MA49379A - Synthèse de phosphate protides diastéréoisomériquement substantiellement purs - Google Patents

Synthèse de phosphate protides diastéréoisomériquement substantiellement purs

Info

Publication number
MA49379A
MA49379A MA049379A MA49379A MA49379A MA 49379 A MA49379 A MA 49379A MA 049379 A MA049379 A MA 049379A MA 49379 A MA49379 A MA 49379A MA 49379 A MA49379 A MA 49379A
Authority
MA
Morocco
Prior art keywords
pure
diasterereoisomerically
protides
synthesis
phosphate
Prior art date
Application number
MA049379A
Other languages
English (en)
Inventor
Venkata Lakshmi Narasimha Rao Dammalapati
Hugh Griffith
Gordon Kennovin
Mani Bushan Kotala
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of MA49379A publication Critical patent/MA49379A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA049379A 2017-06-14 2018-06-14 Synthèse de phosphate protides diastéréoisomériquement substantiellement purs MA49379A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives

Publications (1)

Publication Number Publication Date
MA49379A true MA49379A (fr) 2020-04-22

Family

ID=59358400

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049379A MA49379A (fr) 2017-06-14 2018-06-14 Synthèse de phosphate protides diastéréoisomériquement substantiellement purs

Country Status (16)

Country Link
US (3) US11897913B2 (fr)
EP (2) EP3638685A1 (fr)
JP (3) JP7248209B2 (fr)
KR (1) KR20200016864A (fr)
CN (3) CN110785425B (fr)
AU (3) AU2018284131B2 (fr)
BR (1) BR112019026747A2 (fr)
CA (2) CA3064177A1 (fr)
CL (1) CL2019003632A1 (fr)
EA (1) EA201992873A1 (fr)
GB (1) GB201709471D0 (fr)
IL (2) IL302559B1 (fr)
MA (1) MA49379A (fr)
MX (3) MX2019014907A (fr)
SG (1) SG11201911543UA (fr)
WO (2) WO2018229493A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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CA2828326C (fr) 2011-03-01 2019-05-07 Nucana Biomed Limited Derives phosphoramidates de 5 - fluoro - 2' - desoxyuridine destines a etre utilises dans le traitement d'un cancer
MX2016015629A (es) 2014-06-25 2017-08-02 Nucana Biomed Ltd Formulacion que comprende un profarmaco de gemcitabina.
ES2742167T3 (es) 2014-11-28 2020-02-13 NuCana plc Nuevos derivados éster 2' y/o 5' de fosforamidato de aminoácidos de la 3'-desoxiadenosina como compuestos anticancerígenos
EP3386998B1 (fr) 2015-12-11 2021-11-10 NuCana plc Syntheses diastereoselectives de dérivés phosphates et du promedicament de gemcitabine nuc-1031
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN112409421A (zh) * 2020-12-01 2021-02-26 上海兆维科技发展有限公司 一种3’-磷酸酯核苷的制备方法
WO2023218202A2 (fr) 2022-05-12 2023-11-16 NuCana plc Traitement du cancer

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Also Published As

Publication number Publication date
JP7248209B2 (ja) 2023-03-29
EP3638685A1 (fr) 2020-04-22
US20220402962A1 (en) 2022-12-22
US11414452B2 (en) 2022-08-16
CN110753697B (zh) 2023-10-13
AU2024200428A1 (en) 2024-02-08
AU2022204691B2 (en) 2023-11-23
CN110753697A (zh) 2020-02-04
MX2019014914A (es) 2020-02-13
EA201992873A1 (ru) 2020-05-19
IL271159B1 (en) 2023-06-01
MX2022003822A (es) 2022-05-25
GB201709471D0 (en) 2017-07-26
KR20200016864A (ko) 2020-02-17
JP2020523378A (ja) 2020-08-06
US20200181186A1 (en) 2020-06-11
AU2018284131A1 (en) 2020-01-16
IL271159B2 (en) 2023-10-01
US20200181190A1 (en) 2020-06-11
IL302559B1 (en) 2024-05-01
EP3638684A2 (fr) 2020-04-22
CN110785425A (zh) 2020-02-11
AU2022204691A1 (en) 2022-08-04
BR112019026747A2 (pt) 2020-06-30
JP2023095954A (ja) 2023-07-06
CA3064177A1 (fr) 2018-12-20
CN110785425B (zh) 2023-11-21
US11897913B2 (en) 2024-02-13
JP2020523381A (ja) 2020-08-06
AU2018284131B2 (en) 2022-04-07
JP7279991B2 (ja) 2023-05-23
WO2018229493A3 (fr) 2019-02-07
CL2019003632A1 (es) 2020-08-14
WO2018229495A1 (fr) 2018-12-20
IL302559A (en) 2023-07-01
MX2019014907A (es) 2020-02-13
WO2018229493A2 (fr) 2018-12-20
CA3065682A1 (fr) 2018-12-20
CN117486959A (zh) 2024-02-02
SG11201911543UA (en) 2020-01-30
IL271159A (en) 2020-01-30

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