|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4289872A
(en)
|
1979-04-06 |
1981-09-15 |
Allied Corporation |
Macromolecular highly branched homogeneous compound based on lysine units
|
|
FR2504010B1
(fr)
|
1981-04-15 |
1985-10-25 |
Sanofi Sa |
Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
JPS57206622A
(en)
|
1981-06-10 |
1982-12-18 |
Ajinomoto Co Inc |
Blood substitute
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
DE3218121A1
(de)
|
1982-05-14 |
1983-11-17 |
Leskovar, Peter, Dr.-Ing., 8000 München |
Arzneimittel zur tumorbehandlung
|
|
US4511502A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4512922A
(en)
|
1982-12-22 |
1985-04-23 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511503A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US5089398A
(en)
|
1983-02-22 |
1992-02-18 |
Chiron Corporation |
Enhanced yeast transcription employing hybrid GAPDH promoter region constructs
|
|
CA1341302C
(en)
|
1983-02-22 |
2001-10-09 |
Rae Lyn Burke |
Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein
|
|
US4876197A
(en)
|
1983-02-22 |
1989-10-24 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
US4859600A
(en)
|
1983-04-25 |
1989-08-22 |
Genentech, Inc. |
Recombinant procaryotic cell containing correctly processed human growth hormone
|
|
US4755465A
(en)
|
1983-04-25 |
1988-07-05 |
Genentech, Inc. |
Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
ATE159858T1
(de)
|
1983-09-26 |
1997-11-15 |
Ehrenfeld Udo |
Mittel und erzeugnis für die diagnose und therapie von tumoren sowie zur behandlung von schwächen der zelligen und humoralen immunabwehr
|
|
US4880734A
(en)
|
1984-05-11 |
1989-11-14 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4659839A
(en)
|
1984-10-10 |
1987-04-21 |
Mallinckrodt, Inc. |
Coupling agents for radiolabeled antibody fragments
|
|
US4837148A
(en)
|
1984-10-30 |
1989-06-06 |
Phillips Petroleum Company |
Autonomous replication sequences for yeast strains of the genus pichia
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4680338A
(en)
|
1985-10-17 |
1987-07-14 |
Immunomedics, Inc. |
Bifunctional linker
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
US5186933A
(en)
*
|
1986-12-30 |
1993-02-16 |
Baylor College Of Medicine |
Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system
|
|
EP0349594A4
(en)
|
1987-03-16 |
1990-09-26 |
American Biogenetic Sciences, Inc. |
Recombinant baculovirus occlusion bodies in vaccines and biological insecticides
|
|
CA1304020C
(en)
|
1987-03-23 |
1992-06-23 |
Meher H. Irani |
High level expression in yeast
|
|
US5229490A
(en)
|
1987-05-06 |
1993-07-20 |
The Rockefeller University |
Multiple antigen peptide system
|
|
WO1989001037A1
(en)
|
1987-07-24 |
1989-02-09 |
Cetus Corporation |
Production of ricin toxins in a baculovirus-insect cell expression system
|
|
WO1989001038A1
(en)
|
1987-07-24 |
1989-02-09 |
Cetus Corporation |
PRODUCTION OF BIOLOGICALLY ACTIVE FORMS OF CSF USING A BACULOVIRUS (AcNPV)-INSECT CELL EXPRESSION SYSTEM
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US4929555A
(en)
|
1987-10-19 |
1990-05-29 |
Phillips Petroleum Company |
Pichia transformation
|
|
US4904584A
(en)
|
1987-12-23 |
1990-02-27 |
Genetics Institute, Inc. |
Site-specific homogeneous modification of polypeptides
|
|
CA1340772C
(en)
*
|
1987-12-30 |
1999-09-28 |
Patricia Tekamp-Olson |
Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
|
|
US5674706A
(en)
*
|
1988-05-06 |
1997-10-07 |
Chiron Corporation |
High level expression of proteins in yeast
|
|
CA1324969C
(en)
*
|
1988-05-06 |
1993-12-07 |
Jeffrey R. Shuster |
High level expression of proteins in yeast
|
|
FR2631974B1
(fr)
|
1988-05-31 |
1992-12-11 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede de preparation et son application en tant que vecteur d'expression de genes
|
|
AU4197389A
(en)
|
1988-08-05 |
1990-03-05 |
Mount Sinai School Of Medicine Of The City University Of New York, The |
In vivo infection of live insects with a recombinant baculovirus
|
|
GB8819453D0
(en)
|
1988-08-16 |
1988-09-21 |
Roy P |
Production of bluetongue virus non-structural proteins using baculovirus expression vector
|
|
NZ230425A
(en)
|
1988-09-02 |
1992-07-28 |
Molecular Eng Ass |
Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector
|
|
US6780613B1
(en)
*
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
EP0397834B1
(en)
|
1988-10-28 |
2000-02-02 |
Genentech, Inc. |
Method for identifying active domains and amino acid residues in polypeptides and hormone variants
|
|
WO1990005785A1
(en)
|
1988-11-18 |
1990-05-31 |
The Regents Of The University Of California |
Method for site-specifically incorporating unnatural amino acids into proteins
|
|
WO1990006952A1
(fr)
*
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US4902502A
(en)
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
WO1990010078A1
(en)
|
1989-02-23 |
1990-09-07 |
University Of Ottawa |
Improved baculovirus expression system capable of producing foreign gene proteins at high levels
|
|
WO1990010277A1
(en)
|
1989-02-24 |
1990-09-07 |
Cell Analysis Systems, Inc. |
Method and apparatus for determining a proliferation index of a cell sample
|
|
US5324844A
(en)
*
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
ES2136595T5
(es)
|
1989-04-19 |
2004-04-01 |
Enzon, Inc. |
Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.
