CL2019003632A1 - Síntesis de derivados fosfatos. - Google Patents

Síntesis de derivados fosfatos.

Info

Publication number
CL2019003632A1
CL2019003632A1 CL2019003632A CL2019003632A CL2019003632A1 CL 2019003632 A1 CL2019003632 A1 CL 2019003632A1 CL 2019003632 A CL2019003632 A CL 2019003632A CL 2019003632 A CL2019003632 A CL 2019003632A CL 2019003632 A1 CL2019003632 A1 CL 2019003632A1
Authority
CL
Chile
Prior art keywords
synthesis
phosphate derivatives
compounds
pure
diastereoisomerically
Prior art date
Application number
CL2019003632A
Other languages
English (en)
Inventor
Hugh Griffith
Gordon Kennovin
Mani Bushan Kotala
Venkata Lakshmi Narasimha Rao Dammalapati
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of CL2019003632A1 publication Critical patent/CL2019003632A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCESOS DE PREPARACIÓN DE COMPUESTOS DERIVADOS DE FOSFATOS SUSTANCIALMENTE EN FORMA DIASTEREOISOMÉRICAMENTE PUROS; COMPUESTOS DERIVADOS DE FOSFATOS SUSTANCIALMENTE EN FORMA DIASTEREOISOMÉRICAMENTE PUROS; Y FORMULACIÓN FARMACÉUTICA QUE COMPRENDE A DICHOS COMPUESTOS.
CL2019003632A 2017-06-14 2019-12-11 Síntesis de derivados fosfatos. CL2019003632A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives

Publications (1)

Publication Number Publication Date
CL2019003632A1 true CL2019003632A1 (es) 2020-08-14

Family

ID=59358400

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003632A CL2019003632A1 (es) 2017-06-14 2019-12-11 Síntesis de derivados fosfatos.

Country Status (16)

Country Link
US (3) US11897913B2 (es)
EP (2) EP3638685A1 (es)
JP (3) JP7248209B2 (es)
KR (1) KR20200016864A (es)
CN (3) CN110753697B (es)
AU (3) AU2018284131B2 (es)
BR (1) BR112019026747A2 (es)
CA (2) CA3065682A1 (es)
CL (1) CL2019003632A1 (es)
EA (1) EA201992873A1 (es)
GB (1) GB201709471D0 (es)
IL (2) IL271159B2 (es)
MA (1) MA49379A (es)
MX (3) MX2019014914A (es)
SG (1) SG11201911543UA (es)
WO (2) WO2018229493A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62721B1 (sr) 2011-03-01 2022-01-31 NuCana plc Farmaceutska formulacija koja sadrži fosforamidatni derivat 5-fluoro-2’-deoksiuridina za upotrebu u lečenju kancera
TWI765176B (zh) 2014-06-25 2022-05-21 英商努卡那公眾有限公司 磷酸酯衍生物之調配物
MX2017006942A (es) 2014-11-28 2017-08-24 Nucana Biomed Ltd Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer.
AU2016367237B2 (en) 2015-12-11 2020-12-24 Laurus Labs Limited Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug NUC-1031
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) * 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN112409421A (zh) * 2020-12-01 2021-02-26 上海兆维科技发展有限公司 一种3’-磷酸酯核苷的制备方法
WO2023218202A2 (en) 2022-05-12 2023-11-16 NuCana plc Cancer treatment

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE279248C (es)
US3792039A (en) 1971-12-27 1974-02-12 Miles Lab Poly 2'-fluoro-2'-deoxyuridylic acid
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4357324A (en) 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
AU753155B2 (en) 1998-01-23 2002-10-10 Kiadis Pharma Intellectual Property B.V. Enzyme catalyzed therapeutic agents
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
US8399428B2 (en) 2004-12-09 2013-03-19 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
GB0505781D0 (en) 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
WO2007020193A2 (en) 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Antiviral phosphoramidates of 4 ' -substituted pronucleotides
GB0623493D0 (en) 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
US20080261913A1 (en) * 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20090206007A1 (en) 2008-02-20 2009-08-20 Air Products And Chemicals, Inc. Process and apparatus for upgrading coal using supercritical water
JP2012514657A (ja) 2009-01-09 2012-06-28 ユニバーシテイ・カレツジ・オブ・カーデイフ・コンサルタンツ・リミテツド ウィルス感染を治療するためのグアノシンヌクレオシド化合物のホスホルアミダート誘導体
AU2010226466A1 (en) 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
PE20130151A1 (es) 2010-03-31 2013-02-21 Gilead Pharmasset Llc Sintesis estereoselectiva de activos que contienen fosforo
PL2609923T4 (pl) 2010-03-31 2017-11-30 Gilead Pharmasset Llc Proces krystalizacji 2-(((s)-(perfluorofenoksy) (fenoksy)fosforylo)amino)propanianu (s)-izopropylu
MX2013000656A (es) 2010-07-19 2013-04-03 Gilead Sciences Inc Metodos para la preparacion de profarmacos de fosforamidato diastereomericamente puros.
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
WO2012040126A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
TW201242974A (en) 2010-11-30 2012-11-01 Gilead Pharmasset Llc Compounds
AU2011349278C1 (en) 2010-12-22 2017-01-19 Alios Biopharma, Inc. Cyclic nucleotide analogs
RS62721B1 (sr) 2011-03-01 2022-01-31 NuCana plc Farmaceutska formulacija koja sadrži fosforamidatni derivat 5-fluoro-2’-deoksiuridina za upotrebu u lečenju kancera
EP3150616B1 (en) 2012-11-16 2017-05-10 University College Cardiff Consultants Limited Mixture of rp/sp gemcitabine-[phenyl-(benzyloxy-l-alaninyl)]-phosphate
EP3013340B9 (en) 2013-06-26 2023-10-04 Janssen Pharmaceuticals, Inc. Substituted nucleosides, nucleotides and analogs thereof
PL3043803T3 (pl) 2013-09-11 2022-11-07 Emory University Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie
US9862743B2 (en) 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CA2931458A1 (en) 2013-11-27 2015-06-04 Idenix Pharmaceuticals Llc Nucleotides for the treatment of liver cancer
CZ307789B6 (cs) * 2014-04-15 2019-05-09 Zentiva, K.S. Způsob výroby biologicky účinných fosforamidátových léčiv
TWI758728B (zh) 2014-06-25 2022-03-21 英商努卡那公眾有限公司 前藥
TWI765176B (zh) 2014-06-25 2022-05-21 英商努卡那公眾有限公司 磷酸酯衍生物之調配物
EP3172218B1 (en) 2014-07-22 2020-10-21 NuCana plc Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
CA3128645C (en) * 2014-08-25 2023-06-27 Medivir Ab Dioxolane analogues of uridine for the treatment of cancer
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN105646629A (zh) 2014-11-25 2016-06-08 广州市恒诺康医药科技有限公司 L-核苷类化合物及其应用
MX2017006942A (es) 2014-11-28 2017-08-24 Nucana Biomed Ltd Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer.
WO2016098123A2 (en) * 2014-12-16 2016-06-23 Laurus Labs Private Ltd A recycling process for preparing (s)-2-[(substituted-phenoxy)-phenoxy- phosphorylamino] propionic acid isopropyl ester diastereomers
WO2016145142A1 (en) 2015-03-10 2016-09-15 Emory University Nucleotide and nucleoside therapeutics compositions and uses related thereto
LT3197456T (lt) 2015-05-14 2018-07-10 NuCana plc Vėžio gydymas
CN106543220A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN112156102B (zh) 2015-09-16 2023-10-03 济南高合医疗科技有限公司 一种nuc-1031单一异构体的晶型及其制备方法
CN106543252A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
JP7038653B2 (ja) 2015-10-05 2022-03-18 ニューカナ パブリック リミテッド カンパニー 併用療法
AU2016355429B2 (en) 2015-11-16 2021-05-06 Cerecor, Inc. Nucleic acid prodrugs
AU2016367237B2 (en) * 2015-12-11 2020-12-24 Laurus Labs Limited Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug NUC-1031
MX2018007772A (es) 2015-12-23 2019-07-04 NuCana plc Terapia de combinacion.
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609602D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201713916D0 (en) 2017-08-30 2017-10-11 Nucana Biomed Ltd Treatment regimens

