DK382185D0 - Umaettede 10-substituerede steroider samt fremgangsmaade til deres fremstilling - Google Patents

Umaettede 10-substituerede steroider samt fremgangsmaade til deres fremstilling

Info

Publication number
DK382185D0
DK382185D0 DK382185A DK382185A DK382185D0 DK 382185 D0 DK382185 D0 DK 382185D0 DK 382185 A DK382185 A DK 382185A DK 382185 A DK382185 A DK 382185A DK 382185 D0 DK382185 D0 DK 382185D0
Authority
DK
Denmark
Prior art keywords
preparation
unsatured
procedures
substituted steroids
trichloroethoxycarbonylamino
Prior art date
Application number
DK382185A
Other languages
English (en)
Other versions
DK168538B1 (da
DK382185A (da
Inventor
Martine Moguilewsky
Anne-Marie Moura
Lucien Nedelec
Vesperto Torelli
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of DK382185D0 publication Critical patent/DK382185D0/da
Publication of DK382185A publication Critical patent/DK382185A/da
Application granted granted Critical
Publication of DK168538B1 publication Critical patent/DK168538B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0044—Alkenyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DK382185A 1984-08-24 1985-08-23 Steroider, som i 10-stillingen er substitueret med en gruppe indeholdende en dobbelt eller tredobbelt binding, fremgangsmåde til deres fremstilling samt farmaceutiske præparater indeholdende forbindelserne DK168538B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8413189 1984-08-24
FR8413189A FR2569408B1 (fr) 1984-08-24 1984-08-24 Nouveaux steroides substitues en position 10 par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant

Publications (3)

Publication Number Publication Date
DK382185D0 true DK382185D0 (da) 1985-08-23
DK382185A DK382185A (da) 1986-02-25
DK168538B1 DK168538B1 (da) 1994-04-18

Family

ID=9307209

Family Applications (1)

Application Number Title Priority Date Filing Date
DK382185A DK168538B1 (da) 1984-08-24 1985-08-23 Steroider, som i 10-stillingen er substitueret med en gruppe indeholdende en dobbelt eller tredobbelt binding, fremgangsmåde til deres fremstilling samt farmaceutiske præparater indeholdende forbindelserne

Country Status (21)

Country Link
US (1) US4701449A (da)
EP (2) EP0313960B1 (da)
JP (1) JPH0649717B2 (da)
KR (1) KR940008596B1 (da)
CN (1) CN1029683C (da)
AT (2) ATE42561T1 (da)
AU (1) AU580086B2 (da)
CA (1) CA1260459A (da)
DE (2) DE3569739D1 (da)
DK (1) DK168538B1 (da)
ES (1) ES8604988A1 (da)
FI (1) FI82699C (da)
FR (1) FR2569408B1 (da)
GR (1) GR852037B (da)
HU (1) HU194276B (da)
IE (1) IE64675B1 (da)
IL (1) IL76096A (da)
MX (1) MX159930A (da)
PT (1) PT81020B (da)
SU (1) SU1470198A3 (da)
ZA (1) ZA856427B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
FR2594829B1 (fr) * 1986-02-24 1988-06-03 Roussel Uclaf Nouveaux steroides 9 (11) satures substitues en position 10 par un radical comportant une triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
WO1990002781A1 (en) * 1988-09-16 1990-03-22 Lithium Corporation Of America Thermally stable, reactive organometallic compositions containing copper
US5100575A (en) * 1989-09-08 1992-03-31 Fmc Corporation Thermally stable, reactive organometallic compositions containing copper
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
FR2917975B1 (fr) * 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
US20090270356A1 (en) * 2008-04-28 2009-10-29 Ceva Sante Animale Sa Compositions and treatments of heart failure in non-human mammal animals
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
CN103145785B (zh) * 2013-03-19 2016-03-02 浙江仙居仙乐药业有限公司 一种醋酸环丙孕酮脱氢物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3102127A (en) * 1962-06-12 1963-08-27 Syntex Corp 19-methylene-androstane derivatives
US3218316A (en) * 1963-08-26 1965-11-16 Syntex Corp 10beta-ethynyl-19-norandrostane derivatives
US3275622A (en) * 1963-12-18 1966-09-27 Syntex Corp 19-alkylidene-delta4-3, 20-keto pregnanes
FR1519387A (fr) * 1966-04-20 1968-03-29 Hoffmann La Roche Procédé pour la préparation de 19-alcényl-stéroïdes
FR2344286A1 (fr) * 1976-03-16 1977-10-14 Roussel Uclaf Nouveaux derives 17-spirosultines, les g-hydroxy acides correspondants, leur procede de preparation et leur application comme medicament
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
HU179980B (en) * 1979-12-28 1983-01-28 Gyogyszerkutato Intezet Process for preparing substituted steroid-spiro-oxazolidinone derivatives
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids

Also Published As

Publication number Publication date
US4701449A (en) 1987-10-20
ATE42561T1 (de) 1989-05-15
ZA856427B (en) 1986-10-29
ES546372A0 (es) 1986-03-01
EP0176399B1 (fr) 1989-04-26
FI853254L (fi) 1986-02-25
CN1029683C (zh) 1995-09-06
DK168538B1 (da) 1994-04-18
PT81020B (pt) 1987-12-30
EP0313960A1 (fr) 1989-05-03
FR2569408B1 (fr) 1986-10-03
FI853254A0 (fi) 1985-08-23
EP0313960B1 (fr) 1992-07-29
FR2569408A1 (fr) 1986-02-28
AU4662585A (en) 1986-02-27
KR860001824A (ko) 1986-03-22
DE3569739D1 (en) 1989-06-01
FI82699B (fi) 1990-12-31
GR852037B (da) 1985-12-18
JPH0649717B2 (ja) 1994-06-29
CA1260459A (fr) 1989-09-26
DE3586427T2 (de) 1993-01-07
IE64675B1 (en) 1995-08-23
SU1470198A3 (ru) 1989-03-30
ATE78826T1 (de) 1992-08-15
ES8604988A1 (es) 1986-03-01
CN85106995A (zh) 1987-04-01
DK382185A (da) 1986-02-25
MX159930A (es) 1989-10-06
KR940008596B1 (ko) 1994-09-24
JPS6176499A (ja) 1986-04-18
EP0176399A1 (fr) 1986-04-02
IL76096A0 (en) 1985-12-31
FI82699C (fi) 1991-04-10
AU580086B2 (en) 1988-12-22
DE3586427D1 (de) 1992-09-03
IE852075L (en) 1986-02-24
HU194276B (en) 1988-01-28
HUT39461A (en) 1986-09-29
PT81020A (fr) 1985-09-01
IL76096A (en) 1989-09-10

Similar Documents

Publication Publication Date Title
IT7851783A0 (it) Sistema per l'applicazione di rivetti senza testa
MA21682A1 (fr) Procede de preparation d'agents therapeutiques derives de la quainclidine.
DK382185A (da) Umaettede 10-substituerede steroider samt fremgangsmaade til deres fremstilling
FI903153A0 (fi) 11b-aryl-4-estrener, foerfarande foer deras framstaellning samt deras anvaendning som laekemedel.
KR0148213B1 (en) Phenyla lkan(en)oic acid and pharmaceutical composition comprising the same
GR3015963T3 (en) Emulsion of lipid containing a prostaglandin analogue.
FI922806A (fi) Substituerade 4-fenyl-4 -piperidinkarboxamider med baode lokalbedoevande och smaertstillande effekt samt foerfaranden foer deras framstaellning.
DE3068379D1 (en) Indolobenzoxazines, processes for preparing and pharmaceutical compositions containing the same
EP0186023A3 (en) Biliary acid derivatives, process for their preparation and pharmaceutical compositions containing them
BE863359A (fr) Nouvelles glycoproteines isolees d'hafnia, procede de preparation et compositions pharmaceutiques
IL56901A (en) 2-(p hydroxyphenyl)-5(alkenyl or carboxy)dihydrobenzofuran derivatives and pharmaceutical compositions for the treatment of liver disease containing them
NO903338L (no) Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
GR900100332A (en) Process for preparation of phenoxypropanolamines pharmaceutical compositions containing them and their use as antiobesity agents
JPS549294A (en) 7alpha-methoxycephalosporins and process for their preparation
JPS53116344A (en) Preparation of toluanilides
BE882594A (fr) Preparation des derives hydroxyles de l'isopropylamino-pyrimidine
MA19021A1 (fr) Procede de preparation de compositions pharmaceutiques a base d'alpha-12-bis(i methyl ethyl)amino/alpha-phenyl 2-pyridine acetamide ou de l'un de ses sels
HUT60927A (en) Process for producing pharmaceutical composition inhibiting the formation of activated lymphocytes
EP0194164A3 (en) N-carboxyalcoyl-2-oxo-3-diaryl-5,6-triazines useful as therapeutic agents
FR2694007B1 (fr) Nouveau procédé de préparation de composés stéroïdes 20-céto 21 (S) hydroxy et des intermédiaires.
JPS51141893A (en) Process for preparing 9-substituted-2-cycloalkylthioadenines.

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK