HK1126799A1 - Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof - Google Patents
Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereofInfo
- Publication number
- HK1126799A1 HK1126799A1 HK09105854A HK09105854A HK1126799A1 HK 1126799 A1 HK1126799 A1 HK 1126799A1 HK 09105854 A HK09105854 A HK 09105854A HK 09105854 A HK09105854 A HK 09105854A HK 1126799 A1 HK1126799 A1 HK 1126799A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- influenza virus
- binding molecules
- molecules capable
- human binding
- neutralizing influenza
- Prior art date
Links
- 230000003472 neutralizing effect Effects 0.000 title 1
- 241000712461 unidentified influenza virus Species 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/00061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84293006P | 2006-09-07 | 2006-09-07 | |
EP06120316 | 2006-09-07 | ||
EP06120644 | 2006-09-14 | ||
EP06125107 | 2006-11-30 | ||
EP07111235 | 2007-06-28 | ||
PCT/EP2007/059356 WO2008028946A2 (fr) | 2006-09-07 | 2007-09-06 | Molécules de liaison humaines capables de neutraliser le virus de la grippe h5n1 et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1126799A1 true HK1126799A1 (en) | 2009-09-11 |
Family
ID=39027173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09105854A HK1126799A1 (en) | 2006-09-07 | 2009-06-30 | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
Country Status (16)
Country | Link |
---|---|
US (5) | US8192927B2 (fr) |
EP (2) | EP2059532B1 (fr) |
JP (2) | JP5161882B2 (fr) |
KR (1) | KR101485197B1 (fr) |
AU (1) | AU2007293662B2 (fr) |
CA (1) | CA2663388C (fr) |
EA (1) | EA017203B1 (fr) |
HK (1) | HK1126799A1 (fr) |
HR (1) | HRP20130163T1 (fr) |
IL (2) | IL197390A (fr) |
MX (1) | MX2009002174A (fr) |
MY (1) | MY170607A (fr) |
NO (1) | NO20091321L (fr) |
PL (1) | PL2059532T3 (fr) |
WO (1) | WO2008028946A2 (fr) |
ZA (1) | ZA200901171B (fr) |
Families Citing this family (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
JP4836451B2 (ja) | 2002-07-18 | 2011-12-14 | メルス ベー ヴェー | 抗体混合物の組換え生産 |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
CA2527694C (fr) | 2003-05-30 | 2015-07-14 | Hendricus Renerus Jacobus Mattheus Hoogenboom | Banque de fab pour la preparation de fab anti-vegf et antirabique |
SG128680A1 (en) * | 2003-07-22 | 2007-01-30 | Crucell Holland Bv | Binding molecules against sars-coronavirus and uses thereof |
NZ580607A (en) | 2004-05-27 | 2011-05-27 | Crucell Holland Bv | Binding molecules capable of neutralizing rabies virus and uses thereof |
EP1799259B1 (fr) * | 2004-10-12 | 2012-12-05 | Crucell Holland B.V. | Molécules de liaison pour la détection de cancer |
US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
CA2608058C (fr) | 2005-05-12 | 2013-09-10 | Crucell Holland B.V. | Molecules de liaison specifiques de cellule hote capables de neutraliser des virus et leurs utilisations |
US8148085B2 (en) | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
AU2007255384B2 (en) * | 2006-06-06 | 2012-09-27 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
KR101485197B1 (ko) | 2006-09-07 | 2015-01-23 | 크루셀 홀란드 비.브이. | 인플루엔자 바이러스 h5n1을 중화시킬 수 있는 인간 결합분자 및 그것의 용도 |
CN102046654A (zh) | 2007-03-13 | 2011-05-04 | 胡马斯有限公司 | 针对甲型流感病毒h5n1株系的抗体 |
EP2132312B1 (fr) | 2007-03-27 | 2016-01-27 | Sea Lane Biotechnologies,llc. | Constructions et bibliothèques comprenant des séquences de chaînes légères de substitution d'anticorps |
