HK1127898A1 - A peptide composition comprising immunogenicity used for preventing and treating alzheimer's disease - Google Patents
A peptide composition comprising immunogenicity used for preventing and treating alzheimer's diseaseInfo
- Publication number
- HK1127898A1 HK1127898A1 HK09107043.3A HK09107043A HK1127898A1 HK 1127898 A1 HK1127898 A1 HK 1127898A1 HK 09107043 A HK09107043 A HK 09107043A HK 1127898 A1 HK1127898 A1 HK 1127898A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- peptide
- disease
- alzheimer
- soluble
- reactive
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 4
- 230000005847 immunogenicity Effects 0.000 title 1
- 230000002163 immunogen Effects 0.000 abstract 4
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000004898 n-terminal fragment Anatomy 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/865,294 US6906169B2 (en) | 2001-05-25 | 2001-05-25 | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1127898A1 true HK1127898A1 (en) | 2009-10-09 |
Family
ID=25345158
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05102035.8A HK1068215A1 (en) | 2001-05-25 | 2005-03-08 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
HK09107043.3A HK1127898A1 (en) | 2001-05-25 | 2005-03-08 | A peptide composition comprising immunogenicity used for preventing and treating alzheimer's disease |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05102035.8A HK1068215A1 (en) | 2001-05-25 | 2005-03-08 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
Country Status (16)
Country | Link |
---|---|
US (3) | US6906169B2 (pt) |
EP (2) | EP2123671B1 (pt) |
JP (3) | JP4440544B2 (pt) |
CN (2) | CN101372511B (pt) |
AT (2) | ATE474000T1 (pt) |
AU (2) | AU2002303211B2 (pt) |
BR (1) | BRPI0210010B8 (pt) |
CA (2) | CA2448171A1 (pt) |
DE (2) | DE60237044D1 (pt) |
DK (2) | DK1497313T3 (pt) |
ES (2) | ES2348975T3 (pt) |
HK (2) | HK1068215A1 (pt) |
MX (1) | MXPA03010631A (pt) |
TW (1) | TWI252233B (pt) |
WO (1) | WO2002096350A2 (pt) |
ZA (1) | ZA200308767B (pt) |
Families Citing this family (78)
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US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US20050059591A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US20030147882A1 (en) * | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
KR100879810B1 (ko) * | 2000-02-21 | 2009-01-22 | 하. 룬드벡 아크티에셀스카브 | 아밀로이드의 하향-조절을 위한 신규한 방법 |
JP5025871B2 (ja) * | 2000-02-21 | 2012-09-12 | エイチ.リュンドベック エイ/エス | アミロイドの新規なダウン−レギュレート方法 |
TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
CA2466841A1 (en) * | 2001-11-21 | 2003-06-05 | New York University | Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid .beta., prion protein, amylin, .alpha.-synuclein, or polyglutamine repeats for induction of an immune response thereto |
US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
US20040001848A1 (en) * | 2002-03-01 | 2004-01-01 | Szu-Yi Chou | Method of producing disease-specific antigens |
MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
EP2330113B1 (en) * | 2002-04-19 | 2016-06-29 | The Governing Council Of The University Of Toronto | Immunological methods and compositions for the treatment of Alzheimer's disease |
JP2006513259A (ja) * | 2002-07-24 | 2006-04-20 | イノジェネティックス・ナムローゼ・フェンノートシャップ | ベータ−アミロイド生成および/または凝集に関連した疾病の防止、処置および診断 |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
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EP2460813A1 (en) | 2003-12-17 | 2012-06-06 | Janssen Alzheimer Immunotherapy | A beta immunogenic peptide carrier conjugates and methods of producing same |
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CU23297A1 (es) * | 2004-11-16 | 2008-07-24 | Ct De Inmunologa A Molecular | Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer |
GB0427267D0 (en) * | 2004-12-13 | 2005-01-12 | Maria Teresa De Magistris | Peptide adjuvants |
ES2396555T3 (es) * | 2004-12-15 | 2013-02-22 | Janssen Alzheimer Immunotherapy | Anticuerpos que reconocen péptido beta amiloide |
US8916165B2 (en) * | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
US20060257396A1 (en) * | 2004-12-15 | 2006-11-16 | Jacobsen Jack S | Abeta antibodies for use in improving cognition |
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KR20140087058A (ko) | 2005-11-30 | 2014-07-08 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
EP1959991B1 (en) * | 2005-12-12 | 2013-03-20 | AC Immune S.A. | Therapeutic vaccine |
GB0613977D0 (en) * | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
JP5097695B2 (ja) * | 2006-02-22 | 2012-12-12 | 株式会社林原 | 抗アミロイドβペプチド抗体産生誘導用のペプチドワクチン |
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US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
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US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
AU2008242648B2 (en) * | 2007-04-18 | 2013-09-12 | Janssen Alzheimer Immunotherapy | Prevention and treatment of cerebral amyloid angiopathy |
US8106015B2 (en) | 2007-04-20 | 2012-01-31 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Method for enhancing immune response with peptide |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
