HK1084383A1 - 4-pyrrolidino-phenyl-bezyl ether derivatives - Google Patents

4-pyrrolidino-phenyl-bezyl ether derivatives

Info

Publication number
HK1084383A1
HK1084383A1 HK06103481A HK06103481A HK1084383A1 HK 1084383 A1 HK1084383 A1 HK 1084383A1 HK 06103481 A HK06103481 A HK 06103481A HK 06103481 A HK06103481 A HK 06103481A HK 1084383 A1 HK1084383 A1 HK 1084383A1
Authority
HK
Hong Kong
Prior art keywords
bezyl
pyrrolidino
phenyl
ether derivatives
derivatives
Prior art date
Application number
HK06103481A
Other languages
English (en)
Inventor
Jolidon Synese
Rodriguez-Sarmiento Rosa Maria
Thomas Andrew William
Wostl Wolfgang
Wyler Rene
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1084383A1 publication Critical patent/HK1084383A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK06103481A 2002-09-20 2006-03-20 4-pyrrolidino-phenyl-bezyl ether derivatives HK1084383A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02021319 2002-09-20
PCT/EP2003/010383 WO2004026826A1 (fr) 2002-09-20 2003-09-18 Derives de 4-pyrrolidino-phenyl-benzyl ether

Publications (1)

Publication Number Publication Date
HK1084383A1 true HK1084383A1 (en) 2006-07-28

Family

ID=32010924

Family Applications (3)

Application Number Title Priority Date Filing Date
HK06103481A HK1084383A1 (en) 2002-09-20 2006-03-20 4-pyrrolidino-phenyl-bezyl ether derivatives
HK06103476.1A HK1083499A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors
HK06103475A HK1083498A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK06103476.1A HK1083499A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors
HK06103475A HK1083498A1 (en) 2002-09-20 2006-03-20 Pyrrolidone derivatives as maob inhibitors

Country Status (32)

Country Link
US (4) US7151111B2 (fr)
EP (3) EP1542970B1 (fr)
JP (3) JP4335141B2 (fr)
KR (3) KR100676014B1 (fr)
CN (3) CN100383118C (fr)
AR (3) AR041298A1 (fr)
AT (2) ATE459601T1 (fr)
AU (3) AU2003270213B8 (fr)
BR (4) BRPI0314631B1 (fr)
CA (3) CA2498335A1 (fr)
CY (1) CY1110745T1 (fr)
DE (2) DE60333202D1 (fr)
DK (1) DK1542970T3 (fr)
ES (2) ES2344557T3 (fr)
GT (3) GT200300206A (fr)
HK (3) HK1084383A1 (fr)
HR (3) HRP20050262A2 (fr)
JO (2) JO2604B1 (fr)
MX (3) MXPA05002878A (fr)
MY (3) MY134480A (fr)
NO (3) NO330012B1 (fr)
NZ (3) NZ538049A (fr)
PA (3) PA8583001A1 (fr)
PE (3) PE20050077A1 (fr)
PL (3) PL376018A1 (fr)
PT (1) PT1542970E (fr)
RU (3) RU2323209C2 (fr)
SI (1) SI1542970T1 (fr)
TW (3) TWI286132B (fr)
UY (3) UY27991A1 (fr)
WO (3) WO2004026827A1 (fr)
ZA (3) ZA200501137B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI286132B (en) * 2002-09-20 2007-09-01 Hoffmann La Roche 4-pyrrolidino-phenyl-benzyl ether derivatives
GB0314373D0 (en) * 2003-06-19 2003-07-23 Glaxo Group Ltd Chemical compounds
EP1776337A2 (fr) * 2004-08-02 2007-04-25 F. Hoffmann-Roche AG Derives benzyloxy servant d'inhibiteurs de la maob
KR100845366B1 (ko) * 2004-08-02 2008-07-09 에프. 호프만-라 로슈 아게 모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
CA2598762A1 (fr) 2005-02-25 2006-08-31 F. Hoffmann-La Roche Ag Comprimes presentant une dispersibilite de substance medicamenteuse amelioree
US7501528B2 (en) * 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
CN101142181B (zh) * 2005-03-15 2011-05-04 弗·哈夫曼-拉罗切有限公司 对映异构纯的4-吡咯烷子基苯基苄基醚衍生物的制备方法
TW200730494A (en) * 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
WO2007042250A1 (fr) * 2005-10-10 2007-04-19 Glaxo Group Limited Dérivés de prolinamide en tant que modulateurs des canaux sodiques
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
US8372380B2 (en) * 2007-03-30 2013-02-12 The Regents Of The University Of California In vivo imaging of sulfotransferases
KR101220182B1 (ko) 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) * 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) * 2013-02-28 2019-09-05 삼성디스플레이 주식회사 박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
RU2661156C2 (ru) 2013-03-14 2018-07-12 Дарт Нейросайенс (Кайман) Лтд. Замещенные нафтиридиновые и хинолиновые соединения как ингибиторы мао
CZ305213B6 (cs) * 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
KR20160067208A (ko) * 2013-10-29 2016-06-13 에프. 호프만-라 로슈 아게 알츠하이머 병의 치료에 유용한 피롤리돈 유도체의 결정 형태 및 이의 제조
WO2016102967A1 (fr) 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine
CN107223052A (zh) * 2015-03-27 2017-09-29 豪夫迈·罗氏有限公司 包含sembragiline的药物制剂
EP3689870B1 (fr) 2017-09-27 2022-07-13 Kagoshima University Médicament analgésique utilisant un médicament antagoniste du récepteur pac1
KR20200061381A (ko) 2017-10-05 2020-06-02 바이오젠 인크. 알파-카르복스아미드 피롤리딘 유도체를 제조하기 위한 공정
CN108299272B (zh) * 2018-01-31 2019-10-18 福州大学 一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
JP7405756B2 (ja) * 2018-03-08 2023-12-26 サンシャイン・レイク・ファーマ・カンパニー・リミテッド ピロリジンアミド誘導体及びその使用
WO2020175134A1 (fr) 2019-02-27 2020-09-03 国立大学法人鹿児島大学 Agent antiprurigineux utilisant un antagoniste du récepteur pac1
JP7049637B1 (ja) 2020-05-08 2022-04-07 国立大学法人 鹿児島大学 Ｐａｃ１受容体拮抗薬を用いた抗うつ・抗不安薬
CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (fr) 2021-06-21 2022-12-29 Bayer Aktiengesellschaft Utilisation de pyrrolidinones substituées ou de leurs sels pour augmenter la tolérance au stress des plantes

