HK1003579A1 - Heterologous polypeptide expressed in filamentous fungi processes for their preparation and vectors for their preparation - Google Patents

Heterologous polypeptide expressed in filamentous fungi processes for their preparation and vectors for their preparation

Info

Publication number
HK1003579A1
HK1003579A1 HK98102696A HK98102696A HK1003579A1 HK 1003579 A1 HK1003579 A1 HK 1003579A1 HK 98102696 A HK98102696 A HK 98102696A HK 98102696 A HK98102696 A HK 98102696A HK 1003579 A1 HK1003579 A1 HK 1003579A1
Authority
HK
Hong Kong
Prior art keywords
vectors
preparation
heterologous polypeptide
filamentous fungus
heterologous
Prior art date
Application number
HK98102696A
Other languages
English (en)
Inventor
Randy M Berka
Daniel Cullen
Gregory L Gray
Kirk J Hayenga
Virgil B Lawlis
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27118452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1003579(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genencor Int filed Critical Genencor Int
Publication of HK1003579A1 publication Critical patent/HK1003579A1/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411Amylases
    • C12N9/2428Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478Aspartic endopeptidases (3.4.23)
    • C12N9/6481Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/61Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
HK98102696A 1985-08-29 1998-03-31 Heterologous polypeptide expressed in filamentous fungi processes for their preparation and vectors for their preparation HK1003579A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77137485A 1985-08-29 1985-08-29
US88222486A 1986-07-07 1986-07-07

Publications (1)

Publication Number Publication Date
HK1003579A1 true HK1003579A1 (en) 1998-10-30

Family

ID=27118452

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98102696A HK1003579A1 (en) 1985-08-29 1998-03-31 Heterologous polypeptide expressed in filamentous fungi processes for their preparation and vectors for their preparation

Country Status (10)

