HK1200844A1 - Improved assembly of bispecific antibodies - Google Patents
Improved assembly of bispecific antibodiesInfo
- Publication number
- HK1200844A1 HK1200844A1 HK15101182.9A HK15101182A HK1200844A1 HK 1200844 A1 HK1200844 A1 HK 1200844A1 HK 15101182 A HK15101182 A HK 15101182A HK 1200844 A1 HK1200844 A1 HK 1200844A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bispecific antibodies
- improved assembly
- assembly
- improved
- bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545863P | 2011-10-11 | 2011-10-11 | |
| US201161546503P | 2011-10-12 | 2011-10-12 | |
| US201161560704P | 2011-11-16 | 2011-11-16 | |
| US201261676837P | 2012-07-27 | 2012-07-27 | |
| PCT/US2012/059810 WO2013055958A1 (en) | 2011-10-11 | 2012-10-11 | Improved assembly of bispecific antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1200844A1 true HK1200844A1 (en) | 2015-08-14 |
Family
ID=47073551
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15101182.9A HK1200844A1 (en) | 2011-10-11 | 2015-02-04 | Improved assembly of bispecific antibodies |
| HK15103323.5A HK1202878A1 (en) | 2011-10-11 | 2015-04-01 | Improved assembly of bispecific antibodies |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15103323.5A HK1202878A1 (en) | 2011-10-11 | 2015-04-01 | Improved assembly of bispecific antibodies |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9862778B2 (es) |
| EP (2) | EP3418306B1 (es) |
| JP (1) | JP6216321B2 (es) |
| KR (3) | KR102219217B1 (es) |
| CN (2) | CN104093744A (es) |
| BR (1) | BR112014008684B1 (es) |
| CA (1) | CA2850818A1 (es) |
| ES (1) | ES2682081T3 (es) |
| HK (2) | HK1200844A1 (es) |
| HR (1) | HRP20181189T1 (es) |
| MX (1) | MX359384B (es) |
| PL (2) | PL2766397T3 (es) |
| RU (1) | RU2654567C2 (es) |
| SI (1) | SI2766397T1 (es) |
| TR (1) | TR201809151T4 (es) |
| WO (1) | WO2013055958A1 (es) |
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| EP3000827B1 (en) | 2013-05-22 | 2020-04-22 | Seoul National University Hospital | Anti-tnf-alpha/cxcl10 double-targeting antibody and use thereof |
| US10370776B2 (en) * | 2013-09-25 | 2019-08-06 | Idea Orchard, Llc | Antibody like protein |
| MX2016006572A (es) | 2013-11-27 | 2016-12-09 | Zymeworks Inc | Construcciones de union a antigenos biespecificas dirigidas a her2. |
| BR112016018980A2 (pt) | 2014-02-21 | 2017-10-10 | Genentech Inc | método de tratamento de um distúrbio, anticorpo multiespecífico, ácido nucleico isolado, célula hospedeira, métodos de produzir um anticorpo, de produção de uma metade de anticorpo ou de um anticorpo multiespecífico e de produção de um anticorpo multiespecífico, imunoconjugado e formulação farmacêutica |
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