HK1008417A1 - Sublingual or buccal pharmaceutical composition - Google Patents

Sublingual or buccal pharmaceutical composition Download PDF

Info

Publication number
HK1008417A1
HK1008417A1 HK98109126A HK98109126A HK1008417A1 HK 1008417 A1 HK1008417 A1 HK 1008417A1 HK 98109126 A HK98109126 A HK 98109126A HK 98109126 A HK98109126 A HK 98109126A HK 1008417 A1 HK1008417 A1 HK 1008417A1
Authority
HK
Hong Kong
Prior art keywords
sublingual
pharmaceutical composition
oxepino
methyl
chloro
Prior art date
Application number
HK98109126A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1008417B (en
Inventor
Petrus Carla Delbressine Leonardus
Hubertus Wieringa Johannes
Original Assignee
Merck Sharp & Dohme B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1008417(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme B.V. filed Critical Merck Sharp & Dohme B.V.
Publication of HK1008417B publication Critical patent/HK1008417B/en
Publication of HK1008417A1 publication Critical patent/HK1008417A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK98109126A 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition HK1008417A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94200521 1994-03-02
EP94200521 1994-03-02
PCT/EP1995/000765 WO1995023600A1 (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Publications (2)

Publication Number Publication Date
HK1008417B HK1008417B (en) 1999-05-07
HK1008417A1 true HK1008417A1 (en) 1999-05-07

Family

ID=8216678

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98109126A HK1008417A1 (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Country Status (23)