Country Link
EP (2) EP0215594B2 (xx)
JP (1) JPH08280388A (xx)
AT (1) ATE117020T1 (xx)
AU (1) AU607398B2 (xx)
CA (1) CA1341532C (xx)
DE (1) DE3650202T3 (xx)
DK (1) DK175460B1 (xx)
HK (1) HK1003579A1 (xx)
IE (2) IE65794B1 (xx)
NZ (1) NZ217373A (xx)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
GB8508800D0 (en) * 1985-04-04 1985-05-09 Glaxo Group Ltd Microbiological process
US5198345A (en) * 1985-04-15 1993-03-30 Gist-Brocades N.V. Vectors in use in filamentous fungi
AU606033B2 (en) * 1985-04-15 1991-01-31 Dsm Ip Assets B.V. Promotors of filamentous fungi and use thereof
US5766912A (en) 1986-03-17 1998-06-16 Novo Nordisk A/S Humicola lipase produced in aspergillus
US5536661A (en) * 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
DK122686D0 (da) * 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5780292A (en) * 1987-04-29 1998-07-14 Alko Group Ltd. Production of phytate degrading enzymes in trichoderma
GB8610600D0 (en) * 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US5610034A (en) * 1987-04-29 1997-03-11 Alko Group Ltd. Immunoglobulin production by trichoderma
ATE125865T1 (de) * 1987-08-28 1995-08-15 Novo Nordisk As Rekombinante humicola-lipase und verfahren zur herstellung von rekombinanten humicola-lipasen.
JP2703598B2 (ja) * 1987-09-04 1998-01-26 ノボ―ノルディスク アクティーゼルスカブ アスペルギルス菌中でのタンパク質生産物の生産方法およびアスペルギルス菌中で使用するためのプロモーター
CA1333777C (en) * 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
EP0429628B1 (en) * 1989-06-16 1998-09-02 Genencor International, Inc. Dna sequences, vectors, and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
FR2649120B1 (fr) * 1989-06-30 1994-01-28 Cayla Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
WO1991013971A1 (en) * 1990-03-13 1991-09-19 Hawaii Biotechnology Group, Inc. Neurospora expression system
CA2084189A1 (en) * 1990-07-16 1992-01-17 Alko Group Limited Immunoglobulin production by trichoderma
ATE193727T1 (de) * 1991-03-22 2000-06-15 Novo Nordisk As Verfahren zur herstellung von peroxidasen in einem aspergillusstamm
ATE123524T1 (de) * 1991-03-22 1995-06-15 Novo Nordisk As Herstellungsverfahren für chymosin.
DK36592D0 (da) * 1992-03-20 1992-03-20 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
EP0655890B1 (en) * 1992-07-31 2005-01-26 AB Enzymes GmbH Recombinant cells, dna constructs, vectors and methods for expression phytate degrading enzymes in desired ratios
EP0635574B1 (en) * 1993-07-23 2003-04-23 Dsm N.V. Selection marker gene free recombinant strains, a method for obtaining them and the use of these strains
US5935836A (en) * 1994-07-29 1999-08-10 Rohm Enzyme Finland Oy Actinomadura xylanase sequences and methods of use
US6300114B1 (en) 1994-07-29 2001-10-09 Rohm Enzyme Finland Oy Sequences of xylanase and xylanase expression vectors
US7816129B2 (en) 1994-07-29 2010-10-19 Ab Enzymes Gmbh Production and secretion of proteins of bacterial origin in filamentous fungi
US5700686A (en) * 1995-06-06 1997-12-23 Iogen Corporation Protease-treated and purified cellulase compositions and methods for reducing backstaining during enzymatic stonewashing
US7883872B2 (en) 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
AU771539C (en) 1998-10-06 2005-01-13 Dyadic International (Usa), Inc. Transformation system in the field of filamentous fungal hosts
US7189538B2 (en) * 1999-03-24 2007-03-13 Genencor International, Inc. Hyphal growth in fungi
AU7398100A (en) * 1999-09-13 2001-04-17 Concordia University A multifunctional system for the efficient manipulation of protein expression infilamentous fungi and method using same
EP1346057A2 (de) * 2000-12-29 2003-09-24 Rhein Biotech Gesellschaft Für Neue Biotechnologische Prozesse Und Produkte Mbh Verfahren zum herstellen von heterologen proteinen in einem homothallischen pilz der familie sordariaceae
