HK1017682A1 - Novel indole-2,3-dione-3-oxime derivatives - Google Patents

Novel indole-2,3-dione-3-oxime derivatives

Info

Publication number
HK1017682A1
HK1017682A1 HK99102769A HK99102769A HK1017682A1 HK 1017682 A1 HK1017682 A1 HK 1017682A1 HK 99102769 A HK99102769 A HK 99102769A HK 99102769 A HK99102769 A HK 99102769A HK 1017682 A1 HK1017682 A1 HK 1017682A1
Authority
HK
Hong Kong
Prior art keywords
dione
het
oxime derivatives
novel indole
ring
Prior art date
Application number
HK99102769A
Other languages
English (en)
Inventor
Frank Waetjen
Jorgen Drejer
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of HK1017682A1 publication Critical patent/HK1017682A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK99102769A 1996-10-01 1999-06-30 Novel indole-2,3-dione-3-oxime derivatives HK1017682A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK106996 1996-10-01
DK127796 1996-11-13
PCT/DK1997/000418 WO1998014447A1 (en) 1996-10-01 1997-10-01 Novel indole-2,3-dione-3-oxime derivatives

Publications (1)

Publication Number Publication Date
HK1017682A1 true HK1017682A1 (en) 1999-11-26

Family

ID=26065167

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99102769A HK1017682A1 (en) 1996-10-01 1999-06-30 Novel indole-2,3-dione-3-oxime derivatives

Country Status (29)

Country Link
US (3) US6124285A (ja)
EP (1) EP0869958B1 (ja)
JP (1) JP3319762B2 (ja)
KR (1) KR100492052B1 (ja)
CN (1) CN1093859C (ja)
AT (1) ATE286052T1 (ja)
AU (1) AU716435B2 (ja)
BG (1) BG63874B1 (ja)
BR (1) BR9706765A (ja)
CA (1) CA2238410C (ja)
CZ (1) CZ297938B6 (ja)
DE (1) DE69732090T2 (ja)
DK (1) DK0869958T3 (ja)
EE (1) EE9800144A (ja)
ES (1) ES2235253T3 (ja)
HK (1) HK1017682A1 (ja)
HU (1) HU225145B1 (ja)
IL (1) IL124563A (ja)
IS (1) IS2123B (ja)
NO (1) NO310722B1 (ja)
NZ (1) NZ330456A (ja)
PL (1) PL193041B1 (ja)
PT (1) PT869958E (ja)
RU (1) RU2190612C2 (ja)
SI (1) SI0869958T1 (ja)
SK (1) SK282729B6 (ja)
TR (1) TR199800956T1 (ja)
UA (1) UA54403C2 (ja)
WO (1) WO1998014447A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
DE69922936T2 (de) 1998-03-31 2005-12-08 Neurosearch A/S Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
DE60041399D1 (de) 1999-05-19 2009-03-05 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
ES2266214T3 (es) * 2000-01-24 2007-03-01 Neurosearch A/S Derivados de isatina con actividad neurotrofica.
IT1318636B1 (it) * 2000-07-21 2003-08-27 Roberto Pellicciari Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
WO2002064139A1 (en) * 2001-02-15 2002-08-22 Neurosearch A/S Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
MXPA04000358A (es) 2001-07-13 2004-05-04 Pharmacia & Up John Company Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht.
WO2004018466A2 (en) * 2002-08-22 2004-03-04 Neurosearch A/S A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
EP1957486A4 (en) * 2005-11-23 2009-11-11 Painceptor Pharma Corp COMPOSITIONS AND METHODS FOR MODULATION OF IONIC CHANNELS
WO2007115403A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2007115409A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US20100041691A1 (en) * 2006-09-12 2010-02-18 Neurosearch A/S Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108622A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
US20080108603A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) * 2011-03-04 2012-09-05 爱斯医药科技(南京)有限公司 Spd-502的制备方法
WO2016176457A1 (en) 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators
CA2984305C (en) * 2015-04-29 2021-12-28 Janssen Pharmaceutica Nv Indolone compounds and their use as ampa receptor modulators
CA2984290C (en) 2015-04-29 2022-03-01 Janssen Pharmaceutica Nv Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators
UY36654A (es) 2015-04-29 2016-10-31 Janssen Pharmaceutica Nv Azabenzimidazoles con propiedades moduladoras del receptor ampa y composiciones farmacéuticas que los contienen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076948C (en) * 1991-08-28 2002-04-16 Frank Watjen Isatineoxime derivatives, their preparation and use
US5721230A (en) 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
WO1994026747A1 (en) * 1993-05-13 1994-11-24 Neurosearch A/S Ampa antagonists and a method of treatment therewith
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
AU687255B2 (en) * 1994-09-14 1998-02-19 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
US5801174A (en) * 1994-09-14 1998-09-01 Neurosearch A/S Fused indole and quinoxaline derivatives, their preparation and use
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

Also Published As

Publication number Publication date
ATE286052T1 (de) 2005-01-15
KR19990071823A (ko) 1999-09-27
BG63874B1 (bg) 2003-04-30
CA2238410A1 (en) 1998-04-09
IS4748A (is) 1998-05-18
CZ160698A3 (cs) 1998-10-14
IS2123B (is) 2006-07-14
CA2238410C (en) 2007-06-12
PL193041B1 (pl) 2007-01-31
JP3319762B2 (ja) 2002-09-03
AU4376897A (en) 1998-04-24
IL124563A0 (en) 1998-12-06
HU225145B1 (en) 2006-07-28
SK282729B6 (sk) 2002-11-06
HUP9901630A2 (hu) 1999-08-30
BR9706765A (pt) 1999-09-14
JP2000501432A (ja) 2000-02-08
DK0869958T3 (da) 2005-04-18
EP0869958B1 (en) 2004-12-29
IL124563A (en) 2005-05-17
KR100492052B1 (ko) 2005-09-30
EE9800144A (et) 1998-10-15
NO982466D0 (no) 1998-05-29
CN1093859C (zh) 2002-11-06
USRE38200E1 (en) 2003-07-22
HUP9901630A3 (en) 2001-11-28
EP0869958A1 (en) 1998-10-14
SI0869958T1 (en) 2005-06-30
CZ297938B6 (cs) 2007-05-02
AU716435B2 (en) 2000-02-24
CN1207100A (zh) 1999-02-03
US6693111B1 (en) 2004-02-17
NZ330456A (en) 1998-11-25
NO310722B1 (no) 2001-08-20
BG102489A (en) 1999-04-30
US6124285A (en) 2000-09-26
NO982466L (no) 1998-07-31
ES2235253T3 (es) 2005-07-01
PT869958E (pt) 2005-05-31
MX9804365A (es) 1998-10-31
DE69732090D1 (de) 2005-02-03
TR199800956T1 (xx) 1998-12-21
DE69732090T2 (de) 2005-12-29
SK67698A3 (en) 1998-11-04
WO1998014447A1 (en) 1998-04-09
RU2190612C2 (ru) 2002-10-10
PL327073A1 (en) 1998-11-23
UA54403C2 (uk) 2003-03-17

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111001