GB201709471D0 - Diastereoselective synthesis of hosphate derivatives - Google Patents

Diastereoselective synthesis of hosphate derivatives

Info

Publication number
GB201709471D0
GB201709471D0 GBGB1709471.5A GB201709471A GB201709471D0 GB 201709471 D0 GB201709471 D0 GB 201709471D0 GB 201709471 A GB201709471 A GB 201709471A GB 201709471 D0 GB201709471 D0 GB 201709471D0
Authority
GB
United Kingdom
Prior art keywords
hosphate
derivatives
diastereoselective synthesis
diastereoselective
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1709471.5A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nucana PLC
Original Assignee
Nucana Biomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nucana Biomed Ltd filed Critical Nucana Biomed Ltd
Priority to GBGB1709471.5A priority Critical patent/GB201709471D0/en
Publication of GB201709471D0 publication Critical patent/GB201709471D0/en
Priority to CA3064177A priority patent/CA3064177A1/en
Priority to NZ759692A priority patent/NZ759692A/en
Priority to SG11201911543UA priority patent/SG11201911543UA/en
Priority to IL302559A priority patent/IL302559B2/en
Priority to NZ800534A priority patent/NZ800534A/en
Priority to AU2018284131A priority patent/AU2018284131B2/en
Priority to PCT/GB2018/051641 priority patent/WO2018229495A1/en
Priority to KR1020247026745A priority patent/KR102920287B1/ko
Priority to US16/623,263 priority patent/US11414452B2/en
Priority to MA049379A priority patent/MA49379A/fr
Priority to MX2019014907A priority patent/MX391332B/es
Priority to IL312228A priority patent/IL312228B2/en
Priority to CN202311430904.3A priority patent/CN117486959A/zh
Priority to CN201880039189.1A priority patent/CN110785425B/zh
Priority to BR112019026747-6A priority patent/BR112019026747A2/pt
Priority to EP18735380.0A priority patent/EP3638684A2/en
Priority to CN201880039747.4A priority patent/CN110753697B/zh
Priority to IL271159A priority patent/IL271159B2/en
Priority to EP18735381.8A priority patent/EP3638685A1/en
Priority to MX2019014914A priority patent/MX390901B/es
Priority to EA201992873A priority patent/EA201992873A1/ru
Priority to JP2019569286A priority patent/JP7279991B2/ja
Priority to KR1020197036989A priority patent/KR102695300B1/ko
Priority to JP2019569336A priority patent/JP7248209B2/ja
Priority to PH1/2019/502825A priority patent/PH12019502825A1/en
Priority to US16/623,272 priority patent/US11897913B2/en
Priority to PCT/GB2018/051638 priority patent/WO2018229493A2/en
Priority to CA3065682A priority patent/CA3065682A1/en
Priority to MX2022003822A priority patent/MX2022003822A/es
Priority to CL2019003632A priority patent/CL2019003632A1/es
Priority to SA519410795A priority patent/SA519410795B1/ar
Priority to AU2022204691A priority patent/AU2022204691B2/en
Priority to US17/888,312 priority patent/US12054511B2/en
Priority to JP2023076006A priority patent/JP7525687B2/ja
Priority to AU2024200428A priority patent/AU2024200428C1/en
Priority to US18/749,420 priority patent/US20250171487A1/en
Priority to JP2024114519A priority patent/JP2024138523A/ja
Priority to JP2025266864A priority patent/JP2026034703A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GBGB1709471.5A 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives Ceased GB201709471D0 (en)