CA2441580A1 (en) 2001-03-22 2002-10-03 Novo Nordisk Health Care Ag Coagulation factor vii derivatives
CZ2004427A3 (cs) 2001-09-27 2004-08-18 Novoánordiskáhealthácareáag Polypeptidy lidského koagulačního faktoru VII
DK1495055T3 (da) 2002-04-18 2013-11-11 Genencor Int Produktion af funktionelle antistoffer i filamentøse svampe
AU2003298577A1 (en) 2002-09-10 2004-05-04 Genencor International, Inc. Induction of gene expression using a high concentration sugar mixture
WO2004072225A2 (en) 2003-02-12 2004-08-26 Ramot At Tel Aviv University Ltd. Transgenic fungi expressing bcl-2 and methods of using bcl-2 or portions thereof for improving biomass production, survival, longevity, stress resistance and pathogenicity of fungi
EP2392655A3 (en) 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Coagulation factor VII polypeptides
EP1689766B1 (en) 2003-11-06 2012-04-25 Danisco US Inc. Expression in filamentous fungi of protease inhibitors and variants thereof
SI1685244T1 (sl) 2003-11-21 2012-06-29 Danisco Us Inc Ekspresija encimov, ki hidrolizirajo zrnat škrob, v Trichodermi in postopek za proizvajanje glukoze iz zrnatih škrobnih substratov
US7413887B2 (en) 2004-05-27 2008-08-19 Genecor International, Inc. Trichoderma reesei glucoamylase and homologs thereof
US7332319B2 (en) 2004-05-27 2008-02-19 Genencor International, Inc. Heterologous alpha amylase expression in Aspergillus
WO2005117756A2 (en) 2004-05-27 2005-12-15 Genencor International, Inc. Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions
AU2004320371B2 (en) 2004-05-27 2011-09-22 Genencor International, Inc. Heterologous expression of an aspergillus kawachi acid-stable alpha amylase and applications in granular starch hydrolysis
MX2007007862A (es) 2004-12-30 2007-08-17 Genencor Int Proteasas fungales acidas.
WO2006089107A1 (en) 2005-02-18 2006-08-24 Genencor International, Inc. Polypeptides having alpha-amylase and granular starch hydrolyzing activity
DK2123746T3 (en) 2005-04-12 2017-02-27 Danisco Us Inc GEN-INACTIVATED MUTANTS WITH CHANGED PROTEIN PRODUCTION
JP5690047B2 (ja) 2005-09-14 2015-03-25 ノボ ノルディスク ヘルス ケア アーゲー ヒト凝固第vii因子ポリペプチド
US20080026376A1 (en) 2006-07-11 2008-01-31 Huaming Wang KEX2 cleavage regions of recombinant fusion proteins
US8198046B2 (en) 2006-07-11 2012-06-12 Danisco Us Inc. KEX2 cleavage regions of recombinant fusion proteins
US7968691B2 (en) 2006-08-23 2011-06-28 Danisco Us Inc. Pullulanase variants with increased productivity
CA2661808A1 (en) 2006-08-29 2008-03-06 Danisco Us, Inc., Genencor Division Compositions and methods for improved protein production
EP2061882A2 (en) 2006-10-10 2009-05-27 Danisco US, INC., Genencor Division Glucoamylase variants with altered properties
EP2102366A4 (en) 2006-12-10 2010-01-27 Dyadic International Inc EXPRESSION AND HIGH-DROP SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FADENED MUSHROOMS
US8143046B2 (en) 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
US20080220498A1 (en) 2007-03-06 2008-09-11 Cervin Marguerite A Variant Buttiauxella sp. phytases having altered properties
DK2132307T3 (da) 2007-03-14 2012-03-05 Danisco Us Inc Trichoderma reesei-amylase er et maltogent enzym
US8093016B2 (en) 2007-05-21 2012-01-10 Danisco Us Inc. Use of an aspartic protease (NS24) signal sequence for heterologous protein expression
WO2008153712A2 (en) 2007-05-21 2008-12-18 Danisco Us, Inc., Genencor Division Method for introducing nucleic acids into fungal cells
EP2197893B1 (en) 2007-09-07 2013-07-24 Dyadic International, Inc. Novel fungal enzymes
EP2195435B1 (en) 2007-09-12 2012-10-10 Danisco US Inc. Trichoderma promoter
US8592194B2 (en) 2007-10-09 2013-11-26 Danisco Us Inc. Glucoamylase variants with altered properties