|
|
WO1990014428A1
(en)
|
1989-05-17 |
1990-11-29 |
University Of Georgia Research Foundation, Inc. |
Improved baculovirus expression vectors
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5162601A
(en)
|
1989-11-22 |
1992-11-10 |
The Upjohn Company |
Plant potyvirus expression vector with a gene for protease
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
FR2664905B1
(fr)
|
1990-07-18 |
1994-08-12 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede d'obtention, et vecteurs d'expression obtenus a partir dudit baculovirus.
|
|
WO1992001800A1
(en)
*
|
1990-07-20 |
1992-02-06 |
Chiron Corporation |
Method for integrative transformation of yeast using dispersed repetitive elements
|
|
WO1992002628A1
(en)
|
1990-08-02 |
1992-02-20 |
Chiron Corporation |
Expression of human cmv glycoprotein-h using the baculovirus-insect cell expression system
|
|
CA2090969C
(en)
|
1990-09-04 |
2001-08-21 |
Russell Arthur Brierley |
Production of insulin-like growth factor-1 in methylotrophic yeast cells
|
|
EP0513332A4
(en)
*
|
1990-11-14 |
1993-03-17 |
Cargill, Incorporated |
Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
ES2113940T3
(es)
*
|
1990-12-03 |
1998-05-16 |
Genentech Inc |
Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
|
|
US5231178A
(en)
|
1991-01-16 |
1993-07-27 |
The Salk Institute Biotechnology/Industrial Associates, Inc. |
Method for the purification of intact, correctly-folded insulin-like growth factor-1
|
|
WO1992016555A1
(en)
|
1991-03-18 |
1992-10-01 |
Enzon, Inc. |
Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
|
|
AU1651992A
(en)
|
1991-03-19 |
1992-10-21 |
United States of America, as represented by the Secretary, U.S. Department of Commerce, The |
Expression of influenza nucleoprotein antigens in baculovirus
|
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US6126944A
(en)
*
|
1991-04-26 |
2000-10-03 |
The United States Of America As Represented By The Department Of Health And Human Services |
Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
US5290686A
(en)
|
1991-07-31 |
1994-03-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Expression of influenza a M2 protein in baculovirus
|
|
IT1260468B
(it)
|
1992-01-29 |
1996-04-09 |
|
Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
|
|
ATE156158T1
(de)
|
1992-04-14 |
1997-08-15 |
Cornell Res Foundation Inc |
Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung
|
|
US5516657A
(en)
|
1992-05-11 |
1996-05-14 |
Cambridge Biotech Corporation |
Baculovirus vectors for expression of secretory and membrane-bound proteins
|
|
ZA933926B
(en)
|
1992-06-17 |
1994-01-03 |
Amgen Inc |
Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
|
|
WO1994004193A1
(en)
|
1992-08-21 |
1994-03-03 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
WO1994015625A1
(en)
|
1993-01-15 |
1994-07-21 |
Enzon, Inc. |
Factor viii - polymeric conjugates
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
US5532142A
(en)
|
1993-02-12 |
1996-07-02 |
Board Of Regents, The University Of Texas System |
Method of isolation and purification of fusion polypeptides
|
|
IL104734A0
(en)
|
1993-02-15 |
1993-06-10 |
Univ Bar Ilan |
Bioactive conjugates of cellulose with amino compounds
|
|
WO1994028024A1
(en)
|
1993-06-01 |
1994-12-08 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
WO1995000162A1
(en)
|
1993-06-21 |
1995-01-05 |
Enzon, Inc. |
Site specific synthesis of conjugated peptides
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5762939A
(en)
*
|
1993-09-13 |
1998-06-09 |
Mg-Pmc, Llc |
Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5491076A
(en)
*
|
1993-11-01 |
1996-02-13 |
The Texas A&M University System |
Expression of foreign genes using a replicating polyprotein producing virus vector
|
|
US5605792A
(en)
*
|
1993-11-04 |
1997-02-25 |
The Ohio State University Research Foundation |
Infectious bursal disease virus VP2 fusion protein expressed by baculovirus, use as diagnostic
|
|
DE69430251T2
(de)
|
1993-11-10 |
2002-11-07 |
Enzon, Inc. |
Verbesserte interferon-polymerkonjugate
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US5446090A
(en)
*
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
FR2715664B1
(fr)
|
1994-01-31 |
1996-04-12 |
Proteine Performance Sa |
Baculovirus recombinant et son utilisation pour la production d'anticorps monoclonaux.
