HK1053113A1 - Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same - Google Patents

Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same

Info

Publication number
HK1053113A1
HK1053113A1 HK03105391.1A HK03105391A HK1053113A1 HK 1053113 A1 HK1053113 A1 HK 1053113A1 HK 03105391 A HK03105391 A HK 03105391A HK 1053113 A1 HK1053113 A1 HK 1053113A1
Authority
HK
Hong Kong
Prior art keywords
same
aminoalkylbenzoyl
benzofuran
compositions containing
benzothiophene derivatives
Prior art date
Application number
HK03105391.1A
Other languages
English (en)
Inventor
Jean-Louis Assens
Claude Bernhart
Frederique Cabanel-Haudricourt
Patrick Gautier
Dino Nisato
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of HK1053113A1 publication Critical patent/HK1053113A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
HK03105391.1A 2000-08-23 2003-07-25 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same HK1053113A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0010834A FR2813306B1 (fr) 2000-08-23 2000-08-23 Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
PCT/FR2001/002640 WO2002016339A1 (fr) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Publications (1)

Publication Number Publication Date
HK1053113A1 true HK1053113A1 (en) 2003-10-10

Family

ID=8853674

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03105391.1A HK1053113A1 (en) 2000-08-23 2003-07-25 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same

Country Status (36)

Country Link
US (1) US6949583B2 (US06949583-20050927-C00130.png)
EP (1) EP1315709B1 (US06949583-20050927-C00130.png)
JP (2) JP5081363B2 (US06949583-20050927-C00130.png)
KR (1) KR100911280B1 (US06949583-20050927-C00130.png)
CN (1) CN1246315C (US06949583-20050927-C00130.png)
AR (1) AR032892A1 (US06949583-20050927-C00130.png)
AT (1) ATE469138T1 (US06949583-20050927-C00130.png)
AU (2) AU2001284149B2 (US06949583-20050927-C00130.png)
BG (1) BG66240B1 (US06949583-20050927-C00130.png)
BR (1) BR0113425B1 (US06949583-20050927-C00130.png)
CA (1) CA2415847C (US06949583-20050927-C00130.png)
CY (1) CY1110738T1 (US06949583-20050927-C00130.png)
CZ (1) CZ304003B6 (US06949583-20050927-C00130.png)
DE (1) DE60142240D1 (US06949583-20050927-C00130.png)
DK (1) DK1315709T3 (US06949583-20050927-C00130.png)
EA (1) EA006237B1 (US06949583-20050927-C00130.png)
ES (1) ES2346291T3 (US06949583-20050927-C00130.png)
FR (1) FR2813306B1 (US06949583-20050927-C00130.png)
HK (1) HK1053113A1 (US06949583-20050927-C00130.png)
HU (1) HU229456B1 (US06949583-20050927-C00130.png)
IL (2) IL153632A0 (US06949583-20050927-C00130.png)
IS (1) IS2821B (US06949583-20050927-C00130.png)
MA (1) MA26943A1 (US06949583-20050927-C00130.png)
ME (2) ME00106B (US06949583-20050927-C00130.png)
MX (1) MXPA03001463A (US06949583-20050927-C00130.png)
NO (1) NO328138B1 (US06949583-20050927-C00130.png)
NZ (1) NZ523446A (US06949583-20050927-C00130.png)
OA (1) OA12359A (US06949583-20050927-C00130.png)
PL (1) PL219848B1 (US06949583-20050927-C00130.png)
PT (1) PT1315709E (US06949583-20050927-C00130.png)
RS (1) RS51603B (US06949583-20050927-C00130.png)
SI (1) SI1315709T1 (US06949583-20050927-C00130.png)
SK (1) SK288126B6 (US06949583-20050927-C00130.png)
TW (1) TWI290920B (US06949583-20050927-C00130.png)
WO (1) WO2002016339A1 (US06949583-20050927-C00130.png)
ZA (1) ZA200300744B (US06949583-20050927-C00130.png)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7401072B2 (en) * 2003-06-10 2008-07-15 Google Inc. Named URL entry
WO2007086911A2 (en) * 2005-05-05 2007-08-02 Sanofi-Aventis U.S. Llc Stable nanoparticle formulations
FR2893616B1 (fr) * 2005-11-23 2008-01-04 Sanofi Aventis Sa Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
EP2308488A1 (en) 2009-10-09 2011-04-13 Sanofi-Aventis Use of celivarone for the preparation of a medicament for use in the prevention of implantable cardioverter defibrillator interventions or death
US20110207811A1 (en) * 2010-02-19 2011-08-25 Sanofi-Aventis Use of celivarone for reducing occurrences of cardiovascular hospitalization
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
FR2967067A1 (fr) 2010-11-10 2012-05-11 Sanofi Aventis Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
CN102757444B (zh) * 2011-04-29 2016-02-10 南京信诺泰医药有限公司 具有一氧化氮供体性质的苯并呋喃类化合物
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
CN105315245B (zh) * 2014-06-16 2018-10-12 华润赛科药业有限责任公司 苯并呋喃类衍生物、其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
GB1345872A (en) * 1970-09-03 1974-02-06 Wyeth John & Brother Ltd Amino-and acylamino-pyridine and hydropyridine derivatives
US4806663A (en) * 1987-04-06 1989-02-21 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4851554A (en) 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
AT391316B (de) * 1988-09-15 1990-09-25 Ebewe Arzneimittel Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
JPH10130258A (ja) * 1996-10-10 1998-05-19 Eli Lilly & Co ベンゾ［ｂ］チオフェン化合物、中間体、製剤、および方法