PL2514818T3 (pl) 2007-10-09 2014-11-28 Danisco Us Inc Odmiany glukoamylazy
ES2527586T3 (es) 2007-11-20 2015-01-27 Danisco Us Inc. Variantes de glucoamilasa con propiedades modificadas
MX2010006576A (es) 2007-12-13 2010-10-15 Danisco Us Inc Composiciones y metodos para producir isopreno.
WO2009088465A2 (en) 2008-01-02 2009-07-16 Danisco Us Inc., Genencor Division A process of obtaining ethanol without glucoamylase using pseudomonas saccharophila g4-amylase and variants thereof
DK2268806T3 (da) 2008-02-11 2013-07-15 Danisco Us Inc Enzym med mikrobiel lyseaktivitet fra Trichoderma reesei
US8673609B2 (en) 2008-04-18 2014-03-18 Danisco Us Inc. Buttiauxella sp. phytase variants
WO2009132220A2 (en) 2008-04-23 2009-10-29 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
SG167566A1 (en) 2008-07-02 2011-01-28 Danisco Us Inc Compositions and methods for producing isoprene free of C5 hydrocarbons under decoupling conditions and/or safe operating ranges
WO2010031068A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
MY156562A (en) 2008-09-15 2016-02-26 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
DK2344629T3 (en) 2008-09-15 2018-03-05 Danisco Us Inc SYSTEMS USING CELL CULTURE TO MAKE ISOPRENE
ZA201102109B (en) 2008-09-15 2013-10-30 Goodyear Tire & Rubber Conversion of prenyl derivatives to isoprene
CA2746118A1 (en) 2008-12-15 2010-07-01 Danisco Us Inc. Hybrid alpha-amylases
JP5793424B2 (ja) 2008-12-30 2015-10-14 ダニスコ・ユーエス・インク イソプレンと副生成物の産出方法
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
DK3473711T3 (da) 2009-05-19 2021-01-04 Dupont Nutrition Biosci Aps Amylasepolypeptider
TWI427149B (zh) 2009-06-17 2014-02-21 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
CN102712687A (zh) 2009-07-17 2012-10-03 丹麦国家医院 作为补体激活的抑制剂的masp同种型
WO2011022465A1 (en) 2009-08-19 2011-02-24 Danisco Us Inc. Combinatorial variants of glucoamylase with improved specific activity and/or thermostability
JP5827227B2 (ja) 2009-08-19 2015-12-02 デュポン ニュートリション バイオサイエンシーズ エーピーエスDuPont Nutrition Biosciences ApS グルコアミラーゼの変異体
WO2011067283A1 (en) 2009-12-01 2011-06-09 Novo Nordisk A/S Novel peptidyl alpha-hydroxyglycine alpha-amidating lyases
CA2791841C (en) 2010-03-05 2023-01-03 Rigshospitalet Chimeric inhibitor molecules of complement activation
US9107440B2 (en) 2010-03-29 2015-08-18 Dupont Nutrition Biosciences Aps Polypeptides having transgalactosylating activity
BR112012032276A2 (pt) 2010-06-17 2016-11-16 Danisco Us Inc composições de combustível compreendendo derivados de isopreno
WO2012010592A1 (en) * 2010-07-21 2012-01-26 Novozymes A/S Process for preparing a baked product with anti -staling amylase and peptidase
WO2012019169A1 (en) 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
BR112013001179A2 (pt) 2010-08-06 2016-05-31 Danisco Us Inc sacrificação e fermentação em ph neutro.
US20130142903A1 (en) 2010-08-24 2013-06-06 Danisco Us Inc Food product comprising a low temperature rice protein concentrate
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
US8691541B2 (en) 2010-12-22 2014-04-08 Danisco Us Inc. Biological production of pentose sugars using recombinant cells
CA2834393A1 (en) 2011-04-29 2012-11-01 Danisco Us Inc. Single ph process for starch liquefaction and saccharification for high-density glucose syrups
EP2739742A1 (en) 2011-08-05 2014-06-11 Danisco US Inc. PRODUCTION OF ISOPRENOIDS UNDER NEUTRAL pH CONDITIONS
WO2013067026A1 (en) 2011-10-31 2013-05-10 Bp Corporation North America Inc. Use of plant promoters in filamentous fungi
US20130109055A1 (en) 2011-10-31 2013-05-02 Bp Corporation North America Inc. Use of mammalian promoters in filamentous fungi
SG10201606195UA (en) 2012-02-09 2016-09-29 Var2 Pharmaceuticals Aps Targeting of chondroitin sulfate glycans