WO2009006931A1 (fr) * | 2007-07-11 | 2009-01-15 | Cairos Technologies Ag | Procédé de suivi vidéo et appareil pour exécuter le procédé |
AU2008297594B2 (en) | 2007-09-13 | 2013-06-20 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof |
WO2009035412A1 (fr) | 2007-09-13 | 2009-03-19 | Temasek Life Sciences Laboratory Limited | Anticorps monoclonaux spécifiques de l'hémagglutinine pour le sous-type h5 du virus de la grippe et leurs utilisations |
WO2009079259A2 (fr) | 2007-12-06 | 2009-06-25 | Dana-Farber Cancer Institute, Inc. | Anticorps contre le virus de la grippe et procédés pour leur utilisation |
ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
CN102046656A (zh) | 2008-03-28 | 2011-05-04 | 航道生物技术有限责任公司 | 针对病毒抗原的中和性分子 |
CN101550188B (zh) * | 2008-04-01 | 2012-05-02 | 南方医科大学 | H5亚型禽流感病毒h5n1血凝素单克隆抗体及其核苷酸序列和制备方法 |
ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
RU2553325C2 (ru) * | 2008-07-25 | 2015-06-10 | Институт Фо Ресёч Ин Биомедицин | Нейтрализующие антитела против вируса гриппа а и их использование |
US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
GB0818356D0 (en) * | 2008-10-07 | 2008-11-12 | Istituto Superiore Di Sanito | Antibodies |
TWI381848B (zh) * | 2008-10-20 | 2013-01-11 | Imclone Llc | 抗纖維母細胞生長因子受體-3 (fgfr-3) 抗體及包含其之醫藥組合物 |
JP5837820B2 (ja) | 2008-10-22 | 2015-12-24 | インスティテュート・フォー・リサーチ・イン・バイオメディシンInstitute For Research In Biomedicine | 形質細胞から抗体を産生する方法 |
JP5933975B2 (ja) * | 2008-11-12 | 2016-06-15 | メディミューン,エルエルシー | 抗体製剤 |
SG172333A1 (en) * | 2008-12-24 | 2011-07-28 | Temasek Life Sciences Lab Ltd | Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza a viruses and uses thereof |
JP2012521786A (ja) | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
US8894997B2 (en) | 2009-04-30 | 2014-11-25 | Vanderbilt University | Monoclonal antibodies to influenza H1N1 virus uses thereof |
JP5813629B2 (ja) * | 2009-05-11 | 2015-11-17 | クルセル ホランド ベー ヴェー | インフルエンザウイルスh3n2を中和可能なヒト抗体及び/または抗原結合フラグメントおよびその使用 |
EP2430047B1 (fr) * | 2009-05-13 | 2018-03-28 | i2 Pharmaceuticals, Inc. | Molécules neutralisantes dirigées contre les virus de la grippe |
EP2435475B1 (fr) | 2009-05-26 | 2018-10-17 | Icahn School of Medicine at Mount Sinai | Anticorps monoclonaux dirigés contre le virus de la grippe, générés par administration cyclique, et leurs utilisations |
EP2464383A4 (fr) * | 2009-08-14 | 2013-02-13 | Theraclone Sciences Inc | Compositions et méthodes utilisables dans le cadre du traitement et du diagnostic de la grippe |
WO2011044570A2 (fr) | 2009-10-09 | 2011-04-14 | Emory University | Anticorps recombinants contre la grippe h1n1 |
WO2011094445A1 (fr) * | 2010-01-27 | 2011-08-04 | Massachusetts Institute Of Technology | Agents polypeptidiques techniques pour la neutralisation de la grippe à large spectre ciblée |
BR112012020839A2 (pt) | 2010-02-18 | 2017-11-21 | Sinai School Medicine | vacinas para uso na profilaxe e tratamento de doença de vírus da influenza |
MX338758B (es) * | 2010-03-08 | 2016-04-29 | Celltrion Inc | Anticuerpos monoclonales humanos, derivados de celulas b humanas, y que tienen actividad neutralizante contra el virus de la influenza a. |
EP2552479A4 (fr) | 2010-03-30 | 2015-03-04 | Sinai School Medicine | Vaccins contre le virus de la grippe et utilisations associées |
CN102241768B (zh) * | 2010-05-14 | 2013-12-25 | 中国科学院上海生命科学研究院 | 一种抗甲型h1n1流感病毒血凝素蛋白的抗体 |
