HK1017692A1 - Endothelial cell proliferation inhibitor and method of use - Google Patents

Endothelial cell proliferation inhibitor and method of use

Info

Publication number
HK1017692A1
HK1017692A1 HK99102688.5A HK99102688A HK1017692A1 HK 1017692 A1 HK1017692 A1 HK 1017692A1 HK 99102688 A HK99102688 A HK 99102688A HK 1017692 A1 HK1017692 A1 HK 1017692A1
Authority
HK
Hong Kong
Prior art keywords
cell proliferation
endothelial cell
proliferation inhibitor
inhibitor
endothelial
Prior art date
Application number
HK99102688.5A
Other languages
English (en)
Inventor
Cao Y Yihai
Moses Judah Folkman
Michael S O'reilly
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/763,528 external-priority patent/US5854221A/en
Application filed by Childrens Medical Center filed Critical Childrens Medical Center
Publication of HK1017692A1 publication Critical patent/HK1017692A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Plant Substances (AREA)
HK99102688.5A 1995-12-13 1999-06-23 Endothelial cell proliferation inhibitor and method of use HK1017692A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US851995P 1995-12-13 1995-12-13
US08/763,528 US5854221A (en) 1996-12-12 1996-12-12 Endothelial cell proliferation inhibitor and method of use
PCT/US1996/020447 WO1997023500A1 (en) 1995-12-13 1996-12-13 Endothelial cell proliferation inhibitor and method of use

Publications (1)

Publication Number Publication Date
HK1017692A1 true HK1017692A1 (en) 1999-11-26

Family

ID=26678280

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99102688.5A HK1017692A1 (en) 1995-12-13 1999-06-23 Endothelial cell proliferation inhibitor and method of use

Country Status (20)

Country Link
US (1) US20010016644A1 (xx)
EP (1) EP0869970B1 (xx)
JP (1) JP3684371B2 (xx)
KR (1) KR100477280B1 (xx)
CN (1) CN1554444A (xx)
AT (1) ATE262537T1 (xx)
AU (1) AU710612B2 (xx)
BR (1) BR9612115A (xx)
CA (1) CA2240296C (xx)
CZ (1) CZ298612B6 (xx)
DE (1) DE69631972T2 (xx)
DK (1) DK0869970T3 (xx)
ES (1) ES2217340T3 (xx)
HK (1) HK1017692A1 (xx)
HU (1) HUP9900979A3 (xx)
NO (1) NO321775B1 (xx)
NZ (1) NZ330537A (xx)
PL (1) PL188719B1 (xx)
PT (1) PT869970E (xx)
WO (1) WO1997023500A1 (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ330537A (en) * 1995-12-13 2001-06-29 Childrens Medical Center Kringle 5 rerion of plasminogen as an endothelial cell proliferation inhibitor
US6699838B1 (en) 1996-05-03 2004-03-02 Abbott Laboratories Antiangiogenic peptides
DE69733756T2 (de) * 1996-05-03 2006-06-01 Abbott Laboratories, Abbott Park Antiangiogenische peptiden, dafür kodierende polynukleotide und verfahren zur hemmung der angiogenesis
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
US5801012A (en) 1996-09-17 1998-09-01 Northwestern University Methods and compositions for generating angiostatin
JP2002510209A (ja) * 1997-06-26 2002-04-02 カロリンスカ イノベイションズ アクチボラゲット インビボで血管形成を調節することができるプラスミノーゲンのクリングルドメイン１−５
WO1999026480A1 (en) * 1997-11-20 1999-06-03 Genetix Pharmaceuticals, Inc. Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases
US6632961B1 (en) 1998-05-22 2003-10-14 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
US7144854B1 (en) 1999-09-10 2006-12-05 Conjuchem, Inc. Long lasting anti-angiogenic peptides
CA2373252C (en) * 1999-05-17 2007-08-07 Conjuchem Inc. Long lasting anti-angiogenic peptides
WO2000069911A1 (en) 1999-05-17 2000-11-23 Conjuchem, Inc. Long lasting insulinotropic peptides
JP2003517007A (ja) * 1999-12-15 2003-05-20 エントレメッド インコーポレイテッド 内皮細胞増殖阻害組成物および方法
CA2421251A1 (en) 2000-09-05 2002-03-14 Karolinska Innovations Ab Recombinant endothelial cell growth inhibitors derived from a mammalian plasminogen
AU2002239414A1 (en) * 2000-11-02 2002-05-27 Bristol-Myers Squibb Company Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
EP1714151A4 (en) * 2004-01-21 2009-06-10 Fujirebio America Inc DETECTION OF PEPTIDES RELATED TO MESOTHELIN / MEGAKARYOCYTIC POTENTIAL FACTOR IN PERITONEAL LIQUID FOR THE ASSESSMENT OF THE PERITONEUM AND PERITONEAL CAVE
CN100355458C (zh) * 2005-03-16 2007-12-19 北京大学 人增殖抑制基因－腺病毒表达载体的应用
US20120220015A1 (en) 2009-05-26 2012-08-30 Biolex Therapeutics Compositions and methods for production of aglycosylated plasminogen
CN103060265B (zh) * 2013-01-23 2014-12-03 山东大学 老年大鼠脑血管内皮细胞原代培养方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
US5491129A (en) * 1992-07-30 1996-02-13 Yeda Research And Development Co. Ltd. Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them
EP0758390B1 (en) * 1994-04-26 2007-02-28 The Children's Medical Center Corporation Angiostatin and method of use for inhibition of angiogenesis
JPH09512426A (ja) * 1994-04-26 1997-12-16 ファルマシア・アンド・アップジョン・カンパニー 好中球の接着および移動の遮断に有用なＭａｃ−１ Ｉ−ドメイン蛋白質
CZ334097A3 (cs) * 1995-04-26 1998-04-15 The Children's Medical Center Corporation Fragmenty angiostatinu, agregovaný angiostatin a způsoby jeho použití
NZ330537A (en) * 1995-12-13 2001-06-29 Childrens Medical Center Kringle 5 rerion of plasminogen as an endothelial cell proliferation inhibitor

