HK1115011A1 - Potassium salt of an hiv integrase inhibitor hiv - Google Patents

Potassium salt of an hiv integrase inhibitor hiv

Info

Publication number
HK1115011A1
HK1115011A1 HK08104747.0A HK08104747A HK1115011A1 HK 1115011 A1 HK1115011 A1 HK 1115011A1 HK 08104747 A HK08104747 A HK 08104747A HK 1115011 A1 HK1115011 A1 HK 1115011A1
Authority
HK
Hong Kong
Prior art keywords
hiv
potassium salt
integrase inhibitor
hiv integrase
inhibitor
Prior art date
Application number
HK08104747.0A
Other languages
English (en)
Inventor
Kevin M Belyk
Henry G Morrison
Philip Jones
Vincenzo Summa
V Brett Cooper
Amar J Mahajan
Daniel J Kumke
Hsien-Hsin Tung
Lawrence Wai
Vanessa Pruzinsky
Philip Pye
Remy Angelaud
Danny Mancheno
Original Assignee
Merck Sharp & Dohme
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36171569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1115011(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Angeletti P Ist Richerche Bio filed Critical Merck Sharp & Dohme
Publication of HK1115011A1 publication Critical patent/HK1115011A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02Seven-membered rings
    • C07D313/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12[b,e]-condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK08104747.0A 2004-12-03 2008-04-29 Potassium salt of an hiv integrase inhibitor hiv HK1115011A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63313204P 2004-12-03 2004-12-03
PCT/US2005/043781 WO2006060730A2 (en) 2004-12-03 2005-12-02 Potassium salt of an hiv integrase inhibitor

Publications (1)

Publication Number Publication Date
HK1115011A1 true HK1115011A1 (en) 2008-11-14

Family

ID=36171569

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08104747.0A HK1115011A1 (en) 2004-12-03 2008-04-29 Potassium salt of an hiv integrase inhibitor hiv

Country Status (36)

Country Link
US (2) US7754731B2 (sr)
EP (2) EP1819683B1 (sr)
JP (1) JP4705956B2 (sr)
KR (2) KR101350420B1 (sr)
CN (1) CN101068793B (sr)
AR (2) AR052034A1 (sr)
AT (2) ATE534645T1 (sr)
AU (1) AU2005311671B8 (sr)
BR (1) BRPI0518760A8 (sr)
CA (1) CA2588398C (sr)
CR (1) CR9146A (sr)
CY (1) CY1112859T1 (sr)
DK (1) DK1819700T3 (sr)
EA (1) EA012418B1 (sr)
ES (2) ES2370136T3 (sr)
GE (1) GEP20105086B (sr)
HK (1) HK1115011A1 (sr)
HR (1) HRP20120066T1 (sr)
IL (1) IL183614A (sr)
MA (1) MA29120B1 (sr)
ME (1) ME01985B (sr)
MX (1) MX2007006639A (sr)
MY (1) MY144320A (sr)
NI (1) NI200700138A (sr)
NO (1) NO338784B1 (sr)
NZ (1) NZ555376A (sr)
PE (1) PE20061148A1 (sr)
PL (1) PL1819700T3 (sr)
PT (1) PT1819700E (sr)
RS (1) RS52197B (sr)
SI (1) SI1819700T1 (sr)
TN (1) TNSN07215A1 (sr)
TW (1) TWI344463B (sr)
UA (1) UA87884C2 (sr)
WO (2) WO2006060712A2 (sr)
ZA (1) ZA200704130B (sr)