KR101849738B1 (ko) | 2010-06-17 | 2018-04-17 | 트렐리스 바이오싸이언스 인코포레이티드 | 수동 인플루엔자 면역에 유용한 항체 |
AU2011282423B2 (en) | 2010-07-22 | 2015-05-14 | Schrader, Sabariah | Cross-protective pathogen protection, methods and compositions thereof |
EP3578205A1 (fr) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | Compositions pharmaceutiques a base d'acides nucléiques modifiés et leur utilisation medicale |
EP2603237A4 (fr) * | 2010-08-12 | 2014-05-21 | Theraclone Sciences Inc | Compositions d'anticorps anti-hemagglutinine et ses méthodes d'utilisation |
US9534042B2 (en) | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
EP2616545B1 (fr) * | 2010-09-14 | 2018-08-29 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Antigènes contre la grippe à réactivité large optimisés par ordinateur |
NZ608972A (en) | 2010-10-01 | 2015-09-25 | Moderna Therapeutics Inc | Engineered nucleic acids and methods of use thereof |
US9469685B2 (en) * | 2011-01-10 | 2016-10-18 | Emory University | Antibodies directed against influenza |
SG192727A1 (en) | 2011-02-14 | 2013-09-30 | Theraclone Sciences Inc | Compositions and methods for the therapy and diagnosis of influenza |
JP2014509588A (ja) * | 2011-03-01 | 2014-04-21 | アムジエン・インコーポレーテツド | 二特異性結合剤 |
US8710200B2 (en) | 2011-03-31 | 2014-04-29 | Moderna Therapeutics, Inc. | Engineered nucleic acids encoding a modified erythropoietin and their expression |
JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
AU2012273039B2 (en) | 2011-06-20 | 2016-12-01 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for H1N1 influenza |
EA027054B1 (ru) | 2011-07-14 | 2017-06-30 | Круселл Холланд Б.В. | Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b |
HUE051756T2 (hu) | 2011-07-18 | 2021-03-29 | Inst Res Biomedicine | Influenza A vírus elleni semlegesítõ antitestek és alkalmazásuk |
EP2736928B1 (fr) | 2011-07-28 | 2019-01-09 | i2 Pharmaceuticals, Inc. | Proteines "sur"-liantes dirigees contre erbb3 |
US20130084301A1 (en) * | 2011-08-30 | 2013-04-04 | Steven Foung | Cluster of Neutralizing Antibodies to Hepatitis C Virus |
GB201115214D0 (en) | 2011-09-02 | 2011-10-19 | Health Prot Agency | Influenza virus antibody compositions |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
JP6498439B2 (ja) | 2011-09-20 | 2019-04-17 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン及びその使用 |
CA2791109C (fr) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation de molecules de liaison |
CA2850624A1 (fr) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Nucleosides, nucleotides et acides nucleiques modifies, et leurs utilisations |
US9321829B2 (en) | 2011-10-18 | 2016-04-26 | Emory University | Antibodies directed against influenza |
MY170927A (en) | 2011-11-28 | 2019-09-19 | Janssen Vaccines & Prevention Bv | Influenza virus vaccines and uses thereof |
US9718874B2 (en) | 2011-12-02 | 2017-08-01 | Aimm Therapeutics B.V. | Influenza A virus specific antibodies |
EP2793945B1 (fr) | 2011-12-05 | 2018-08-15 | Trellis Bioscience, LLC | Anticorps utiles dans l'immunisation passive contre la grippe |
WO2013089496A1 (fr) * | 2011-12-15 | 2013-06-20 | (주)에이프로젠 | Anticorps monoclonal neutralisant à large spectre ayant un potentiel élevé issu de patients infectés par h1n1, et composition contenant celui-ci pour le traitement du virus |
CN110201187A (zh) | 2011-12-16 | 2019-09-06 | 现代泰克斯公司 | 经修饰的核苷、核苷酸和核酸组合物 |