Also Published As

Publication number Publication date
US20200181186A1 (en) 2020-06-11
US20220402962A1 (en) 2022-12-22
MX2022003822A (es) 2022-05-25
MX2019014907A (es) 2020-02-13
CN110785425A (zh) 2020-02-11
CN110753697B (zh) 2023-10-13
BR112019026747A2 (pt) 2020-06-30
IL302559A (en) 2023-07-01
EP3638684A2 (en) 2020-04-22
IL302559B1 (en) 2024-05-01
AU2022204691B2 (en) 2023-11-23
JP7248209B2 (ja) 2023-03-29
CA3064177A1 (en) 2018-12-20
EP3638685A1 (en) 2020-04-22
AU2024200428A1 (en) 2024-02-08
WO2018229493A3 (en) 2019-02-07
EA201992873A1 (ru) 2020-05-19
IL271159B1 (en) 2023-06-01
JP2020523381A (ja) 2020-08-06
IL271159A (en) 2020-01-30
SG11201911543UA (en) 2020-01-30
AU2022204691A1 (en) 2022-08-04
JP7279991B2 (ja) 2023-05-23
US20200181190A1 (en) 2020-06-11
AU2018284131B2 (en) 2022-04-07
US11897913B2 (en) 2024-02-13
CA3065682A1 (en) 2018-12-20
GB201709471D0 (en) 2017-07-26
WO2018229493A2 (en) 2018-12-20
JP2023095954A (ja) 2023-07-06
AU2018284131A1 (en) 2020-01-16
IL271159B2 (en) 2023-10-01
CN110785425B (zh) 2023-11-21
KR20200016864A (ko) 2020-02-17
US11414452B2 (en) 2022-08-16
CN110753697A (zh) 2020-02-04
MX2019014914A (es) 2020-02-13
WO2018229495A1 (en) 2018-12-20
MA49379A (fr) 2020-04-22
CN117486959A (zh) 2024-02-02
JP2020523378A (ja) 2020-08-06

Similar Documents

Publication Publication Date Title
CL2019003632A1 (es) Síntesis de derivados fosfatos.
CO2020007244A2 (es) Inhibidores de kras g12c
PH12018502516B1 (en) New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
MY196909A (en) Boronic acid derivatives and therapeutic uses thereof
MX2018010427A (es) Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion.
DOP2016000299A (es) Derivados de pirrolidina-2,5-diona, composiciones farmacéuticas y su uso como inhibidores ido1
PH12016501693A1 (en) 2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom
NI201600165A (es) Inhibidores de desmetilasa 1 específica a lisina
CR20150228A (es) Inhibidores de la tirosina-quinasa de bruton
PH12018501224A1 (en) Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
CU20170015A7 (es) Compuesto de (pirazolilamino) pirimidinil biciclo (3.2.1)oct-8-il
UY36175A (es) 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas
BR112018072168A2 (pt) compostos derivados da pirimidina como inibidores da quinase jak
CR20180168A (es) Derivados de heteroarilo como inhibidores de parp
MY194116A (en) Pharmaceutical compounds
CL2019000169A1 (es) Derivados de piperidina.
PH12019501178A1 (en) Thiopene derivatives as antiviral agents
MY178745A (en) Isoquinoline compounds, a process for their preparation, and pharmaceutical compositions containing them
MX2017003589A (es) Compuestos de indolinona y usos de los mismos.
CR20180181A (es) Nuevos derivados de imidazol[4,5-b]piridina, un proceso para su preparación y composiciones farmacéuticas que los contienen
PH12016502544B1 (en) Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor
MX2017008074A (es) DERIVADOS DE IMIDAZOPIRIDAZINA COMO INHIBIDORES DE FOSFOINOSITIDA-3-QUINASAS BETA (PI3Kß).
MY182634A (en) Pharmaceutical containing sodium-dependent phosphate transporter inhibitor
EA201791397A1 (ru) СВЯЗАННЫЕ С ГЕТЕРОЦИКЛИЛАМИ ПРОИЗВОДНЫЕ ИМИДАЗОПИРИДАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ
WO2018075598A8 (en) SYNTHESIS OF EZH2 INHIBITORS