IL125732A - Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it - Google Patents

Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it

Info

Publication number
IL125732A
IL125732A IL12573298A IL12573298A IL125732A IL 125732 A IL125732 A IL 125732A IL 12573298 A IL12573298 A IL 12573298A IL 12573298 A IL12573298 A IL 12573298A IL 125732 A IL125732 A IL 125732A
Authority
IL
Israel
Prior art keywords
weak
modification
medium
triazole
carboxamide
Prior art date
Application number
IL12573298A
Other languages
English (en)
Hebrew (he)
Other versions
IL125732A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL125732(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL125732A0 publication Critical patent/IL125732A0/xx
Publication of IL125732A publication Critical patent/IL125732A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12573298A 1997-06-10 1998-06-08 Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it IL125732A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (2)

Publication Number Publication Date
IL125732A0 IL125732A0 (en) 1999-04-11
IL125732A true IL125732A (en) 2002-12-01

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
IL12573298A IL125732A (en) 1997-06-10 1998-06-08 Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it
IL12573398A IL125733A (en) 1997-06-10 1998-06-08 Crystal modification of the compound -1 (-6,2 difluorobenzyl) - 1H- -3,2,1 triazole - 4 carboxamide and medicinal preparations for the treatment of epilepsy containing it

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL12573398A IL125733A (en) 1997-06-10 1998-06-08 Crystal modification of the compound -1 (-6,2 difluorobenzyl) - 1H- -3,2,1 triazole - 4 carboxamide and medicinal preparations for the treatment of epilepsy containing it

Country Status (37)