CA2859744A1 (fr) | 2011-12-22 | 2013-06-27 | Sea Lane Biotechnologies, Llc | Proteines substitutives de liaison |
RU2653756C2 (ru) | 2012-02-07 | 2018-05-14 | Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн | Оптимизированные с помощью компьютера антигены с широким спектром реактивности для вирусов гриппа h3n2 |
US9566327B2 (en) | 2012-02-13 | 2017-02-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for human and avian H5N1 influenza |
US8834881B2 (en) | 2012-03-08 | 2014-09-16 | Crucell Holland B.V. | Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof |
MX345150B (es) | 2012-03-30 | 2017-01-18 | Univ Of Pittsburgh - Of The Commonwealth System Of Higher Education | Antigenos ampliamente reactivos computacionalmente optimizados para virus de influenza h5n1 y h1n1. |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
AU2013243952A1 (en) | 2012-04-02 | 2014-10-30 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
JP6272299B2 (ja) | 2012-04-20 | 2018-01-31 | メルス ナムローゼ フェンノートシャップ | Ig様分子を生産する方法、Ig様分子の混合物、組み換え宿主細胞、医薬組成物、宿主細胞を作成する方法、および培養物 |
US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
EP2712626A1 (fr) | 2012-09-28 | 2014-04-02 | Fabentech | Immunisation passive contre la grippe, en particulier H5N1 |
EP3461501A1 (fr) | 2012-11-13 | 2019-04-03 | F. Hoffmann-La Roche AG | Anticorps anti-hémagglutinine et procédés d'utilisation |
PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
WO2014085616A1 (fr) | 2012-11-27 | 2014-06-05 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Antigènes largement réactifs optimisés par ordinateur pour la grippe h1n1 |
MX2015007755A (es) | 2012-12-18 | 2016-01-14 | Icahn School Med Mount Sinai | Vacunas contra virus de la influenza y sus usos. |
US9624272B2 (en) | 2013-03-14 | 2017-04-18 | University Of Washington Through Its Center For Commercialization | Polypeptides for treating and/or limiting influenza infection |
WO2014159960A1 (fr) * | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Anticorps contre l'hémagglutinine du virus de la grippe et utilisations correspondantes |
MX2015012397A (es) | 2013-03-14 | 2016-07-26 | Contrafect Corp | Composiciones y metodos basados en anticuerpos neutralizados suministrados intranasalmente para eficacia terapeutica aumentada. |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
EP2982691B1 (fr) | 2013-04-02 | 2020-05-06 | Xiamen University | Anticorps monoclonal à spectre large identifiant le domaine structurel ha1 des protéines d'hémagglutinine de virus de la grippe |
WO2014191435A1 (fr) | 2013-05-30 | 2014-12-04 | Crucell Holland B.V. | Vaccins contre le virus influenza et leurs utilisations |
JPWO2015025900A1 (ja) | 2013-08-23 | 2017-03-02 | 学校法人藤田学園 | 抗インフルエンザウイルス中和抗体 |
EP3037819A4 (fr) * | 2013-08-23 | 2017-03-29 | Fujita Health University | Procédé de détermination de la résistance au virus de la grippe |
WO2015048744A2 (fr) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucléotides codant des polypeptides de modulation immunitaire |
EP3733244A1 (fr) | 2013-10-02 | 2020-11-04 | Medlmmune, LLC | Anticorps neutralisant la grippe a et leurs utilisations |
US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
US20160264648A1 (en) * | 2013-11-06 | 2016-09-15 | Osaka University | Antibody having broad neutralization activity against group 1 influenza a viruses |
US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
