HK1157755A1 - Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) (adp-)(parp) - Google Patents

Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) (adp-)(parp)

Info

Publication number
HK1157755A1
HK1157755A1 HK11111926.3A HK11111926A HK1157755A1 HK 1157755 A1 HK1157755 A1 HK 1157755A1 HK 11111926 A HK11111926 A HK 11111926A HK 1157755 A1 HK1157755 A1 HK 1157755A1
Authority
HK
Hong Kong
Prior art keywords
parp
adp
ribose
polymerase
poly
Prior art date
Application number
HK11111926.3A
Other languages
English (en)
Chinese (zh)
Inventor
Bing Wang
Daniel Chu
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of HK1157755A1 publication Critical patent/HK1157755A1/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

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HK11111926.3A 2008-08-06 2011-11-04 Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) (adp-)(parp) HK1157755A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8668708P 2008-08-06 2008-08-06
US15103609P 2009-02-09 2009-02-09
US17308809P 2009-04-27 2009-04-27
PCT/US2009/051879 WO2010017055A2 (en) 2008-08-06 2009-07-27 Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)

Publications (1)

Publication Number Publication Date
HK1157755A1 true HK1157755A1 (en) 2012-07-06

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ID=41129519

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11111926.3A HK1157755A1 (en) 2008-08-06 2011-11-04 Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) (adp-)(parp)
HK15101138.4A HK1200813A1 (en) 2008-08-06 2015-02-03 Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) (adp-)(parp)

Family Applications After (1)

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HK15101138.4A HK1200813A1 (en) 2008-08-06 2015-02-03 Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) (adp-)(parp)

Country Status (31)

Country Link
US (7) US8012976B2 (ko)
EP (3) EP2767537B1 (ko)
JP (3) JP5984389B2 (ko)
KR (1) KR101846029B1 (ko)
CN (3) CN102171214B (ko)
AR (1) AR072970A1 (ko)
AU (1) AU2009279944B2 (ko)
BR (1) BRPI0917119B1 (ko)
CA (1) CA2732797C (ko)
CY (3) CY1115022T1 (ko)
DK (2) DK2767537T3 (ko)
ES (2) ES2625817T3 (ko)
FR (1) FR19C1071I2 (ko)
GB (1) GB2462361A (ko)
HK (2) HK1157755A1 (ko)
HR (1) HRP20170982T1 (ko)
HU (2) HUE035295T2 (ko)
IL (1) IL211070A (ko)
LT (2) LT2767537T (ko)
LU (1) LUC00140I2 (ko)
MX (1) MX2011001328A (ko)
NL (1) NL301021I2 (ko)
NO (1) NO2019042I1 (ko)
NZ (1) NZ591166A (ko)
PL (2) PL2767537T3 (ko)
PT (2) PT2326650E (ko)
SG (2) SG10201809895YA (ko)
SI (2) SI2767537T1 (ko)
TW (2) TWI448464B (ko)
WO (1) WO2010017055A2 (ko)
ZA (1) ZA201100897B (ko)

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WO2013028495A1 (en) * 2011-08-19 2013-02-28 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma
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DK2797921T3 (en) * 2011-12-31 2017-10-02 Beigene Ltd FUSED TETRA- OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARB INHIBITORS
JP2015511936A (ja) 2012-01-20 2015-04-23 ブラウン、デニス 多形神経膠芽腫及び髄芽腫を含む新生物疾患及び癌幹細胞を処置するためのジアンヒドロガラクチトール及び類似体を含めた置換ヘキシトールの使用
CN108478577A (zh) 2012-04-05 2018-09-04 沃泰克斯药物股份有限公司 可用作atr激酶抑制剂的化合物及其组合疗法
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