Country Link
US (6) US6740669B1 (zh)
EP (2) EP0994864B1 (zh)
JP (2) JP3672574B2 (zh)
KR (2) KR100409168B1 (zh)
CN (3) CN1132820C (zh)
AR (4) AR012945A1 (zh)
AT (2) ATE232852T1 (zh)
AU (2) AU725517B2 (zh)
BR (2) BR9804947A (zh)
CA (3) CA2256013C (zh)
CO (2) CO4940452A1 (zh)
CY (1) CY2007014I2 (zh)
CZ (2) CZ292481B6 (zh)
DE (3) DE69811500T2 (zh)
DK (2) DK0994863T3 (zh)
ES (2) ES2197485T3 (zh)
FR (1) FR07C0037I2 (zh)
HK (3) HK1028242A1 (zh)
HU (2) HU226107B1 (zh)
ID (2) ID27660A (zh)
IL (2) IL125732A (zh)
LU (1) LU91345I2 (zh)
MY (2) MY120156A (zh)
NL (1) NL300284I2 (zh)
NO (2) NO329315B1 (zh)
NZ (2) NZ331371A (zh)
PE (2) PE79799A1 (zh)
PL (2) PL191943B1 (zh)
PT (1) PT994864E (zh)
RU (2) RU2198167C2 (zh)
SI (2) SI0994863T1 (zh)
SK (2) SK283734B6 (zh)
TR (2) TR199801631T1 (zh)
TW (2) TW403740B (zh)
UY (1) UY25844A1 (zh)
WO (2) WO1998056772A1 (zh)
ZA (2) ZA984966B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
ES2299720T3 (es) * 2002-05-31 2008-06-01 Schering Corporation Formas polimorfas de un inhibidor de xantina-fosfodiesterasa v.
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
JP2012505191A (ja) * 2008-10-13 2012-03-01 シプラ・リミテッド ルフィナマイドの製造方法
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
EP2473051B1 (en) * 2009-09-04 2016-02-10 Tactical Therapeutics, Inc. Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
US8884026B2 (en) 2010-04-30 2014-11-11 Laboratorios Lesvi, S.L. Process for preparing rufinamide intermediate
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
FI93544C (fi) * 1985-04-18 1995-04-25 Ciba Geigy Ag Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
JPH04506967A (ja) 1989-07-27 1992-12-03 ジー．ディー．サール　アンド　カンパニー 高血圧症治療用腎選択性生成物
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
DK0556393T3 (da) 1990-11-06 2000-10-16 Yamanouchi Pharma Co Ltd Tilkondenseret pyrazinderivat
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
DE69609314T2 (de) 1995-02-22 2001-06-13 Aventis Pharma Ltd Amorph piretanide, polymorphe davon, verfahren zur dessen herstellung und ihre verwendung
CA2260065C (en) * 1996-07-11 2006-10-17 Novartis Ag Process for preparing 1-substituted 4-cyano-1,2,3-triazoles
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
CA2614926C (en) 2010-02-09
PL191943B1 (pl) 2006-07-31
KR100409168B1 (ko) 2004-01-31
JP3672575B2 (ja) 2005-07-20
CA2614926A1 (en) 1998-12-17
US8076362B2 (en) 2011-12-13
SI0994863T1 (en) 2003-08-31
DK0994864T3 (da) 2003-07-21
CA2256015C (en) 2008-06-03
CZ292260B6 (cs) 2003-08-13
SI0994864T1 (en) 2003-10-31
PE80999A1 (es) 1999-09-06
MY125854A (en) 2006-08-30
DE69813560D1 (de) 2003-05-22
JP2000516259A (ja) 2000-12-05
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
ES2197485T3 (es) 2004-01-01
SK109398A3 (en) 1998-12-02
CO4940452A1 (es) 2000-07-24
CA2256013A1 (en) 1998-12-17
HK1028031A1 (en) 2001-02-02
AU8437298A (en) 1998-12-30
LU91345I9 (zh) 2018-12-31
US6455556B2 (en) 2002-09-24
TW526195B (en) 2003-04-01
RU2198167C2 (ru) 2003-02-10
US20040167186A1 (en) 2004-08-26
CN1132820C (zh) 2003-12-31
AR012946A1 (es) 2000-11-22
SK109498A3 (en) 1998-12-02
IL125732A0 (en) 1999-04-11
DE122007000051I2 (de) 2009-02-19
AR012945A1 (es) 2000-11-22
SK283685B6 (sk) 2003-12-02
NZ331371A (en) 2000-08-25
US7750028B2 (en) 2010-07-06
TR199801630T1 (xx) 1999-06-21
NO983667L (no) 1998-12-17
NO983666L (no) 1998-12-17
UY25844A1 (es) 2001-08-27
HU226107B1 (en) 2008-04-28
CA2256015A1 (en) 1998-12-17
HUP0002113A2 (hu) 2001-02-28
KR19990087835A (ko) 1999-12-27
DK0994863T3 (da) 2003-05-26
US20030125568A1 (en) 2003-07-03
PL330798A1 (en) 1999-06-07
CN1572789A (zh) 2005-02-02
CN1217716A (zh) 1999-05-26
US6740669B1 (en) 2004-05-25
LU91345I2 (fr) 2007-09-04
BR9804947A (pt) 1999-08-24
CZ253498A3 (cs) 1999-04-14
TW403740B (en) 2000-09-01
ATE237599T1 (de) 2003-05-15
HUP0000798A3 (en) 2000-10-30
MY120156A (en) 2005-09-30
CZ292481B6 (cs) 2003-09-17
CN1259127A (zh) 2000-07-05
BR9804946A (pt) 1999-08-24
ID21014A (id) 1999-04-08
HK1028242A1 (en) 2001-02-09
CO4940448A1 (es) 2000-07-24
PE79799A1 (es) 1999-09-03
EP0994863B1 (en) 2003-02-19
AR061005A2 (es) 2008-07-30
PL330764A1 (en) 1999-05-24
CN1159300C (zh) 2004-07-28
US20060116520A1 (en) 2006-06-01
EP0994864A1 (en) 2000-04-26
NO983666D0 (no) 1998-08-11
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
ZA984967B (en) 1999-01-11
IL125733A0 (en) 1999-04-11
JP2000516258A (ja) 2000-12-05
IL125733A (en) 2002-12-01
US20100310655A1 (en) 2010-12-09
ATE232852T1 (de) 2003-03-15
AU725517B2 (en) 2000-10-12
ES2192779T3 (es) 2003-10-16
NZ331370A (en) 2000-08-25
EP0994864B1 (en) 2003-04-16
ID27660A (id) 2001-04-19
TR199801631T1 (xx) 1999-06-21
NO329315B1 (no) 2010-09-27
KR19990087836A (ko) 1999-12-27
DE69811500T2 (de) 2004-04-01
HK1028241A1 (en) 2001-02-09
WO1998056772A1 (en) 1998-12-17
AU725528B2 (en) 2000-10-12
DE122007000051I1 (de) 2007-11-08
FR07C0037I2 (zh) 2008-05-16
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
HUP0002113A3 (en) 2002-09-30
CY2007014I2 (el) 2009-11-04
NL300284I2 (nl) 2007-11-01
FR07C0037I1 (zh) 2007-08-17
CZ253398A3 (cs) 1999-04-14
EP0994863A1 (en) 2000-04-26
DE69813560T2 (de) 2004-02-05
CN1298708C (zh) 2007-02-07
ZA984966B (en) 1999-01-11
KR100425656B1 (ko) 2004-05-17
NO329314B1 (no) 2010-09-27
HUP0000798A2 (hu) 2000-10-30
US20010037029A1 (en) 2001-11-01
AR061004A2 (es) 2008-07-30
PL192114B1 (pl) 2006-08-31
JP3672574B2 (ja) 2005-07-20
RU2194041C2 (ru) 2002-12-10
CA2256013C (en) 2007-10-16
HU225153B1 (en) 2006-07-28
PT994864E (pt) 2003-07-31
DE69811500D1 (de) 2003-03-27

Similar Documents

Publication Publication Date Title
US20060116520A1 (en) Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
MXPA98006950A (en) Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic
MXPA98006951A (en) Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic

Legal Events

Date Code Title Description
FF Patent granted
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired