GEP20022803B - Steroid Sulphatase Inhibitors - Google Patents

Steroid Sulphatase Inhibitors

Info

Publication number
GEP20022803B
GEP20022803B GEAP19925402A GEAP1992005402A GEP20022803B GE P20022803 B GEP20022803 B GE P20022803B GE AP19925402 A GEAP19925402 A GE AP19925402A GE AP1992005402 A GEAP1992005402 A GE AP1992005402A GE P20022803 B GEP20022803 B GE P20022803B
Authority
GE
Georgia
Prior art keywords
oestron
sulfamate
sterol
steroid sulphatase
sulphatase inhibitors
Prior art date
Application number
GEAP19925402A
Other languages
English (en)
Inventor
L Barry V Potter
Michael J Reed
Original Assignee
Sterix Ltd Ge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd Ge filed Critical Sterix Ltd Ge
Publication of GEP20022803B publication Critical patent/GEP20022803B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GEAP19925402A 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors GEP20022803B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
GEP20022803B true GEP20022803B (en) 2002-09-25

Family

ID=10700604

Family Applications (6)

Application Number Title Priority Date Filing Date
GEAP19925402A GEP20022803B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GEAP19922403A GEP20022637B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GEAP19925442A GEP20022766B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GE4958A GEP20063773B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GEAP19925403A GEP20022802B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GEAP19926071A GEP20033094B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors

Family Applications After (5)

Application Number Title Priority Date Filing Date
GEAP19922403A GEP20022637B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GEAP19925442A GEP20022766B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GE4958A GEP20063773B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GEAP19925403A GEP20022802B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors
GEAP19926071A GEP20033094B (en) 1991-08-29 1992-08-28 Steroid Sulphatase Inhibitors

Country Status (25)

Country Link
US (3) US5616574A (forum.php)
EP (6) EP0641355B1 (forum.php)
JP (6) JP3219408B2 (forum.php)
KR (4) KR100258396B1 (forum.php)
AT (5) ATE246706T1 (forum.php)
AU (2) AU689043B2 (forum.php)
BR (1) BR9206434A (forum.php)
CA (4) CA2305758A1 (forum.php)
CY (4) CY2253B1 (forum.php)
CZ (1) CZ295939B6 (forum.php)
DE (5) DE69233020T2 (forum.php)
DK (4) DK0921130T3 (forum.php)
ES (4) ES2193475T3 (forum.php)
FI (5) FI940903A7 (forum.php)
GB (1) GB9118478D0 (forum.php)
GE (6) GEP20022803B (forum.php)
GR (1) GR3034579T3 (forum.php)
HU (1) HUT66097A (forum.php)
LV (1) LV12618B (forum.php)
NO (6) NO307301B1 (forum.php)
RU (4) RU2182152C2 (forum.php)
SG (7) SG88782A1 (forum.php)
SK (4) SK282186B6 (forum.php)
UA (4) UA41875C2 (forum.php)
WO (1) WO1993005064A1 (forum.php)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) 1991-08-28 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6013642A (en) * 1994-04-05 2000-01-11 Foulkes; Roland Use of estrone derivatives as steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
EP0885211B1 (en) * 1996-03-05 2004-12-29 Sterix Limited Compounds with a sulfamate group
US6087347A (en) * 1996-09-12 2000-07-11 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-D-homo-1,3,5(10)-estratriene derivatives
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6288050B1 (en) 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
GB9807779D0 (en) 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
ES2310943T3 (es) 1998-06-10 2009-01-16 Sterix Limited Composicion farmaceutica con factor de necrosis tumoral a y 2-metoxiestrona-3-o-sulfamato para la inhibicion de la estrona sulfatasa.
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
EP1173182A2 (en) * 1999-04-30 2002-01-23 Sterix Limited Use of estrone derivatives as antitumour agents
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
JP4931312B2 (ja) * 1999-12-13 2012-05-16 ステリックス リミテッド ステロイドスルファターゼのインヒビターとしてのハロゲン化スルファメート−、ホスホネート−、チオホスホネート−、スルホネート−、およびスルホンアミド−化合物
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
JPWO2001081364A1 (ja) * 2000-04-24 2004-01-08 協和醗酵工業株式会社 エストラ−１，３，５（１０）−トリエン誘導体
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
EP1406634A1 (en) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
WO2003009815A2 (en) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
ES2258174T3 (es) 2001-10-18 2006-08-16 Sterix Limited Compuestos esteroideos para la inhibicion de la sulfatasa esteroidea.
EP1448592B1 (en) * 2001-10-18 2006-03-08 Sterix Limited Steroidal compounds for inhibiting steroid sulphatase
US20040254241A1 (en) * 2002-08-28 2004-12-16 Yoji Ino Aryl sulfamate derivatives
AU2003272964A1 (en) * 2002-10-09 2004-05-04 Kyowa Hakko Kogyo Co., Ltd. Remedy for hormone-dependent cancer
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
BR0318295A (pt) * 2003-05-16 2006-07-11 Theramex derivados de sulfamato de benzotiofeno utilizados como inibidores da esteróide sulfatase
CN100467449C (zh) * 2003-05-21 2009-03-11 Aska制药株式会社 氨基磺酸环状氨基苯基酯衍生物
TWI331154B (en) * 2003-11-12 2010-10-01 Solvay Pharm Gmbh Novel 17-hydroxysteroid dehydrogenase type i inhibitors
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
AU2006239221C1 (en) 2005-04-28 2012-08-16 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
US20100204146A1 (en) 2007-09-17 2010-08-12 Preglem S.A. Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women
EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN110974840A (zh) * 2019-12-27 2020-04-10 天津市肿瘤医院 一种类固醇硫酸酯酶抑制剂及其药物用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE114806C (forum.php) *
DE1593846A1 (de) * 1967-01-28 1971-02-25 Hoechst Ag Verfahren zur Herstellung von Sulfamidsaeure-arylestern
US3647738A (en) * 1970-11-03 1972-03-07 Union Carbide Corp Alpha-olefin polymer compositions
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DE2418217A1 (de) * 1974-04-13 1975-11-06 Hoechst Ag Sulfamidsaeureester und verfahren zu ihrer herstellung
DD114806A1 (forum.php) * 1974-10-11 1975-08-20
US4340602A (en) * 1978-10-18 1982-07-20 Wayne State University Compositions inhibiting estrogen sulfotransferase activity
US4810700A (en) * 1978-10-18 1989-03-07 Wayne State University Compositions inhibiting estrogen sulfotransferase activity
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
PT94305B (pt) * 1989-06-12 1997-02-28 Robins Co Inc A H Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP0885211B1 (en) * 1996-03-05 2004-12-29 Sterix Limited Compounds with a sulfamate group
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Also Published As

Publication number Publication date
EP0641355B1 (en) 2000-07-19
FI20002260A7 (fi) 2000-10-13
JPH07501515A (ja) 1995-02-16
NO20025725L (no) 1994-04-29
KR100322650B1 (ko) 2002-03-20
DK0921130T3 (da) 2003-07-21
DE69233149T2 (de) 2004-06-24
ATE239753T1 (de) 2003-05-15
SK282189B6 (sk) 2001-12-03
RU2207134C2 (ru) 2003-06-27
FI940903A7 (fi) 1994-04-20
CA2114630C (en) 2003-09-30
CZ295939B6 (cs) 2005-12-14
EP0982032A2 (en) 2000-03-01
DE69231280T2 (de) 2000-11-30
SG88782A1 (en) 2002-05-21
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
JP3219408B2 (ja) 2001-10-15
NO940635L (forum.php) 1994-04-29
RU2182152C2 (ru) 2002-05-10
GB9118478D0 (en) 1991-10-16
DE69233053T2 (de) 2003-11-20
CA2305767A1 (en) 1993-03-18
RU2210574C2 (ru) 2003-08-20
DK0982032T3 (da) 2003-11-03
SK282186B6 (sk) 2001-12-03
DE69233020D1 (de) 2003-05-22
JP2000355598A (ja) 2000-12-26
JP3581820B2 (ja) 2004-10-27
EP1522543A1 (en) 2005-04-13
EP0921130A3 (en) 2001-09-05
UA41875C2 (uk) 2001-10-15
NO307301B1 (no) 2000-03-13
CA2305749A1 (en) 1993-03-18
UA70956C2 (uk) 2004-11-15
FI20002259L (fi) 2000-10-13
NO2595A (no) 1994-04-29
JP3581821B2 (ja) 2004-10-27
JP2000038341A (ja) 2000-02-08
UA70957C2 (uk) 2004-11-15
US5616574A (en) 1997-04-01
GEP20033094B (en) 2003-10-27
FI940903A0 (fi) 1994-02-25
JP2000355542A (ja) 2000-12-26
FI20002259A7 (fi) 2000-10-13
ATE278704T1 (de) 2004-10-15
CY2253B1 (en) 2003-07-04
FI20050991A7 (fi) 2005-10-03
DE69233020T2 (de) 2003-11-06
DK0928609T3 (da) 2003-07-21
ES2193475T3 (es) 2003-11-01
EP0928609A2 (en) 1999-07-14
GEP20022766B (en) 2002-08-26
NO20002595D0 (no) 2000-05-19
KR100321018B1 (ko) 2002-03-20
AU668882B2 (en) 1996-05-23
SG73391A1 (en) 2006-08-30
EP0641355A1 (en) 1995-03-08
CZ44094A3 (en) 1995-01-18
ATE194843T1 (de) 2000-08-15
EP0921130A2 (en) 1999-06-09
KR100321019B1 (ko) 2002-03-20
US6159960A (en) 2000-12-12
ES2196483T3 (es) 2003-12-16
NO995075L (no) 1994-04-29
SG103820A1 (en) 2004-05-26
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
SG115508A1 (en) 2005-10-28
FI20002260L (fi) 2000-10-13
AU1007799A (en) 1999-03-04
ES2204059T3 (es) 2004-04-16
ES2148178T3 (es) 2000-10-16
NO318009B1 (no) 2005-01-17
CA2114630A1 (en) 1993-03-18
FI20002261L (fi) 2000-10-13
BR9206434A (pt) 1994-09-27
AU689043B2 (en) 1998-03-19
DE69233431T2 (de) 2006-02-23
EP0921130B1 (en) 2003-05-07
SG88783A1 (en) 2002-05-21
GR3034579T3 (en) 2001-01-31
ATE246706T1 (de) 2003-08-15
EP0982032A3 (en) 2002-03-20
DE69233053D1 (de) 2003-06-12
LV12618B (en) 2001-07-20
CA2305758A1 (en) 1993-03-18
NO995075D0 (no) 1999-10-18
FI20050991L (fi) 2005-10-03
JP3581802B2 (ja) 2004-10-27
JP2003176297A (ja) 2003-06-24
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
GEP20022802B (en) 2002-09-25
ATE237333T1 (de) 2003-05-15
HK1025051A1 (en) 2000-11-03
EP1099706B1 (en) 2004-10-06
GEP20022637B (en) 2002-02-25
LV12618A (en) 2001-02-20
CY2397B1 (en) 2004-09-10
NO995076D0 (no) 1999-10-18
DE69231280D1 (de) 2000-08-24
NO308903B1 (no) 2000-11-13
GEP20063773B (en) 2006-03-27
RU2001125673A (ru) 2003-06-27
AU5837396A (en) 1996-09-05
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
NO940635D0 (no) 1994-02-24
EP1099706A3 (en) 2002-09-04
SG106116A1 (en) 2004-09-30
KR100258396B1 (ko) 2000-08-01
HK1020672A1 (en) 2000-05-19
CY2398B1 (en) 2004-09-10
SK282187B6 (sk) 2001-12-03
NO20044458L (no) 1994-04-29
NO20025725D0 (no) 2002-11-28
US5830886A (en) 1998-11-03
SG103374A1 (en) 2004-04-29
EP0982032B1 (en) 2003-08-06
EP1099706A2 (en) 2001-05-16
WO1993005064A1 (en) 1993-03-18
SK24694A3 (en) 1994-11-09
SK282188B6 (sk) 2001-12-03
HUT66097A (en) 1994-09-28
HK1019753A1 (en) 2000-02-25
HU9400583D0 (en) 1994-05-30
NO995076L (no) 1994-04-29
JP2002255993A (ja) 2002-09-11
FI20002261A7 (fi) 2000-10-13
NO308774B1 (no) 2000-10-30
NO314287B1 (no) 2003-03-03
EP0928609A3 (en) 2001-11-07
AU717116B2 (en) 2000-03-16

