ATE472530T1 - Pyrrolidonderivate als mao-b hemmer - Google Patents

Pyrrolidonderivate als mao-b hemmer

Info

Publication number
ATE472530T1
ATE472530T1 AT03750564T AT03750564T ATE472530T1 AT E472530 T1 ATE472530 T1 AT E472530T1 AT 03750564 T AT03750564 T AT 03750564T AT 03750564 T AT03750564 T AT 03750564T AT E472530 T1 ATE472530 T1 AT E472530T1
Authority
AT
Austria
Prior art keywords
hemmer
mao
pyrrolidone derivatives
pyrrolidone
derivatives
Prior art date
Application number
AT03750564T
Other languages
English (en)
Inventor
Hans Iding
Synese Jolidon
Daniela Krummenacher
Rosa Rodriguez-Sarmiento
Andrew Thomas
Beat Wirz
Wolfgang Wostl
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE472530T1 publication Critical patent/ATE472530T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03750564T 2002-09-20 2003-09-18 Pyrrolidonderivate als mao-b hemmer ATE472530T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02021319 2002-09-20
PCT/EP2003/010356 WO2004026825A1 (en) 2002-09-20 2003-09-18 Pyrrolidone derivatives as maob inhibitors

Publications (1)

Publication Number Publication Date
ATE472530T1 true ATE472530T1 (de) 2010-07-15

Family

ID=32010924

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03750564T ATE472530T1 (de) 2002-09-20 2003-09-18 Pyrrolidonderivate als mao-b hemmer
AT03748052T ATE459601T1 (de) 2002-09-20 2003-09-18 Pyrrolidonderivate als mao-b hemmer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03748052T ATE459601T1 (de) 2002-09-20 2003-09-18 Pyrrolidonderivate als mao-b hemmer

Country Status (32)

Country Link
US (4) US7151111B2 (de)
EP (3) EP1542971A1 (de)
JP (3) JP4335140B2 (de)
KR (3) KR100681586B1 (de)
CN (3) CN100383118C (de)
AR (3) AR041299A1 (de)
AT (2) ATE472530T1 (de)
AU (3) AU2003273901B2 (de)
BR (4) BR0314631A (de)
CA (3) CA2496756C (de)
CY (1) CY1110745T1 (de)
DE (2) DE60333202D1 (de)
DK (1) DK1542970T3 (de)
ES (2) ES2338646T3 (de)
GT (3) GT200300205A (de)
HK (3) HK1083499A1 (de)
HR (3) HRP20050261A2 (de)
JO (2) JO2605B1 (de)
MX (3) MXPA05002881A (de)
MY (3) MY134480A (de)
NO (3) NO329754B1 (de)
NZ (3) NZ538049A (de)
PA (3) PA8583001A1 (de)
PE (3) PE20050077A1 (de)
PL (3) PL376019A1 (de)
PT (1) PT1542970E (de)
RU (3) RU2323209C2 (de)
SI (1) SI1542970T1 (de)
TW (3) TWI286132B (de)
UY (3) UY27990A1 (de)
WO (3) WO2004026825A1 (de)
ZA (3) ZA200501137B (de)

Families Citing this family (27)

