GB972962A - A process for the manufacture of benzodiazepine derivatives - Google Patents

A process for the manufacture of benzodiazepine derivatives

Info

Publication number
GB972962A
GB972962A GB42400/60A GB4240060A GB972962A GB 972962 A GB972962 A GB 972962A GB 42400/60 A GB42400/60 A GB 42400/60A GB 4240060 A GB4240060 A GB 4240060A GB 972962 A GB972962 A GB 972962A
Authority
GB
United Kingdom
Prior art keywords
amino
nitro
group
alkyl
halogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB42400/60A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB972962A publication Critical patent/GB972962A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GB42400/60A 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives Expired GB972962A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
GB972962A true GB972962A (en) 1964-10-21

Family

ID=27485190

Family Applications (13)

Application Number Title Priority Date Filing Date
GB42405/60A Expired GB972967A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42403/60A Expired GB972965A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42408/60A Expired GB972968A (en) 1959-12-10 1960-12-09 Benzodiazepine derivatives
GB42402/60A Expired GB972964A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB20071/63A Expired GB972976A (en) 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof
GB42399/60A Expired GB972961A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42401/60A Expired GB972963A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB40979/62A Expired GB972973A (en) 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof
GB40978/62A Expired GB972972A (en) 1959-12-10 1960-12-09 Novel 2-amino-benzophenones and the preparation thereof
GB42404/60A Expired GB972966A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42400/60A Expired GB972962A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB29834/62A Expired GB972970A (en) 1959-12-10 1961-01-11 Novel quinazoline 3-oxides and a process for the manufacture thereof
GB1168/61A Expired GB972969A (en) 1959-12-10 1961-01-11 Benzodiazepine derivatives and a process for the manufacture of same

Family Applications Before (10)

Application Number Title Priority Date Filing Date
GB42405/60A Expired GB972967A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42403/60A Expired GB972965A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42408/60A Expired GB972968A (en) 1959-12-10 1960-12-09 Benzodiazepine derivatives
GB42402/60A Expired GB972964A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB20071/63A Expired GB972976A (en) 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof
GB42399/60A Expired GB972961A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB42401/60A Expired GB972963A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives
GB40979/62A Expired GB972973A (en) 1959-12-10 1960-12-09 Novel trifluoromethyl-benzophenones and the preparation thereof
GB40978/62A Expired GB972972A (en) 1959-12-10 1960-12-09 Novel 2-amino-benzophenones and the preparation thereof
GB42404/60A Expired GB972966A (en) 1959-12-10 1960-12-09 A process for the manufacture of benzodiazepine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB29834/62A Expired GB972970A (en) 1959-12-10 1961-01-11 Novel quinazoline 3-oxides and a process for the manufacture thereof
GB1168/61A Expired GB972969A (en) 1959-12-10 1961-01-11 Benzodiazepine derivatives and a process for the manufacture of same

Country Status (11)

Country Link
BE (4) BE598013A (de)
BR (1) BR6024755D0 (de)
CH (9) CH408045A (de)
CY (1) CY324A (de)
DE (5) DE1288609B (de)
ES (2) ES263124A1 (de)
GB (13) GB972967A (de)
MY (1) MY6500178A (de)
NL (2) NL6412250A (de)
OA (7) OA00816A (de)
SE (2) SE310887B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795231C3 (de) * 1963-05-29 1978-07-13 American Home Products Corp., New York, N.Y. (V.St.A.) Verfahren zur Herstellung von 5-Aryl-1,2-dihydro -3H-1,4-benzodiazepin-2-on-4-oxyden
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA2446696A1 (fr) 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
NZ566263A (en) * 2002-05-24 2009-09-25 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
BE598013A (fr) 1961-06-09
OA00816A (fr) 1967-11-15
GB972970A (en) 1964-10-21
GB972961A (en) 1964-10-21
DE1445073A1 (de) 1968-10-31
GB972967A (en) 1964-10-21
CH408045A (de) 1966-02-28
CY324A (en) 1965-11-03
OA00959A (fr) 1968-03-22
CH414652A (de) 1966-06-15
MY6500178A (en) 1965-12-31
CH414653A (de) 1966-06-15
SE310887B (de) 1969-05-19
ES263124A1 (es) 1961-06-01
NL6412251A (de) 1966-01-25
GB972964A (en) 1964-10-21
GB972963A (en) 1964-10-21
CH396016A (de) 1965-07-31
BE598012A (fr) 1961-06-09
SE318283B (de) 1969-12-08
DE1288610B (de) 1969-02-06
DE1445908A1 (de) 1969-04-17
OA02385A (fr) 1970-05-05
DE1288609B (de) 1969-02-06
OA02384A (fr) 1970-05-05
CH408940A (de) 1966-03-15
OA00958A (fr) 1968-03-22
DE1290143B (de) 1969-03-06
CH418341A (de) 1966-08-15
OA00817A (fr) 1967-11-15
CH418342A (de) 1966-08-15
GB972976A (en) 1964-10-21
GB972965A (en) 1964-10-21
GB972968A (en) 1964-10-21
ES263123A1 (es) 1961-06-01
CH411910A (de) 1966-04-30
GB972972A (en) 1964-10-21
CH408029A (de) 1966-02-28
NL6412250A (de) 1966-01-25
GB972966A (en) 1964-10-21
BR6024755D0 (pt) 1973-05-24
GB972973A (en) 1964-10-21
GB972969A (en) 1964-10-21
BE598008A (fr) 1961-06-09
BE598015A (fr) 1961-06-09
OA00953A (fr) 1968-03-22

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