HK1028241A1 - Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic - Google Patents
Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepilepticInfo
- Publication number
- HK1028241A1 HK1028241A1 HK00106804A HK00106804A HK1028241A1 HK 1028241 A1 HK1028241 A1 HK 1028241A1 HK 00106804 A HK00106804 A HK 00106804A HK 00106804 A HK00106804 A HK 00106804A HK 1028241 A1 HK1028241 A1 HK 1028241A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antiepileptic
- difluorobenzyl
- carboxamide
- triazole
- crystal modification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH140497 | 1997-06-10 | ||
PCT/EP1998/003427 WO1998056772A1 (en) | 1997-06-10 | 1998-06-08 | Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1028241A1 true HK1028241A1 (en) | 2001-02-09 |
Family
ID=4209650
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00106807A HK1028242A1 (en) | 1997-06-10 | 2000-10-25 | Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3,-triazole-4-carboxamide and its use as antiepileptic |
HK00106804A HK1028241A1 (en) | 1997-06-10 | 2000-10-25 | Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic |
HK00107340A HK1028031A1 (en) | 1997-06-10 | 2000-11-17 | Crystal modification of 1-(2,6-difluorobenzyl)-IH-1,2,3-triazole-4-carboxamide and its use as antiepileptic. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00106807A HK1028242A1 (en) | 1997-06-10 | 2000-10-25 | Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3,-triazole-4-carboxamide and its use as antiepileptic |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00107340A HK1028031A1 (en) | 1997-06-10 | 2000-11-17 | Crystal modification of 1-(2,6-difluorobenzyl)-IH-1,2,3-triazole-4-carboxamide and its use as antiepileptic. |
Country Status (37)
Country | Link |
---|---|
US (6) | US6740669B1 (es) |
EP (2) | EP0994863B1 (es) |
JP (2) | JP3672574B2 (es) |
KR (2) | KR100409168B1 (es) |
CN (3) | CN1132820C (es) |
AR (4) | AR012945A1 (es) |
AT (2) | ATE237599T1 (es) |
AU (2) | AU725528B2 (es) |
BR (2) | BR9804947A (es) |
CA (3) | CA2256015C (es) |
CO (2) | CO4940448A1 (es) |
CY (1) | CY2007014I1 (es) |
CZ (2) | CZ292481B6 (es) |
DE (3) | DE69813560T2 (es) |
DK (2) | DK0994864T3 (es) |
ES (2) | ES2197485T3 (es) |
FR (1) | FR07C0037I2 (es) |
HK (3) | HK1028242A1 (es) |
HU (2) | HU226107B1 (es) |
ID (2) | ID27660A (es) |
IL (2) | IL125733A (es) |
LU (1) | LU91345I2 (es) |
MY (2) | MY120156A (es) |
NL (1) | NL300284I2 (es) |
NO (2) | NO329315B1 (es) |
NZ (2) | NZ331371A (es) |
PE (2) | PE79799A1 (es) |
PL (2) | PL191943B1 (es) |
PT (1) | PT994864E (es) |
RU (2) | RU2194041C2 (es) |
SI (2) | SI0994864T1 (es) |
SK (2) | SK283734B6 (es) |
TR (2) | TR199801631T1 (es) |
TW (2) | TW526195B (es) |
UY (1) | UY25844A1 (es) |
WO (2) | WO1998056773A1 (es) |
ZA (2) | ZA984966B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW526195B (en) | 1997-06-10 | 2003-04-01 | Novartis Ag | Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use |
WO2003101991A1 (en) * | 2002-05-31 | 2003-12-11 | Schering Corporation | Xanthine phosphodiesterase v inhibitor polymorphs |
GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20090069390A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched rufinamide |
