GB2104522B - Tetrazine derivatives - Google Patents

Tetrazine derivatives

Info

Publication number
GB2104522B
GB2104522B GB08224155A GB8224155A GB2104522B GB 2104522 B GB2104522 B GB 2104522B GB 08224155 A GB08224155 A GB 08224155A GB 8224155 A GB8224155 A GB 8224155A GB 2104522 B GB2104522 B GB 2104522B
Authority
GB
United Kingdom
Prior art keywords
tetrazine derivatives
tetrazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08224155A
Other languages
English (en)
Other versions
GB2104522A (en
Inventor
Edward Lunt
Malcolm Francis Graham Stevens
Robert Stone
Kenneth Robert Harr Wooldridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Priority to GB08224155A priority Critical patent/GB2104522B/en
Publication of GB2104522A publication Critical patent/GB2104522A/en
Application granted granted Critical
Publication of GB2104522B publication Critical patent/GB2104522B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GB08224155A 1981-08-24 1982-08-23 Tetrazine derivatives Expired GB2104522B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB08224155A GB2104522B (en) 1981-08-24 1982-08-23 Tetrazine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24
GB08224155A GB2104522B (en) 1981-08-24 1982-08-23 Tetrazine derivatives

Publications (2)

Publication Number Publication Date
GB2104522A GB2104522A (en) 1983-03-09
GB2104522B true GB2104522B (en) 1985-06-12

Family

ID=10524141

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08224155A Expired GB2104522B (en) 1981-08-24 1982-08-23 Tetrazine derivatives

Country Status (29)

Country Link
JP (1) JPS5843975A (nl)
KR (1) KR890000094B1 (nl)
AT (1) AT380256B (nl)
AU (1) AU571430B2 (nl)
BE (1) BE894175A (nl)
CA (1) CA1197247A (nl)
CH (1) CH655114A5 (nl)
DE (2) DE3231255A1 (nl)
DK (1) DK161147C (nl)
ES (1) ES8400438A1 (nl)
FI (1) FI73434C (nl)
FR (1) FR2511679A1 (nl)
GB (1) GB2104522B (nl)
GE (1) GEP19960641B (nl)
GR (1) GR76863B (nl)
HU (1) HU186107B (nl)
IE (1) IE53408B1 (nl)
IL (1) IL66606A (nl)
IT (1) IT1152505B (nl)
LT (1) LT2436B (nl)
LU (1) LU84347A1 (nl)
LV (2) LV5511A3 (nl)
NL (2) NL192739C (nl)
NZ (1) NZ201668A (nl)
OA (1) OA07174A (nl)
SE (1) SE448543B (nl)
SU (1) SU1447284A3 (nl)
UA (1) UA5971A1 (nl)
ZA (1) ZA826120B (nl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
FR2531958B1 (fr) * 1982-08-17 1986-10-31 May & Baker Ltd Nouveaux derive
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
CA2552095A1 (en) * 2003-12-30 2005-07-14 Chemagis Ltd. Novel crystalline forms of temozolomide
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
AR060635A1 (es) 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2213673B1 (en) 2007-10-23 2013-06-05 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
PE20091101A1 (es) * 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
CA2744560A1 (en) * 2008-11-24 2010-05-27 Reliance Life Sciences Pvt. Ltd. Process for the preparation of tetrazine derivatives
US8481503B2 (en) 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
ES2583006T3 (es) 2009-06-23 2016-09-16 Pharminox Limited Compuestos de 3-sustituido-8-sustituido-3H-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona y su uso
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ
EP2766041B1 (en) 2011-10-12 2018-12-05 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
EP3429571A1 (en) 2016-03-15 2019-01-23 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors for use in the treatment of solid tumors
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Also Published As

