HK1017682A1 - Novel indole-2,3-dione-3-oxime derivatives - Google Patents
Novel indole-2,3-dione-3-oxime derivativesInfo
- Publication number
- HK1017682A1 HK1017682A1 HK99102769A HK99102769A HK1017682A1 HK 1017682 A1 HK1017682 A1 HK 1017682A1 HK 99102769 A HK99102769 A HK 99102769A HK 99102769 A HK99102769 A HK 99102769A HK 1017682 A1 HK1017682 A1 HK 1017682A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- dione
- het
- oxime derivatives
- novel indole
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK106996 | 1996-10-01 | ||
DK127796 | 1996-11-13 | ||
PCT/DK1997/000418 WO1998014447A1 (en) | 1996-10-01 | 1997-10-01 | Novel indole-2,3-dione-3-oxime derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1017682A1 true HK1017682A1 (en) | 1999-11-26 |
Family
ID=26065167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK99102769A HK1017682A1 (en) | 1996-10-01 | 1999-06-30 | Novel indole-2,3-dione-3-oxime derivatives |
Country Status (29)
Country | Link |
---|---|
US (3) | USRE38200E1 (de) |
EP (1) | EP0869958B1 (de) |
JP (1) | JP3319762B2 (de) |
KR (1) | KR100492052B1 (de) |
CN (1) | CN1093859C (de) |
AT (1) | ATE286052T1 (de) |
AU (1) | AU716435B2 (de) |
BG (1) | BG63874B1 (de) |
BR (1) | BR9706765A (de) |
CA (1) | CA2238410C (de) |
CZ (1) | CZ297938B6 (de) |
DE (1) | DE69732090T2 (de) |
DK (1) | DK0869958T3 (de) |
EE (1) | EE9800144A (de) |
ES (1) | ES2235253T3 (de) |
HK (1) | HK1017682A1 (de) |
HU (1) | HU225145B1 (de) |
IL (1) | IL124563A (de) |
IS (1) | IS2123B (de) |
NO (1) | NO310722B1 (de) |
NZ (1) | NZ330456A (de) |
PL (1) | PL193041B1 (de) |
PT (1) | PT869958E (de) |
RU (1) | RU2190612C2 (de) |
SI (1) | SI0869958T1 (de) |
SK (1) | SK282729B6 (de) |
TR (1) | TR199800956T1 (de) |
UA (1) | UA54403C2 (de) |
WO (1) | WO1998014447A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
ATE285772T1 (de) * | 1998-03-31 | 2005-01-15 | Neurosearch As | Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten |
AU4910500A (en) | 1999-05-19 | 2000-12-12 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
CN1298704C (zh) | 2000-01-24 | 2007-02-07 | 神经研究公司 | 具有神经营养活性的靛红衍生物 |
IT1318636B1 (it) * | 2000-07-21 | 2003-08-27 | Roberto Pellicciari | Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato. |
JP2004523543A (ja) * | 2001-02-15 | 2004-08-05 | ニューロサーチ、アクティーゼルスカブ | 神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法 |
ATE307133T1 (de) | 2001-07-13 | 2005-11-15 | Pharmacia & Upjohn Co Llc | Hexahydroazepino(4,5-g)indole und -indoline als 5-ht-rezeptor-liganden |
AU2003250323A1 (en) | 2002-08-22 | 2004-03-11 | Neurosearch A/S | A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives |
GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
CA2630617C (en) * | 2005-11-23 | 2014-03-25 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
WO2007115403A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
WO2008031831A2 (en) * | 2006-09-12 | 2008-03-20 | Neurosearch A/S | Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein |
US20080108622A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
US20080108603A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
WO2010104324A2 (ko) * | 2009-03-10 | 2010-09-16 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도 |
CN102653538A (zh) * | 2011-03-04 | 2012-09-05 | 爱斯医药科技(南京)有限公司 | Spd-502的制备方法 |
WO2016176460A1 (en) | 2015-04-29 | 2016-11-03 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as ampa receptor modulators |
AU2016256413B2 (en) * | 2015-04-29 | 2020-10-08 | Janssen Pharmaceutica Nv | Indolone compounds and their use as AMPA receptor modulators |
BR112017023038A2 (pt) | 2015-04-29 | 2018-07-03 | Janssen Pharmaceutica Nv | imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa |
JP6804469B2 (ja) | 2015-04-29 | 2020-12-23 | ヤンセン ファーマシューティカ エヌ.ベー. | ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにampa受容体調節因子としてのそれらの使用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2076948C (en) * | 1991-08-28 | 2002-04-16 | Frank Watjen | Isatineoxime derivatives, their preparation and use |
US5721230A (en) | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
AU679075B2 (en) * | 1993-05-13 | 1997-06-19 | Neurosearch A/S | Ampa antagonists and a method of treatment therewith |
DK81593D0 (da) * | 1993-07-07 | 1993-07-07 | Neurosearch As | Nye isatinoximderivater, deres fremstilling og anvendelse |
EP0781284B1 (de) * | 1994-09-14 | 2000-01-12 | Neurosearch A/S | Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung |
US5801174A (en) * | 1994-09-14 | 1998-09-01 | Neurosearch A/S | Fused indole and quinoxaline derivatives, their preparation and use |
UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
-
1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 EP EP97941880A patent/EP0869958B1/de not_active Expired - Lifetime
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active IP Right Cessation
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en active IP Right Grant
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
-
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
-
1999
- 1999-06-30 HK HK99102769A patent/HK1017682A1/xx not_active IP Right Cessation
-
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL124563A0 (en) | Novel indole-2, 3-dione-3-oxime | |
TW349098B (en) | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor | |
HUP0204418A2 (hu) | NHE-1 inhibitor hatású N-[(helyettesített öttagú, di- vagy triaza-, kétszeresen telítetlen gyűrű)-karbonil]-guanidin-származékok és alkalmazásuk | |
BG105969A (en) | Amine derivatives as protein inhibitors | |
ATE157355T1 (de) | 3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga | |
NZ334531A (en) | Quinoxalin derivatives as Protein kinase C inhibitors | |
NO174387C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive isoindolonderivater | |
IL102703A (en) | N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them | |
DE69924292D1 (de) | Pyrazol verbindungen und ihre verwendung | |
NO305287B1 (no) | AMPA antagonister | |
ATE302772T1 (de) | 2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung | |
CO5140116A1 (es) | Compuestos espiro derivados de imidazo-benzazepina con actividad antihistaminica y sus procesos de obtencion a partir de sus intermediarios de sintesis | |
NZ335252A (en) | Substituted 3-thia-1,2,3,4-tetrahydrocarbazole, 6,7,8,9-tetrahydropyrido[1,2-a]indole, 4,5-dihydro-thiopyrano[3,4-b]indole, pyrano[3,4-b]indole or beta-carbolinyl derivatives | |
HUP0203976A2 (hu) | Adenozin a3 receptor antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
IL91648A (en) | Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them | |
TW367328B (en) | Benzofuro[3,2-b]pyridine derivatives, process for the preparation thereof and pharmaceutical composition containing the same | |
AR019390A1 (es) | Derivados de acidos sulfonilaminofosfinicos y sulfonilaminofosfonicos, procedimiento para su preparacion, compuestos intermediarios, medicamentos, procedimiento para su preparacion y empleo de dichos derivados para la preparacion de un medicamento. | |
HUP9900748A1 (hu) | Pirrolidinszármazékok alkalmazása alkoholizmus kezelésére alkalmas gyógyszerkészítmények előállítására | |
ES455436A1 (es) | Procedimiento de preparacion de acidos tienotienilcarbonife-nilalcanoicos. | |
DE69108728D1 (de) | [3H,7H]THIAZOLO[3,4-a]PYRIDINE MIT ANTIASTHMATISCHER UND ENTZÜNDUNGSHEMMENDER WIRKUNG AUF DIE ATMUNGSWEGE. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20111001 |