CA2736703A1 (en) * | 2008-10-13 | 2010-04-22 | Cipla Limited | Process for the preparation of rufinamide |
CN101768124B (zh) * | 2008-12-30 | 2012-01-04 | 北京本草天源药物研究院 | 一种药物晶体及其制备方法和用途 |
IT1395736B1 (it) * | 2009-08-04 | 2012-10-19 | Dipharma Francis Srl | Forme cristalline di rufinamide |
JP2013503861A (ja) * | 2009-09-04 | 2013-02-04 | タクティカル セラピューティクス インコーポレイテッド | 新規の組成物、ならびに5−アミノまたは置換アミノ1,2,3−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
EP2465853A1 (en) | 2010-12-14 | 2012-06-20 | Laboratorios Lesvi, S.L. | Polymorph of rufinamide and process for obtaining it |
WO2011135105A1 (en) | 2010-04-30 | 2011-11-03 | Laboratorios Lesvi, S.L. | Improved process for preparing rufinamide intermediate |
ITMI20110718A1 (it) | 2011-04-29 | 2012-10-30 | Dipharma Francis Srl | Procedimento per la purificazione di rufinamide |
US10206874B2 (en) | 2012-07-20 | 2019-02-19 | Hetero Research Foundation | Rufinamide solid dispersion |
WO2021099481A1 (en) | 2019-11-20 | 2021-05-27 | Medichem, S.A. | Solid composition containing rufinamide |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3992378A (en) | 1973-12-26 | 1976-11-16 | Eli Lilly And Company | Fluoralkyl quinoxadinediones |
US4156734A (en) * | 1976-02-13 | 1979-05-29 | Merck & Co., Inc. | Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid |
GB1511195A (en) | 1976-10-18 | 1978-05-17 | Ici America Inc | Triazole derivatives |
US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
US4346097A (en) * | 1980-09-30 | 1982-08-24 | Warner-Lambert Company | Method for treating convulsions with pyrazole-4-carboxamide derivatives |
US4789680A (en) * | 1982-12-23 | 1988-12-06 | Ciba-Geigy Corporation | Aralkyltriazole compounds |
FI834666A (fi) | 1982-12-23 | 1984-06-24 | Ciba Geigy Ag | Foerfarande foer framstaellning av nya aralkyltriazolfoereningar. |
US4511572A (en) * | 1983-03-18 | 1985-04-16 | The University Of Kentucky Research Foundation | Triazoline anticonvulsant drugs |
PH22568A (en) * | 1985-04-18 | 1988-10-17 | Ciba Geigy Ag | Fluorinated benzyl triazoles and pharmaceutical compositions containing the same |
CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
JPH02214504A (ja) | 1989-02-15 | 1990-08-27 | Nissan Chem Ind Ltd | 光学活性キノキサリン化合物の晶析法 |
JPH04506967A (ja) | 1989-07-27 | 1992-12-03 | ジー.ディー.サール アンド カンパニー | 高血圧症治療用腎選択性生成物 |
IL96507A0 (en) | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
EP0556393B1 (en) | 1990-11-06 | 2000-07-26 | Yamanouchi Pharmaceutical Co. Ltd. | Fused pyrazine derivative |
JP2753911B2 (ja) | 1991-12-06 | 1998-05-20 | キッセイ薬品工業株式会社 | N−tert−ブチル−1−メチル−3,3−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法 |
DE4217952A1 (de) | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
US5248699A (en) * | 1992-08-13 | 1993-09-28 | Pfizer Inc. | Sertraline polymorph |
US5631373A (en) | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
GB9418443D0 (en) | 1994-09-13 | 1994-11-02 | Pfizer Ltd | Therapeutic agents |
GB9419318D0 (en) | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
KR100419355B1 (ko) | 1995-02-22 | 2004-06-04 | 훽스트파마슈티칼스앤드케미칼스가부시키가이샤 | 무정형피레타나이드,피레타나이드다형체,이들의제조방법및이를포함하는약제학적조성물 |
