SI0994864T1 - Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic - Google Patents

Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Info

Publication number
SI0994864T1
SI0994864T1 SI9830450T SI9830450T SI0994864T1 SI 0994864 T1 SI0994864 T1 SI 0994864T1 SI 9830450 T SI9830450 T SI 9830450T SI 9830450 T SI9830450 T SI 9830450T SI 0994864 T1 SI0994864 T1 SI 0994864T1
Authority
SI
Slovenia
Prior art keywords
antiepileptic
difluorobenzyl
carboxamide
triazole
crystal modification
Prior art date
Application number
SI9830450T
Other languages
English (en)
Slovenian (sl)
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0994864(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI0994864T1 publication Critical patent/SI0994864T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI9830450T 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic SI0994864T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic
EP98934930A EP0994864B1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (1)

Publication Number Publication Date
SI0994864T1 true SI0994864T1 (en) 2003-10-31

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9830405T SI0994863T1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic
SI9830450T SI0994864T1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI9830405T SI0994863T1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Country Status (37)

Country Link
US (6) US6740669B1 (zh)
EP (2) EP0994863B1 (zh)
JP (2) JP3672574B2 (zh)
KR (2) KR100409168B1 (zh)
CN (3) CN1298708C (zh)
AR (4) AR012945A1 (zh)
AT (2) ATE237599T1 (zh)
AU (2) AU725517B2 (zh)
BR (2) BR9804946A (zh)
CA (3) CA2256013C (zh)
CO (2) CO4940448A1 (zh)
CY (1) CY2007014I1 (zh)
CZ (2) CZ292481B6 (zh)
DE (3) DE69811500T2 (zh)
DK (2) DK0994863T3 (zh)
ES (2) ES2197485T3 (zh)
FR (1) FR07C0037I2 (zh)
HK (3) HK1028241A1 (zh)
HU (2) HU226107B1 (zh)
ID (2) ID27660A (zh)
IL (2) IL125732A (zh)
LU (1) LU91345I2 (zh)
MY (2) MY125854A (zh)
NL (1) NL300284I2 (zh)
NO (2) NO329315B1 (zh)
NZ (2) NZ331370A (zh)
PE (2) PE79799A1 (zh)
PL (2) PL191943B1 (zh)
PT (1) PT994864E (zh)
RU (2) RU2194041C2 (zh)
SI (2) SI0994863T1 (zh)
SK (2) SK283685B6 (zh)
TR (2) TR199801630T1 (zh)
TW (2) TW526195B (zh)
UY (1) UY25844A1 (zh)
WO (2) WO1998056773A1 (zh)
ZA (2) ZA984966B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
WO2003101991A1 (en) * 2002-05-31 2003-12-11 Schering Corporation Xanthine phosphodiesterase v inhibitor polymorphs
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
AU2009305255B2 (en) 2008-10-13 2014-02-06 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
MX2012002730A (es) * 2009-09-04 2012-07-20 Tactical Therapeutics Inc Nuevas composiciones y procesos para preparar formulaciones de 1,2,3-triazoles 5-amino o amino sustituidos y triazol orotato.
EP2465853A1 (en) 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
US8884026B2 (en) 2010-04-30 2014-11-11 Laboratorios Lesvi, S.L. Process for preparing rufinamide intermediate
ITMI20110718A1 (it) * 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
ES2150417T3 (es) 1990-11-06 2000-12-01 Yamanouchi Pharma Co Ltd Derivados de pirazina fusionados.
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
KR100419355B1 (ko) 1995-02-22 2004-06-04 훽스트파마슈티칼스앤드케미칼스가부시키가이샤 무정형피레타나이드,피레타나이드다형체,이들의제조방법및이를포함하는약제학적조성물
HU226425B1 (en) * 1996-07-11 2008-12-29 Novartis Ag Process for preparing 1-substituted 4-cyano-1,2,3-triazoles
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
NO983667L (no) 1998-12-17
AR061005A2 (es) 2008-07-30
US20010037029A1 (en) 2001-11-01
CY2007014I2 (el) 2009-11-04
AU8437298A (en) 1998-12-30
BR9804947A (pt) 1999-08-24
AR012946A1 (es) 2000-11-22
ATE232852T1 (de) 2003-03-15
IL125733A0 (en) 1999-04-11
ID27660A (id) 2001-04-19
NO983666L (no) 1998-12-17
SK283685B6 (sk) 2003-12-02
US20030125568A1 (en) 2003-07-03
NO329314B1 (no) 2010-09-27
CN1159300C (zh) 2004-07-28
TR199801630T1 (xx) 1999-06-21
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
DE69811500D1 (de) 2003-03-27
NO329315B1 (no) 2010-09-27
DE122007000051I2 (de) 2009-02-19
ES2197485T3 (es) 2004-01-01
CA2256015A1 (en) 1998-12-17
CZ292481B6 (cs) 2003-09-17
SK109498A3 (en) 1998-12-02
FR07C0037I2 (zh) 2008-05-16
HK1028242A1 (en) 2001-02-09
RU2198167C2 (ru) 2003-02-10
US6740669B1 (en) 2004-05-25
TW526195B (en) 2003-04-01
HU226107B1 (en) 2008-04-28
UY25844A1 (es) 2001-08-27
DK0994864T3 (da) 2003-07-21
CO4940448A1 (es) 2000-07-24
KR19990087836A (ko) 1999-12-27
CN1572789A (zh) 2005-02-02
HUP0000798A3 (en) 2000-10-30
DE122007000051I1 (de) 2007-11-08
US20060116520A1 (en) 2006-06-01
NL300284I2 (nl) 2007-11-01
LU91345I2 (fr) 2007-09-04
EP0994863A1 (en) 2000-04-26
MY125854A (en) 2006-08-30
IL125732A0 (en) 1999-04-11
AR012945A1 (es) 2000-11-22
IL125732A (en) 2002-12-01
CO4940452A1 (es) 2000-07-24
CN1298708C (zh) 2007-02-07
JP2000516258A (ja) 2000-12-05
US7750028B2 (en) 2010-07-06
KR19990087835A (ko) 1999-12-27
CA2614926A1 (en) 1998-12-17
PE79799A1 (es) 1999-09-03
PL191943B1 (pl) 2006-07-31
FR07C0037I1 (zh) 2007-08-17
CA2256013C (en) 2007-10-16
CN1217716A (zh) 1999-05-26
PT994864E (pt) 2003-07-31
ATE237599T1 (de) 2003-05-15
PL192114B1 (pl) 2006-08-31
US6455556B2 (en) 2002-09-24
WO1998056772A1 (en) 1998-12-17
HUP0002113A3 (en) 2002-09-30
AU725517B2 (en) 2000-10-12
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
EP0994864B1 (en) 2003-04-16
ZA984967B (en) 1999-01-11
HUP0000798A2 (hu) 2000-10-30
HK1028031A1 (en) 2001-02-02
US20100310655A1 (en) 2010-12-09
TR199801631T1 (xx) 1999-06-21
CA2256013A1 (en) 1998-12-17
CA2614926C (en) 2010-02-09
LU91345I9 (zh) 2018-12-31
DE69811500T2 (de) 2004-04-01
CN1132820C (zh) 2003-12-31
IL125733A (en) 2002-12-01
NZ331370A (en) 2000-08-25
SK109398A3 (en) 1998-12-02
PL330798A1 (en) 1999-06-07
CA2256015C (en) 2008-06-03
PL330764A1 (en) 1999-05-24
AU725528B2 (en) 2000-10-12
CZ253498A3 (cs) 1999-04-14
MY120156A (en) 2005-09-30
ES2192779T3 (es) 2003-10-16
RU2194041C2 (ru) 2002-12-10
ID21014A (id) 1999-04-08
JP3672575B2 (ja) 2005-07-20
CZ253398A3 (cs) 1999-04-14
US8076362B2 (en) 2011-12-13
NO983666D0 (no) 1998-08-11
DK0994863T3 (da) 2003-05-26
DE69813560D1 (de) 2003-05-22
HU225153B1 (en) 2006-07-28
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
KR100409168B1 (ko) 2004-01-31
CZ292260B6 (cs) 2003-08-13
CN1259127A (zh) 2000-07-05
KR100425656B1 (ko) 2004-05-17
BR9804946A (pt) 1999-08-24
TW403740B (en) 2000-09-01
HK1028241A1 (en) 2001-02-09
HUP0002113A2 (hu) 2001-02-28
NZ331371A (en) 2000-08-25
EP0994864A1 (en) 2000-04-26
ZA984966B (en) 1999-01-11
JP3672574B2 (ja) 2005-07-20
DE69813560T2 (de) 2004-02-05
JP2000516259A (ja) 2000-12-05
EP0994863B1 (en) 2003-02-19
AR061004A2 (es) 2008-07-30
SI0994863T1 (en) 2003-08-31
US20040167186A1 (en) 2004-08-26
PE80999A1 (es) 1999-09-06

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