HK1011365A1 - Heterocyclic compounds having anti-diabetic activity, their preparation and their use - Google Patents
Heterocyclic compounds having anti-diabetic activity, their preparation and their useInfo
- Publication number
- HK1011365A1 HK1011365A1 HK98112512A HK98112512A HK1011365A1 HK 1011365 A1 HK1011365 A1 HK 1011365A1 HK 98112512 A HK98112512 A HK 98112512A HK 98112512 A HK98112512 A HK 98112512A HK 1011365 A1 HK1011365 A1 HK 1011365A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- group
- formula
- heterocyclic compounds
- carboxylic acyl
- atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7208394 | 1994-04-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1011365A1 true HK1011365A1 (en) | 1999-07-09 |
Family
ID=13479165
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98112512A HK1011365A1 (en) | 1994-04-11 | 1998-11-30 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use |
HK00108123A HK1029338A1 (en) | 1994-04-11 | 1998-11-30 | Intermediates for the preparation of oxazolidinedione and thiazolidinedione derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00108123A HK1029338A1 (en) | 1994-04-11 | 1998-11-30 | Intermediates for the preparation of oxazolidinedione and thiazolidinedione derivatives |
Country Status (22)
Country | Link |
---|---|
US (6) | US5624935A (fr) |
EP (2) | EP0676398B1 (fr) |
KR (1) | KR950032188A (fr) |
CN (1) | CN1060173C (fr) |
AT (2) | ATE207488T1 (fr) |
AU (1) | AU683348B2 (fr) |
CA (1) | CA2146701A1 (fr) |
CZ (1) | CZ289317B6 (fr) |
DE (2) | DE69528000T2 (fr) |
DK (2) | DK0676398T3 (fr) |
ES (2) | ES2165895T3 (fr) |
FI (1) | FI951731A (fr) |
HK (2) | HK1011365A1 (fr) |
HU (1) | HU219887B (fr) |
ID (1) | ID20564A (fr) |
IL (1) | IL113313A (fr) |
NO (2) | NO305987B1 (fr) |
NZ (1) | NZ270917A (fr) |
PT (2) | PT676398E (fr) |
RU (2) | RU2151145C1 (fr) |
TW (2) | TW503237B (fr) |
ZA (1) | ZA952990B (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ289317B6 (cs) * | 1994-04-11 | 2002-01-16 | Sankyo Company Limited | Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití |
TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
IL118474A (en) * | 1995-06-01 | 2001-08-08 | Sankyo Co | Benzimideol derivatives and pharmaceutical preparations containing them |
NO318765B1 (no) * | 1995-07-03 | 2005-05-02 | Sankyo Co | Anvendelse av en HMG-CoA reduktaseinhibitor og en insulinsensibilisator til fremstilling av et medikament for forebyggelse eller behandling av arteriosklerose eller xantom, samt pakket farmasoytisk preparat som omfatter de to midlene i separate porsjoner. |
EP0783888A1 (fr) | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Utilisation de la troglitazone et de thiazolidinediones apparentées dans la fabrication d'un médicament destiné au traitement et la prévention de l'ostéoporose |
NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
CA2257284C (fr) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remede pour maladies auto-immunes |
USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
CZ298812B6 (cs) | 1996-07-01 | 2008-02-13 | Dr. Reddy's Laboratories Limited | Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí |
US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6114526A (en) | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
US6011036A (en) * | 1997-04-15 | 2000-01-04 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
WO1997041121A1 (fr) * | 1997-05-02 | 1997-11-06 | Dr. Reddy's Research Foundation | Nouveaux composes heterocycliques presentant des proprietes antidiabetiques, hypolipidemiantes, antihypertensives, leur procede de preparation et compositions pharmaceutiques les contenant |
PL200859B1 (pl) | 1997-10-08 | 2009-02-27 | Sankyo Co | Podstawiony skondensowany związek heterocykliczny, kompozycja farmaceutyczna zawierająca podstawiony skondensowany związek heterocykliczny oraz zastosowanie podstawionego skondensowanego związku heterocyklicznego |
HUP9902721A2 (hu) | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
EP1036075B1 (fr) * | 1997-12-02 | 2004-06-23 | Dr. Reddy's Laboratories Ltd. | Oxalidinedione et thiazolidinedione a substitution, antidiabetiques, hypolipidemiques et antihypertenseurs |
US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
