HK1095738A1 - Methods and compositions for delivering polynucleotides - Google Patents

Methods and compositions for delivering polynucleotides

Info

Publication number
HK1095738A1
HK1095738A1 HK07101416.7A HK07101416A HK1095738A1 HK 1095738 A1 HK1095738 A1 HK 1095738A1 HK 07101416 A HK07101416 A HK 07101416A HK 1095738 A1 HK1095738 A1 HK 1095738A1
Authority
HK
Hong Kong
Prior art keywords
methods
compositions
delivering polynucleotides
polynucleotides
delivering
Prior art date
Application number
HK07101416.7A
Other languages
English (en)
Inventor
Shaharyar Khan
Original Assignee
Gencia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gencia Corp filed Critical Gencia Corp
Publication of HK1095738A1 publication Critical patent/HK1095738A1/xx

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Microbiology (AREA)
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  • Hematology (AREA)
  • Pulmonology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
HK07101416.7A 2003-10-24 2007-02-07 Methods and compositions for delivering polynucleotides HK1095738A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51398303P 2003-10-24 2003-10-24
US56843604P 2004-05-05 2004-05-05
PCT/US2004/035137 WO2005056752A2 (fr) 2003-10-24 2004-10-25 Procedes et compositions permettant de distribuer des polynucleotides

Publications (1)

Publication Number Publication Date
HK1095738A1 true HK1095738A1 (en) 2007-05-18

Family

ID=34681406

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07101416.7A HK1095738A1 (en) 2003-10-24 2007-02-07 Methods and compositions for delivering polynucleotides

Country Status (8)

Country Link
US (2) US8039587B2 (fr)
EP (2) EP1687017B1 (fr)
JP (2) JP4838722B2 (fr)
AU (2) AU2004297533B2 (fr)
CA (1) CA2543257C (fr)
ES (1) ES2411962T3 (fr)
HK (1) HK1095738A1 (fr)
WO (1) WO2005056752A2 (fr)

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US20050147993A1 (en) 2005-07-07
JP2007508846A (ja) 2007-04-12
WO2005056752A9 (fr) 2009-07-23
WO2005056752A2 (fr) 2005-06-23
EP2418281A3 (fr) 2012-09-19
JP4838722B2 (ja) 2011-12-14
WO2005056752A3 (fr) 2005-09-29
US20110300600A1 (en) 2011-12-08
AU2010206037A1 (en) 2010-08-19
EP1687017B1 (fr) 2013-03-06
AU2004297533A1 (en) 2005-06-23
EP2418281B1 (fr) 2016-06-01
EP1687017A2 (fr) 2006-08-09
ES2411962T3 (es) 2013-07-09
AU2004297533B2 (en) 2010-04-29
CA2543257C (fr) 2013-12-31
US8541550B2 (en) 2013-09-24
US8039587B2 (en) 2011-10-18
JP2011137001A (ja) 2011-07-14
CA2543257A1 (fr) 2005-06-23
EP2418281A2 (fr) 2012-02-15

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