HK1028242A1 - Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3,-triazole-4-carboxamide and its use as antiepileptic - Google Patents

Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3,-triazole-4-carboxamide and its use as antiepileptic

Info

Publication number
HK1028242A1
HK1028242A1 HK00106807A HK00106807A HK1028242A1 HK 1028242 A1 HK1028242 A1 HK 1028242A1 HK 00106807 A HK00106807 A HK 00106807A HK 00106807 A HK00106807 A HK 00106807A HK 1028242 A1 HK1028242 A1 HK 1028242A1
Authority
HK
Hong Kong
Prior art keywords
antiepileptic
difluorobenzyl
carboxamide
triazole
crystal modification
Prior art date
Application number
HK00106807A
Other languages
English (en)
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1028242(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1028242A1 publication Critical patent/HK1028242A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK00106807A 1997-06-10 2000-10-25 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3,-triazole-4-carboxamide and its use as antiepileptic HK1028242A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (1)

Publication Number Publication Date
HK1028242A1 true HK1028242A1 (en) 2001-02-09

Family

ID=4209650

Family Applications (3)

Application Number Title Priority Date Filing Date
HK00106807A HK1028242A1 (en) 1997-06-10 2000-10-25 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3,-triazole-4-carboxamide and its use as antiepileptic
HK00106804A HK1028241A1 (en) 1997-06-10 2000-10-25 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic
HK00107340A HK1028031A1 (en) 1997-06-10 2000-11-17 Crystal modification of 1-(2,6-difluorobenzyl)-IH-1,2,3-triazole-4-carboxamide and its use as antiepileptic.

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK00106804A HK1028241A1 (en) 1997-06-10 2000-10-25 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic
HK00107340A HK1028031A1 (en) 1997-06-10 2000-11-17 Crystal modification of 1-(2,6-difluorobenzyl)-IH-1,2,3-triazole-4-carboxamide and its use as antiepileptic.

Country Status (37)

