DE69631972D1 - Proliferationsinhibitor von endothellzellen und dessen verwendung - Google Patents

Proliferationsinhibitor von endothellzellen und dessen verwendung

Info

Publication number
DE69631972D1
DE69631972D1 DE69631972T DE69631972T DE69631972D1 DE 69631972 D1 DE69631972 D1 DE 69631972D1 DE 69631972 T DE69631972 T DE 69631972T DE 69631972 T DE69631972 T DE 69631972T DE 69631972 D1 DE69631972 D1 DE 69631972D1
Authority
DE
Germany
Prior art keywords
endothell
cells
proliferation inhibitor
inhibitor
cell proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69631972T
Other languages
English (en)
Other versions
DE69631972T2 (de
Inventor
Yihai Cao
Judah Folkman
S O'reilly
Donald J Davidson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
THE CHILDERN'S MEDICAL CENTER CORP., BOSTON, MASS.
Abbott Laboratories
Original Assignee
Childrens Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/763,528 external-priority patent/US5854221A/en
Application filed by Childrens Medical Center Corp filed Critical Childrens Medical Center Corp
Application granted granted Critical
Publication of DE69631972D1 publication Critical patent/DE69631972D1/de
Publication of DE69631972T2 publication Critical patent/DE69631972T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69631972T 1995-12-13 1996-12-13 Proliferationsinhibitor von endothellzellen und dessen verwendung Expired - Lifetime DE69631972T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US851995P 1995-12-13 1995-12-13
US8519P 1995-12-13
US763528 1996-12-12
US08/763,528 US5854221A (en) 1996-12-12 1996-12-12 Endothelial cell proliferation inhibitor and method of use
PCT/US1996/020447 WO1997023500A1 (en) 1995-12-13 1996-12-13 Endothelial cell proliferation inhibitor and method of use

Publications (2)

Publication Number Publication Date
DE69631972D1 true DE69631972D1 (de) 2004-04-29
DE69631972T2 DE69631972T2 (de) 2005-01-05

Family

ID=26678280

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631972T Expired - Lifetime DE69631972T2 (de) 1995-12-13 1996-12-13 Proliferationsinhibitor von endothellzellen und dessen verwendung

Country Status (20)

