HK1161876A1 - Process for the production of alpha tocotrienol and derivatives - Google Patents
Process for the production of alpha tocotrienol and derivativesInfo
- Publication number
- HK1161876A1 HK1161876A1 HK12101813.9A HK12101813A HK1161876A1 HK 1161876 A1 HK1161876 A1 HK 1161876A1 HK 12101813 A HK12101813 A HK 12101813A HK 1161876 A1 HK1161876 A1 HK 1161876A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- derivatives
- production
- alpha tocotrienol
- tocotrienol
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19758508P | 2008-10-28 | 2008-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1161876A1 true HK1161876A1 (en) | 2012-08-10 |
Family
ID=42118126
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12101813.9A HK1161876A1 (en) | 2008-10-28 | 2012-02-23 | Process for the production of alpha tocotrienol and derivatives |
| HK16107746.4A HK1219718A1 (zh) | 2008-10-28 | 2016-07-04 | 含α-生育三烯酚醌及其中間體的組合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16107746.4A HK1219718A1 (zh) | 2008-10-28 | 2016-07-04 | 含α-生育三烯酚醌及其中間體的組合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US8106223B2 (fr) |
| EP (3) | EP3450431B1 (fr) |
| JP (7) | JP5775459B2 (fr) |
| CN (2) | CN105753829B (fr) |
| BR (1) | BRPI0920414B1 (fr) |
| CA (2) | CA2741767C (fr) |
| DK (2) | DK2963006T3 (fr) |
| EA (2) | EA201692046A1 (fr) |
| ES (2) | ES2553557T3 (fr) |
| HK (2) | HK1161876A1 (fr) |
| HU (1) | HUE041714T2 (fr) |
| MX (1) | MX2011004440A (fr) |
| MY (2) | MY157119A (fr) |
| PL (2) | PL2362875T3 (fr) |
| PT (2) | PT2362875E (fr) |
| SI (1) | SI2963006T1 (fr) |
| TR (1) | TR201819154T4 (fr) |
| WO (1) | WO2010051277A1 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050065099A1 (en) | 2003-09-19 | 2005-03-24 | Gail Walkinshaw | Treatment of mitochondrial diseases |
| EP2564843B1 (fr) | 2005-06-01 | 2018-12-26 | Bioelectron Technology Corporation | Produits thérapeutiques actifs en réduction-oxydation destines au traitement de maladies mitochondriales et d'autres états ainsi que la modulation de bio-marqueurs d'énergie |
| US9278085B2 (en) | 2006-02-22 | 2016-03-08 | Edison Pharmaceuticals, Inc. | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| CA2704473C (fr) | 2007-11-06 | 2016-10-04 | Edison Pharmaceuticals, Inc. | Derives de 4-(p-quinolyl)-2-hydroxybutanamide pour le traitement de maladies mitochondriales |
| WO2009089224A1 (fr) * | 2008-01-08 | 2009-07-16 | Edison Pharmaceuticals, Inc. | Dérivés de (hét)aryl-p-quinone pour le traitement de maladies mitochondriales |
| JP5710277B2 (ja) | 2008-03-05 | 2015-04-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患の処置のための２−置換−ｐ−キノン誘導体 |
| EP2303824B1 (fr) * | 2008-06-25 | 2015-03-25 | Edison Pharmaceuticals, Inc. | Dérivés 2-hétérocyclylaminoalkyl-(p-quinone) pour traiter les maladies liées à un stress oxydatif |
| JP2012502064A (ja) | 2008-09-10 | 2012-01-26 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| WO2010045220A1 (fr) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Traitement d'affections liées au stress oxydatif, notamment de la néphropathie aux produits de contraste, des radiolésions et des perturbations de la fonction des globules rouges |
| WO2010051277A1 (fr) * | 2008-10-28 | 2010-05-06 | Edison Pharmaceuticals, Inc. | Procédé de production d'alpha-tocotriénol et de ses dérivés |
