BR9612115A - Inibidor de proliferação de célula endotelial e processo de uso - Google Patents

Inibidor de proliferação de célula endotelial e processo de uso

Info

Publication number
BR9612115A
BR9612115A BR9612115A BR9612115A BR9612115A BR 9612115 A BR9612115 A BR 9612115A BR 9612115 A BR9612115 A BR 9612115A BR 9612115 A BR9612115 A BR 9612115A BR 9612115 A BR9612115 A BR 9612115A
Authority
BR
Brazil
Prior art keywords
cell proliferation
endothelial cell
proliferation inhibitor
inhibitor
endothelial
Prior art date
Application number
BR9612115A
Other languages
English (en)
Inventor
Judah Folkamm
Yihai Cao
Michael S O'reilly
Original Assignee
Childrens Medical Center
Moses
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/763,528 external-priority patent/US5854221A/en
Application filed by Childrens Medical Center, Moses filed Critical Childrens Medical Center
Publication of BR9612115A publication Critical patent/BR9612115A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Plant Substances (AREA)
BR9612115A 1995-12-13 1996-12-13 Inibidor de proliferação de célula endotelial e processo de uso BR9612115A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US851995P 1995-12-13 1995-12-13
US08/763,528 US5854221A (en) 1996-12-12 1996-12-12 Endothelial cell proliferation inhibitor and method of use
PCT/US1996/020447 WO1997023500A1 (en) 1995-12-13 1996-12-13 Endothelial cell proliferation inhibitor and method of use

Publications (1)

Publication Number Publication Date
BR9612115A true BR9612115A (pt) 1999-02-17

Family

ID=26678280

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9612115A BR9612115A (pt) 1995-12-13 1996-12-13 Inibidor de proliferação de célula endotelial e processo de uso

Country Status (20)

Country Link
US (1) US20010016644A1 (pt)
EP (1) EP0869970B1 (pt)
JP (1) JP3684371B2 (pt)
KR (1) KR100477280B1 (pt)
CN (1) CN1554444A (pt)
AT (1) ATE262537T1 (pt)
AU (1) AU710612B2 (pt)
BR (1) BR9612115A (pt)
CA (1) CA2240296C (pt)
CZ (1) CZ298612B6 (pt)
DE (1) DE69631972T2 (pt)
DK (1) DK0869970T3 (pt)
ES (1) ES2217340T3 (pt)
HK (1) HK1017692A1 (pt)
HU (1) HUP9900979A3 (pt)
NO (1) NO321775B1 (pt)
NZ (1) NZ330537A (pt)
PL (1) PL188719B1 (pt)
PT (1) PT869970E (pt)
WO (1) WO1997023500A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT869970E (pt) * 1995-12-13 2004-08-31 Childrens Medical Center Inibidor da proliferacao de celulas endoteliais e sua utilizacao
BR9708911A (pt) * 1996-05-03 1999-08-03 Abbott Lab Composto fragmento de peptídeo processo par tratar uma doença em um paciente em necessidade de terapia antioangiogênese composição polinucleotídeo único ou de duplo-filamento isolado vetor e processo para produzir um fragmento de peptídeo de kringle 5 ou proteína de fusão de kringle 5 solúvel
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
US6699838B1 (en) 1996-05-03 2004-03-02 Abbott Laboratories Antiangiogenic peptides
US5801012A (en) 1996-09-17 1998-09-01 Northwestern University Methods and compositions for generating angiostatin
EP1001985A1 (en) * 1997-06-26 2000-05-24 Karolinska Innovations AB Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo
WO1999026480A1 (en) * 1997-11-20 1999-06-03 Genetix Pharmaceuticals, Inc. Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases
US6632961B1 (en) 1998-05-22 2003-10-14 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
US7144854B1 (en) 1999-09-10 2006-12-05 Conjuchem, Inc. Long lasting anti-angiogenic peptides
US6329336B1 (en) 1999-05-17 2001-12-11 Conjuchem, Inc. Long lasting insulinotropic peptides
WO2000070665A2 (en) * 1999-05-17 2000-11-23 Conjuchem, Inc. Long lasting anti-angiogenic peptides
EP1242451A2 (en) * 1999-12-15 2002-09-25 EntreMed, Inc. Compositions and methods for inhibiting endothelial cell proliferation
JP2004508048A (ja) 2000-09-05 2004-03-18 カロリンスカ　イノベーションズ　アクティーエボラーグ 内皮細胞増殖阻害物質に関する材料と方法
US20030054988A1 (en) * 2000-11-02 2003-03-20 Weidong-Richard Ji Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
US20060014211A1 (en) * 2004-01-21 2006-01-19 Fujirebio Diagnostics, Inc. Detection of mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of the peritoneum and the peritoneal cavity
CN100355458C (zh) * 2005-03-16 2007-12-19 北京大学 人增殖抑制基因－腺病毒表达载体的应用
US20120220015A1 (en) 2009-05-26 2012-08-30 Biolex Therapeutics Compositions and methods for production of aglycosylated plasminogen
CN103060265B (zh) * 2013-01-23 2014-12-03 山东大学 老年大鼠脑血管内皮细胞原代培养方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
HUT64977A (en) * 1992-07-30 1994-03-28 Yeda Res & Dev Synthetical peptone derivatives of vitronectine and pharmaceutical preparaties containing them
NZ285501A (en) * 1994-04-26 1998-02-26 Childrens Medical Center Plasminogen analogs (angiostatin), endothelial inhibitors, assays and kits
EP0758393A1 (en) * 1994-04-26 1997-02-19 PHARMACIA & UPJOHN COMPANY Mac-1 i-domain protein useful in blocking adhesion and migration of neutrophils
EP0824546B1 (en) * 1995-04-26 2007-07-25 The Children's Medical Center Corporation Angiostatin fragments and methods of use
PT869970E (pt) * 1995-12-13 2004-08-31 Childrens Medical Center Inibidor da proliferacao de celulas endoteliais e sua utilizacao

Also Published As

Publication number Publication date
AU710612B2 (en) 1999-09-23
KR100477280B1 (ko) 2005-07-18
CN1554444A (zh) 2004-12-15
US20010016644A1 (en) 2001-08-23
EP0869970A1 (en) 1998-10-14
PL188719B1 (pl) 2005-04-29
CZ298612B6 (cs) 2007-11-21
DE69631972T2 (de) 2005-01-05
CA2240296A1 (en) 1997-07-03
NZ330537A (en) 2001-06-29
DE69631972D1 (de) 2004-04-29
PL327200A1 (en) 1998-11-23
HK1017692A1 (en) 1999-11-26
JP2002502359A (ja) 2002-01-22
HUP9900979A3 (en) 2001-10-29
KR19990072126A (ko) 1999-09-27
DK0869970T3 (da) 2004-07-05
ES2217340T3 (es) 2004-11-01
HUP9900979A2 (hu) 1999-07-28
NO982715L (no) 1998-08-12
ATE262537T1 (de) 2004-04-15
PT869970E (pt) 2004-08-31
NO321775B1 (no) 2006-07-03
CA2240296C (en) 2004-05-04
EP0869970A4 (en) 2002-01-30
JP3684371B2 (ja) 2005-08-17
EP0869970B1 (en) 2004-03-24
AU1687097A (en) 1997-07-17
WO1997023500A1 (en) 1997-07-03
CZ182898A3 (cs) 1998-10-14
NO982715D0 (no) 1998-06-12

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, COM BASE NOS ARTS. 8, 10 (IX), 11 E 37O.

B12B Appeal against refusal [chapter 12.2 patent gazette]