CA3064177A1 - Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738) - Google Patents

Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738) Download PDF

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Publication number
CA3064177A1
CA3064177A1 CA3064177A CA3064177A CA3064177A1 CA 3064177 A1 CA3064177 A1 CA 3064177A1 CA 3064177 A CA3064177 A CA 3064177A CA 3064177 A CA3064177 A CA 3064177A CA 3064177 A1 CA3064177 A1 CA 3064177A1
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compound
formula
mixture
group
optionally substituted
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CA3064177A
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English (en)
French (fr)
Inventor
Venkata Lakshmi Narasimha Rao Dammalapati
Mani Bushan Kotala
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Nucana PLC
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Publication of CA3064177A1 publication Critical patent/CA3064177A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3064177A 2017-06-14 2018-06-14 Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738) Pending CA3064177A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1709471.5 2017-06-14
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives
PCT/GB2018/051641 WO2018229495A1 (en) 2017-06-14 2018-06-14 Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738)

Publications (1)

Publication Number Publication Date
CA3064177A1 true CA3064177A1 (en) 2018-12-20

Family

ID=59358400

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3064177A Pending CA3064177A1 (en) 2017-06-14 2018-06-14 Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738)
CA3065682A Pending CA3065682A1 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3065682A Pending CA3065682A1 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides

Country Status (19)

Country Link
US (4) US11897913B2 (https=)
EP (2) EP3638685A1 (https=)
JP (5) JP7279991B2 (https=)
KR (2) KR102920287B1 (https=)
CN (3) CN117486959A (https=)
AU (2) AU2018284131B2 (https=)
BR (1) BR112019026747A2 (https=)
CA (2) CA3064177A1 (https=)
CL (1) CL2019003632A1 (https=)
EA (1) EA201992873A1 (https=)
GB (1) GB201709471D0 (https=)
IL (3) IL302559B2 (https=)
MA (1) MA49379A (https=)
MX (3) MX390901B (https=)
NZ (2) NZ800534A (https=)
PH (1) PH12019502825A1 (https=)
SA (1) SA519410795B1 (https=)
SG (1) SG11201911543UA (https=)
WO (2) WO2018229493A2 (https=)

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RS62593B1 (sr) 2015-12-11 2021-12-31 NuCana plc Dijastereoselektivna sinteza derivata fosfata i proleka gemcitabina nuc-1031
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AU2023268725A1 (en) 2022-05-12 2024-12-12 NuCana plc Cancer treatment with nuc-7738
JP2025539267A (ja) 2022-12-07 2025-12-04 ニューカナ パブリック リミテッド カンパニー ヌクレオシド誘導体ｎｕｃ－３３７３の合成

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JP2020523378A (ja) 2020-08-06
US20220402962A1 (en) 2022-12-22
SA519410795B1 (ar) 2023-11-19
IL302559B2 (en) 2024-09-01
US20200181190A1 (en) 2020-06-11
CN110753697B (zh) 2023-10-13
BR112019026747A2 (pt) 2020-06-30
IL302559B1 (en) 2024-05-01
NZ759692A (en) 2026-03-27
KR102920287B1 (ko) 2026-01-30
MX391332B (es) 2025-03-21
CA3065682A1 (en) 2018-12-20
JP7248209B2 (ja) 2023-03-29
JP2026034703A (ja) 2026-02-27
US11897913B2 (en) 2024-02-13
MX2022003822A (es) 2022-05-25
KR20240127483A (ko) 2024-08-22
AU2022204691B2 (en) 2023-11-23
IL271159B1 (en) 2023-06-01
IL271159B2 (en) 2023-10-01
IL271159A (en) 2020-01-30
IL312228B1 (en) 2025-02-01
AU2018284131A1 (en) 2020-01-16
US20250171487A1 (en) 2025-05-29
KR102695300B1 (ko) 2024-08-16
US20200181186A1 (en) 2020-06-11
US11414452B2 (en) 2022-08-16
EA201992873A1 (ru) 2020-05-19
JP7279991B2 (ja) 2023-05-23
IL312228A (en) 2024-06-01
CN117486959A (zh) 2024-02-02
WO2018229495A1 (en) 2018-12-20
AU2018284131B2 (en) 2022-04-07
IL312228B2 (en) 2025-06-01
CL2019003632A1 (es) 2020-08-14
KR20200016864A (ko) 2020-02-17
CN110785425A (zh) 2020-02-11
MX2019014907A (es) 2020-02-13
PH12019502825A1 (en) 2020-10-26
AU2024200428B2 (en) 2025-10-16
CN110785425B (zh) 2023-11-21
GB201709471D0 (en) 2017-07-26
IL302559A (en) 2023-07-01
JP2023095954A (ja) 2023-07-06
WO2018229493A3 (en) 2019-02-07
SG11201911543UA (en) 2020-01-30
CN110753697A (zh) 2020-02-04
AU2022204691A1 (en) 2022-08-04
MA49379A (fr) 2020-04-22
NZ800534A (en) 2026-03-27
JP7525687B2 (ja) 2024-07-30
EP3638684A2 (en) 2020-04-22
EP3638685A1 (en) 2020-04-22
WO2018229493A2 (en) 2018-12-20
US12054511B2 (en) 2024-08-06
AU2024200428A1 (en) 2024-02-08
MX390901B (es) 2025-03-21
JP2024138523A (ja) 2024-10-08
MX2019014914A (es) 2020-02-13
JP2020523381A (ja) 2020-08-06

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