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2500831A1 (fr) * 1981-02-27 1982-09-03 Delalande Sa Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
EP0393607B1 (fr) 1989-04-19 1996-02-21 Otsuka Pharmaceutical Co., Ltd. Dérivés d'acides phényl carboxyliques contenant un hétérocycle
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
JP3258027B2 (ja) 1996-03-15 2002-02-18 サマーセット・ファーマシューティカルズ・インコーポレイテッド セレジリン投与による末梢ニューロパシーの予防および治療方法
US5683404A (en) * 1996-06-05 1997-11-04 Metagen, Llc Clamp and method for its use
DE19841895A1 (de) 1998-09-11 2000-03-23 Degussa Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
WO2000059285A2 (fr) * 1999-04-02 2000-10-12 Du Pont Pharmaceuticals Company Nouveaux inhibiteurs de lactame de metalloproteases matricielles, de tnf-alpha, et de l'aggrecanase
AU1359801A (en) 1999-11-05 2001-06-06 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome
MXPA02007649A (es) * 2000-02-10 2004-08-23 Potencia Medical Ag Tratamiento para la incontinencia urinaria con suministro de energia inalambrica.
EP1255513B1 (fr) * 2000-02-14 2005-05-25 Potencia Medical AG Prothese penienne
TWI286132B (en) * 2002-09-20 2007-09-01 Hoffmann La Roche 4-pyrrolidino-phenyl-benzyl ether derivatives
US20040267292A1 (en) * 2003-06-27 2004-12-30 Byrum Randal T. Implantable band with transverse attachment mechanism
US20040267291A1 (en) * 2003-06-27 2004-12-30 Byrum Randal T. Implantable band with non-mechanical attachment mechanism