Also Published As

Publication number Publication date
FR2813306A1 (fr) 2002-03-01
OA12359A (fr) 2006-05-16
DK1315709T3 (da) 2010-09-20
PL219848B1 (pl) 2015-07-31
RS51603B (sr) 2011-08-31
NO328138B1 (no) 2009-12-14
MA26943A1 (fr) 2004-12-20
PT1315709E (pt) 2010-07-29
IS6677A (is) 2003-01-13
IL153632A (en) 2007-07-24
CA2415847A1 (fr) 2002-02-28
IS2821B (is) 2013-02-15
EA200300062A1 (ru) 2003-08-28
ATE469138T1 (de) 2010-06-15
AR032892A1 (es) 2003-12-03
CA2415847C (fr) 2011-09-27
FR2813306B1 (fr) 2005-10-21
SK2162003A3 (en) 2003-08-05
BG66240B1 (bg) 2012-08-31
MEP23008A (en) 2010-06-10
NO20030800D0 (no) 2003-02-20
IL153632A0 (en) 2003-07-06
AU2001284149B2 (en) 2006-09-21
JP2004506727A (ja) 2004-03-04
BR0113425B1 (pt) 2014-02-25
JP5603849B2 (ja) 2014-10-08
DE60142240D1 (de) 2010-07-08
SI1315709T1 (sl) 2010-09-30
NZ523446A (en) 2004-12-24
TWI290920B (en) 2007-12-11
BR0113425A (pt) 2003-07-15
US6949583B2 (en) 2005-09-27
EP1315709B1 (fr) 2010-05-26
PL362119A1 (en) 2004-10-18
ZA200300744B (en) 2004-02-05
HUP0302968A3 (en) 2005-02-28
EA006237B1 (ru) 2005-10-27
CN1471521A (zh) 2004-01-28
KR20030023767A (ko) 2003-03-19
AU8414901A (en) 2002-03-04
MXPA03001463A (es) 2004-05-04
WO2002016339A1 (fr) 2002-02-28
YU12903A (sh) 2006-05-25
JP2012097100A (ja) 2012-05-24
ES2346291T3 (es) 2010-10-14
JP5081363B2 (ja) 2012-11-28
US20030225100A1 (en) 2003-12-04
HUP0302968A2 (hu) 2003-12-29
SK288126B6 (sk) 2013-10-02
KR100911280B1 (ko) 2009-08-11
ME00106B (me) 2010-10-10
CN1246315C (zh) 2006-03-22
HU229456B1 (en) 2013-12-30
CY1110738T1 (el) 2015-06-10
BG107527A (bg) 2003-10-31
CZ2003521A3 (cs) 2003-05-14
CZ304003B6 (cs) 2013-08-14
NO20030800L (no) 2003-04-23
EP1315709A1 (fr) 2003-06-04

Similar Documents

Publication Publication Date Title
HUP0302968A3 (en) Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
HUP0302060A3 (en) Method for preparing compositions
AU2001284149A1 (en) Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
PL354809A1 (en) Piperidine quinolyl propyl derivatives, preparation method and compositions containing same
HUP0303118A3 (en) Novel 1,3-dihydro-2h-indol-one derivatives, method for preparing same and pharmaceutical compositions containing them
HUP0303568A3 (en) Benzothiophene derivatives, process for their preparation and use thereof
HUP0302961A3 (en) Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
EP1218016A4 (en) COMPOSITION AND METHOD FOR PRODUCING A Germicidal Foam-Like Lubricant
ZA200109602B (en) Purine derivatives, preparation method and pharmaceutical compositions containing same.
PL356911A1 (en) Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same
EG22199A (en) Method for reducing or eliminating smoking
IL154240A0 (en) 4-pyrimidinamine derivatives, pharmaceutical compositions and related methods
ZA200110087B (en) Morphine sulphate microgranules, method for preparing same and compositions containing same.
HUP0103316A3 (en) 2-ureido-pyrimidone derivatives, method for producing them, pharmaceutical compositions containing them and their use
IL147746A0 (en) Benzenamine derivatives as anti-coagulants
HUP0204001A3 (en) Substituted aminomethyl-phenyl-cyclohexane derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0303361A3 (en) Substituted 1-aminobutan-3-ol derivatives, process for their preparation and pharmaceutical compositions containing them
PL360090A1 (en) Novel aminotriazolone compounds, method for preparing same and pharmaceutical compositions containing same
HUP0302892A3 (en) Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
IL154986A0 (en) Triazolo-epothilone derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
HUP0204572A3 (en) Substituierte bisindolylmaleinimide derivatives, process for their preparation and use and pharmaceutcial compositions containing them
HUP0302821A2 (hu) Eljárás szubsztituált 5-amino-N-fenil-1,2,4-triazol-3-szulfonamid-származékok előállítására
IL156160A0 (en) Klainetins and their derivatives, method for their preparation and use thereof
HUP0103194A3 (en) 17-halogenated-19-nor-steroids, method for preparing same, pharmaceutical compositions containing same and intermediates
HUP0303349A3 (en) Subtituted biphenyl derivatives, method for preparing them and pharmaceutical compositions containing the same

Legal Events

Date Code Title Description
CHPA Change of a particular in the register (except of change of ownership)
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170821