|
|
JP3090586B2
(ja)
*
|
1994-03-15 |
2000-09-25 |
片倉工業株式会社 |
システインプロテアーゼ遺伝子欠損バキュロウイルスおよびその製造法並びにこれを利用する有用タンパク質の製造法
|
|
US5473034A
(en)
|
1994-03-18 |
1995-12-05 |
Hyogo Prefectural Government |
Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
|
|
US5629384A
(en)
*
|
1994-05-17 |
1997-05-13 |
Consiglio Nazionale Delle Ricerche |
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
|
|
WO1995033490A1
(en)
|
1994-06-02 |
1995-12-14 |
Enzon, Inc. |
Method of solubilizing substantially water insoluble materials
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US6403375B1
(en)
|
1994-08-24 |
2002-06-11 |
Boyce Thompson Institute For Plant Research, Inc. |
Establishment of Trichoplusia ni cell lines in serum-free medium for recombinant protein and baculovirus production
|
|
US5650234A
(en)
|
1994-09-09 |
1997-07-22 |
Surface Engineering Technologies, Division Of Innerdyne, Inc. |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
|
|
US5871986A
(en)
*
|
1994-09-23 |
1999-02-16 |
The General Hospital Corporation |
Use of a baculovirus to express and exogenous gene in a mammalian cell
|
|
US5824784A
(en)
*
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
EP0788375A2
(en)
|
1994-11-09 |
1997-08-13 |
Robin Ewart Offord |
Functionalized polymers for site-specific attachment
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
AU720337B2
(en)
|
1995-02-17 |
2000-05-25 |
Stichting Dienst Landbouwkundig Onderzoek |
Production of biologically active recombinant bovine follicle stimulating hormone (REC bFSH) in the baculovirus expression system
|
|
FR2732035B1
(fr)
|
1995-03-23 |
1997-05-30 |
Agronomique Inst Nat Rech |
Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede
|
|
NZ308772A
(en)
*
|
1995-05-17 |
1999-04-29 |
Du Pont |
Recombinant baculovirus insecticides
|
|
AU5893696A
(en)
|
1995-06-07 |
1996-12-30 |
Novo Nordisk A/S |
Modification of polypeptides
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US5861279A
(en)
*
|
1996-01-17 |
1999-01-19 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
|
|
AU1690697A
(en)
|
1996-01-17 |
1997-08-11 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin antagonists
|
|
US5747639A
(en)
|
1996-03-06 |
1998-05-05 |
Amgen Boulder Inc. |
Use of hydrophobic interaction chromatography to purify polyethylene glycols
|
|
IL128229A0
(en)
|
1996-08-02 |
1999-11-30 |
Ortho Mcneil Pharm Inc |
Polypeptides having a single covalently bound n-terminal water-soluble polymer
|
|
US5980948A
(en)
*
|
1996-08-16 |
1999-11-09 |
Osteotech, Inc. |
Polyetherester copolymers as drug delivery matrices
|
|
US6214966B1
(en)
*
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
WO1998026080A1
(en)
*
|
1996-12-13 |
1998-06-18 |
Chiron Corporation |
Method for expression of heterologous proteins in yeast
|
|
JP2001508783A
(ja)
|
1997-01-29 |
2001-07-03 |
ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー |
Ｐｅｇ化法
|
|
GB9703406D0
(en)
*
|
1997-02-19 |
1997-04-09 |
Chiron Spa |
Expression of heterologous proteins
|
|
AU7266698A
(en)
|
1997-04-30 |
1998-11-24 |
Enzon, Inc. |
Polyalkylene oxide-modified single chain polypeptides
|
|
US5990237A
(en)
*
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
US5965393A
(en)
*
|
1997-07-01 |
1999-10-12 |
National Institute Of Immunology |
Method for enhancing foreign gene expression in baculovirus expression vector system
|
|
CN1269805A
(zh)
|
1997-07-14 |
2000-10-11 |
博尔德生物技术公司 |
生长激素和相关蛋白的衍生物
|
|
GB9715660D0
(en)
|
1997-07-25 |
1997-10-01 |
Zeneca Ltd |
Proteins
|
|
EP1003889A1
(en)
|
1997-08-05 |
