GR852611B - - Google Patents

Info

Publication number
GR852611B
GR852611B GR852611A GR850102611A GR852611B GR 852611 B GR852611 B GR 852611B GR 852611 A GR852611 A GR 852611A GR 850102611 A GR850102611 A GR 850102611A GR 852611 B GR852611 B GR 852611B
Authority
GR
Greece
Application number
GR852611A
Other languages
Greek (el)
Inventor
David Womack Stroman
Paul Frederick Brust
Steven Bradley Ellis
Thomas Raymond Gingeras
Michael Miller Harpold
Juerg Friedrich Tschopp
Original Assignee
Phillips Petroleum Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/666,391 external-priority patent/US4808537A/en
Application filed by Phillips Petroleum Co filed Critical Phillips Petroleum Co
Publication of GR852611B publication Critical patent/GR852611B/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • C12N15/68Stabilisation of the vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
GR852611A 1984-10-30 1985-10-29 GR852611B (en:Method)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/666,391 US4808537A (en) 1984-10-30 1984-10-30 Methanol inducible genes obtained from pichia and methods of use
US06/780,102 US4855231A (en) 1984-10-30 1985-09-25 Regulatory region for heterologous gene expression in yeast

Publications (1)

Publication Number Publication Date
GR852611B true GR852611B (en:Method) 1986-03-04

Family

ID=27099454

Family Applications (1)

Application Number Title Priority Date Filing Date
GR852611A GR852611B (en:Method) 1984-10-30 1985-10-29

Country Status (23)

Country Link
US (1) US4855231A (en:Method)
EP (2) EP0483115A3 (en:Method)
JP (5) JP2502508B2 (en:Method)
KR (1) KR930001117B1 (en:Method)
CN (1) CN1011243B (en:Method)
AR (1) AR242988A1 (en:Method)
AT (1) ATE83263T1 (en:Method)
AU (1) AU572002B2 (en:Method)
CA (1) CA1340733C (en:Method)
DD (1) DD254211A5 (en:Method)
DE (1) DE3586889T2 (en:Method)
DK (1) DK496385A (en:Method)
ES (1) ES8609458A1 (en:Method)
FI (1) FI94427C (en:Method)
GR (1) GR852611B (en:Method)
HU (1) HU205627B (en:Method)
IE (1) IE930804L (en:Method)
IL (1) IL76765A (en:Method)
NO (1) NO178076C (en:Method)
NZ (1) NZ213842A (en:Method)
PL (1) PL158965B1 (en:Method)
PT (1) PT81399B (en:Method)
YU (1) YU46695B (en:Method)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741672A (en) * 1984-07-27 1998-04-21 Unilever Patent Holdings B.V. Expression and production of polypeptides using the promoters of the hansenula polymorpha MOX and DAS genes
US4879231A (en) * 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US5032516A (en) * 1985-10-25 1991-07-16 Phillips Petroleum Company Pichia pastoris alcohol oxidase II regulatory region
US4818700A (en) * 1985-10-25 1989-04-04 Phillips Petroleum Company Pichia pastoris argininosuccinate lyase gene and uses thereof
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4895800A (en) * 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
IL81817A0 (en) * 1986-03-14 1987-10-20 Phillips Petroleum Co Methanol and glucose responsive yeast regulatory regions
ZA872534B (en) * 1986-05-08 1987-11-25 Phillips Petroleum Co Yeast production of streptokinase
IL82935A0 (en) * 1986-08-12 1987-12-20 Phillips Petroleum Co Secretion of heterologous proteins from yeast
US5002876A (en) * 1986-09-22 1991-03-26 Phillips Petroleum Company Yeast production of human tumor necrosis factor
ES2056799T3 (es) * 1987-07-17 1994-10-16 Rhein Biotech Ges Fur Biotechn Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso.
ATE248925T1 (de) * 1988-01-05 2003-09-15 Roche Diagnostics Gmbh Verfahren zur herstellung von proteinen oder proteinhaltigen genprodukten
SE8901264L (sv) * 1988-04-11 1989-10-12 Phillips Petroleum Co Uttryck av laxtillvaexthormon i metylotropisk jaest av slaektet pichia
IL89992A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human serum albumin in methylotrophic yeasts
IL89993A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of the hiv 24kda gag protein in methylotrophic yeasts
IL89989A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human interleukin-2 in methylotrophic yeasts
IL90021A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Process for the production of interferon
IL89991A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of hepatitis b pres2 protein in methylotrophic yeasts
DE3851535T2 (de) * 1988-12-20 1995-02-02 Rhein Biotech Proz & Prod Gmbh Mutanter Stamm von einem methylotrophen Organismus und Verfahren zur Herstellung eines Proteins in methylotrophen Organismus.
DD297841A5 (de) * 1989-02-13 1992-01-23 The Salk Institute Biotechnology/Industrial Associates,Us Herstellung von superoxiddismutase in pichia pastoris hefezellen
GB8924883D0 (en) * 1989-11-03 1989-12-20 Shell Int Research Expression vector and polypeptide synthesis
US5264554A (en) * 1990-01-19 1993-11-23 The Blood Center Of Southeastern Wisconsin, Inc. Platelet cell adhesion molecule and variants thereof
US6440681B1 (en) 1990-04-03 2002-08-27 Merck & Co., Inc. Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US5258302A (en) * 1990-07-03 1993-11-02 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA for expression of aprotinin in methylotrophic yeast cells
CA2090969C (en) * 1990-09-04 2001-08-21 Russell Arthur Brierley Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5268273A (en) * 1990-12-14 1993-12-07 Phillips Petroleum Company Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same
WO1992013951A1 (en) * 1991-02-04 1992-08-20 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of human serum albumin in methylotrophic yeast cells
WO1992017595A1 (en) * 1991-04-01 1992-10-15 The Salk Institute Biotechnology/Industrial Associates, Inc. Genes which influence pichia proteolytic activity, and uses therefor