Country Link
US (1) US20010016644A1 (de)
EP (1) EP0869970B1 (de)
JP (1) JP3684371B2 (de)
KR (1) KR100477280B1 (de)
CN (1) CN1554444A (de)
AT (1) ATE262537T1 (de)
AU (1) AU710612B2 (de)
BR (1) BR9612115A (de)
CA (1) CA2240296C (de)
CZ (1) CZ298612B6 (de)
DE (1) DE69631972T2 (de)
DK (1) DK0869970T3 (de)
ES (1) ES2217340T3 (de)
HK (1) HK1017692A1 (de)
HU (1) HUP9900979A3 (de)
NO (1) NO321775B1 (de)
NZ (1) NZ330537A (de)
PL (1) PL188719B1 (de)
PT (1) PT869970E (de)
WO (1) WO1997023500A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ330537A (en) * 1995-12-13 2001-06-29 Childrens Medical Center Kringle 5 rerion of plasminogen as an endothelial cell proliferation inhibitor
US6699838B1 (en) 1996-05-03 2004-03-02 Abbott Laboratories Antiangiogenic peptides
DE69733756T2 (de) * 1996-05-03 2006-06-01 Abbott Laboratories, Abbott Park Antiangiogenische peptiden, dafür kodierende polynukleotide und verfahren zur hemmung der angiogenesis
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
US5801012A (en) 1996-09-17 1998-09-01 Northwestern University Methods and compositions for generating angiostatin
JP2002510209A (ja) * 1997-06-26 2002-04-02 カロリンスカ イノベイションズ アクチボラゲット インビボで血管形成を調節することができるプラスミノーゲンのクリングルドメイン１−５
WO1999026480A1 (en) * 1997-11-20 1999-06-03 Genetix Pharmaceuticals, Inc. Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases
US6632961B1 (en) 1998-05-22 2003-10-14 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
US7144854B1 (en) 1999-09-10 2006-12-05 Conjuchem, Inc. Long lasting anti-angiogenic peptides
CA2373252C (en) * 1999-05-17 2007-08-07 Conjuchem Inc. Long lasting anti-angiogenic peptides
WO2000069911A1 (en) 1999-05-17 2000-11-23 Conjuchem, Inc. Long lasting insulinotropic peptides
JP2003517007A (ja) * 1999-12-15 2003-05-20 エントレメッド インコーポレイテッド 内皮細胞増殖阻害組成物および方法
CA2421251A1 (en) 2000-09-05 2002-03-14 Karolinska Innovations Ab Recombinant endothelial cell growth inhibitors derived from a mammalian plasminogen
AU2002239414A1 (en) * 2000-11-02 2002-05-27 Bristol-Myers Squibb Company Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
EP1714151A4 (de) * 2004-01-21 2009-06-10 Fujirebio America Inc Nachweis von mit mesothelin-/megakaryozyt-potenzierungsfaktor verwandten peptiden in peritonealflüssigkeit zur beurteilung des peritoneums und der peritonealhöhle
CN100355458C (zh) * 2005-03-16 2007-12-19 北京大学 人增殖抑制基因－腺病毒表达载体的应用
US20120220015A1 (en) 2009-05-26 2012-08-30 Biolex Therapeutics Compositions and methods for production of aglycosylated plasminogen
CN103060265B (zh) * 2013-01-23 2014-12-03 山东大学 老年大鼠脑血管内皮细胞原代培养方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
US5491129A (en) * 1992-07-30 1996-02-13 Yeda Research And Development Co. Ltd. Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them
EP0758390B1 (de) * 1994-04-26 2007-02-28 The Children's Medical Center Corporation Angiostatin und verfahren zu seiner nutzung zur vermeidung der angiogenese
JPH09512426A (ja) * 1994-04-26 1997-12-16 ファルマシア・アンド・アップジョン・カンパニー 好中球の接着および移動の遮断に有用なＭａｃ−１ Ｉ−ドメイン蛋白質
CZ334097A3 (cs) * 1995-04-26 1998-04-15 The Children's Medical Center Corporation Fragmenty angiostatinu, agregovaný angiostatin a způsoby jeho použití
NZ330537A (en) * 1995-12-13 2001-06-29 Childrens Medical Center Kringle 5 rerion of plasminogen as an endothelial cell proliferation inhibitor

Also Published As

Publication number Publication date
KR19990072126A (ko) 1999-09-27
CA2240296A1 (en) 1997-07-03
PL188719B1 (pl) 2005-04-29
HUP9900979A3 (en) 2001-10-29
AU1687097A (en) 1997-07-17
BR9612115A (pt) 1999-02-17
NO321775B1 (no) 2006-07-03
KR100477280B1 (ko) 2005-07-18
PT869970E (pt) 2004-08-31
HK1017692A1 (en) 1999-11-26
CZ182898A3 (cs) 1998-10-14
NO982715L (no) 1998-08-12
NO982715D0 (no) 1998-06-12
NZ330537A (en) 2001-06-29
DE69631972T2 (de) 2005-01-05
US20010016644A1 (en) 2001-08-23
JP2002502359A (ja) 2002-01-22
ATE262537T1 (de) 2004-04-15
EP0869970B1 (de) 2004-03-24
PL327200A1 (en) 1998-11-23
ES2217340T3 (es) 2004-11-01
CA2240296C (en) 2004-05-04
JP3684371B2 (ja) 2005-08-17
HUP9900979A2 (hu) 1999-07-28
EP0869970A1 (de) 1998-10-14
WO1997023500A1 (en) 1997-07-03
AU710612B2 (en) 1999-09-23
CZ298612B6 (cs) 2007-11-21
CN1554444A (zh) 2004-12-15
DK0869970T3 (da) 2004-07-05
EP0869970A4 (de) 2002-01-30

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: THE CHILDERN'S MEDICAL CENTER CORP., BOSTON, MASS.

Owner name: ABBOTT LABORATORIES, ABBOTT PARK, ILL., US

8364 No opposition during term of opposition