Country Link
US (1) US5763476A (cs)
EP (1) EP0746317B1 (cs)
JP (2) JP4099224B2 (cs)
KR (1) KR100330942B1 (cs)
CN (1) CN1079670C (cs)
AT (1) ATE167057T1 (cs)
AU (1) AU692530B2 (cs)
BR (2) BR9506924A (cs)
CA (1) CA2182981C (cs)
CZ (1) CZ284633B6 (cs)
DE (2) DE122010000050I2 (cs)
DK (1) DK0746317T3 (cs)
ES (1) ES2118584T3 (cs)
FI (1) FI117923B (cs)
FR (1) FR10C0056I2 (cs)
HK (1) HK1008417A1 (cs)
HU (1) HU225051B1 (cs)
LU (1) LU91751I2 (cs)
NO (2) NO308772B1 (cs)
NZ (1) NZ282394A (cs)
PL (1) PL180465B1 (cs)
RU (1) RU2139051C1 (cs)
WO (1) WO1995023600A1 (cs)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032108A1 (en) * 1997-12-19 1999-07-01 Akzo Nobel N.V. Org-5222 in the treatment of depression
EP1485296B1 (en) * 2002-02-13 2011-07-20 Michael K. Weibel Drug dose - form and method of manufacture
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
RU2005135454A (ru) * 2003-05-16 2006-06-27 Пфайзер Продактс Инк. (Us) Терапевтические комбинации атипичных нейролептиков с модуляторами гамк и/или противосудорожными препаратами
TWI327915B (en) * 2003-06-12 2010-08-01 Organon Nv Pharmaceutical composition comprising antipsychotic agent and use of the antipsychotic agent for treating patients with overweight
NZ545744A (en) * 2003-09-22 2009-12-24 Baxter Int High-pressure sterilization to terminally sterilize pharmaceutical preparations and medical products
CA2565996A1 (en) * 2004-05-11 2005-11-17 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
GB0416861D0 (en) * 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
WO2006040314A1 (en) * 2004-10-15 2006-04-20 Pfizer Inc. Treatment of bipolar disorders and associated symptoms
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
SI1710245T1 (sl) * 2005-04-07 2007-12-31 Organon Nv Kristalna oblika asenapin maleata
DK1710241T3 (da) 2005-04-07 2010-03-01 Organon Nv Intermediatforbindelser til fremstilling af trans-5-chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
CA2727573A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
WO2010127674A1 (en) * 2009-05-06 2010-11-11 Sunin K/S Transdermal compositions of asenapine for the treatment of psychiatric disorders
WO2010149727A2 (en) 2009-06-24 2010-12-29 N.V. Organon Injectable formulations containing asenapine and method of treatment using same
TW201118102A (en) 2009-07-29 2011-06-01 Organon Nv Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same
AU2011268335A1 (en) 2010-06-18 2013-01-10 Dr. Reddy's Laboratories Ltd. Asenapine maleate
EP2598496B1 (en) 2010-07-29 2014-03-19 Laboratorios Lesvi, S.L. Novel process for the preparation of asenapine
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
EP2640391B1 (en) 2010-11-15 2015-11-11 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
WO2012066565A2 (en) 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
EP2524919A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
US9533994B2 (en) 2011-05-18 2017-01-03 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
EP2709616B1 (en) 2011-05-18 2018-01-24 Laboratorios Lesvi, S.L. Synthesis of a stable micronised monoclinic form of asenapine maleate
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
EP2572703A1 (en) 2011-09-21 2013-03-27 Hexal AG Compressed oral dosage form for asenapine maleate
CN102657635B (zh) * 2012-05-04 2013-08-07 上海现代药物制剂工程研究中心有限公司 具有微孔的海绵状的阿塞那平舌下膜剂及其制备方法
ITMI20121810A1 (it) 2012-10-24 2014-04-25 Chemo Iberica Sa Poliformi di maleato di asenapina e processo per la loro preparazione
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014090386A1 (en) 2012-12-11 2014-06-19 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Orally disintegrating tablet containing asenapine
WO2014100418A2 (en) 2012-12-20 2014-06-26 Kashiv Pharma, Llc Orally disintegrating tablet formulation for enhanced bioavailability
CN103893139B (zh) * 2012-12-28 2018-06-08 石药集团中奇制药技术（石家庄）有限公司 一种阿塞那平组合物及其制备方法
CN103120688A (zh) * 2013-01-11 2013-05-29 盛世泰科生物医药技术(苏州)有限公司 一种闪释制剂的药物组合
US9545376B2 (en) 2013-01-23 2017-01-17 Arx, Llc Production of unit dose constructs
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
WO2014207664A2 (en) * 2013-06-28 2014-12-31 Alembic Pharmaceuticals Limited Stable pharmaceutical composition of asenapine
CN106068256B (zh) 2013-12-20 2020-10-23 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂*衍生物、组合物和方法
US20170007537A1 (en) * 2014-02-18 2017-01-12 Hetero Research Foundation Pharmaceutical compositions of asenapine
MX365969B (es) 2014-04-04 2019-06-21 Intra Cellular Therapies Inc Gamma-carbolinas fusionadas con heterociclos sustituidas con deuterio.
TR201509009A1 (en) * 2014-12-11 2017-02-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi THIN FILM STRIP OF ASENAPINE
CA2987081C (en) 2015-06-11 2022-08-30 Alrise Biosystems Gmbh Process for the preparation of drug loaded microparticles
EA036844B1 (ru) 2015-06-19 2020-12-28 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения
ES2863471T3 (es) 2016-01-26 2021-10-11 Intra Cellular Therapies Inc Compuestos de piridopirroloquinoxalina, sus composiciones y usos
RU2733975C2 (ru) 2016-03-25 2020-10-08 Интра-Селлулар Терапиз, Инк. Органические соединения
US10085971B2 (en) 2016-08-22 2018-10-02 Navinta Iii Inc Pharmaceutical solution of asenapine for sublingual or buccal use
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3558276B1 (en) 2016-12-20 2024-11-06 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
KR102506333B1 (ko) 2016-12-20 2023-03-06 에르테에스 로만 테라피-시스테메 아게 아세나핀을 함유하는 경피흡수 치료 시스템
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
US10906906B2 (en) 2016-12-29 2021-02-02 Intra-Cellular Therapies, Inc. Organic compounds
KR102398194B1 (ko) 2017-03-24 2022-05-18 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 조성물 및 방법
BR112019027037B1 (pt) 2017-06-26 2022-04-05 Lts Lohmann Therapie-Systeme Ag Sistema terapêutico transdérmico contendo asenapina e polímero híbrido acrílico de silicone, e processo para fabricar uma camada contendo asenapina para uso no referido sistema
US11980617B2 (en) 2018-03-16 2024-05-14 Intra-Cellular Therapies, Inc. Methods of treating acute depression and/or acute anxiety
MX2020009928A (es) 2018-03-23 2021-01-08 Intra Cellular Therapies Inc Compuestos organicos.
NZ772066A (en) 2018-06-19 2025-05-30 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102802121B1 (ko) 2018-06-20 2025-05-02 에르테에스 로만 테라피-시스테메 아게 아세나핀을 함유하는 경피 치료 시스템
CN112533593A (zh) 2018-06-20 2021-03-19 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
JP7457000B2 (ja) 2018-08-31 2024-03-27 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
EP3843738A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS
US20210000822A1 (en) 2019-07-07 2021-01-07 Intra-Cellular Therapies, Inc. Novel methods
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
JP2025529834A (ja) 2022-08-19 2025-09-09 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾアゼピン誘導体、組成物および方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
IE45770B1 (en) * 1976-10-06 1982-11-17 Wyeth John & Brother Ltd Pharmaceutical dosage forms
GB1548022A (en) * 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
FR2480283A1 (fr) * 1980-04-10 1981-10-16 Science Union & Cie Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament
JPS5967218A (ja) * 1982-10-07 1984-04-16 Grelan Pharmaceut Co Ltd 軟質な口腔製剤
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
CA2027243A1 (en) * 1989-10-17 1991-04-18 Everett H. Ellinwood, Jr. Intraoral formulated trifluorobenzodiazepines and the use thereof
KR100225153B1 (ko) * 1991-04-08 1999-10-15 다께우찌 마사야쓰 단백성 생리학적 활성 물질을 함유하는 다공성 고형 제제
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation
ZA933134B (en) * 1992-05-08 1993-11-30 Akzo Nv Depot preparation