Also Published As

Publication number Publication date
KR19990072126A (ko) 1999-09-27
CA2240296A1 (en) 1997-07-03
PL188719B1 (pl) 2005-04-29
HUP9900979A3 (en) 2001-10-29
AU1687097A (en) 1997-07-17
BR9612115A (pt) 1999-02-17
NO321775B1 (no) 2006-07-03
KR100477280B1 (ko) 2005-07-18
PT869970E (pt) 2004-08-31
CZ182898A3 (cs) 1998-10-14
NO982715L (no) 1998-08-12
NO982715D0 (no) 1998-06-12
NZ330537A (en) 2001-06-29
DE69631972T2 (de) 2005-01-05
US20010016644A1 (en) 2001-08-23
JP2002502359A (ja) 2002-01-22
ATE262537T1 (de) 2004-04-15
EP0869970B1 (en) 2004-03-24
PL327200A1 (en) 1998-11-23
ES2217340T3 (es) 2004-11-01
CA2240296C (en) 2004-05-04
JP3684371B2 (ja) 2005-08-17
HUP9900979A2 (hu) 1999-07-28
DE69631972D1 (de) 2004-04-29
EP0869970A1 (en) 1998-10-14
WO1997023500A1 (en) 1997-07-03
AU710612B2 (en) 1999-09-23
CZ298612B6 (cs) 2007-11-21
CN1554444A (zh) 2004-12-15
DK0869970T3 (da) 2004-07-05
EP0869970A4 (en) 2002-01-30

Similar Documents

Publication Publication Date Title
HK1017692A1 (en) Endothelial cell proliferation inhibitor and method of use
ZA981936B (en) Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
NZ330897A (en) Human trk receptors and neurotropic factor inhibitors
BG103977A (en) Low molecular rotamase enzymic activity inhibitors
ATE232106T1 (de) Regulierung von essgewohnheiten
BG102362A (en) New derivatives of amino acids, their preparation and application
EP0675728A4 (en) MEANS AND METHODS FOR IMPROVING KERATINOYCTE ADHESION TO THE SKIN.
EP0754229A1 (en) Alfamin: a human serum albumin-like protein
MY104909A (en) Peptide compounds.
AU7334291A (en) Merosin, nucleic acids encoding, fragments and uses thereof
ZA934777B (en) Novel piperidyl amides, sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis.
IL109761A0 (en) Oligopeptides derived from c-reactive protein fragments
SE9600742L (sv) Vridbart arrangemang
BG104119A (en) A new composition
FI960839A0 (fi) Uusia tripeptidejä, jotka ovat käyttökelpoisia immuuni- ja CNS-terapiassa
MX9205978A (es) Nuevas proteinas inhibidoras de trombina de garrapatas.
NZ326769A (en) High-content famciclovir tablets
DE69635457D1 (de) Deprenyl induziertes protein
MY106261A (en) Anti-inflammatory 1-heteroaryl oxindole-3-carboxamides.
RU95114125A (ru) Ингибитор пролиферации стволовых кроветворных клеток
MX9701904A (es) Proteinas de enlace de pka novedosas y usos de las mismas.
IL106081A0 (en) Pharmaceutical agents combining antiinflammatory,free radical inhibitor and protein modification inhibitor properties

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20141213