AU719148B2 (en) * | 1996-07-11 | 2000-05-04 | Novartis Ag | Process for preparing 1-substituted 4-cyano-1,2,3-triazoles |
TW526195B (en) * | 1997-06-10 | 2003-04-01 | Novartis Ag | Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use |
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1998
- 1998-06-04 TW TW087108858A patent/TW526195B/zh not_active IP Right Cessation
- 1998-06-04 TW TW087108859A patent/TW403740B/zh not_active IP Right Cessation
- 1998-06-08 ID IDW980065D patent/ID27660A/id unknown
- 1998-06-08 SI SI9830450T patent/SI0994864T1/xx unknown
- 1998-06-08 AU AU84371/98A patent/AU725528B2/en not_active Expired
- 1998-06-08 CN CN988000113A patent/CN1132820C/zh not_active Expired - Lifetime
- 1998-06-08 EP EP98934929A patent/EP0994863B1/en not_active Expired - Lifetime
- 1998-06-08 NZ NZ331371A patent/NZ331371A/xx not_active IP Right Cessation
- 1998-06-08 PE PE1998000478A patent/PE79799A1/es not_active IP Right Cessation
- 1998-06-08 RU RU99104299/04A patent/RU2194041C2/ru active
- 1998-06-08 PE PE1998000479A patent/PE80999A1/es not_active IP Right Cessation
- 1998-06-08 US US09/125,329 patent/US6740669B1/en not_active Expired - Lifetime
- 1998-06-08 EP EP98934930A patent/EP0994864B1/en not_active Expired - Lifetime
- 1998-06-08 RU RU99104300/04A patent/RU2198167C2/ru active
- 1998-06-08 WO PCT/EP1998/003428 patent/WO1998056773A1/en active IP Right Grant
- 1998-06-08 BR BR9804947A patent/BR9804947A/pt not_active Application Discontinuation
- 1998-06-08 IL IL12573398A patent/IL125733A/en active Protection Beyond IP Right Term
- 1998-06-08 SK SK1094-98A patent/SK283734B6/sk not_active IP Right Cessation
- 1998-06-08 PL PL330764A patent/PL191943B1/pl unknown
- 1998-06-08 TR TR1998/01631T patent/TR199801631T1/xx unknown
- 1998-06-08 AT AT98934930T patent/ATE237599T1/de active
- 1998-06-08 DE DE69813560T patent/DE69813560T2/de not_active Expired - Lifetime
- 1998-06-08 DK DK98934930T patent/DK0994864T3/da active
- 1998-06-08 BR BR9804946A patent/BR9804946A/pt not_active Application Discontinuation
- 1998-06-08 CA CA002256015A patent/CA2256015C/en not_active Expired - Lifetime
- 1998-06-08 ES ES98934930T patent/ES2197485T3/es not_active Expired - Lifetime
- 1998-06-08 ID IDW980066D patent/ID21014A/id unknown
- 1998-06-08 JP JP53628898A patent/JP3672574B2/ja not_active Expired - Lifetime
- 1998-06-08 CZ CZ19982533A patent/CZ292481B6/cs not_active IP Right Cessation
- 1998-06-08 HU HU0000798A patent/HU226107B1/hu unknown
- 1998-06-08 KR KR10-1998-0708149A patent/KR100409168B1/ko not_active IP Right Cessation
- 1998-06-08 TR TR1998/01630T patent/TR199801630T1/xx unknown
- 1998-06-08 KR KR10-1998-0708150A patent/KR100425656B1/ko not_active IP Right Cessation
- 1998-06-08 ES ES98934929T patent/ES2192779T3/es not_active Expired - Lifetime
- 1998-06-08 DK DK98934929T patent/DK0994863T3/da active
- 1998-06-08 SK SK1093-98A patent/SK283685B6/sk not_active IP Right Cessation
- 1998-06-08 NZ NZ331370A patent/NZ331370A/xx not_active IP Right Cessation
- 1998-06-08 AU AU84372/98A patent/AU725517B2/en not_active Expired
- 1998-06-08 PL PL330798A patent/PL192114B1/pl unknown
- 1998-06-08 WO PCT/EP1998/003427 patent/WO1998056772A1/en active IP Right Grant