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PA8583001A1 (es) * 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
GB0314373D0 (en) 2003-06-19 2003-07-23 Glaxo Group Ltd Chemical compounds
KR100845366B1 (ko) * 2004-08-02 2008-07-09 에프. 호프만-라 로슈 아게 모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
MX2007001169A (es) * 2004-08-02 2007-03-12 Hoffmann La Roche Derivados de benciloxi como inhibidores de la oxidasa de monoamina b.
NZ560232A (en) 2005-02-25 2010-11-26 Hoffmann La Roche Tablets with improved drug substance dispersibility
CN101142181B (zh) * 2005-03-15 2011-05-04 弗·哈夫曼-拉罗切有限公司 对映异构纯的4-吡咯烷子基苯基苄基醚衍生物的制备方法
US7501528B2 (en) * 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
TW200730494A (en) * 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
US7855218B2 (en) * 2005-10-10 2010-12-21 Convergence Pharmaceuticals Limited Compounds
US8372380B2 (en) * 2007-03-30 2013-02-12 The Regents Of The University Of California In vivo imaging of sulfotransferases
KR101220182B1 (ko) 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) * 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) * 2013-02-28 2019-09-05 삼성디스플레이 주식회사 박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
BR112015022202A2 (pt) 2013-03-14 2017-07-18 Dart Neuroscience Cayman Ltd compostos substituídos de naftiridina e quinolina como inibidores da mao
CZ305213B6 (cs) * 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
BR112016003288A8 (pt) 2013-10-29 2020-02-04 Hoffmann La Roche processos para sintetizar n-[(3s)-1-[4-[(3-fluorofenil)metóxi]fenil]-5-oxo-pirrolidin-3-il]acetamida cristalina, e seu intermediário
WO2016102967A1 (en) 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide pyrrolidine derivatives
JP2018509400A (ja) * 2015-03-27 2018-04-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ セムブラギリンを含む医薬製剤
US11365194B2 (en) 2017-09-27 2022-06-21 Kagoshima University Analgesic drug using PAC1 receptor antagonistic drug
US11192856B2 (en) 2017-10-05 2021-12-07 Biogen Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives
CN108299272B (zh) * 2018-01-31 2019-10-18 福州大学 一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
US11225460B2 (en) 2018-03-08 2022-01-18 Sunshine Lake Pharma Co., Ltd. Pyrrolidineamide derivatives and uses thereof
EP3932490A4 (de) 2019-02-27 2022-11-16 Kagoshima University Antipruritisches mittel unter verwendung von pac1-rezeptorantagonisten
US20230181587A1 (en) 2020-05-08 2023-06-15 Kagoshima University Antidepressant/anxiolytic drug in which pac1 receptor antagonist is used
CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de) 2021-06-21 2022-12-29 Bayer Aktiengesellschaft Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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PA8583001A1 (es) * 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
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TW200413350A (en) 2004-08-01
CA2498785A1 (en) 2004-04-01
PA8583501A1 (es) 2004-04-23
NO20050701L (no) 2005-03-02
GT200300206A (es) 2004-04-29
UY27990A1 (es) 2004-03-31
MY134480A (en) 2007-12-31
CN100503562C (zh) 2009-06-24
CA2498335A1 (en) 2004-04-01
TWI286132B (en) 2007-09-01
NZ538048A (en) 2007-05-31
JP2006503834A (ja) 2006-02-02
KR20050057450A (ko) 2005-06-16
US20040097578A1 (en) 2004-05-20
US7122562B2 (en) 2006-10-17
US20040106650A1 (en) 2004-06-03
RU2005111969A (ru) 2006-01-20
CN1681778A (zh) 2005-10-12
RU2323209C2 (ru) 2008-04-27
MY135696A (en) 2008-06-30
BR0314631A (pt) 2005-08-02
JO2605B1 (en) 2011-11-01
AR041297A1 (es) 2005-05-11
JP2006510596A (ja) 2006-03-30
PL216030B1 (pl) 2014-02-28
AR041299A1 (es) 2005-05-11
JP4335141B2 (ja) 2009-09-30
ZA200501557B (en) 2005-09-08
AU2003273901B2 (en) 2008-07-10
TWI331994B (en) 2010-10-21
EP1542970B1 (de) 2010-06-30
NZ538046A (en) 2007-08-31
WO2004026827A1 (en) 2004-04-01
NO330012B1 (no) 2011-02-07
HK1083498A1 (en) 2006-07-07
PA8583001A1 (es) 2004-04-23
GT200300204A (es) 2004-04-29
CA2498785C (en) 2011-07-26
BR0314314A (pt) 2005-07-26
NO20050652L (no) 2005-03-08
CN1681779A (zh) 2005-10-12
HK1083499A1 (en) 2006-07-07
HRP20050263A2 (en) 2006-12-31
HRP20050263B1 (hr) 2013-09-30
EP1542969B1 (de) 2010-03-03
EP1542970A1 (de) 2005-06-22
CN1681777A (zh) 2005-10-12
GT200300205A (es) 2004-04-29
DE60333202D1 (de) 2010-08-12
KR100681586B1 (ko) 2007-02-09
EP1542971A1 (de) 2005-06-22
NO20050665L (no) 2005-04-18
PE20050079A1 (es) 2005-03-01
BR0314299A (pt) 2005-12-13
CA2496756C (en) 2012-01-10
AR041298A1 (es) 2005-05-11
PE20050078A1 (es) 2005-02-28
HRP20050261A2 (en) 2006-05-31
NZ538049A (en) 2007-05-31
RU2005111968A (ru) 2006-11-10
JP4335140B2 (ja) 2009-09-30
ES2338646T3 (es) 2010-05-11
NO329754B1 (no) 2010-12-13
US7037935B2 (en) 2006-05-02
PA8583601A1 (es) 2004-09-16
PT1542970E (pt) 2010-07-19
PL376018A1 (en) 2005-12-12
ES2344557T3 (es) 2010-08-31
MXPA05002880A (es) 2005-05-27
KR20050057456A (ko) 2005-06-16
RU2005111974A (ru) 2006-01-20
ZA200501137B (en) 2006-12-27
ZA200501311B (en) 2006-10-25
TW200408624A (en) 2004-06-01
WO2004026825A1 (en) 2004-04-01
ATE459601T1 (de) 2010-03-15
RU2336268C2 (ru) 2008-10-20
PL376021A1 (en) 2005-12-12
WO2004026826A1 (en) 2004-04-01
US7235581B2 (en) 2007-06-26
MY133332A (en) 2007-11-30
AU2003273901A1 (en) 2004-04-08
CN100383118C (zh) 2008-04-23
DK1542970T3 (da) 2010-08-02
AU2003267381B2 (en) 2009-08-27
HK1084383A1 (en) 2006-07-28
CA2496756A1 (en) 2004-04-01
CY1110745T1 (el) 2015-06-10
KR20050057466A (ko) 2005-06-16
RU2336267C2 (ru) 2008-10-20
AU2003270213B2 (en) 2009-02-12
JP4335142B2 (ja) 2009-09-30
AU2003270213B8 (en) 2009-03-05
AU2003267381A1 (en) 2004-04-08
MXPA05002878A (es) 2005-05-27
US20060122235A1 (en) 2006-06-08
KR100676015B1 (ko) 2007-01-30
UY27991A1 (es) 2004-03-31
HRP20050262A2 (en) 2006-06-30
EP1542969A1 (de) 2005-06-22
PL376019A1 (en) 2005-12-12
AU2003270213A1 (en) 2004-04-08
UY27993A1 (es) 2004-03-31
CN100400509C (zh) 2008-07-09
KR100676014B1 (ko) 2007-01-30
US20040116707A1 (en) 2004-06-17
US7151111B2 (en) 2006-12-19
BRPI0314631B1 (pt) 2018-04-17
SI1542970T1 (sl) 2010-08-31
DE60331559D1 (de) 2010-04-15
TWI337604B (en) 2011-02-21
PE20050077A1 (es) 2005-03-01
JP2006503833A (ja) 2006-02-02
TW200410935A (en) 2004-07-01
MXPA05002881A (es) 2005-05-27
JO2604B1 (en) 2011-11-01

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