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WO2009009531A2 (en) * 2007-07-09 2009-01-15 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives for the treatment of hiv infections
WO2009088729A1 (en) * 2008-01-08 2009-07-16 Merck & Co., Inc. Process for preparing n-substituted hydroxypyrimidinone carboxamides
US8742105B2 (en) 2009-06-02 2014-06-03 Hetero Research Foundation Polymorphs of raltegravir potassium
WO2011024192A2 (en) 2009-07-27 2011-03-03 Matrix Laboratories Ltd Novel polymorphs of raltegravir
AU2010313571B2 (en) * 2009-10-26 2014-07-31 Merck Sharp & Dohme Llc Solid pharmaceutical compositions containing an integrase inhibitor
DE102009056636A1 (de) 2009-12-02 2011-06-09 Ratiopharm Gmbh Raltegravir-Polymorphe
KR20120094098A (ko) * 2009-12-07 2012-08-23 유니버시티 오브 조지아 리서치 파운데이션, 인코포레이티드 피리디논 하이드록시사이클로펜틸 카복사미드: 치료 용도의 hiv 인테그라제 억제제
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CN101914067B (zh) * 2010-08-26 2012-07-11 陈岱岭 N-甲基嘧啶酮的合成方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
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WO2012106534A2 (en) * 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
WO2012137142A1 (en) 2011-04-06 2012-10-11 Lupin Limited Novel salts of raltegravir
JP2014512386A (ja) * 2011-04-22 2014-05-22 メルク・シャープ・アンド・ドーム・コーポレーション 味がマスクされたラルテグラビル製剤
US9968607B2 (en) 2011-04-25 2018-05-15 Hetero Research Foundation Pharmaceutical compositions of raltegravir, methods of preparation and methods of use therof
EP2522665A1 (en) 2011-05-03 2012-11-14 Sandoz Ag Crystalline sodium salt of an HIV integrase inhibitor
ES2450944T3 (es) 2011-06-01 2014-03-25 Ratiopharm Gmbh Composición y comprimido que comprenden raltegravir
WO2013037731A1 (de) 2011-09-16 2013-03-21 Hexal Ag Neue polymorphe form von raltegravir-kalium
CN103130788B (zh) * 2011-11-24 2015-09-02 南开大学 嘧啶酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
CN103130787B (zh) * 2011-11-24 2015-06-10 南开大学 嘧啶酮酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
EP2804607B1 (en) 2011-12-26 2020-09-16 Emcure Pharmaceuticals Limited Synthesis of raltegravir
BR112014018247A8 (pt) 2012-01-25 2017-07-11 Lupin Ltd Pré-mistura de potássio de raltegravir amorfa e estável; processo; formulação farmacêutica; e método
WO2014064711A2 (en) * 2012-10-22 2014-05-01 Hetero Research Foundation Methods of administering raltegravir and raltegravir compositions
EP2818470A1 (en) 2013-06-27 2014-12-31 Basf Se Cocrystals of raltegravir potassium
EP3022209B1 (en) 2013-07-17 2018-03-07 ratiopharm GmbH Dolutegravir potassium salt
CA2938387C (en) 2014-02-03 2021-03-02 Mylan Laboratories Ltd Processes for the preparation of intermediates of raltegravir
WO2015140765A1 (en) 2014-03-21 2015-09-24 Mylan Laboratories Ltd. A premix of crystalline raltegravir potassium salt and a process for the preparation thereof
US10257840B2 (en) 2014-10-22 2019-04-09 Telefonaktiebolaget Lm Ericsson (Publ) Operation of wireless local area network in the presence of periodic interference
US10259778B2 (en) 2014-11-10 2019-04-16 Aurobindo Pharma Ltd Process for the preparation of raltegravir
WO2017220208A1 (en) * 2016-06-21 2017-12-28 Pharmathen S.A. Process for preparing compounds useful as intermediates for the preparation of raltegravir
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CN108610338A (zh) * 2016-12-12 2018-10-02 天津国际生物医药联合研究院 一种嘧啶酮酰胺类化合物的制备方法
HRP20220613T1 (hr) 2017-11-14 2022-06-24 Cambrex Profarmaco Milano S.R.L. Postupak priprave raltegavira
US20210290548A1 (en) * 2018-06-06 2021-09-23 Merck Sharp & Dohme Corp. Formulations of raltegravir
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JP2008521934A (ja) 2004-12-03 2008-06-26 メルク エンド カムパニー インコーポレーテッド Ugt1a1によって代謝される薬物の薬物動態を改善するためのアタザナビルの使用

Also Published As

Publication number Publication date
EP1819683B1 (en) 2011-08-03
KR101350420B1 (ko) 2014-02-17
HRP20120066T1 (hr) 2012-03-31
ATE518844T1 (de) 2011-08-15
JP4705956B2 (ja) 2011-06-22
US20100249410A1 (en) 2010-09-30
EP1819700A2 (en) 2007-08-22
BRPI0518760A8 (pt) 2017-12-12
CR9146A (es) 2007-10-04
NO20073404L (no) 2007-07-02
MY144320A (en) 2011-08-29
EA200701204A1 (ru) 2007-12-28
EP1819700B1 (en) 2011-11-23
EA012418B1 (ru) 2009-10-30
WO2006060730A3 (en) 2006-08-17
TWI344463B (en) 2011-07-01
AU2005311671B2 (en) 2011-01-27
AR101429A2 (es) 2016-12-21
IL183614A0 (en) 2007-09-20
KR20130122031A (ko) 2013-11-06
IL183614A (en) 2012-03-29
CY1112859T1 (el) 2016-04-13
WO2006060712A9 (en) 2006-07-27
RS52197B (sr) 2012-10-31
NZ555376A (en) 2009-11-27
AU2005311671A1 (en) 2006-06-08
WO2006060712A2 (en) 2006-06-08
US7754731B2 (en) 2010-07-13
TW200631944A (en) 2006-09-16
ATE534645T1 (de) 2011-12-15
NO338784B1 (no) 2016-10-17
EP1819683A2 (en) 2007-08-22
CA2588398C (en) 2011-07-12
CN101068793B (zh) 2011-05-25
CA2588398A1 (en) 2006-06-08
JP2008521933A (ja) 2008-06-26
UA87884C2 (uk) 2009-08-25
CN101068793A (zh) 2007-11-07
TNSN07215A1 (en) 2008-11-21
GEP20105086B (en) 2010-10-11
ES2375788T3 (es) 2012-03-06
ZA200704130B (en) 2008-08-27
AR052034A1 (es) 2007-02-28
NI200700138A (es) 2008-05-13
PT1819700E (pt) 2012-02-01
WO2006060712A3 (en) 2006-09-21
ES2370136T3 (es) 2011-12-13
US8357798B2 (en) 2013-01-22
SI1819700T1 (sl) 2012-07-31
US20060122205A1 (en) 2006-06-08
KR20070089990A (ko) 2007-09-04
PL1819700T3 (pl) 2012-04-30
DK1819700T3 (da) 2012-03-19
PE20061148A1 (es) 2006-11-09
BRPI0518760A2 (pt) 2008-12-09
ME01985B (me) 2012-10-31
MX2007006639A (es) 2007-06-19
AU2005311671B8 (en) 2011-02-10
WO2006060730A2 (en) 2006-06-08
MA29120B1 (fr) 2007-12-03

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