- 1998-06-08 CA CA002256013A patent/CA2256013C/en not_active Expired - Lifetime
- 1998-06-08 HU HU0002113A patent/HU225153B1/hu unknown
- 1998-06-08 IL IL12573298A patent/IL125732A/en not_active IP Right Cessation
- 1998-06-08 CN CNB988056755A patent/CN1159300C/zh not_active Expired - Lifetime
- 1998-06-08 AT AT98934929T patent/ATE232852T1/de active
- 1998-06-08 CZ CZ19982534A patent/CZ292260B6/cs not_active IP Right Cessation
- 1998-06-08 SI SI9830405T patent/SI0994863T1/xx unknown
- 1998-06-08 PT PT98934930T patent/PT994864E/pt unknown
- 1998-06-08 CN CNB2004100473675A patent/CN1298708C/zh not_active Expired - Lifetime
- 1998-06-08 DE DE69811500T patent/DE69811500T2/de not_active Expired - Lifetime
- 1998-06-08 CA CA2614926A patent/CA2614926C/en not_active Expired - Lifetime
- 1998-06-08 JP JP53628998A patent/JP3672575B2/ja not_active Expired - Lifetime
- 1998-06-08 DE DE122007000051C patent/DE122007000051I2/de active Active
- 1998-06-09 MY MYPI98002570A patent/MY120156A/en unknown
- 1998-06-09 CO CO98032885A patent/CO4940448A1/es unknown
- 1998-06-09 ZA ZA984966A patent/ZA984966B/xx unknown
- 1998-06-09 CO CO98032879A patent/CO4940452A1/es unknown
- 1998-06-09 AR ARP980102707A patent/AR012945A1/es not_active Application Discontinuation
- 1998-06-09 AR ARP980102708A patent/AR012946A1/es not_active Application Discontinuation
- 1998-06-09 ZA ZA984967A patent/ZA984967B/xx unknown
- 1998-06-09 MY MYPI98002572A patent/MY125854A/en unknown
- 1998-08-11 NO NO19983667A patent/NO329315B1/no not_active IP Right Cessation
- 1998-08-11 NO NO19983666A patent/NO329314B1/no not_active IP Right Cessation
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1999
- 1999-12-10 UY UY25844A patent/UY25844A1/es not_active Application Discontinuation
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2000
- 2000-10-25 HK HK00106807A patent/HK1028242A1/xx not_active IP Right Cessation
- 2000-10-25 HK HK00106804A patent/HK1028241A1/xx not_active IP Right Cessation
- 2000-11-17 HK HK00107340A patent/HK1028031A1/xx not_active IP Right Cessation
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2001
- 2001-05-31 US US09/871,366 patent/US6455556B2/en not_active Expired - Lifetime
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2002
- 2002-11-14 US US10/294,408 patent/US20030125568A1/en not_active Abandoned
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2004
- 2004-02-26 US US10/787,528 patent/US20040167186A1/en not_active Abandoned
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2006
- 2006-01-11 US US11/329,945 patent/US7750028B2/en not_active Expired - Fee Related
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2007
- 2007-05-17 AR ARP070102132A patent/AR061005A2/es not_active Application Discontinuation
- 2007-05-17 AR ARP070102131A patent/AR061004A2/es unknown
- 2007-07-03 NL NL300284C patent/NL300284I2/nl unknown
- 2007-07-04 LU LU91345C patent/LU91345I2/fr unknown
- 2007-07-06 FR FR07C0037C patent/FR07C0037I2/fr active Active
- 2007-07-13 CY CY200700014C patent/CY2007014I1/el unknown
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2010
- 2010-04-26 US US12/767,003 patent/US8076362B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20180607 |