Priority Applications (39)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives
CA3065682A CA3065682A1 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides
IL271159A IL271159B2 (en) 2017-06-14 2018-06-14 Synthesis of diastereomerically pure proteid phosphates
EP18735381.8A EP3638685A1 (en) 2017-06-14 2018-06-14 Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738)
SG11201911543UA SG11201911543UA (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides
IL302559A IL302559B2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives
NZ800534A NZ800534A (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives
AU2018284131A AU2018284131B2 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides
PCT/GB2018/051641 WO2018229495A1 (en) 2017-06-14 2018-06-14 Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738)
KR1020247026745A KR102920287B1 (ko) 2017-06-14 2018-06-14 인산염 유도체의 합성
US16/623,263 US11414452B2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives
MA049379A MA49379A (fr) 2017-06-14 2018-06-14 Synthèse de phosphate protides diastéréoisomériquement substantiellement purs
MX2019014907A MX391332B (es) 2017-06-14 2018-06-14 Sintesis de derivados de fosfato
IL312228A IL312228B2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives
CN202311430904.3A CN117486959A (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
CN201880039189.1A CN110785425B (zh) 2017-06-14 2018-06-14 3′-脱氧腺苷-5′-o-[苯基(苄氧基-l-丙氨酰基)]磷酸酯(nuc-7738)的合成
BR112019026747-6A BR112019026747A2 (pt) 2017-06-14 2018-06-14 síntese de derivados de fosfato
EP18735380.0A EP3638684A2 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides
NZ759692A NZ759692A (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives
CA3064177A CA3064177A1 (en) 2017-06-14 2018-06-14 Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738)
MX2019014914A MX390901B (es) 2017-06-14 2018-06-14 Síntesis de 3'-desoxiadenosina-5'-0-[fenil(benciloxi-l-alaninil)]fosfato (nuc-7738).
CN201880039747.4A CN110753697B (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
JP2019569336A JP7248209B2 (ja) 2017-06-14 2018-06-14 ３’－デオキシアデノシン－５’－ｏ－［フェニル（ベンジルオシキ－ｌ－アラニニル）］ホスフェート（ｎｕｃ－７７３８）の合成
JP2019569286A JP7279991B2 (ja) 2017-06-14 2018-06-14 ホスフェート誘導体の合成
KR1020197036989A KR102695300B1 (ko) 2017-06-14 2018-06-14 인산염 유도체의 합성
EA201992873A EA201992873A1 (ru) 2017-06-14 2018-06-14 Получение фосфатных производных
PH1/2019/502825A PH12019502825A1 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides
US16/623,272 US11897913B2 (en) 2017-06-14 2018-06-14 Synthesis of 3′-deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)]phosphate (NUC-738)
PCT/GB2018/051638 WO2018229493A2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives
MX2022003822A MX2022003822A (es) 2017-06-14 2019-12-10 Sintesis de derivados de fosfato.
CL2019003632A CL2019003632A1 (es) 2017-06-14 2019-12-11 Síntesis de derivados fosfatos.
SA519410795A SA519410795B1 (ar) 2017-06-14 2019-12-12 تخليق مشتقات فوسفات
AU2022204691A AU2022204691B2 (en) 2017-06-14 2022-06-30 Synthesis of substantially diastereomerically pure phosphate protides
US17/888,312 US12054511B2 (en) 2017-06-14 2022-08-15 Synthesis of phosphate derivatives
JP2023076006A JP7525687B2 (ja) 2017-06-14 2023-05-02 ホスフェート誘導体の合成
AU2024200428A AU2024200428C1 (en) 2017-06-14 2024-01-24 Synthesis of substantially diastereomerically pure phosphate protides
US18/749,420 US20250171487A1 (en) 2017-06-14 2024-06-20 Synthesis of phosphate derivatives
JP2024114519A JP2024138523A (ja) 2017-06-14 2024-07-18 ホスフェート誘導体の合成
JP2025266864A JP2026034703A (ja) 2017-06-14 2025-12-19 ホスフェート誘導体の合成

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives

Publications (1)

Publication Number Publication Date
GB201709471D0 true GB201709471D0 (en) 2017-07-26

Family

ID=59358400

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1709471.5A Ceased GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives

Country Status (19)

Country Link
US (4) US11897913B2 (https=)
EP (2) EP3638685A1 (https=)
JP (5) JP7248209B2 (https=)
KR (2) KR102920287B1 (https=)
CN (3) CN110785425B (https=)
AU (2) AU2018284131B2 (https=)
BR (1) BR112019026747A2 (https=)
CA (2) CA3065682A1 (https=)
CL (1) CL2019003632A1 (https=)
EA (1) EA201992873A1 (https=)
GB (1) GB201709471D0 (https=)
IL (3) IL271159B2 (https=)
MA (1) MA49379A (https=)
MX (3) MX390901B (https=)
NZ (2) NZ759692A (https=)
PH (1) PH12019502825A1 (https=)
SA (1) SA519410795B1 (https=)
SG (1) SG11201911543UA (https=)
WO (2) WO2018229493A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029022T2 (en) 2011-03-01 2017-02-28 Nucana Biomed Ltd Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer
JP6855248B2 (ja) 2014-06-25 2021-04-07 ヌカナ ピーエルシー ゲムシタビン−プロドラッグを含む製剤
IL291927A (en) 2014-11-28 2022-06-01 NuCana plc Oligonucleotides containing modified nucleosides
HRP20211812T1 (hr) 2015-12-11 2022-03-04 NuCana plc Dijastereoselektivna sinteza derivata fosfata i prolijeka gemcitabina nuc-1031
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN112409421A (zh) * 2020-12-01 2021-02-26 上海兆维科技发展有限公司 一种3’-磷酸酯核苷的制备方法
AU2023268725A1 (en) 2022-05-12 2024-12-12 NuCana plc Cancer treatment with nuc-7738
JP2025539267A (ja) 2022-12-07 2025-12-04 ニューカナ パブリック リミテッド カンパニー ヌクレオシド誘導体ｎｕｃ－３３７３の合成

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE279248C (https=)
US3792039A (en) 1971-12-27 1974-02-12 Miles Lab Poly 2'-fluoro-2'-deoxyuridylic acid
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4357324A (en) 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
CA2317505C (en) 1998-01-23 2011-01-04 Newbiotics, Inc. Enzyme catalyzed therapeutic agents
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
CA2589935A1 (en) 2004-12-09 2006-06-15 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
GB0505781D0 (en) * 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
WO2007020193A2 (en) 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Antiviral phosphoramidates of 4 ' -substituted pronucleotides
GB0623493D0 (en) 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
US20080261913A1 (en) * 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20090206007A1 (en) 2008-02-20 2009-08-20 Air Products And Chemicals, Inc. Process and apparatus for upgrading coal using supercritical water
SG172921A1 (en) 2009-01-09 2011-08-29 Univ Cardiff Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
AU2010226466A1 (en) 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
PT2609923T (pt) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
UY33312A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidato de nucleosido de purina
KR101995598B1 (ko) 2010-07-19 2019-07-02 길리애드 사이언시즈, 인코포레이티드 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법
US20120070411A1 (en) 2010-09-22 2012-03-22 Alios Biopharma, Inc. Substituted nucleotide analogs
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
AU2011349278C1 (en) 2010-12-22 2017-01-19 Alios Biopharma, Inc. Cyclic nucleotide analogs
HUE029022T2 (en) 2011-03-01 2017-02-28 Nucana Biomed Ltd Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer
EP2890704B1 (en) 2012-08-31 2018-02-28 Novartis AG 2'-ethynyl nucleoside derivatives for treatment of viral infections
SG11201503750YA (en) 2012-11-16 2015-06-29 Univ Cardiff Process for preparing nucleoside prodrugs
HK1224229A1 (zh) 2013-06-26 2017-08-18 Alios Biopharma, Inc. 取代的核苷，核苷酸及其类似物
SI3043803T1 (sl) 2013-09-11 2022-09-30 Emory University Nukleotidne in nukleozidne sestave in njihova uporaba
EP3055319A4 (en) 2013-10-11 2018-01-10 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
RU2016125213A (ru) 2013-11-27 2017-12-29 АЙДЕНИКС ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Нуклеотиды для лечения рака печени
CZ307789B6 (cs) * 2014-04-15 2019-05-09 Zentiva, K.S. Způsob výroby biologicky účinných fosforamidátových léčiv
WO2015161137A1 (en) 2014-04-16 2015-10-22 Idenix Pharmaceuticals, Inc. 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
JP6855248B2 (ja) 2014-06-25 2021-04-07 ヌカナ ピーエルシー ゲムシタビン−プロドラッグを含む製剤
HRP20230584T1 (hr) 2014-06-25 2023-09-15 NuCana plc Prolijekovi gemcitabina
WO2016012781A1 (en) 2014-07-22 2016-01-28 Nucana Biomed Limited Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
SG10202001117YA (en) * 2014-08-25 2020-04-29 Medivir Ab Dioxolane analogues of uridine for the treatment of cancer
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN105646629A (zh) 2014-11-25 2016-06-08 广州市恒诺康医药科技有限公司 L-核苷类化合物及其应用
IL291927A (en) 2014-11-28 2022-06-01 NuCana plc Oligonucleotides containing modified nucleosides
WO2016098123A2 (en) * 2014-12-16 2016-06-23 Laurus Labs Private Ltd A recycling process for preparing (s)-2-[(substituted-phenoxy)-phenoxy- phosphorylamino] propionic acid isopropyl ester diastereomers
WO2016145142A1 (en) 2015-03-10 2016-09-15 Emory University Nucleotide and nucleoside therapeutics compositions and uses related thereto
EP3415149A1 (en) 2015-05-14 2018-12-19 NuCana plc Cancer treatments
CN106539810B (zh) 2015-09-16 2021-03-09 济南高合医疗科技有限公司 一种富集了nuc-1031单一异构体的组合物及其制备方法和用途
CN106543220A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN106543252A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
PH12018500691B1 (en) 2015-10-05 2022-08-10 NuCana plc Combination therapy
US10745435B2 (en) * 2015-11-16 2020-08-18 Cerecor, Inc. Nucleic acid prodrugs
HRP20211812T1 (hr) 2015-12-11 2022-03-04 NuCana plc Dijastereoselektivna sinteza derivata fosfata i prolijeka gemcitabina nuc-1031
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
MA51576A (fr) 2015-12-23 2020-11-18 NuCana plc Polythérapie
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609602D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201713916D0 (en) 2017-08-30 2017-10-11 Nucana Biomed Ltd Treatment regimens