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
EA201492221A1 (ru) 2012-06-08 2015-04-30 ДюПон НЬЮТРИШН БАЙОСАЙЕНСИЗ АпС Полипептиды, имеющие активность трансгалактозилирования
MX2015002099A (es) 2012-08-22 2015-05-11 Dupont Nutrition Biosci Aps Variantes que tienen actividad glucoamilasa.
JP2015532307A (ja) 2012-10-15 2015-11-09 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 凝固因子viiポリペプチド
WO2014145768A2 (en) 2013-03-15 2014-09-18 Bp Corporation North America Inc. Use of non-fungal 5' utrs in filamentous fungi
US10683523B2 (en) 2013-12-11 2020-06-16 Dupont Nutrition Biosciences Aps Method for preparing a dairy product having a stable content of galacto-oligosaccharide(s)
AU2015341684B2 (en) 2014-11-07 2021-01-07 Dupont Nutrition Biosciences Aps Recombinant host cell expressing beta-galactosidase and/or transgalactosylating activity deficient in mannanase, cellulase and pectinase
JP2018504936A (ja) 2015-02-09 2018-02-22 ダニスコ・ユーエス・インク 真菌株および使用方法
PL3298138T3 (pl) 2015-05-22 2022-12-05 Dupont Nutrition Biosciences Aps Dekarboksylaza acetomleczanowa
EP3320106A1 (en) 2015-07-07 2018-05-16 Danisco US Inc. Induction of gene expression using a high concentration sugar mixture
ES2835067T3 (es) 2015-09-02 2021-06-21 Dupont Nutrition Biosci Aps Glucósido hidrolasas y su uso en la prevención y/o tratamiento de infección patógena en un animal
CN109642226A (zh) 2016-06-30 2019-04-16 丹尼斯科美国公司 天冬氨酸蛋白酶
EP3512941B1 (en) 2016-09-16 2021-03-24 DuPont Nutrition Biosciences ApS Acetolactate decarboxylase variants having improved specific activity
CA3037875A1 (en) 2016-09-23 2018-03-29 Dupont Nutrition Biosciences Aps Use of low ph active alpha-1,4/1,6-glycoside hydrolases as a feed additive for ruminants to enhance starch digestion
CN109790510B (zh) 2016-10-04 2024-04-12 丹尼斯科美国公司 在不存在诱导底物下丝状真菌细胞中的蛋白产生
WO2018093752A1 (en) 2016-11-15 2018-05-24 Danisco Us Inc. Filamentous fungi with improved protein production
CN110505903A (zh) 2017-03-06 2019-11-26 杜邦营养生物科学有限公司 新型真菌岩藻糖苷酶及其在预防和/或治疗动物病原体感染中的用途
US20210278406A1 (en) 2018-07-13 2021-09-09 Varct Diagnostic Aps Isolation of circulating cells of fetal origin using recombinant malaria protein var2csa
JP2022525057A (ja) 2019-03-08 2022-05-11 ダニスコ・ユーエス・インク 融合ポリペプチド
CN113874392A (zh) 2019-03-28 2021-12-31 丹尼斯科美国公司 工程化抗体
KR20220116504A (ko) 2019-12-19 2022-08-23 바스프 에스이 정밀 화학물의 제조에서 공시 수율, 탄소-전환-효율 및 탄소 기질 적응성의 증가
BR112022011895A2 (pt) 2019-12-20 2022-09-06 Basf Se Diminuição da toxidez de terpenos e aumento da produção potencial em microrganismos
WO2021202473A2 (en) 2020-03-30 2021-10-07 Danisco Us Inc Engineered antibodies
JP2023523925A (ja) 2020-04-22 2023-06-08 ダニスコ・ユーエス・インク 糸状菌細胞におけるタンパク質産生の増強のための組成物及び方法
EP4373943A2 (en) 2021-07-19 2024-05-29 Danisco Us Inc Compositions and methods for enhanced protein production in fungal cells
CN116135979A (zh) * 2021-11-16 2023-05-19 中国科学院天津工业生物技术研究所 一种基于流式细胞术的免涂板操作的菌株工程改造的方法及应用
WO2023102315A1 (en) 2021-12-01 2023-06-08 Danisco Us Inc. Compositions and methods for enhanced protein production in fungal cells
WO2024015953A1 (en) 2022-07-15 2024-01-18 Danisco Us Inc. Methods for producing monoclonal antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
NO840200L (no) * 1983-01-28 1984-07-30 Cefus Corp Glukoamylase cdna.
DK601984D0 (da) * 1984-12-14 1984-12-14 Hansens Lab Fremgangsmaade til fremstilling af genprodukter
AU606033B2 (en) * 1985-04-15 1991-01-31 Dsm Ip Assets B.V. Promotors of filamentous fungi and use thereof
DK122686D0 (da) * 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
FI872102A (fi) * 1986-06-06 1987-12-07 Panlabs Inc Expressionssystem hos filamentala fungi.

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EP0215594A2 (en) 1987-03-25
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