2000-05-31 |
Chiron Corporation |
NOVEL $i(PICHIA PASTORIS) GENE SEQUENCES AND METHODS FOR THEIR USE
|
|
DE19735593C2
(de)
|
1997-08-15 |
1999-08-26 |
Hepavec Ag Fuer Gentherapie |
Hüllprotein-modifizierter Baculovirus-Vektor für die Gentherapie
|
|
US6090584A
(en)
|
1997-08-21 |
2000-07-18 |
University Technologies International Inc. |
Baculovirus artificial chromosomes and methods of use
|
|
US5989868A
(en)
*
|
1997-09-12 |
1999-11-23 |
The Board Of Regents Of The University Of Oklahoma |
Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
|
|
EP1538206B1
(en)
*
|
1997-09-16 |
2010-03-24 |
Centocor, Inc. |
Method for the complete chemical synthesis and assembly of genes and genomes
|
|
JP2001517686A
(ja)
*
|
1997-09-26 |
2001-10-09 |
ユーエイビー リサーチ ファンデーション |
抗原性を減弱させた血球および、その利用法
|
|
US6201072B1
(en)
*
|
1997-10-03 |
2001-03-13 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
US6004573A
(en)
|
1997-10-03 |
1999-12-21 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
DE19748489A1
(de)
*
|
1997-11-03 |
1999-05-06 |
Roche Diagnostics Gmbh |
Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
|
|
US6448369B1
(en)
*
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
EP0924298A1
(en)
|
1997-12-18 |
1999-06-23 |
Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) |
Protein expression in baculovirus vector expression systems
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
JP2002505110A
(ja)
*
|
1998-03-04 |
2002-02-19 |
オニックス ファーマシューティカルズ，インコーポレイティド |
遺伝物質の高生産性発現のためのバキュロウイルス発現系及び方法
|
|
DE69921102T2
(de)
*
|
1998-03-05 |
2006-02-02 |
Chiron Corp., Emeryville |
Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen
|
|
US6362254B2
(en)
*
|
1998-03-12 |
2002-03-26 |
Shearwater Corporation |
Poly(ethylene glycol) derivatives with proximal reactive groups
|
|
KR100264953B1
(ko)
|
1998-04-03 |
2001-03-02 |
박현우 |
재조합 베큘로바이러스, 이의 제조방법 및 이를 포함하는 미생물 살충제
|
|
US6451986B1
(en)
|
1998-06-22 |
2002-09-17 |
Immunex Corporation |
Site specific protein modification
|
|
US6168932B1
(en)
*
|
1998-07-13 |
2001-01-02 |
Parker Hughes Institute |
Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system
|
|
US6245528B1
(en)
*
|
1998-07-28 |
2001-06-12 |
Academia Sinica |
Latent baculovirus expression system
|
|
US6368825B1
(en)
*
|
1998-08-10 |
2002-04-09 |
Academia Sinica |
Baculovirus containing minimal CMV promoter
|
|
HK1043801A1
(zh)
|
1998-08-28 |
2002-09-27 |
格莱风科学公司 |
精确长度的聚酰胺链、其制备方法和其与蛋白质的缀合物
|
|
US6214499B1
(en)
*
|
1998-09-11 |
2001-04-10 |
Eastman Kodak Company |
Liquid crystalline filter dyes for imaging elements
|
|
WO2000020032A1
(en)
|
1998-10-06 |
2000-04-13 |
Trustees Of Dartmouth College |
RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
|
|
US6420339B1
(en)
*
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
ATE365210T1
(de)
|
1998-10-30 |
2007-07-15 |
Novozymes As |
Glykosylierte proteine mit reduzierter allergenität
|
|
US6451346B1
(en)
*
|
1998-12-23 |
2002-09-17 |
Amgen Inc |
Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
|
|
US6281211B1
(en)
*
|
1999-02-04 |
2001-08-28 |
Euro-Celtique S.A. |
Substituted semicarbazides and the use thereof
|
|
US6342216B1
(en)
|
1999-03-17 |
2002-01-29 |
The Board Of Regents, The University Of Texas System |
Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
|
|
JP4707237B2
(ja)
|
1999-03-17 |
2011-06-22 |
ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ |
外因性アミノ酸および新規ａｔｐ再生システムを用いたインビトロ高分子生合成の方法
|
|
US6994986B2
(en)
*
|
1999-03-17 |
2006-02-07 |
The Board Of Trustees Of The Leland Stanford University |