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CA2496756A1 (fr) 2004-04-01
TWI331994B (en) 2010-10-21
AU2003267381A1 (en) 2004-04-08
MY134480A (en) 2007-12-31
PA8583601A1 (es) 2004-09-16
HRP20050263A2 (en) 2006-12-31
ES2338646T3 (es) 2010-05-11
US20040097578A1 (en) 2004-05-20
RU2336268C2 (ru) 2008-10-20
AR041298A1 (es) 2005-05-11
RU2323209C2 (ru) 2008-04-27
MXPA05002881A (es) 2005-05-27
PL216030B1 (pl) 2014-02-28
AR041299A1 (es) 2005-05-11
NZ538049A (en) 2007-05-31
JP4335140B2 (ja) 2009-09-30
CA2498335A1 (fr) 2004-04-01
UY27993A1 (es) 2004-03-31
BR0314631A (pt) 2005-08-02
BR0314299A (pt) 2005-12-13
CN100503562C (zh) 2009-06-24
GT200300205A (es) 2004-04-29
GT200300206A (es) 2004-04-29
KR20050057466A (ko) 2005-06-16
PE20050077A1 (es) 2005-03-01
ZA200501557B (en) 2005-09-08
NZ538046A (en) 2007-08-31
HRP20050263B1 (hr) 2013-09-30
WO2004026827A1 (fr) 2004-04-01
RU2005111969A (ru) 2006-01-20
KR100676014B1 (ko) 2007-01-30
TWI286132B (en) 2007-09-01
UY27990A1 (es) 2004-03-31
SI1542970T1 (sl) 2010-08-31
MY135696A (en) 2008-06-30
AU2003273901A1 (en) 2004-04-08
EP1542969B1 (fr) 2010-03-03
EP1542970A1 (fr) 2005-06-22
TW200410935A (en) 2004-07-01
EP1542970B1 (fr) 2010-06-30
US7122562B2 (en) 2006-10-17
MY133332A (en) 2007-11-30
PA8583501A1 (es) 2004-04-23
JP2006503833A (ja) 2006-02-02
PT1542970E (pt) 2010-07-19
US20040116707A1 (en) 2004-06-17
US20040106650A1 (en) 2004-06-03
CA2496756C (fr) 2012-01-10
NO329754B1 (no) 2010-12-13
WO2004026826A1 (fr) 2004-04-01
AU2003270213A1 (en) 2004-04-08
CN1681779A (zh) 2005-10-12
EP1542971A1 (fr) 2005-06-22
PE20050078A1 (es) 2005-02-28
MXPA05002878A (es) 2005-05-27
WO2004026825A1 (fr) 2004-04-01
NO330012B1 (no) 2011-02-07
KR20050057456A (ko) 2005-06-16
CA2498785C (fr) 2011-07-26
PA8583001A1 (es) 2004-04-23
JP2006510596A (ja) 2006-03-30
DE60333202D1 (de) 2010-08-12
NO20050652L (no) 2005-03-08
PE20050079A1 (es) 2005-03-01
EP1542969A1 (fr) 2005-06-22
ZA200501137B (en) 2006-12-27
KR20050057450A (ko) 2005-06-16
GT200300204A (es) 2004-04-29
RU2005111974A (ru) 2006-01-20
JO2604B1 (en) 2011-11-01
US20060122235A1 (en) 2006-06-08
NZ538048A (en) 2007-05-31
TWI337604B (en) 2011-02-21
AU2003273901B2 (en) 2008-07-10
HK1083499A1 (en) 2006-07-07
US7037935B2 (en) 2006-05-02
HK1083498A1 (en) 2006-07-07
TW200408624A (en) 2004-06-01
PL376018A1 (en) 2005-12-12
CN1681778A (zh) 2005-10-12
NO20050701L (no) 2005-03-02
RU2336267C2 (ru) 2008-10-20
BRPI0314631B1 (pt) 2018-04-17
CA2498785A1 (fr) 2004-04-01
AR041297A1 (es) 2005-05-11
ATE472530T1 (de) 2010-07-15
AU2003267381B2 (en) 2009-08-27
CN1681777A (zh) 2005-10-12
CY1110745T1 (el) 2015-06-10
UY27991A1 (es) 2004-03-31
NO20050665L (no) 2005-04-18
JP4335142B2 (ja) 2009-09-30
ZA200501311B (en) 2006-10-25
US7151111B2 (en) 2006-12-19
HRP20050261A2 (en) 2006-05-31
JP4335141B2 (ja) 2009-09-30
KR100676015B1 (ko) 2007-01-30
MXPA05002880A (es) 2005-05-27
US7235581B2 (en) 2007-06-26
ES2344557T3 (es) 2010-08-31
AU2003270213B8 (en) 2009-03-05
BR0314314A (pt) 2005-07-26
JO2605B1 (en) 2011-11-01
CN100400509C (zh) 2008-07-09
PL376019A1 (en) 2005-12-12
KR100681586B1 (ko) 2007-02-09
DE60331559D1 (de) 2010-04-15
DK1542970T3 (da) 2010-08-02
ATE459601T1 (de) 2010-03-15
TW200413350A (en) 2004-08-01
RU2005111968A (ru) 2006-11-10
CN100383118C (zh) 2008-04-23
JP2006503834A (ja) 2006-02-02
PL376021A1 (en) 2005-12-12
HRP20050262A2 (en) 2006-06-30
AU2003270213B2 (en) 2009-02-12

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