WO2015120097A2 (fr) | 2014-02-04 | 2015-08-13 | Contrafect Corporation | Anticorps utiles dans l'immunisation passive contre la grippe, et compositions, combinaisons et leurs méthodes d'utilisation |
WO2015120474A1 (fr) | 2014-02-10 | 2015-08-13 | Igm Biosciences, Inc. | Molécules de liaison multispécifiques iga |
EP3119804A2 (fr) | 2014-03-19 | 2017-01-25 | Dana-Farber Cancer Institute, Inc. | Restriction immunogénétique sur l'élicitation des anticorps |
SG11201608798YA (en) | 2014-04-23 | 2016-11-29 | Modernatx Inc | Nucleic acid vaccines |
MY187261A (en) | 2014-07-10 | 2021-09-16 | Janssen Vaccines & Prevention Bv | Influenza virus vaccines and uses thereof |
SG11201610456UA (en) * | 2014-07-10 | 2017-01-27 | Janssen Vaccines & Prevention Bv | Influenza virus vaccines and uses thereof |
AU2015289805B2 (en) | 2014-07-15 | 2020-06-25 | Humabs Biomed Sa | Neutralizing anti-influenza B antibodies and uses thereof |
TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
US10370435B2 (en) | 2015-02-05 | 2019-08-06 | Janssen Vaccines & Prevention B.V. | Binding molecules directed against influenza hemagglutinin and uses thereof |
WO2016124682A1 (fr) | 2015-02-05 | 2016-08-11 | Janssen Vaccines & Prevention B.V. | Anticorps neutralisants humains se liant à la neuraminidase de la grippe |
WO2016180826A1 (fr) | 2015-05-11 | 2016-11-17 | Janssen Vaccines & Prevention B.V. | Composés peptidomimétiques neutralisant le virus influenza |
RS62446B1 (sr) | 2015-06-01 | 2021-11-30 | Medimmune Llc | Neutrališući vezujući molekuli protiv gripa i njihova primena |
WO2017083627A1 (fr) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions et méthodes pour traiter et prévenir la grippe |
CA3010313A1 (fr) | 2016-01-13 | 2017-07-20 | Medimmune, Llc | Methode de traitement de la grippe a |
US10703803B2 (en) | 2016-03-01 | 2020-07-07 | Janssen Vaccines & Prevention B.V. | Human neutralizing antibodies binding to influenza B neuraminidase |
WO2017218624A1 (fr) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Hémagglutinines du virus de la grippe et utilisations de celles-ci |
KR101835009B1 (ko) | 2016-08-19 | 2018-03-07 | 주식회사 하이딥 | 터치 입력 장치 |
WO2018075954A2 (fr) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anticorps contre le virus respiratoire syncytial et leurs méthodes de génération et d'utilisation |
AU2017345786A1 (en) * | 2016-10-21 | 2019-05-23 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
IL293585B2 (en) | 2016-10-21 | 2023-11-01 | Adimab Llc | Respiratory syncytial virus antibodies and methods for their production and use |
AU2017350304B2 (en) | 2016-10-27 | 2022-03-03 | Janssen Vaccines & Prevention B.V. | Influenza virus neutralizing compounds |
EP3574008B1 (fr) | 2017-01-27 | 2023-11-08 | National Research Council of Canada | Anticorps spécifiques de l'hémagglutinine et leurs utilisations |
JP2020506192A (ja) | 2017-02-02 | 2020-02-27 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | インフルエンザウイルスを阻害するためのピペラジン誘導体 |
WO2018141854A1 (fr) | 2017-02-02 | 2018-08-09 | Janssen Vaccines & Prevention B.V. | Dérivés de pipérazine pour l'inhibition du virus de la grippe |
SG11201907299XA (en) | 2017-02-08 | 2019-09-27 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
CN110944661A (zh) | 2017-02-20 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 结合her2、nkg2d和cd16的蛋白质 |
CN110352201A (zh) | 2017-04-03 | 2019-10-18 | 免疫医疗公司 | 用于癌症疗法的抗体药物缀合物的皮下施用 |