Also Published As

Publication number Publication date
CZ254196A3 (en) 1997-10-15
PL180465B1 (pl) 2001-02-28
DE122010000050I2 (de) 2011-07-21
PL316080A1 (en) 1996-12-23
FR10C0056I1 (cs) 2011-01-28
BR1100625A (pt) 1999-12-28
FI963398A0 (fi) 1996-08-30
CN1143320A (zh) 1997-02-19
FR10C0056I2 (cs) 2011-11-25
CA2182981C (en) 2006-10-17
LU91751I2 (fr) 2011-01-04
FI117923B (fi) 2007-04-30
MX9603713A (es) 1997-12-31
KR100330942B1 (ko) 2002-11-16
JP4616810B2 (ja) 2011-01-19
AU692530B2 (en) 1998-06-11
NO2010024I1 (no) 2011-01-03
RU2139051C1 (ru) 1999-10-10
CA2182981A1 (en) 1995-09-08
DE69502939T2 (de) 1998-10-22
FI963398L (fi) 1996-08-30
CZ284633B6 (cs) 1999-01-13
NO2010024I2 (no) 2012-04-10
NO308772B1 (no) 2000-10-30
AU1947895A (en) 1995-09-18
NZ282394A (en) 1997-12-19
JP4099224B2 (ja) 2008-06-11
WO1995023600A1 (en) 1995-09-08
HUT76319A (en) 1997-08-28
ES2118584T3 (es) 1998-09-16
DE122010000050I1 (de) 2011-05-05
US5763476A (en) 1998-06-09
JP2006342178A (ja) 2006-12-21
DK0746317T3 (da) 1999-03-22
CN1079670C (zh) 2002-02-27
ATE167057T1 (de) 1998-06-15
NO963639L (no) 1996-10-30
NO963639D0 (no) 1996-08-30
EP0746317A1 (en) 1996-12-11
HU9602383D0 (en) 1996-10-28
JPH09509674A (ja) 1997-09-30
BR9506924A (pt) 1997-09-30
DE69502939D1 (de) 1998-07-16
HU225051B1 (en) 2006-05-29
EP0746317B1 (en) 1998-06-10

Similar Documents

Publication Publication Date Title
EP0746317B1 (en) Sublingual or buccal pharmaceutical composition
HK1008417B (en) Sublingual or buccal pharmaceutical composition
EP1246668B1 (en) An rapid acting freeze dired oral pharmaceutical composition for treating migraine
US20020002172A1 (en) Pharmaceutical formulations
KR100292124B1 (ko) 온단세트론을포함하는경구조성물
KR20140104986A (ko) 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
US20090280172A1 (en) Galenic formulations of organic compounds
AU2004266731A1 (en) Compositions for delivering 5-HT agonists across the oral mucosa and methods of use thereof
WO2006133349A2 (en) Orally disintegrable sleep aid formulations
TWI343262B (en) Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
JPH0812575A (ja) 口腔乾燥症治療剤
MXPA96003713A (en) Sublingual pharmaceutical composition or bu
CA2556450A1 (en) Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
JPH11116465A (ja) 迅速溶解性製剤およびその製造法
KR20160105935A (ko) 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20150228