EP2106802A1 (en) | 2008-04-02 | 2009-10-07 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Modified peptides as synthetic vaccines in amyloid-associated disease |
JP5559789B2 (ja) | 2008-08-07 | 2014-07-23 | マーシア・ファーマ・インコーポレイテッド | アルツハイマー病の処置のための免疫治療組成物 |
WO2010080188A2 (en) * | 2008-10-14 | 2010-07-15 | The Regents Of The University Of Michigan | Epitope targeted anthrax vaccine |
KR101640147B1 (ko) * | 2008-10-16 | 2016-07-18 | 잇빤 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 변성된 아밀로이드 베타 펩티드 |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
DE102008037564A1 (de) * | 2008-11-19 | 2010-05-20 | Forschungszentrum Jülich GmbH | Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden |
EP2440234A4 (en) | 2009-06-10 | 2013-11-06 | Univ New York | IMMUNOLOGICAL TARGETING OF PATHOLOGICAL TAU PROTEINS |
US20110221240A1 (en) * | 2010-03-11 | 2011-09-15 | Ziming Shen | Compact children's table and stool set |
ES2684475T3 (es) | 2010-04-15 | 2018-10-03 | Abbvie Inc. | Proteínas que se unen a beta amiloide |
WO2012005732A1 (en) | 2010-07-08 | 2012-01-12 | United Biomedical, Inc | Designer peptide-based pcv2 vaccine |
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US20120328605A1 (en) * | 2010-10-27 | 2012-12-27 | Daniel Larocque | Compositions and uses |
GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
CN102775478B (zh) * | 2012-08-10 | 2013-06-19 | 申联生物医药(上海)有限公司 | 口蹄疫病毒抗原多肽及疫苗 |
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JP2021508672A (ja) * | 2017-06-16 | 2021-03-11 | ユナイテッド ニューロサイエンスUnited Neuroscience | シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のc末端からのペプチド免疫原及びその製剤 |
AU2018355574A1 (en) * | 2017-10-27 | 2020-05-14 | United Neuroscience | Tau peptide immunogen constructs |
JP7239203B2 (ja) * | 2017-12-31 | 2023-03-14 | ユナイテッド・バイオメディカル・インコーポレーテッド | IgE媒介型アレルギー性疾患治療のための、膜結合型IgEを標的とするペプチド免疫原及びそれらの製剤 |
MX2020011733A (es) * | 2018-05-04 | 2021-01-15 | Ubi Ip Holdings | Epítopos de células t cooperadoras promiscuos artificiales que facilitan la producción de anticuerpos diana con respuesta inflamatoria de células t limitada. |
AU2019354291A1 (en) * | 2018-10-01 | 2021-05-06 | United Neuroscience | Peptide immunogen constructs directed against dipeptide repeat proteins from C9ORF72 |
CN110684122B (zh) * | 2019-10-29 | 2021-03-02 | 中国人民解放军军事科学院军事医学研究院 | 重组Tau表位嵌合多聚体抗原、其制备方法和应用 |
CN113603773B (zh) * | 2021-08-17 | 2023-05-09 | 中国医科大学附属第一医院 | 靶向淀粉样蛋白的单克隆抗体7b8、分泌该抗体的杂交瘤细胞株及应用 |
TW202323275A (zh) * | 2021-09-01 | 2023-06-16 | 美商瓦辛尼帝股份有限公司 | 預防及治療突觸核蛋白病的方法 |
CN116063447B (zh) * | 2022-09-13 | 2023-11-03 | 北京湃德智健科技有限公司 | 用于检测adap自身抗体的抗原多肽及其应用 |
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US5753624A (en) * | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
CA2081482C (en) | 1990-04-27 | 2000-11-21 | Ellis L. Kline | Method and composition for treatment of central nervous system disease states associated with abnormal amyloid beta protein molecular organization |
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US5955317A (en) * | 1993-01-25 | 1999-09-21 | Takeda Chemical Industries, Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
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JP3795914B2 (ja) * | 1993-04-27 | 2006-07-12 | ユナイテッド・バイオメディカル・インコーポレイテッド | ワクチン用免疫原性lhrhペプチド構築体および合成普遍免疫刺激器 |
WO1994028412A1 (en) * | 1993-05-28 | 1994-12-08 | The Miriam Hospital | Composition and method for in vivo imaging of amyloid deposits |
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US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US6025468A (en) | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
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UA81216C2 (en) * | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
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PT1237930E (pt) * | 1999-12-08 | 2007-02-28 | Intellect Neurosciences Inc | Péptidos beta amiloides quiméricos |
US20030165481A1 (en) | 2000-02-24 | 2003-09-04 | Hersh Louis B. | Amyloid peptide inactivating enzyme to treat Alzheimer's disease |
US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
-
2001
- 2001-05-25 US US09/865,294 patent/US6906169B2/en not_active Expired - Lifetime
-
2002
- 2002-03-18 TW TW091105087A patent/TWI252233B/zh not_active IP Right Cessation
- 2002-04-02 BR BR0210010-0 patent/BRPI0210010B8/pt not_active IP Right Cessation
- 2002-04-02 CN CN2008101692748A patent/CN101372511B/zh not_active Expired - Fee Related
- 2002-04-02 CA CA002448171A patent/CA2448171A1/en not_active Abandoned
- 2002-04-02 WO PCT/US2002/010293 patent/WO2002096350A2/en active Search and Examination
- 2002-04-02 AT AT02731223T patent/ATE474000T1/de active
- 2002-04-02 DE DE60237044T patent/DE60237044D1/de not_active Expired - Lifetime
- 2002-04-02 AT AT09168110T patent/ATE496937T1/de active
- 2002-04-02 DK DK02731223.0T patent/DK1497313T3/da active
- 2002-04-02 MX MXPA03010631A patent/MXPA03010631A/es active IP Right Grant
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2003
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2004
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