ATE285772T1 - Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten - Google Patents

Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten

Info

Publication number
ATE285772T1
ATE285772T1 AT99910150T AT99910150T ATE285772T1 AT E285772 T1 ATE285772 T1 AT E285772T1 AT 99910150 T AT99910150 T AT 99910150T AT 99910150 T AT99910150 T AT 99910150T AT E285772 T1 ATE285772 T1 AT E285772T1
Authority
AT
Austria
Prior art keywords
dione
indole
oxime derivatives
ampa antagonists
ampa
Prior art date
Application number
AT99910150T
Other languages
English (en)
Inventor
Frank Waetjen
Joergen Drejer
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE285772T1 publication Critical patent/ATE285772T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99910150T 1998-03-31 1999-03-30 Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten ATE285772T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK45298 1998-03-31
DK46298 1998-04-01
PCT/DK1999/000194 WO1999049864A1 (en) 1998-03-31 1999-03-30 Indole-2,3-dione-3-oxime derivatives for therapeutic use

Publications (1)

Publication Number Publication Date
ATE285772T1 true ATE285772T1 (de) 2005-01-15

Family

ID=26064032

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99910150T ATE285772T1 (de) 1998-03-31 1999-03-30 Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten

Country Status (10)

Country Link
US (1) US6239128B1 (de)
EP (1) EP1066037B1 (de)
JP (1) JP2002509885A (de)
AT (1) ATE285772T1 (de)
AU (1) AU751414B2 (de)
BG (1) BG104801A (de)
CA (1) CA2326576A1 (de)
DE (1) DE69922936T2 (de)
NZ (1) NZ507259A (de)
WO (1) WO1999049864A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1183025T3 (da) * 1999-05-19 2009-05-04 Painceptor Pharma Corp Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser
EP1255734B1 (de) * 2000-01-24 2006-06-21 NeuroSearch A/S Isatinderivate mit neurotropen aktivität
BR0211140A (pt) 2001-07-13 2005-10-25 Upjohn Co Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht
DE60303825T2 (de) * 2002-08-22 2006-08-17 Neurosearch A/S Verfahren zum herstellen von enantiomeren von indol-2,3-dion-3-oxim-derivaten
WO2007059608A1 (en) * 2005-11-23 2007-05-31 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US20080021034A1 (en) * 2006-04-10 2008-01-24 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2008031831A2 (en) * 2006-09-12 2008-03-20 Neurosearch A/S Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
CN102653538A (zh) * 2011-03-04 2012-09-05 爱斯医药科技(南京)有限公司 Spd-502的制备方法
CN104725372B (zh) * 2015-01-28 2017-02-22 天津科技大学 四环吲哚生物碱衍生物及其制备和应用
JP7576921B2 (ja) 2020-03-30 2024-11-01 東ソー株式会社 Ｏ－置換ヒドロキシルアミン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026747A1 (en) * 1993-05-13 1994-11-24 Neurosearch A/S Ampa antagonists and a method of treatment therewith
GB9418357D0 (en) * 1994-09-12 1994-11-02 Chiroscience Ltd Amidation process
AU687255B2 (en) * 1994-09-14 1998-02-19 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

Also Published As

Publication number Publication date
NZ507259A (en) 2003-07-25
AU2921999A (en) 1999-10-18
DE69922936T2 (de) 2005-12-08
AU751414B2 (en) 2002-08-15
US6239128B1 (en) 2001-05-29
JP2002509885A (ja) 2002-04-02
EP1066037A1 (de) 2001-01-10
BG104801A (en) 2001-04-30
WO1999049864A1 (en) 1999-10-07
DE69922936D1 (de) 2005-02-03
EP1066037B1 (de) 2004-12-29
CA2326576A1 (en) 1999-10-07

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