CA2058820C (en) * 1991-04-25 2003-07-15 Kotikanyad Sreekrishna Expression cassettes and vectors for the secretion of human serum albumin in pichia pastoris cells
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
US5834262A (en) * 1992-01-06 1998-11-10 E. I. Du Pont De Nemours And Company Oxidation of glycolic acid to glyoxylic acid using a microbial cell transformant as catalyst
JP3113435B2 (ja) * 1992-02-28 2000-11-27 サントリー株式会社 メタノールおよび/またはグリセロール添加により誘導可能なプロモーターを有する新規ベクター
US5708141A (en) * 1992-05-11 1998-01-13 Corvas International, Inc. Neutrophil inhibitors
JP3541949B2 (ja) * 1993-03-03 2004-07-14 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン メチロトローフ酵母におけるグリコレートオキシダーゼの製造
EP0688361B1 (en) * 1993-03-08 2004-10-13 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
WO1994021802A1 (en) * 1993-03-25 1994-09-29 Biosource Genetics Corporation PICHIA PASTORIS ALCOHOL OXIDASE ZZA1 and $i(ZZA2)
WO1994024284A1 (en) 1993-04-20 1994-10-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Human n-methyl-d-aspartate receptor subunits, nucleic acids encoding same and uses therefor
US5912122A (en) 1993-06-04 1999-06-15 Sibia Neurosciences, Inc. Nucleic acids encoding and method for detecting nucleic acid encoding human metabotropic glutamate receptor subtype mGluR6
US5521297A (en) 1993-06-04 1996-05-28 Salk Institute Biotechnology/Industrial Associates Nucleic acids encoding human metabotropic glutamate receptors
US6001581A (en) * 1993-06-04 1999-12-14 Sibia Neurosciences, Inc. Cation-based bioassay using human metabotropic glutamate receptors
US6638905B2 (en) * 1993-06-18 2003-10-28 The Salk Institute For Biological Studies Cloning and recombinant production of CFR receptor(s)
US6495343B1 (en) 1993-06-18 2002-12-17 The Salk Institute For Biological Studies Cloning and recombinant production of CRF receptor(s)
WO1995013299A1 (en) * 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
US5453161A (en) * 1993-11-12 1995-09-26 Enichem S.P.A. Polyamic acid to polyimide conversion by microwave heating
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
WO1996012021A2 (en) * 1994-10-18 1996-04-25 Corvas International, Inc. Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US6143557A (en) 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US6720140B1 (en) * 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US7670823B1 (en) 1999-03-02 2010-03-02 Life Technologies Corp. Compositions for use in recombinational cloning of nucleic acids
US6485967B1 (en) 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
CA2237039A1 (en) * 1995-11-09 1997-05-15 Zymogenetics, Inc. Production of gad65 in methylotrophic yeast
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
EP0911416B1 (en) 1997-10-01 2006-05-17 DSM IP Assets B.V. Protein production process
CN100342008C (zh) * 1997-10-24 2007-10-10 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
CN101125873A (zh) * 1997-10-24 2008-02-20 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
DE69927375T2 (de) * 1998-07-06 2006-06-22 Tosoh Corp., Shinnanyo Fusionsprotein mit direkter verknüpfung des il-6-rezeptors mit il-6
JP4524816B2 (ja) * 1998-07-06 2010-08-18 東ソー株式会社 Il−6レセプター・il−6直結融合蛋白質
EP1114148A4 (en) * 1998-08-28 2004-12-22 Invitrogen Corp SYSTEM FOR RAPID HANDLING OF NUCLEIC ACID SEQUENCES
US6780615B1 (en) 1998-12-31 2004-08-24 Genway Biotech Inc. Production of recombinant monellin using methylotrophic yeast expression system
US6720174B1 (en) 1999-01-28 2004-04-13 Novozymes A/S Phytases
US7504253B2 (en) * 1999-06-11 2009-03-17 The Burnham Institute For Medical Research Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof
US6440414B1 (en) * 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6261820B1 (en) * 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
EP2345721A1 (en) 1999-11-12 2011-07-20 Fibrogen, Inc. Recombinant gelatin in vaccines
DE60038572T2 (de) 1999-12-10 2009-04-30 Invitrogen Corp., Carlsbad Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
WO2001077351A1 (en) * 2000-04-07 2001-10-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Vectors and methods for dual protein expression in pichia pastoris and escherichia coli
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
EP1522590B1 (en) * 2000-06-28 2009-08-26 Glycofi, Inc. Methods for producing modified glycoproteins
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
KR100820367B1 (ko) 2000-06-30 2008-04-07 프랜더스 인터유니버시티 인스티튜트 포 바이오테크놀로지 (브이아이비) 피히아 파스토리스에서의 단백질 글리코실화 변형
US7009045B2 (en) * 2000-07-14 2006-03-07 Archer-Daniels-Midland Company Transformation systems for flavinogenic yeast
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
CA2442935A1 (en) * 2001-04-05 2002-10-17 The Board Of Regents Of The University Of Nebraska Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
CA2448505A1 (en) * 2001-05-21 2002-11-28 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
US6645739B2 (en) 2001-07-26 2003-11-11 Phoenix Pharmacologies, Inc. Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
WO2003089589A2 (en) * 2002-04-15 2003-10-30 Merck & Co., Inc. Matrix analysis of gene expression in cells (magec)
US7252933B2 (en) 2002-06-26 2007-08-07 Flanders Interuniversity Institute For Biotechnology Protein glycosylation modification in methylotrophic yeast
US20040204953A1 (en) * 2002-07-17 2004-10-14 Lincoln Muir Subscription based systems, methods and components for providing genomic and proteomic products and services
ATE494367T1 (de) * 2002-12-18 2011-01-15 Hoffmann La Roche Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität
ATE387494T1 (de) * 2002-12-20 2008-03-15 Hoffmann La Roche Hitzelabile desoxyribonuklease i-varianten
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
EP1460425A1 (en) * 2003-03-17 2004-09-22 Boehringer Mannheim Gmbh Deglycosylated enzymes for conjugates
CA2536635C (en) 2003-08-25 2015-05-12 Funzyme Biotechnologies Sa Novel fungal proteins and nucleic acids encoding same
US8293503B2 (en) 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
WO2005054438A2 (en) 2003-12-01 2005-06-16 Invitrogen Corporation Nucleic acid molecules containing recombination sites and methods of using the same
DE602004025192D1 (de) * 2003-12-05 2010-03-11 Roche Diagnostics Gmbh Rekombinante Carboxypeptidase B und ihre Aufreinigung
BRPI0616054B8 (pt) * 2005-09-14 2021-05-25 Sanofi Aventis Deutschland processo para a preparação de insulina, um análogo de insulina ou um derivado de insulina, tripsina porcina, método para sua produção, dna e vetor
AT504588B1 (de) * 2006-11-16 2008-08-15 Univ Graz Tech Nukleinsäure-promotor
EP2257638B1 (en) * 2008-03-03 2014-12-31 AbbVie Inc. Methods for transforming yeast
CN102439118B (zh) 2008-12-12 2015-04-01 纳幕尔杜邦公司 从可再生资源制备直链二元羧酸的方法
EP2258855A1 (en) 2009-05-28 2010-12-08 Universität für Bodenkultur Wien Expression sequences
WO2011077359A2 (en) 2009-12-21 2011-06-30 Centre Hospitalier Universitaire Vaudois (Chuv) Synergic action of a prolyl protease and tripeptidyl proteases
PT2710114T (pt) 2011-05-20 2021-12-09 H Lundbeck As Produção com pureza elevada de proteínas de múltiplas subunidades, como sejam anticorpos, em microrganismos transformados tais como pichia pastoris
WO2013028635A1 (en) 2011-08-19 2013-02-28 Alderbio Holdings Llc Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as a antibodies in transformed microbes such as pichia pastoris
CA2849856C (en) 2011-10-07 2023-03-14 Lonza Ltd Regulatable promoter
US9150870B2 (en) 2013-03-15 2015-10-06 Lonza Ltd. Constitutive promoter
KR102202477B1 (ko) 2013-03-15 2021-01-13 룬드벡 시애틀 바이오파마슈티컬즈, 인크. 효모 및 기타 형질전환 세포에서 폴리펩티드의 고수율 발현을 위한 온도 전환
JP6472786B2 (ja) 2013-03-15 2019-02-20 アルダー・バイオファーマシューティカルズ・インコーポレーテッド 抗体の精製及び純度のモニタリング
HK1213292A1 (zh) 2013-03-15 2016-06-30 龙沙有限公司 组成型启动子
EP2976352B1 (en) 2013-03-21 2021-08-18 Evonik Operations GmbH Purification of triple helical proteins
CA2910745A1 (en) 2013-04-30 2014-11-06 Donald Danforth Plant Science Center Antifungal plant proteins, peptides, and methods of use
TWI738631B (zh) 2013-09-09 2021-09-11 德商贏創運營有限公司 經修飾之細菌類膠原蛋白蛋白質
WO2016120764A1 (en) 2015-01-26 2016-08-04 Centre Hospitalier Universitaire Vaudois (Chuv) Aspergillus oryzae prolyl endopeptidases and use thereof in degradation of polypeptides
WO2021126129A1 (en) * 2019-12-19 2021-06-24 Atatürk Üni̇versi̇tesi̇ Bi̇li̇msel Araştirma Projeleri̇ Bi̇ri̇mi̇ A method for recombinant protein production

