CL2019003632A1 - Síntesis de derivados fosfatos. - Google Patents

Síntesis de derivados fosfatos.

Info

Publication number
CL2019003632A1
CL2019003632A1 CL2019003632A CL2019003632A CL2019003632A1 CL 2019003632 A1 CL2019003632 A1 CL 2019003632A1 CL 2019003632 A CL2019003632 A CL 2019003632A CL 2019003632 A CL2019003632 A CL 2019003632A CL 2019003632 A1 CL2019003632 A1 CL 2019003632A1
Authority
CL
Chile
Prior art keywords
synthesis
phosphate derivatives
compounds
pure
diastereoisomerically
Prior art date
Application number
CL2019003632A
Other languages
English (en)
Inventor
Hugh Griffith
Gordon Kennovin
Mani Bushan Kotala
Venkata Lakshmi Narasimha Rao Dammalapati
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of CL2019003632A1 publication Critical patent/CL2019003632A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCESOS DE PREPARACIÓN DE COMPUESTOS DERIVADOS DE FOSFATOS SUSTANCIALMENTE EN FORMA DIASTEREOISOMÉRICAMENTE PUROS; COMPUESTOS DERIVADOS DE FOSFATOS SUSTANCIALMENTE EN FORMA DIASTEREOISOMÉRICAMENTE PUROS; Y FORMULACIÓN FARMACÉUTICA QUE COMPRENDE A DICHOS COMPUESTOS.
CL2019003632A 2017-06-14 2019-12-11 Síntesis de derivados fosfatos. CL2019003632A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives

Publications (1)

Publication Number Publication Date
CL2019003632A1 true CL2019003632A1 (es) 2020-08-14

Family

ID=59358400

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003632A CL2019003632A1 (es) 2017-06-14 2019-12-11 Síntesis de derivados fosfatos.

Country Status (16)

Country Link
US (3) US11897913B2 (es)
EP (2) EP3638685A1 (es)
JP (3) JP7248209B2 (es)
KR (1) KR20200016864A (es)
CN (3) CN117486959A (es)
AU (3) AU2018284131B2 (es)
BR (1) BR112019026747A2 (es)
CA (2) CA3064177A1 (es)
CL (1) CL2019003632A1 (es)
EA (1) EA201992873A1 (es)
GB (1) GB201709471D0 (es)
IL (2) IL271159B2 (es)
MA (1) MA49379A (es)
MX (3) MX2019014907A (es)
SG (1) SG11201911543UA (es)
WO (2) WO2018229495A1 (es)

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JP6855248B2 (ja) 2014-06-25 2021-04-07 ヌカナ ピーエルシー ゲムシタビン−プロドラッグを含む製剤
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HUE059026T2 (hu) 2015-12-11 2022-10-28 NuCana plc Foszfát-származékok és a gemcitabin-prodrug NUC-1031 diasztereoszelektív szintézise
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Also Published As

Publication number Publication date
US20200181186A1 (en) 2020-06-11
CN110785425B (zh) 2023-11-21
CN110753697A (zh) 2020-02-04
JP2020523381A (ja) 2020-08-06
US20220402962A1 (en) 2022-12-22
JP7279991B2 (ja) 2023-05-23
IL271159A (en) 2020-01-30
AU2022204691A1 (en) 2022-08-04
CN110753697B (zh) 2023-10-13
MX2019014907A (es) 2020-02-13
EP3638684A2 (en) 2020-04-22
CA3064177A1 (en) 2018-12-20
IL271159B1 (en) 2023-06-01
WO2018229495A1 (en) 2018-12-20
KR20200016864A (ko) 2020-02-17
BR112019026747A2 (pt) 2020-06-30
CN110785425A (zh) 2020-02-11
IL302559A (en) 2023-07-01
WO2018229493A2 (en) 2018-12-20
IL271159B2 (en) 2023-10-01
CA3065682A1 (en) 2018-12-20
MA49379A (fr) 2020-04-22
AU2018284131B2 (en) 2022-04-07
JP2023095954A (ja) 2023-07-06
EA201992873A1 (ru) 2020-05-19
US20200181190A1 (en) 2020-06-11
JP2020523378A (ja) 2020-08-06
MX2019014914A (es) 2020-02-13
US11897913B2 (en) 2024-02-13
MX2022003822A (es) 2022-05-25
SG11201911543UA (en) 2020-01-30
JP7248209B2 (ja) 2023-03-29
GB201709471D0 (en) 2017-07-26
WO2018229493A3 (en) 2019-02-07
US11414452B2 (en) 2022-08-16
AU2022204691B2 (en) 2023-11-23
AU2024200428A1 (en) 2024-02-08
CN117486959A (zh) 2024-02-02
EP3638685A1 (en) 2020-04-22
IL302559B1 (en) 2024-05-01
AU2018284131A1 (en) 2020-01-16

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