WO2000061581A1 (fr) | 1999-04-07 | 2000-10-19 | Sankyo Company, Limited | Derives amine |
WO2000061582A1 (fr) * | 1999-04-08 | 2000-10-19 | Sankyo Company, Limited | Derives imidazole condenses substitues |
IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
EP1194147B1 (fr) * | 1999-06-18 | 2007-01-10 | Merck & Co., Inc. | Derives d'arylthiazolidinedione et d'aryloxazolidinedione |
WO2001068136A1 (fr) * | 2000-03-17 | 2001-09-20 | Ajinomoto Co., Inc. | Medicaments permettant de traiter les complications du diabete et des neuropathies et utilisation de ces medicaments |
US6921762B2 (en) * | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
AU2005278099A1 (en) * | 2004-05-28 | 2006-03-02 | Merck & Co., Inc. | Benzoureas having anti-diabetic activity |
KR20070102694A (ko) * | 2005-01-31 | 2007-10-19 | 아지노모토 가부시키가이샤 | 혈당 강하제를 함유하는, 내당능 이상, 경계형 당뇨병,인슐린 저항성 및 고인슐린혈증 개선 또는 치료용 의약조성물 |
WO2006138328A1 (fr) * | 2005-06-14 | 2006-12-28 | Merck & Co., Inc. | Procede de production d'oxazolidinediones anti-diabetiques |
WO2007018956A2 (fr) * | 2005-07-20 | 2007-02-15 | Merck & Co., Inc. | Oxazolidinediones et thiazolidinediones antidiabetiques |
EP3208272B1 (fr) | 2005-11-08 | 2020-01-08 | Vertex Pharmaceuticals Incorporated | Modulateurs hétérocycliques de transporteurs de cassette à liaison atp |
EP2164840A2 (fr) | 2007-05-09 | 2010-03-24 | Vertex Pharmaceuticals Incorporated | Modulateurs de cftr |
EP2203433B1 (fr) * | 2007-09-14 | 2012-10-31 | Metabolic Solutions Development Company LLC | 5-(4-(2-(3-methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione pour le traitement de la diabète |
US8143280B2 (en) | 2007-09-27 | 2012-03-27 | Hoffmann-La Roche Inc. | Glucocorticoid receptor antagonists |
RS55559B1 (sr) | 2007-12-07 | 2017-05-31 | Vertex Pharma | Čvrste forme 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il) benzoeve kiseline |
EA201070700A1 (ru) * | 2007-12-07 | 2011-06-30 | Вертекс Фармасьютикалз Инкорпорейтед | Способы получения циклоалкилкарбоксамидопиридинбензойных кислот |
CN101463031B (zh) * | 2007-12-20 | 2014-02-12 | 中国医学科学院药物研究所 | 吲唑及四氢吲唑类化合物及其制法和其药物组合物与用途 |
JP5523352B2 (ja) | 2008-02-28 | 2014-06-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | Cftr修飾因子としてのへテロアリール誘導体 |
UY31952A (es) * | 2008-07-02 | 2010-01-29 | Astrazeneca Ab | 5-metilideno-1,3-tiazolidina-2,4-dionas sustituidas como inhibidores de quinasa pim |
NZ602838A (en) | 2010-04-07 | 2015-06-26 | Vertex Pharma | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
JP6963896B2 (ja) | 2013-11-12 | 2021-11-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Cftr媒介性疾患の処置のための医薬組成物を調製する方法 |
RU2691136C2 (ru) | 2014-11-18 | 2019-06-11 | Вертекс Фармасьютикалз Инкорпорейтед | Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии |
CN111883832A (zh) * | 2020-07-24 | 2020-11-03 | 香河昆仑化学制品有限公司 | 一种锂离子电池电解液以及电池负极和电化学储能器件 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4097594A (en) * | 1977-03-30 | 1978-06-27 | Fmc Corporation | Mono-5-substituted-3-chloro-4H-1,2,6-thiadiazin-4-one antifungal agents |
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
JPS60226873A (ja) * | 1984-03-28 | 1985-11-12 | Sankyo Co Ltd | 1,3−ベンゾオキサチオ−ル誘導体及びその製法 |
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
DK173350B1 (da) * | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
US4681940A (en) * | 1985-11-19 | 1987-07-21 | American Home Products Corporation | 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles |
US4873255A (en) * | 1987-02-04 | 1989-10-10 | Sankyo Company Limited | Thiazolidinone derivatives, their preparation and their use |
JPH0764866B2 (ja) * | 1987-02-24 | 1995-07-12 | 財団法人微生物化学研究会 | 1−n−(4−アミノ−3−フルオロ−2−ヒドロキシブチリル)カナマイシン類 |
EP0842925A1 (fr) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Thiazolidinédiones substituées |
GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
WO1991007107A1 (fr) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Agents d'oxazolidinedione hypoglycemiques |
US5143930A (en) * | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
DE69132713D1 (de) * | 1990-04-27 | 2001-10-11 | Sankyo Co | Benzylidenthiazolidinderivate, ihre Herstellung und ihre Anwendung als Lipidperoxid-Inhibitoren |
GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