US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
WO2019035630A2 (fr) * | 2017-08-14 | 2019-02-21 | 사회복지법인 삼성생명공익재단 | Anticorps se liant au variant iii du récepteur du facteur de croissance épidermique humain et fragment de celui-ci |
EP4279086A3 (fr) | 2017-09-15 | 2024-02-28 | Lentigen Technology, Inc. | Compositions et méthodes pour le traitement du cancer avec une immunothérapie anti-cd19 |
KR20200113226A (ko) | 2018-01-23 | 2020-10-06 | 얀센 백신스 앤드 프리벤션 비.브이. | 인플루엔자 바이러스 백신 및 이의 용도 |
MX2020007772A (es) | 2018-01-26 | 2020-09-18 | Regeneron Pharma | Anticuerpos humanos contra hemaglutinina de influenza. |
EP3749346A4 (fr) | 2018-02-08 | 2021-12-15 | Dragonfly Therapeutics, Inc. | Domaines variables d'anticorps ciblant le récepteur nkg2d |
CN111057718A (zh) * | 2018-10-17 | 2020-04-24 | 南京大学 | 一种稳定表达绿色荧光蛋白的egfp-sp2/0细胞株及其构建方法 |
KR102113302B1 (ko) * | 2018-12-24 | 2020-05-20 | 원광대학교산학협력단 | 상보성결정부 기반 조류 인플루엔자 바이러스의 h5 아형에 특이적으로 결합하는 펩티드 및 이의 용도 |
US11230593B2 (en) | 2019-03-25 | 2022-01-25 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
CN114430742A (zh) | 2019-09-05 | 2022-05-03 | 扬森疫苗与预防公司 | 流感病毒疫苗及其用途 |
WO2021173965A1 (fr) | 2020-02-28 | 2021-09-02 | Massachusetts Institute Of Technology | Identification de résidus de grippe variables et leurs utilisations |
CN111440228B (zh) * | 2020-03-09 | 2021-08-24 | 扬州大学 | 多种亚型流感病毒ha2蛋白共同抗原表位、抗体、鉴定方法和应用 |
WO2021201677A1 (fr) | 2020-04-01 | 2021-10-07 | Kiadis Pharma Intellectual Property B.V. | Compositions et procédés ciblant la grippe |
WO2021216103A1 (fr) * | 2020-04-20 | 2021-10-28 | Mahna Satish | Exposition commandée à des agents pathogènes pour générer une immunité |
CN116761605A (zh) | 2021-02-04 | 2023-09-15 | 四川海思科制药有限公司 | Ha抑制剂化合物的盐及晶型 |
TW202309075A (zh) * | 2021-04-30 | 2023-03-01 | 美商亞得捷歐治療公司 | 對冠狀病毒s蛋白質具特異性之化合物及其用途 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA836080B (en) * | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
US4625015A (en) * | 1982-08-23 | 1986-11-25 | Scripps Clinic & Research Foundation | Broad spectrum influenza antisera |
NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
NL9101953A (nl) | 1991-11-21 | 1993-06-16 | Seed Capital Investments | Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen. |
JP3037554B2 (ja) * | 1993-04-20 | 2000-04-24 | 寳酒造株式会社 | 免疫原性人工ポリペプチド |
JP3061960B2 (ja) * | 1992-09-17 | 2000-07-10 | 寳酒造株式会社 | 抗ヒトインフルエンザウイルス抗体 |
US5589174A (en) * | 1992-09-17 | 1996-12-31 | Takara Shuzo Co., Ltd. | Anti-human influenza virus antibody |
US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
JP3584990B2 (ja) * | 1994-05-09 | 2004-11-04 | タカラバイオ株式会社 | 抗ヒトインフルエンザウイルス抗体 |
US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
DE69718341T2 (de) | 1996-10-08 | 2003-10-30 | Bisys B V U | Verfahren und mittel zur auswahl von peptiden und proteinen mit spezifischer affinität zu einem zielmolekül |
US6440736B1 (en) | 1998-10-16 | 2002-08-27 | U-Bisys B.V. | Altering the properties of cells or of particles with membranes derived from cells by means of lipid-modified proteinaceous molecules |
US20030161813A1 (en) | 1998-04-30 | 2003-08-28 | Ton Logtenberg | Altering the properties of cells or of particles with membranes derived from cells by means of lipid-modified proteinaceous molecules |
US7091324B2 (en) * | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