Publication number Publication date
NZ201668A (en) 1985-08-16
LU84347A1 (fr) 1983-06-07
NL192739C (nl) 1998-01-06
DE3231255A1 (de) 1983-03-03
IL66606A (en) 1987-07-31
GEP19960641B (en) 1996-11-15
SE448543B (sv) 1987-03-02
LV5621A3 (lv) 1994-05-10
DK377882A (da) 1983-02-25
GB2104522A (en) 1983-03-09
AU8749382A (en) 1983-03-03
FR2511679A1 (fr) 1983-02-25
AU571430B2 (en) 1988-04-21
NL990010I1 (nl) 1999-07-01
ZA826120B (en) 1983-07-27
OA07174A (fr) 1984-04-30
IE822026L (en) 1983-02-24
NL192739B (nl) 1997-09-01
CA1197247A (fr) 1985-11-26
FI822921L (fi) 1983-02-25
FI73434B (fi) 1987-06-30
AT380256B (de) 1986-05-12
FI73434C (fi) 1987-10-09
BE894175A (fr) 1983-02-23
KR890000094B1 (ko) 1989-03-07
FR2511679B1 (nl) 1985-02-01
ATA319182A (de) 1985-09-15
LT2436B (lt) 1994-02-15
IL66606A0 (en) 1982-12-31
DE3231255C2 (nl) 1992-02-27
DE19975037I2 (de) 2001-06-13
GR76863B (nl) 1984-09-04
JPH045029B2 (nl) 1992-01-30
ES515176A0 (es) 1983-11-01
JPS5843975A (ja) 1983-03-14
HU186107B (en) 1985-06-28
NL8203286A (nl) 1983-03-16
SE8204817D0 (sv) 1982-08-23
LV5511A3 (lv) 1994-03-10
DK161147B (da) 1991-06-03
KR840001175A (ko) 1984-03-28
ES8400438A1 (es) 1983-11-01
SE8204817L (sv) 1983-02-25
UA5971A1 (uk) 1994-12-29
SU1447284A3 (ru) 1988-12-23
DK161147C (da) 1991-11-18
CH655114A5 (fr) 1986-03-27
IE53408B1 (en) 1988-11-09
IT1152505B (it) 1987-01-07
IT8222938A0 (it) 1982-08-23
NL990010I2 (nl) 1999-09-01
FI822921A0 (fi) 1982-08-23

Similar Documents

Publication Publication Date Title
ZA821308B (en) N-naphthoylglycine derivatives
GB8417905D0 (en) Hydroxymethyl-5 oxazolidinic derivatives
GB2104522B (en) Tetrazine derivatives
IL65799A0 (en) 2-amino-1-alkanol derivatives
GB2111483B (en) 3-acylamino-4-hydroxy-phenethylamine derivatives
GB2101986B (en) Thiazolinoazetidinone derivatives
IL64774A0 (en) Hexahydro-trans-and tetrahydropyridoindole derivatives
GB2099424B (en) Isoprenylamine derivatives
GB8321942D0 (en) Tetrazine derivatives
GB2155932B (en) Phenylhydrazinomethylenemalononitrile derivatives
GB2099419B (en) Imidazothizole derivatives
GB2098613B (en) Polyisoprenylamine derivatives
GB2094297B (en) Apovincaminol derivatives
GB2099423B (en) Isopyrenylamine derivatives
GB2103602B (en) Pthalide derivative
IL66123A0 (en) Benzoyl-phenyl-piperidine derivatives
GB2112781B (en) Aminopropylaminobleomycin derivatives
ZA825824B (en) Furano-chromone derivatives
EP0066144A3 (en) Benzylazole derivatives
GB2100728B (en) 3-substituted -2- cyclopentenone derivatives
GB2106908B (en) Alkoxyvincamone derivatives
GB2108105B (en) Isoprenylamine derivatives
ZA818413B (en) Indoloquinolizine derivatives
GB2096609B (en) Thiazolotriazine derivatives
GB2098202B (en) Tetrachloropentene derivatives

Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
CTFF Supplementary protection certificate filed

Free format text: SPC/GB99/025, 19990616

CTFG Supplementary protection certificate granted

Free format text: SPC/GB99/025, 20000207, EXPIRES: 20070822

PE20 Patent expired after termination of 20 years

Effective date: 20020822

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB99/025: 20020823, EXPIRES: 20070822

SPCE Supplementary protection certificate expired

Free format text: SPC/GB99/025:, EXPIRES: 20070822

Spc suppl protection certif: SPC/GB99/025

Expiry date: 20070822