HK1116349A1 - Pyrrolopyrimidines useful as inhibitors of protein kinase - Google Patents
Pyrrolopyrimidines useful as inhibitors of protein kinaseInfo
- Publication number
- HK1116349A1 HK1116349A1 HK08106688.6A HK08106688A HK1116349A1 HK 1116349 A1 HK1116349 A1 HK 1116349A1 HK 08106688 A HK08106688 A HK 08106688A HK 1116349 A1 HK1116349 A1 HK 1116349A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitors
- protein kinase
- useful
- pyrrolopyrimidines
- pyrrolopyrimidines useful
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64978105P | 2005-02-03 | 2005-02-03 | |
PCT/US2006/004019 WO2006096270A1 (fr) | 2005-02-03 | 2006-02-02 | Pyrrolopyrimidines utiles en tant qu’inhibiteurs de la protéine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1116349A1 true HK1116349A1 (en) | 2008-12-19 |
Family
ID=36498734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08106688.6A HK1116349A1 (en) | 2005-02-03 | 2008-06-18 | Pyrrolopyrimidines useful as inhibitors of protein kinase |
Country Status (17)
Country | Link |
---|---|
US (2) | US8633205B2 (fr) |
EP (1) | EP1844050B1 (fr) |
JP (2) | JP5227032B2 (fr) |
KR (1) | KR20070104641A (fr) |
CN (1) | CN101142218B (fr) |
AT (1) | ATE420883T1 (fr) |
AU (1) | AU2006221065A1 (fr) |
CA (1) | CA2596830A1 (fr) |
DE (1) | DE602006004844D1 (fr) |
ES (1) | ES2320487T3 (fr) |
HK (1) | HK1116349A1 (fr) |
IL (1) | IL184898A0 (fr) |
MX (1) | MX2007009429A (fr) |
NO (1) | NO20074431L (fr) |
RU (1) | RU2434871C2 (fr) |
WO (1) | WO2006096270A1 (fr) |
ZA (1) | ZA200707342B (fr) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
MX2007014619A (es) * | 2005-05-20 | 2009-02-13 | Vertex Pharma | Pirrolopiridinas de utilidad como inhibidores de proteina quinasa. |
CA2621261C (fr) | 2005-09-22 | 2014-05-20 | Incyte Corporation | Inhibiteurs tetracycliques de janus kinases |
CN103214483B (zh) * | 2005-12-13 | 2014-12-17 | 因塞特公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
AU2015201850B2 (en) * | 2005-12-13 | 2017-03-02 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
TWI424999B (zh) | 2006-01-17 | 2014-02-01 | Vertex Pharma | 適合作為傑納斯激酶(janus kinase)抑制劑之氮雜吲哚 |
US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
EP2001884A1 (fr) * | 2006-04-05 | 2008-12-17 | Vertex Pharmaceuticals, Inc. | Désazapurines utiles comme inhibiteurs des kinases janus |
US7919490B2 (en) | 2006-10-04 | 2011-04-05 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
AR063141A1 (es) | 2006-10-04 | 2008-12-30 | Pharmacopeia Inc | Derivados de 2- ( benzimidazolil ) purina 8- sustituida para inmunosupresion |
US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
KR20090082453A (ko) | 2006-11-01 | 2009-07-30 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물 |
EP2099800A1 (fr) * | 2006-11-16 | 2009-09-16 | Pharmacopeia, LLC | Dérivés de purine substitués en 7, destinés à l'immunosuppression |
MX2009006700A (es) | 2006-12-21 | 2009-06-30 | Vertex Pharma | Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas. |
ES2415863T3 (es) | 2006-12-22 | 2013-07-29 | Incyte Corporation | Heterociclos sustituidos como inhibidores de Janus Quinasas |
KR20100015353A (ko) * | 2007-04-02 | 2010-02-12 | 팔라우 파르마 에스에이 | Jak3 억제제로서의 피롤로피리미딘 유도체 |
CL2008001709A1 (es) * | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