JPH0678326B2 (ja) * | 1990-08-23 | 1994-10-05 | フアイザー・インコーポレイテツド | 血糖低下性ヒドロキシ尿素誘導体 |
GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
HUT68370A (en) * | 1991-04-11 | 1995-06-28 | Takeda Chemical Industries Ltd | Thiazolidine derivatives, pharmaceutical compositions containing them and process for their production |
FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
NO302519B1 (no) * | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
ZA936324B (en) * | 1992-08-31 | 1994-03-22 | Sankyo Co | Oxazolidine derivatives having anti-diabetic and anti-obesity properties their preparation and their therapeutic uses |
US5614544A (en) * | 1993-09-14 | 1997-03-25 | Takeda Chemical Industries, Ltd. | Oxazolidinedione derivatives and their use |
CZ289317B6 (cs) * | 1994-04-11 | 2002-01-16 | Sankyo Company Limited | Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití |
-
1995
- 1995-04-10 CZ CZ1995910A patent/CZ289317B6/cs not_active IP Right Cessation
- 1995-04-10 CA CA002146701A patent/CA2146701A1/fr not_active Abandoned
- 1995-04-10 RU RU95118736/04A patent/RU2151145C1/ru not_active IP Right Cessation
- 1995-04-10 NO NO951398A patent/NO305987B1/no not_active IP Right Cessation
- 1995-04-10 IL IL11331395A patent/IL113313A/xx not_active IP Right Cessation
- 1995-04-10 RU RU95105423/04A patent/RU2114844C1/ru not_active IP Right Cessation
- 1995-04-11 NZ NZ270917A patent/NZ270917A/en unknown
- 1995-04-11 ID IDP981611A patent/ID20564A/id unknown
- 1995-04-11 DE DE69528000T patent/DE69528000T2/de not_active Expired - Fee Related
- 1995-04-11 KR KR1019950008429A patent/KR950032188A/ko active IP Right Grant
- 1995-04-11 AT AT95302409T patent/ATE207488T1/de not_active IP Right Cessation
- 1995-04-11 DK DK95302409T patent/DK0676398T3/da active
- 1995-04-11 ES ES95302409T patent/ES2165895T3/es not_active Expired - Lifetime
- 1995-04-11 ES ES00102313T patent/ES2180477T3/es not_active Expired - Lifetime
- 1995-04-11 CN CN95105765A patent/CN1060173C/zh not_active Expired - Fee Related
- 1995-04-11 ZA ZA952990A patent/ZA952990B/xx unknown
- 1995-04-11 EP EP95302409A patent/EP0676398B1/fr not_active Expired - Lifetime
- 1995-04-11 HU HU9501040A patent/HU219887B/hu not_active IP Right Cessation
- 1995-04-11 DK DK00102313T patent/DK1022274T3/da active
- 1995-04-11 TW TW087114283A patent/TW503237B/zh not_active IP Right Cessation
- 1995-04-11 TW TW084103469A patent/TW407156B/zh not_active IP Right Cessation
- 1995-04-11 FI FI951731A patent/FI951731A/fi unknown
- 1995-04-11 US US08/419,919 patent/US5624935A/en not_active Expired - Fee Related
- 1995-04-11 PT PT95302409T patent/PT676398E/pt unknown
- 1995-04-11 AT AT00102313T patent/ATE222895T1/de not_active IP Right Cessation
- 1995-04-11 PT PT00102313T patent/PT1022274E/pt unknown
- 1995-04-11 EP EP00102313A patent/EP1022274B1/fr not_active Expired - Lifetime
- 1995-04-11 DE DE69523358T patent/DE69523358T2/de not_active Expired - Fee Related
- 1995-04-11 AU AU16383/95A patent/AU683348B2/en not_active Ceased
-
1996
- 1996-09-13 US US08/713,543 patent/US5834501A/en not_active Expired - Fee Related
- 1996-11-08 US US08/745,377 patent/US5739345A/en not_active Expired - Fee Related
-
1997
- 1997-12-30 US US09/001,093 patent/US5962470A/en not_active Expired - Fee Related
-
1998
- 1998-07-07 US US09/110,693 patent/US5977365A/en not_active Expired - Fee Related
- 1998-08-25 NO NO983900A patent/NO307299B1/no not_active IP Right Cessation
- 1998-11-30 HK HK98112512A patent/HK1011365A1/xx not_active IP Right Cessation
- 1998-11-30 HK HK00108123A patent/HK1029338A1/xx not_active IP Right Cessation
-
1999
- 1999-03-03 US US09/261,645 patent/US6117893A/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HU9501040D0 (en) | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | |
HU9502512D0 (en) | Anthranilic acid derivative | |
AU2001277723A1 (en) | Ppardelta activators | |
FI965020A0 (fi) | Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita | |
JPS57114573A (en) | Aryl-4-oxonicotinate | |
DE69607890T2 (de) | Aromatische Hydroxamsäure-Verbindungen, ihre Herstellung und Verwendung | |
HU9602534D0 (en) | Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity | |
ES2121036T3 (es) | Derivados de alquilenodiamina. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20060411 |