Also Published As

Publication number Publication date
EP3638685A1 (en) 2020-04-22
NZ800534A (en) 2026-03-27
IL271159B1 (en) 2023-06-01
BR112019026747A2 (pt) 2020-06-30
MX2019014914A (es) 2020-02-13
US20220402962A1 (en) 2022-12-22
SA519410795B1 (ar) 2023-11-19
KR20200016864A (ko) 2020-02-17
CN110785425A (zh) 2020-02-11
JP2020523381A (ja) 2020-08-06
MX2022003822A (es) 2022-05-25
US20200181186A1 (en) 2020-06-11
IL271159B2 (en) 2023-10-01
JP2023095954A (ja) 2023-07-06
IL302559B2 (en) 2024-09-01
NZ759692A (en) 2026-03-27
KR102920287B1 (ko) 2026-01-30
US20250171487A1 (en) 2025-05-29
IL271159A (en) 2020-01-30
IL312228B1 (en) 2025-02-01
MX2019014907A (es) 2020-02-13
JP7248209B2 (ja) 2023-03-29
CA3064177A1 (en) 2018-12-20
AU2018284131A1 (en) 2020-01-16
SG11201911543UA (en) 2020-01-30
JP7525687B2 (ja) 2024-07-30
CN110753697B (zh) 2023-10-13
WO2018229495A1 (en) 2018-12-20
CN117486959A (zh) 2024-02-02
WO2018229493A3 (en) 2019-02-07
JP7279991B2 (ja) 2023-05-23
CA3065682A1 (en) 2018-12-20
WO2018229493A2 (en) 2018-12-20
AU2022204691A1 (en) 2022-08-04
AU2018284131B2 (en) 2022-04-07
IL312228B2 (en) 2025-06-01
EP3638684A2 (en) 2020-04-22
JP2026034703A (ja) 2026-02-27
CN110753697A (zh) 2020-02-04
MX390901B (es) 2025-03-21
US11414452B2 (en) 2022-08-16
IL302559B1 (en) 2024-05-01
US12054511B2 (en) 2024-08-06
MX391332B (es) 2025-03-21
IL302559A (en) 2023-07-01
US20200181190A1 (en) 2020-06-11
CN110785425B (zh) 2023-11-21
PH12019502825A1 (en) 2020-10-26
EA201992873A1 (ru) 2020-05-19
AU2024200428B2 (en) 2025-10-16
JP2020523378A (ja) 2020-08-06
KR20240127483A (ko) 2024-08-22
JP2024138523A (ja) 2024-10-08
MA49379A (fr) 2020-04-22
KR102695300B1 (ko) 2024-08-16
AU2024200428A1 (en) 2024-02-08
CL2019003632A1 (es) 2020-08-14
AU2022204691B2 (en) 2023-11-23
IL312228A (en) 2024-06-01
US11897913B2 (en) 2024-02-13

Similar Documents

Publication Publication Date Title
IL272888A (en) Uses of piperidinyl-indole derivatives
GB201709471D0 (en) Diastereoselective synthesis of hosphate derivatives
IL255817A (en) Synthesis of heterocyclic compounds
PL3645518T3 (pl) Synteza omekamtywu mekarbilu
IL295588A (en) Synthesis of the Lichondrins
HUE056460T2 (hu) Indazolok szintézise
IL259887B (en) Diastereoselective Synthesis of Phosphate Histology and Metres Drug NUC-1031 Gemcitabine
SMT202100551T1 (it) Derivati di sobetirome
IL276592A (en) History of Subtirum
IL262413B (en) Synthesis of indazoles
IL273784A (en) Synthesis of cantharidin
SI3313853T1 (sl) Postopek za sintezo derivatov rapamicina
IL293192A (en) Methods for the preparation of indolinobenzodiazepine derivatives
GB2544486B (en) Synthesis of Ammonia
PL3174849T3 (pl) Synteza pochodnych pirolidyny
GB201710241D0 (en) New route of synthesis for opicapone
ZA202001140B (en) Derivatives of luciferin and methods for their synthesis
IL270703B1 (en) History of Reziquimod
GB201513979D0 (en) Synthesis of benzodiazepine derivatives
GB201602185D0 (en) Diastereoselective synthesis of phosphate derivatives
GB201820685D0 (en) Synthesis of 8-chloroadenosine derivatives
HK1259701A1 (en) Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
SG11201605485QA (en) Synthesis method of 9-allylcamptothecin derivatives

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)