-09 | Second Genome Inc | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND APPLICATIONS THEREOF |
TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為p2x7調節劑之雙環雜芳基化合物與其用途 |
US20100184802A1 (en) | 2006-03-16 | 2010-07-22 | Kelly Michael G | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof |
CA2645652A1 (en) | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
WO2007141267A1 (en) | 2006-06-06 | 2007-12-13 | Glaxo Group Limited | N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration |
GB0611154D0 (en) | 2006-06-06 | 2006-07-19 | Glaxo Group Ltd | Novel receptor antagonists and their methods of use |
ES2385505T3 (es) | 2006-07-06 | 2012-07-25 | Glaxo Group Limited | N-fenilmetil-5-oxo-prolina-2-amidas sustituidas como antagonistas del receptor P2X7 y métodos de uso |
EP2096923B1 (en) | 2006-11-27 | 2014-01-22 | H. Lundbeck A/S | Heteroaryl amide derivatives |
TW200838516A (en) | 2007-01-31 | 2008-10-01 | Merck & Co Inc | Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators |
ES2576643T3 (es) | 2007-03-09 | 2016-07-08 | Second Genome, Inc. | Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos |
CA2680761A1 (en) | 2007-03-22 | 2008-09-25 | Astrazeneca Ab | Quinoline derivatives for the treatment of inflammatory diseases |
GB0705882D0 (en) | 2007-03-27 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
WO2008116845A1 (en) | 2007-03-28 | 2008-10-02 | Glaxo Group Limited | Piperidinone carboxamide derivatives as p2x7 modulators |
JP2010522710A (ja) | 2007-03-29 | 2010-07-08 | グラクソ グループ リミテッド | P2x7調節因子としてのオキサゾリジンおよびモルホリンカルボキサミド誘導体 |
AU2008234855B2 (en) | 2007-04-03 | 2011-01-20 | Glaxo Group Limited | Imidazolidine carboxamide derivatives as P2X7 modulators |
JP2010523668A (ja) | 2007-04-10 | 2010-07-15 | ハー・ルンドベック・アクチエゼルスカベット | P2x7拮抗薬としてのヘテロアリールアミド類似体 |
EP2150535A2 (en) | 2007-04-11 | 2010-02-10 | Glaxo Group Limited | Pyrazole derivatives as p2x7 modulators |
EP2155685B1 (en) | 2007-05-10 | 2011-03-16 | Glaxo Group Limited | Pyrazole derivatives as p2x7 modulators |
UA105758C2 (uk) | 2007-07-19 | 2014-06-25 | Х. Луннбек А/С | 5-членні гетероциклічні аміди та споріднені сполуки |
EP2185560A4 (en) * | 2007-08-10 | 2011-10-05 | Lundbeck & Co As H | HETEROARYLAMIDANALOGE |
US8106073B2 (en) | 2007-11-30 | 2012-01-31 | Astrazeneca Ab | Quinoline derivatives 057 |
GB0724258D0 (en) | 2007-12-12 | 2008-01-30 | Glaxo Group Ltd | Novel combinations |
WO2009074518A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations of prolinamide p2x7 modulators with further therapeutic agents |
GB0724625D0 (en) | 2007-12-18 | 2008-01-30 | Glaxo Group Ltd | Novel compounds |
AU2008337506A1 (en) | 2007-12-18 | 2009-06-25 | Glaxo Group Limited | 5-oxo-3-pyrrolidinecarboxamide derivatives as P2X7 modulators |
WO2009108551A2 (en) | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
PT2105164E (pt) * | 2008-03-25 | 2011-03-24 | Affectis Pharmaceuticals Ag | Novos antagonistas de p2x7r e a sua utilização |
US8431704B2 (en) | 2008-04-22 | 2013-04-30 | Janssen Pharmaceutica Nv | Quinoline or isoquinoline substituted P2X7 antagonists |
AU2010237302A1 (en) | 2009-04-14 | 2011-12-01 | Affectis Pharmaceuticals Ag | Novel P2X7R antagonists and their use |
GB0919594D0 (en) | 2009-11-09 | 2009-12-23 | Glaxo Group Ltd | Compounds |
US20120157494A1 (en) | 2010-12-16 | 2012-06-21 | Harris Iii Ralph New | Isoindolyl compounds |
WO2012114268A1 (en) | 2011-02-22 | 2012-08-30 | Actelion Pharmaceuticals Ltd | Benzamide derivatives as p2x7 receptor antagonists |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
ES2574840T3 (es) | 2011-07-22 | 2016-06-22 | Actelion Pharmaceuticals Ltd. | Derivados de amidas heterocíclicas como antagonistas de receptores p2x7 |
ES2618056T3 (es) | 2012-12-12 | 2017-06-20 | Actelion Pharmaceuticals Ltd. | Derivados de indol carboxamida como antagonistas del receptor P2X7 |
AR094053A1 (es) | 2012-12-18 | 2015-07-08 | Actelion Pharmaceuticals Ltd | Derivados de indol carboxamida como antagonistas del receptor p2x₇ |
ES2616114T3 (es) | 2013-01-22 | 2017-06-09 | Actelion Pharmaceuticals Ltd. | Derivados de amida heterocíclica como antagonistas del receptor P2X7 |
WO2014115078A1 (en) | 2013-01-22 | 2014-07-31 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
-
2013
- 2013-01-18 NZ NZ628910A patent/NZ628910A/en not_active IP Right Cessation
- 2013-01-18 JP JP2014552736A patent/JP6111268B2/ja not_active Expired - Fee Related
- 2013-01-18 EP EP13707053.8A patent/EP2804865B1/en active Active
- 2013-01-18 MX MX2014008736A patent/MX336247B/es unknown
- 2013-01-18 BR BR112014017735-0A patent/BR112014017735B1/pt not_active IP Right Cessation
- 2013-01-18 WO PCT/IB2013/050479 patent/WO2013108227A1/en active Application Filing
- 2013-01-18 AR ARP130100155A patent/AR089753A1/es unknown
- 2013-01-18 KR KR1020147022934A patent/KR102033190B1/ko active IP Right Grant
- 2013-01-18 CN CN201380005966.8A patent/CN104066737B/zh not_active Expired - Fee Related
- 2013-01-18 AU AU2013210682A patent/AU2013210682B2/en not_active Ceased
- 2013-01-18 CA CA2863228A patent/CA2863228C/en active Active
- 2013-01-18 US US14/373,338 patent/US9409917B2/en active Active
- 2013-01-18 EA EA201400822A patent/EA024204B1/ru not_active IP Right Cessation
- 2013-01-18 PL PL13707053T patent/PL2804865T3/pl unknown
- 2013-01-18 TW TW102102130A patent/TWI576347B/zh not_active IP Right Cessation
- 2013-01-18 SG SG11201403933UA patent/SG11201403933UA/en unknown
- 2013-01-18 ES ES13707053.8T patent/ES2563189T3/es active Active
-
2014
- 2014-06-20 PH PH12014501415A patent/PH12014501415A1/en unknown
- 2014-07-01 CL CL2014001772A patent/CL2014001772A1/es unknown
- 2014-07-16 IL IL233662A patent/IL233662A0/en unknown
- 2014-07-31 MA MA37252A patent/MA35893B1/fr unknown
- 2014-08-19 ZA ZA2014/06085A patent/ZA201406085B/en unknown
-
2015
- 2015-05-07 HK HK15104330.4A patent/HK1203932A1/zh unknown
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