In vitro synthesis of polypeptides by optimizing amino acid metabolism
|
|
US6337191B1
(en)
*
|
1999-03-22 |
2002-01-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Vitro protein synthesis using glycolytic intermediates as an energy source
|
|
JP2002542349A
(ja)
*
|
1999-04-16 |
2002-12-10 |
ダブリューエム・マーシュ・ライス・ユニバーシティー |
ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク
|
|
US6261805B1
(en)
|
1999-07-15 |
2001-07-17 |
Boyce Thompson Institute For Plant Research, Inc. |
Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
|
|
WO2001027301A2
(en)
|
1999-10-15 |
2001-04-19 |
The Rockefeller University |
System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae
|
|
CN1298000A
(zh)
*
|
1999-11-30 |
2001-06-06 |
上海博容基因开发有限公司 |
一种新的多肽——人Ⅱ类氨酰基－tRN A合成酶9和编码这种多肽的多核苷酸
|
|
US6348558B1
(en)
*
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
PT1259563E
(pt)
*
|
1999-12-22 |
2009-04-14 |
Nektar Therapeutics Al Corp |
Processo para a preparação de ésteres de 1-benzotriazolil- -carbonato de polímeros solúveis em água
|
|
DE60026073T2
(de)
|
1999-12-22 |
2006-09-28 |
Nektar Therapeutics Al, Corp., Huntsville |
Sterisch gehinderte derivate von wasserlöslichen polymeren
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
US6646110B2
(en)
*
|
2000-01-10 |
2003-11-11 |
Maxygen Holdings Ltd. |
G-CSF polypeptides and conjugates
|
|
US6602498B2
(en)
*
|
2000-02-22 |
2003-08-05 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
|
AU2001257577A1
(en)
*
|
2000-02-28 |
2001-09-03 |
Shearwater Corporation |
Water-soluble polymer conjugates of artelinic acid
|
|
GB0012997D0
(en)
|
2000-05-26 |
2000-07-19 |
Eurogene Limited |
Gene delivery
|
|
US6586207B2
(en)
*
|
2000-05-26 |
2003-07-01 |
California Institute Of Technology |
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
|
|
JP2002030098A
(ja)
|
2000-07-17 |
2002-01-29 |
Institute Of Immunology Co Ltd |
バキュロウィルスの発芽ウイルスからウイルスエンベロープを回収する方法
|
|
US6436386B1
(en)
*
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
TW593427B
(en)
*
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
TWI246524B
(en)
*
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
|
US6908963B2
(en)
*
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
MXPA04004336A
(es)
*
|
2001-11-07 |
2005-05-16 |
Nektar Therapeutics Al Corp |
Polimeros ramificados y sus conjugados.
|
|
US6716821B2
(en)
*
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
WO2003101972A1
(en)
|
2002-05-30 |
2003-12-11 |
The Scripps Research Institute |
Copper-catalysed ligation of azides and acetylenes
|
|
MXPA05003978A
(es)
*
|
2002-10-16 |
2005-06-22 |
Scripps Research Inst |
Sintesis de glicoproteinas.
|
|
WO2004035743A2
(en)
|
2002-10-16 |
2004-04-29 |
The Scripps Research Institute |
Site specific incorporation of keto amino acids into proteins
|
|
MXPA05006836A
(es)
|
2002-12-22 |
2005-08-16 |
Scripps Research Inst |
Colecciones ordenadas de proteinas.
|
|
CN103289960B
(zh)
|
2003-04-17 |
2017-04-26 |
斯克利普斯研究院 |
扩展真核生物遗传密码
|
|
WO2005007624A2
(en)
|
2003-07-07 |
2005-01-27 |
The Scripps Research Institute |
Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
|
|
EP1666604B1
(en)
|
2003-07-07 |
2008-02-13 |
The Scripps Research Institute |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
|
US20060160175A1
(en)
|
2003-07-07 |
2006-07-20 |
The Scripps Research Institute |
Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
|
SG176455A1
(en)
*
|
2003-10-09 |
2011-12-29 |
Ambrx Inc |
Polymer derivatives
|
|
CN103755800B
(zh)
|
2004-02-02 |
2016-02-24 |
Ambrx公司 |
经修饰的人类生长激素多肽与其用途
|