Similar Documents

Publication Publication Date Title
GEP20022803B (en) Steroid Sulphatase Inhibitors
IL87885A (en) Pharmaceutical compositions having antiprogestational and anti-estrogenic activities for the treatment of hormone- dependent tumors
BR9401183A (pt) Composto e formulação farmacêutica
GEP20012530B (en) Neuroactive Steroids of the Androstane and Pregnane Series
MX9702380A (es) Nuevas carboxamidas con actividad antifungica.
ZA905312B (en) Combination therapy for prohylaxsis and/or treatment of benign prostatic hyperplasia
IL97025A0 (en) 17beta-substituted-4-aza-5alpha-androstan-3-one derivatives,their preparation and pharmaceutical compositions containing them
MX9603314A (es) Composiciones que contienen nebivolol micronizado.
MX9702382A (es) Nuevos derivados de pirimidona con actividad antifungica.
IL94819A0 (en) 11beta-aryl-4-estrene derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
MX9207394A (es) Esteroides de 17-espirofuran-3'-ilideno.
NO965444L (no) Triterpen-derivat samt medikamentell sammensetning omfattende dette
MY115016A (en) Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation
ATE208200T1 (de) Transdermales therapeutisches system (tts) zur verabreichung von testosteron
DK382185D0 (da) Umaettede 10-substituerede steroider samt fremgangsmaade til deres fremstilling
MX9203567A (es) Derivado de monocolin, procedimiento para su preparacion y medicamento que contiene este derivado.
DK0719276T3 (da) Ïstradiolestre med stærk oral virkning samt farmaceutiske præparater med indhold deraf
MX9303574A (es) Compuestos heterociclicos que son inhibidores de la enzima aromatasa, proceso para su preparacion ycomposiciones farmaceuticas que los contienen.
DK99987A (da) Oestrogenpraeparater
SG153894G (en) Azelastin embonate, process for its preparation and pharmaceutical compositions containing azelastin embonate as the active ingredient
AR012341A1 (es) Compuesto derivados de estradienos, composicion farmaceutica que los contiene y el uso de los mismos para la fabricacion de medicamentos
ES8206486A1 (es) Procedimiento para la obtencion de esteres de acido n,n-di- metilo-o-(4,6-dihidro-2h-tieno(3,4-c)-pirazol-3-il)-carbami-co, asi como sus 5,oxidos y 5,5-dioxidos de efecto pesticida
ES474052A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridazinas 1-n-sustituidas.
PT986390E (pt) Composicoes farmaceuticas que contem cicloridrato de cinchonina
GR890100519A (en) Diadermic pharmaceutical means containing clycosites