CN117486959A - 磷酸酯衍生物的合成 - Google Patents

磷酸酯衍生物的合成 Download PDF

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Publication number
CN117486959A
CN117486959A CN202311430904.3A CN202311430904A CN117486959A CN 117486959 A CN117486959 A CN 117486959A CN 202311430904 A CN202311430904 A CN 202311430904A CN 117486959 A CN117486959 A CN 117486959A
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China
Prior art keywords
compound
mixture
optionally substituted
nuc
group
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CN202311430904.3A
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English (en)
Chinese (zh)
Inventor
休·格里菲斯
戈登·肯诺温
文卡塔·拉克希米·纳拉辛哈·拉奥·达马拉帕蒂
玛尼·布尚·科塔拉
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Nucana PLC
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Nucana Biomed Ltd
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Publication of CN117486959A publication Critical patent/CN117486959A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202311430904.3A 2017-06-14 2018-06-14 磷酸酯衍生物的合成 Pending CN117486959A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1709471.5 2017-06-14
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives
PCT/GB2018/051638 WO2018229493A2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives
CN201880039747.4A CN110753697B (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880039747.4A Division CN110753697B (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成

Publications (1)

Publication Number Publication Date
CN117486959A true CN117486959A (zh) 2024-02-02

Family

ID=59358400

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202311430904.3A Pending CN117486959A (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
CN201880039747.4A Active CN110753697B (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
CN201880039189.1A Active CN110785425B (zh) 2017-06-14 2018-06-14 3′-脱氧腺苷-5′-o-[苯基(苄氧基-l-丙氨酰基)]磷酸酯(nuc-7738)的合成

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201880039747.4A Active CN110753697B (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
CN201880039189.1A Active CN110785425B (zh) 2017-06-14 2018-06-14 3′-脱氧腺苷-5′-o-[苯基(苄氧基-l-丙氨酰基)]磷酸酯(nuc-7738)的合成

Country Status (19)

Country Link
US (4) US11897913B2 (https=)
EP (2) EP3638685A1 (https=)
JP (5) JP7279991B2 (https=)
KR (2) KR102920287B1 (https=)
CN (3) CN117486959A (https=)
AU (2) AU2018284131B2 (https=)
BR (1) BR112019026747A2 (https=)
CA (2) CA3064177A1 (https=)
CL (1) CL2019003632A1 (https=)
EA (1) EA201992873A1 (https=)
GB (1) GB201709471D0 (https=)
IL (3) IL302559B2 (https=)
MA (1) MA49379A (https=)
MX (3) MX390901B (https=)
NZ (2) NZ800534A (https=)
PH (1) PH12019502825A1 (https=)
SA (1) SA519410795B1 (https=)
SG (1) SG11201911543UA (https=)
WO (2) WO2018229493A2 (https=)

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RS62593B1 (sr) 2015-12-11 2021-12-31 NuCana plc Dijastereoselektivna sinteza derivata fosfata i proleka gemcitabina nuc-1031
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
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CN112409421A (zh) * 2020-12-01 2021-02-26 上海兆维科技发展有限公司 一种3’-磷酸酯核苷的制备方法
AU2023268725A1 (en) 2022-05-12 2024-12-12 NuCana plc Cancer treatment with nuc-7738
JP2025539267A (ja) 2022-12-07 2025-12-04 ニューカナ パブリック リミテッド カンパニー ヌクレオシド誘導体ｎｕｃ－３３７３の合成

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JP2020523378A (ja) 2020-08-06
US20220402962A1 (en) 2022-12-22
SA519410795B1 (ar) 2023-11-19
IL302559B2 (en) 2024-09-01
US20200181190A1 (en) 2020-06-11
CN110753697B (zh) 2023-10-13
BR112019026747A2 (pt) 2020-06-30
IL302559B1 (en) 2024-05-01
NZ759692A (en) 2026-03-27
KR102920287B1 (ko) 2026-01-30
MX391332B (es) 2025-03-21
CA3065682A1 (en) 2018-12-20
JP7248209B2 (ja) 2023-03-29
JP2026034703A (ja) 2026-02-27
US11897913B2 (en) 2024-02-13
MX2022003822A (es) 2022-05-25
KR20240127483A (ko) 2024-08-22
AU2022204691B2 (en) 2023-11-23
IL271159B1 (en) 2023-06-01
IL271159B2 (en) 2023-10-01
IL271159A (en) 2020-01-30
IL312228B1 (en) 2025-02-01
AU2018284131A1 (en) 2020-01-16
US20250171487A1 (en) 2025-05-29
KR102695300B1 (ko) 2024-08-16
US20200181186A1 (en) 2020-06-11
US11414452B2 (en) 2022-08-16
EA201992873A1 (ru) 2020-05-19
JP7279991B2 (ja) 2023-05-23
IL312228A (en) 2024-06-01
CA3064177A1 (en) 2018-12-20
WO2018229495A1 (en) 2018-12-20
AU2018284131B2 (en) 2022-04-07
IL312228B2 (en) 2025-06-01
CL2019003632A1 (es) 2020-08-14
KR20200016864A (ko) 2020-02-17
CN110785425A (zh) 2020-02-11
MX2019014907A (es) 2020-02-13
PH12019502825A1 (en) 2020-10-26
AU2024200428B2 (en) 2025-10-16
CN110785425B (zh) 2023-11-21
GB201709471D0 (en) 2017-07-26
IL302559A (en) 2023-07-01
JP2023095954A (ja) 2023-07-06
WO2018229493A3 (en) 2019-02-07
SG11201911543UA (en) 2020-01-30
CN110753697A (zh) 2020-02-04
AU2022204691A1 (en) 2022-08-04
MA49379A (fr) 2020-04-22
NZ800534A (en) 2026-03-27
JP7525687B2 (ja) 2024-07-30
EP3638684A2 (en) 2020-04-22
EP3638685A1 (en) 2020-04-22
WO2018229493A2 (en) 2018-12-20
US12054511B2 (en) 2024-08-06
AU2024200428A1 (en) 2024-02-08
MX390901B (es) 2025-03-21
JP2024138523A (ja) 2024-10-08
MX2019014914A (es) 2020-02-13
JP2020523381A (ja) 2020-08-06

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