EP2740731B1 (fr) * | 2007-06-13 | 2016-03-23 | Incyte Holdings Corporation | Sels cristallines de l'inhibiteur de janus kinase (r)-3-(4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl)-1h-pyrazol-1-yl) -3-cyclopentylpropanenitrile |
KR20130066703A (ko) * | 2008-02-06 | 2013-06-20 | 노파르티스 아게 | 피롤로[2,3d]피리미딘 및 티로신 키나제 억제제로서 그의 용도 |
DK2288610T3 (en) | 2008-03-11 | 2016-11-28 | Incyte Holdings Corp | Azetidinesulfonic AND CYCLOBUTANDERIVATER AS JAK INHIBITORS |
EP2288260A4 (fr) | 2008-06-20 | 2013-10-23 | Genentech Inc | Composés triazolopyridine inhibiteurs de jak kinase et procédés |
CN102131390A (zh) | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
JOP20190231A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
US8592415B2 (en) * | 2009-02-11 | 2013-11-26 | Reaction Biology Corp. | Selective kinase inhibitors |
KR20110124787A (ko) * | 2009-02-27 | 2011-11-17 | 암비트 바이오사이언시즈 코포레이션 | Jak 키나아제 조절 퀴나졸린 유도체 및 이의 사용 방법 |
DK2432472T3 (da) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer |
BRPI1012159B1 (pt) | 2009-05-22 | 2022-01-25 | Incyte Holdings Corporation | Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos |
KR101702609B1 (ko) | 2009-06-17 | 2017-02-03 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
WO2011003418A1 (fr) | 2009-07-08 | 2011-01-13 | Leo Pharma A/S | Composés hétérocycliques en tant quinhibiteurs du récepteur jak et de la protéine tyrosine kinase |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
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- 2006-02-02 ES ES06734381T patent/ES2320487T3/es active Active
- 2006-02-02 ZA ZA200707342A patent/ZA200707342B/xx unknown
- 2006-02-02 RU RU2007132908/04A patent/RU2434871C2/ru not_active IP Right Cessation
- 2006-02-02 EP EP06734381A patent/EP1844050B1/fr not_active Not-in-force
- 2006-02-02 US US11/346,048 patent/US8633205B2/en not_active Expired - Fee Related
- 2006-02-02 CN CN2006800087780A patent/CN101142218B/zh not_active Expired - Fee Related
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- 2006-02-02 AU AU2006221065A patent/AU2006221065A1/en not_active Abandoned
- 2006-02-02 CA CA002596830A patent/CA2596830A1/fr not_active Abandoned
- 2006-02-02 DE DE602006004844T patent/DE602006004844D1/de active Active
- 2006-02-02 AT AT06734381T patent/ATE420883T1/de active
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WO2006096270A1 (fr) | 2006-09-14 |
ES2320487T3 (es) | 2009-05-22 |
RU2007132908A (ru) | 2009-03-10 |
EP1844050B1 (fr) | 2009-01-14 |
AU2006221065A1 (en) | 2006-09-14 |
MX2007009429A (es) | 2008-03-18 |
ZA200707342B (en) | 2009-03-25 |
US20060183761A1 (en) | 2006-08-17 |
RU2434871C2 (ru) | 2011-11-27 |
KR20070104641A (ko) | 2007-10-26 |
EP1844050A1 (fr) | 2007-10-17 |
US20070004762A9 (en) | 2007-01-04 |
CN101142218B (zh) | 2013-02-06 |
JP2008528705A (ja) | 2008-07-31 |
DE602006004844D1 (de) | 2009-03-05 |
JP5227032B2 (ja) | 2013-07-03 |
IL184898A0 (en) | 2007-12-03 |
US8633205B2 (en) | 2014-01-21 |
NO20074431L (no) | 2007-08-31 |
ATE420883T1 (de) | 2009-01-15 |
US20140171454A1 (en) | 2014-06-19 |
JP2009102361A (ja) | 2009-05-14 |
CA2596830A1 (fr) | 2006-09-14 |
CN101142218A (zh) | 2008-03-12 |
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