ATE447617T1 (de) | 1999-04-15 | 2009-11-15 | Crucell Holland Bv | Verwendung von rekombinanten proteinen in menschlichen zellen |
US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
EP1224943A1 (fr) | 2001-01-19 | 2002-07-24 | Crucell Holland B.V. | Fibronectin comme marqueur de tumeurs, détectée par des anticorps exprimés sur phages |
US7070926B2 (en) | 2001-06-15 | 2006-07-04 | Crucell Holland B.V. | Chimaeric phages |
EP1402025B1 (fr) | 2001-06-15 | 2006-02-01 | Crucell Holland B.V. | Phages chimeriques |
US7371383B2 (en) * | 2002-04-12 | 2008-05-13 | Medimmune, Inc. | Recombinant anti-interleukin-9 antibodies |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
WO2005012337A2 (fr) | 2003-07-15 | 2005-02-10 | Crucell Holland B.V. | Peptides antigeniques du coronavirus du syndrome respiratoire aigu severe et applications de ceux-ci |
SG128680A1 (en) | 2003-07-22 | 2007-01-30 | Crucell Holland Bv | Binding molecules against sars-coronavirus and uses thereof |
ES2378767T3 (es) | 2003-12-23 | 2012-04-17 | Crucell Holland B.V. | Molécula de unión humana contra CD1a |
US20070287163A1 (en) | 2004-05-17 | 2007-12-13 | Crucell Holland B.V. | Methods for Diagnosis of Acute Myeloid Leukemia |
NZ580607A (en) | 2004-05-27 | 2011-05-27 | Crucell Holland Bv | Binding molecules capable of neutralizing rabies virus and uses thereof |
EP1799259B1 (fr) | 2004-10-12 | 2012-12-05 | Crucell Holland B.V. | Molécules de liaison pour la détection de cancer |
AU2005303758B2 (en) | 2004-11-11 | 2011-04-28 | Crucell Holland B.V. | Compositions against SARS-coronavirus and uses thereof |
AU2005318171B2 (en) | 2004-12-20 | 2011-09-29 | Crucell Holland B.V. | Binding molecules capable of neutralizing West Nile virus and uses thereof |
JP4580338B2 (ja) | 2004-12-23 | 2010-11-10 | エーエスエムエル ネザーランズ ビー.ブイ. | リソグラフィ装置、エキシマ・レーザ、およびデバイス製造方法 |
CA2608058C (fr) | 2005-05-12 | 2013-09-10 | Crucell Holland B.V. | Molecules de liaison specifiques de cellule hote capables de neutraliser des virus et leurs utilisations |
JP4758148B2 (ja) * | 2005-06-14 | 2011-08-24 | 泰三 宇田 | インフルエンザウイルスのヘマグルチニンに対する抗体酵素 |
EP1893645A1 (fr) | 2005-06-23 | 2008-03-05 | Crucell Holland B.V. | Optimisation d anticorps anti virus nil ouest |
US7888102B2 (en) | 2005-07-22 | 2011-02-15 | Crucell Holland B.V. | Cell line for producing coronaviruses |
CA2622603C (fr) | 2005-09-15 | 2014-06-17 | Crucell Holland B.V. | Methode permettant de preparer des bibliotheques d'immunoglobuline |
JP5586952B2 (ja) | 2006-06-06 | 2014-09-10 | クルセル ホランド ベー ヴェー | 腸球菌に対する殺活性を有するヒトの結合分子及びその使用方法 |
AU2007255384B2 (en) | 2006-06-06 | 2012-09-27 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
KR101485197B1 (ko) | 2006-09-07 | 2015-01-23 | 크루셀 홀란드 비.브이. | 인플루엔자 바이러스 h5n1을 중화시킬 수 있는 인간 결합분자 및 그것의 용도 |
WO2009083009A2 (fr) | 2008-01-03 | 2009-07-09 | Genmab A/S | Anticorps monoclonaux anti-cd32b |
US8148797B2 (en) | 2008-06-26 | 2012-04-03 | Taiwan Semiconductor Manufacturing Co., Ltd. | Chip pad resistant to antenna effect and method |
JP5813629B2 (ja) | 2009-05-11 | 2015-11-17 | クルセル ホランド ベー ヴェー | インフルエンザウイルスh3n2を中和可能なヒト抗体及び/または抗原結合フラグメントおよびその使用 |
CA2791109C (fr) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation de molecules de liaison |
JP6272299B2 (ja) | 2012-04-20 | 2018-01-31 | メルス ナムローゼ フェンノートシャップ | Ig様分子を生産する方法、Ig様分子の混合物、組み換え宿主細胞、医薬組成物、宿主細胞を作成する方法、および培養物 |
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