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4615974A (en) * 1981-08-25 1986-10-07 Celltech Limited Yeast expression vectors
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0096430B2 (en) * 1982-05-19 1998-04-01 Gist-Brocades N.V. Cloning system for Kluyveromyces species
EP0118551A1 (en) * 1982-09-15 1984-09-19 Collaborative Research Inc. Production of interferon in yeast by use of invertase promoter
DE3583194D1 (de) * 1984-07-27 1991-07-18 Unilever Nv Verfahren zur herstellung von einem polypeptid mittels eines transformierten mikroorganismus, ein dazu geeigneter transformierter mikroorganismus, und zur herstellung dieser mikroorganismen geeignete dns sequenzen.
US4885242A (en) * 1984-10-30 1989-12-05 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4879231A (en) * 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia

Also Published As

Publication number Publication date
HUT38678A (en) 1986-06-30
ES8609458A1 (es) 1986-09-01
AU4875285A (en) 1986-06-12
JPH06233686A (ja) 1994-08-23
PT81399A (en) 1985-11-01
DK496385A (da) 1986-05-01
DK496385D0 (da) 1985-10-29
YU169585A (en) 1991-04-30
AU572002B2 (en) 1988-04-28
NZ213842A (en) 1991-11-26
CN1011243B (zh) 1991-01-16
AR242988A1 (es) 1993-06-30
EP0183071B1 (en) 1992-12-09
PT81399B (pt) 1987-11-11
KR870003197A (ko) 1987-04-15
US4855231A (en) 1989-08-08
EP0483115A3 (en) 1992-05-06
IL76765A (en) 1991-06-30
JP2552807B2 (ja) 1996-11-13
EP0183071A3 (en) 1987-09-23
JPH08196275A (ja) 1996-08-06
NO854312L (no) 1986-05-02
NO178076C (no) 1996-01-17
CN85109718A (zh) 1986-08-20
ATE83263T1 (de) 1992-12-15
JPH0698789A (ja) 1994-04-12
FI854142A0 (fi) 1985-10-23
ES548307A0 (es) 1986-09-01
NO178076B (no) 1995-10-09
JPS61173781A (ja) 1986-08-05
FI94427B (fi) 1995-05-31
YU46695B (sh) 1994-04-05
EP0483115A2 (en) 1992-04-29
IE930804L (en) 1986-04-30
CA1340733C (en) 1999-09-14
JP2552808B2 (ja) 1996-11-13
HU205627B (en) 1992-05-28
JPH08173161A (ja) 1996-07-09
DD254211A5 (de) 1988-02-17
PL158965B1 (pl) 1992-10-30
EP0183071A2 (en) 1986-06-04
FI854142L (fi) 1986-05-01
JP2502508B2 (ja) 1996-05-29
DE3586889D1 (de) 1993-01-21
FI94427C (fi) 1995-09-11
KR930001117B1 (ko) 1993-02-18
DE3586889T2 (de) 1993-04-15
PL256012A1 (en) 1986-09-23

Similar Documents

Publication Publication Date Title
GR852611B (en:Method)
GR851509B (en:Method)
GR852059B (en:Method)
GR851538B (en:Method)
GR852178B (en:Method)
GR851244B (en:Method)
GR850879B (en:Method)
GR850514B (en:Method)
DE3590640T (en:Method)
CH660494B (en:Method)
IN160980B (en:Method)
GR850820B (en:Method)
GR851519B (en:Method)
DE3590659T1 (en:Method)
IN162184B (en:Method)
GR73957B (en:Method)
GR79875B (en:Method)
CH672221GA3 (en:Method)
GR79982B (en:Method)
BG45317A1 (en:Method)
BG45165A1 (en:Method)
IL73623A0 (en:Method)
BG45334A1 (en:Method)
BG45245A1 (en:Method)
BG45182A1 (en:Method)