Country Link
US (6) US6740669B1 (zh)
EP (2) EP0994864B1 (zh)
JP (2) JP3672574B2 (zh)
KR (2) KR100409168B1 (zh)
CN (3) CN1132820C (zh)
AR (4) AR012945A1 (zh)
AT (2) ATE232852T1 (zh)
AU (2) AU725517B2 (zh)
BR (2) BR9804947A (zh)
CA (3) CA2256013C (zh)
CO (2) CO4940452A1 (zh)
CY (1) CY2007014I2 (zh)
CZ (2) CZ292481B6 (zh)
DE (3) DE69811500T2 (zh)
DK (2) DK0994863T3 (zh)
ES (2) ES2197485T3 (zh)
FR (1) FR07C0037I2 (zh)
HK (3) HK1028242A1 (zh)
HU (2) HU226107B1 (zh)
ID (2) ID27660A (zh)
IL (2) IL125732A (zh)
LU (1) LU91345I2 (zh)
MY (2) MY120156A (zh)
NL (1) NL300284I2 (zh)
NO (2) NO329315B1 (zh)
NZ (2) NZ331371A (zh)
PE (2) PE79799A1 (zh)
PL (2) PL191943B1 (zh)
PT (1) PT994864E (zh)
RU (2) RU2198167C2 (zh)
SI (2) SI0994863T1 (zh)
SK (2) SK283734B6 (zh)
TR (2) TR199801631T1 (zh)
TW (2) TW403740B (zh)
UY (1) UY25844A1 (zh)
WO (2) WO1998056772A1 (zh)
ZA (2) ZA984966B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
ES2299720T3 (es) * 2002-05-31 2008-06-01 Schering Corporation Formas polimorfas de un inhibidor de xantina-fosfodiesterasa v.
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
JP2012505191A (ja) * 2008-10-13 2012-03-01 シプラ・リミテッド ルフィナマイドの製造方法
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
EP2473051B1 (en) * 2009-09-04 2016-02-10 Tactical Therapeutics, Inc. Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
US8884026B2 (en) 2010-04-30 2014-11-11 Laboratorios Lesvi, S.L. Process for preparing rufinamide intermediate
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
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CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
JPH04506967A (ja) 1989-07-27 1992-12-03 ジー．ディー．サール　アンド　カンパニー 高血圧症治療用腎選択性生成物
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
DK0556393T3 (da) 1990-11-06 2000-10-16 Yamanouchi Pharma Co Ltd Tilkondenseret pyrazinderivat
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
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CA2260065C (en) * 1996-07-11 2006-10-17 Novartis Ag Process for preparing 1-substituted 4-cyano-1,2,3-triazoles
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
CA2614926C (en) 2010-02-09
PL191943B1 (pl) 2006-07-31
KR100409168B1 (ko) 2004-01-31
JP3672575B2 (ja) 2005-07-20
CA2614926A1 (en) 1998-12-17
US8076362B2 (en) 2011-12-13
SI0994863T1 (en) 2003-08-31
DK0994864T3 (da) 2003-07-21
CA2256015C (en) 2008-06-03
CZ292260B6 (cs) 2003-08-13
SI0994864T1 (en) 2003-10-31
PE80999A1 (es) 1999-09-06
MY125854A (en) 2006-08-30
DE69813560D1 (de) 2003-05-22
JP2000516259A (ja) 2000-12-05
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
ES2197485T3 (es) 2004-01-01
SK109398A3 (en) 1998-12-02
CO4940452A1 (es) 2000-07-24
CA2256013A1 (en) 1998-12-17
HK1028031A1 (en) 2001-02-02
AU8437298A (en) 1998-12-30
LU91345I9 (zh) 2018-12-31
US6455556B2 (en) 2002-09-24
TW526195B (en) 2003-04-01
RU2198167C2 (ru) 2003-02-10
US20040167186A1 (en) 2004-08-26
CN1132820C (zh) 2003-12-31
AR012946A1 (es) 2000-11-22
SK109498A3 (en) 1998-12-02
IL125732A0 (en) 1999-04-11
DE122007000051I2 (de) 2009-02-19
AR012945A1 (es) 2000-11-22
SK283685B6 (sk) 2003-12-02
NZ331371A (en) 2000-08-25
US7750028B2 (en) 2010-07-06
TR199801630T1 (xx) 1999-06-21
NO983667L (no) 1998-12-17
NO983666L (no) 1998-12-17
UY25844A1 (es) 2001-08-27
HU226107B1 (en) 2008-04-28
CA2256015A1 (en) 1998-12-17
HUP0002113A2 (hu) 2001-02-28
KR19990087835A (ko) 1999-12-27
DK0994863T3 (da) 2003-05-26
US20030125568A1 (en) 2003-07-03
PL330798A1 (en) 1999-06-07
CN1572789A (zh) 2005-02-02
CN1217716A (zh) 1999-05-26
US6740669B1 (en) 2004-05-25
LU91345I2 (fr) 2007-09-04
BR9804947A (pt) 1999-08-24
CZ253498A3 (cs) 1999-04-14
TW403740B (en) 2000-09-01
ATE237599T1 (de) 2003-05-15
HUP0000798A3 (en) 2000-10-30
MY120156A (en) 2005-09-30
CZ292481B6 (cs) 2003-09-17
CN1259127A (zh) 2000-07-05
BR9804946A (pt) 1999-08-24
ID21014A (id) 1999-04-08
CO4940448A1 (es) 2000-07-24
PE79799A1 (es) 1999-09-03
EP0994863B1 (en) 2003-02-19
IL125732A (en) 2002-12-01
AR061005A2 (es) 2008-07-30
PL330764A1 (en) 1999-05-24
CN1159300C (zh) 2004-07-28
US20060116520A1 (en) 2006-06-01
EP0994864A1 (en) 2000-04-26
NO983666D0 (no) 1998-08-11
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
ZA984967B (en) 1999-01-11
IL125733A0 (en) 1999-04-11
JP2000516258A (ja) 2000-12-05
IL125733A (en) 2002-12-01
US20100310655A1 (en) 2010-12-09
ATE232852T1 (de) 2003-03-15
AU725517B2 (en) 2000-10-12
ES2192779T3 (es) 2003-10-16
NZ331370A (en) 2000-08-25
EP0994864B1 (en) 2003-04-16
ID27660A (id) 2001-04-19
TR199801631T1 (xx) 1999-06-21
NO329315B1 (no) 2010-09-27
KR19990087836A (ko) 1999-12-27
DE69811500T2 (de) 2004-04-01
HK1028241A1 (en) 2001-02-09
WO1998056772A1 (en) 1998-12-17
AU725528B2 (en) 2000-10-12
DE122007000051I1 (de) 2007-11-08
FR07C0037I2 (zh) 2008-05-16
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
HUP0002113A3 (en) 2002-09-30
CY2007014I2 (el) 2009-11-04
NL300284I2 (nl) 2007-11-01
FR07C0037I1 (zh) 2007-08-17
CZ253398A3 (cs) 1999-04-14
EP0994863A1 (en) 2000-04-26
DE69813560T2 (de) 2004-02-05
CN1298708C (zh) 2007-02-07
ZA984966B (en) 1999-01-11
KR100425656B1 (ko) 2004-05-17
NO329314B1 (no) 2010-09-27
HUP0000798A2 (hu) 2000-10-30
US20010037029A1 (en) 2001-11-01
AR061004A2 (es) 2008-07-30
PL192114B1 (pl) 2006-08-31
JP3672574B2 (ja) 2005-07-20
RU2194041C2 (ru) 2002-12-10
CA2256013C (en) 2007-10-16
HU225153B1 (en) 2006-07-28
PT994864E (pt) 2003-07-31
DE69811500D1 (de) 2003-03-27

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Effective date: 20180607