| BRPI1013376A8 (pt) | 2009-04-28 | 2017-07-11 | Edison Pharmaceuticals Inc | Uso de quinonas de tocotrienol,preparação farmacêutica compreendendo as ditas quinonas e uso desta |
| MX337990B (es) * | 2009-08-26 | 2016-03-30 | Edison Pharmaceuticals Inc | Metodos para la prevencion y tratamiento de isquemia cerebral. |
| WO2012154613A1 (fr) * | 2011-05-06 | 2012-11-15 | Edison Pharmaceuticals, Inc. | Procédé perfectionné pour la préparation de d-alpha-tocotriénol à partir d'extraits naturels |
| EP2720689A4 (fr) | 2011-06-14 | 2014-11-26 | Edison Pharmaceuticals Inc | Dérivés de catéchol pour le traitement de maladies liées au stress oxydatif |
| WO2013013078A1 (fr) | 2011-07-19 | 2013-01-24 | Edison Pharmeceuticals, Inc. | Procédés pour l'oxydation sélective d'alpha-tocotriénol en présence de tocotriénols qui ne sont pas l'alpha-tocotriénol |
| MY162508A (en) * | 2011-07-21 | 2017-06-15 | Sime Darby Malaysia Berhad | External preparation for skin |
| CA2883882A1 (fr) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Derives de benzoquinone de traitement de troubles lies au stress oxydatif |
| US8937191B2 (en) * | 2012-12-20 | 2015-01-20 | Orochem Technologies, Inc. | Recovery of highly pure alpha-tocotrienol from crude palm oil extract |
| JP2016515526A (ja) | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| CN106414580A (zh) * | 2013-11-29 | 2017-02-15 | 沙特基础工业公司 | 稳定化的聚烯烃组合物 |
| US9512098B1 (en) | 2014-02-03 | 2016-12-06 | Board Of Trustees Of The University Of Arkansas | Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates |
| CN104262315A (zh) * | 2014-09-05 | 2015-01-07 | 宁波大红鹰生物工程股份有限公司 | 一种生育三烯酚的分离提纯方法 |
| ES2912585T3 (es) | 2014-12-16 | 2022-05-26 | Ptc Therapeutics Inc | Formas polimórficas y amorfas de la (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida |
| JP2018502127A (ja) | 2015-01-12 | 2018-01-25 | バイオエレクトロン テクノロジー コーポレイション | 放射線被曝に対する防護のためのキノン |
| JP7117241B2 (ja) * | 2015-12-16 | 2022-08-12 | ピーティーシー セラピューティクス， インコーポレイテッド | 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法 |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| CA3011293A1 (fr) | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Derives de tocopherol et de tocotrienol quinone pour augmenter les niveaux de thiosulfate ou reduire les niveaux de sulfure d'hydrogene |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| WO2018191732A1 (fr) | 2017-04-14 | 2018-10-18 | Bioelectron Technology Corporation | Méthodes et compositions pour le traitement d'une inflammation et du stress oxydatif |
| DK3866772T3 (da) | 2018-10-17 | 2024-01-15 | Ptc Therapeutics Inc | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-dien-1,4-dion til undertrykkelse og behandling af alpha-synucleinopathier, tauopathier og andre lidelser |
| WO2021067836A1 (fr) | 2019-10-04 | 2021-04-08 | Stealth Biotherapeutics Corp | Analogues chinone, hydrochinone et naphtochinone de vatiquinone pour le traitement de maladies à troubles mitochondriaux |
| EP4126836A1 (fr) | 2020-04-03 | 2023-02-08 | Stealth BioTherapeutics Inc. | Compositions et méthodes pour la prévention et/ou le traitement d'une maladie mitochondriale, notamment l'ataxie de friedreich |
| KR20240032997A (ko) | 2021-07-08 | 2024-03-12 | 피티씨 테라퓨틱스, 인크. | 2,3,5-트리메틸-6-노닐사이클로헥사-2,5-디엔-1,4-디온을 포함하는 약제학적 조성물 |
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