PL3313853T3 - Sposób syntezy pochodnych rapamycyny - Google Patents
Sposób syntezy pochodnych rapamycynyInfo
- Publication number
- PL3313853T3 PL3313853T3 PL16731862T PL16731862T PL3313853T3 PL 3313853 T3 PL3313853 T3 PL 3313853T3 PL 16731862 T PL16731862 T PL 16731862T PL 16731862 T PL16731862 T PL 16731862T PL 3313853 T3 PL3313853 T3 PL 3313853T3
- Authority
- PL
- Poland
- Prior art keywords
- synthesis
- rapamycin derivatives
- rapamycin
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15173283.1A EP3109250A1 (en) | 2015-06-23 | 2015-06-23 | Method for the synthesis of rapamycin derivatives |
| PCT/EP2016/064389 WO2016207205A1 (en) | 2015-06-23 | 2016-06-22 | Method for the synthesis of rapamycin derivatives |
| EP16731862.5A EP3313853B1 (en) | 2015-06-23 | 2016-06-22 | Method for the synthesis of rapamycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3313853T3 true PL3313853T3 (pl) | 2020-01-31 |
Family
ID=53488213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16731862T PL3313853T3 (pl) | 2015-06-23 | 2016-06-22 | Sposób syntezy pochodnych rapamycyny |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10308665B2 (pl) |
| EP (2) | EP3109250A1 (pl) |
| JP (1) | JP6745823B2 (pl) |
| KR (1) | KR102621941B1 (pl) |
| CN (1) | CN107735398B (pl) |
| AR (1) | AR105091A1 (pl) |
| AU (1) | AU2016282816A1 (pl) |
| ES (1) | ES2741013T3 (pl) |
| HU (1) | HUE045651T2 (pl) |
| MX (1) | MX2017017022A (pl) |
| PL (1) | PL3313853T3 (pl) |
| RU (1) | RU2718058C2 (pl) |
| SI (1) | SI3313853T1 (pl) |
| TW (1) | TWI646100B (pl) |
| UY (1) | UY36746A (pl) |
| WO (1) | WO2016207205A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102641816B1 (ko) | 2016-07-19 | 2024-02-29 | 삼성디스플레이 주식회사 | 디스플레이 장치 |
| CN109206441B (zh) * | 2017-06-30 | 2022-05-20 | 正大天晴药业集团股份有限公司 | 一种依维莫司的纯化方法 |
| UY37900A (es) | 2017-09-26 | 2019-04-30 | Novartis Ag | Nuevos derivados de rapamicina |
| CN109776571B (zh) * | 2019-01-31 | 2021-06-11 | 哈药慈航制药股份有限公司 | 一种雷帕霉素类似物及其制备方法和应用 |
| RU2716714C1 (ru) * | 2019-08-26 | 2020-03-16 | Закрытое Акционерное Общество "Биокад" | Новый способ получения эверолимуса |
| CN113735880B (zh) * | 2020-05-29 | 2023-12-22 | 鲁南制药集团股份有限公司 | 一种依维莫司的制备方法及其中间体 |
| CN115028658A (zh) * | 2022-07-06 | 2022-09-09 | 国药集团川抗制药有限公司 | 雷帕霉素硅醇酯及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| GB0601406D0 (en) * | 2006-01-24 | 2006-03-08 | Novartis Ag | Organic Compounds |
| GB0609962D0 (en) | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
| CN102127092B (zh) * | 2010-01-18 | 2013-04-17 | 东南大学 | 依维莫斯的制备 |
| ES2753529T3 (es) | 2010-11-19 | 2020-04-13 | Biocon Ltd | Procesos para la preparación de everolimús y productos intermedios del mismo |
| WO2012103960A1 (en) * | 2011-02-04 | 2012-08-09 | Synthon Bv | Process for making trisubstituted silyloxyethyl triflates |
| CN102268015B (zh) * | 2011-08-30 | 2013-08-28 | 成都摩尔生物医药有限公司 | 一种依维莫司的合成方法 |
| CN102786534A (zh) * | 2012-05-25 | 2012-11-21 | 上海现代制药股份有限公司 | 一种依维莫司的制备方法 |
| CN104854112A (zh) * | 2012-11-30 | 2015-08-19 | 杭州归创生物医药有限公司 | 雷帕霉素类似物及其制备方法 |
| BR112015029521A2 (pt) | 2013-06-20 | 2017-07-25 | Novartis Ag | alquilação com um sulfonato de alquil fluoroalquila |
| CN103848849B (zh) * | 2014-03-24 | 2016-02-24 | 上海医药工业研究院 | 依维莫司的制备工艺 |
| CN104478898A (zh) | 2014-11-18 | 2015-04-01 | 连云港恒运医药科技有限公司 | 依维莫司及其中间体的制备方法 |
-
2015
- 2015-06-23 EP EP15173283.1A patent/EP3109250A1/en not_active Withdrawn
-
2016
- 2016-06-22 RU RU2017144050A patent/RU2718058C2/ru active
- 2016-06-22 ES ES16731862T patent/ES2741013T3/es active Active
- 2016-06-22 JP JP2017566621A patent/JP6745823B2/ja active Active
- 2016-06-22 SI SI201630337T patent/SI3313853T1/sl unknown
- 2016-06-22 EP EP16731862.5A patent/EP3313853B1/en active Active
- 2016-06-22 MX MX2017017022A patent/MX2017017022A/es unknown
- 2016-06-22 KR KR1020187001488A patent/KR102621941B1/ko active IP Right Grant
- 2016-06-22 AR ARP160101863A patent/AR105091A1/es unknown
- 2016-06-22 PL PL16731862T patent/PL3313853T3/pl unknown
- 2016-06-22 AU AU2016282816A patent/AU2016282816A1/en not_active Abandoned
- 2016-06-22 WO PCT/EP2016/064389 patent/WO2016207205A1/en active Application Filing
- 2016-06-22 HU HUE16731862A patent/HUE045651T2/hu unknown
- 2016-06-22 TW TW105119625A patent/TWI646100B/zh active
- 2016-06-22 CN CN201680036479.1A patent/CN107735398B/zh active Active
- 2016-06-22 US US15/737,861 patent/US10308665B2/en active Active
- 2016-06-22 UY UY0001036746A patent/UY36746A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018518504A (ja) | 2018-07-12 |
| US20190010168A1 (en) | 2019-01-10 |
| KR102621941B1 (ko) | 2024-01-05 |
| RU2718058C2 (ru) | 2020-03-30 |
| UY36746A (es) | 2016-12-30 |
| TW201713669A (zh) | 2017-04-16 |
| US10308665B2 (en) | 2019-06-04 |
| ES2741013T3 (es) | 2020-02-07 |
| RU2017144050A3 (pl) | 2019-11-11 |
| HUE045651T2 (hu) | 2020-01-28 |
| EP3313853B1 (en) | 2019-05-08 |
| RU2017144050A (ru) | 2019-07-23 |
| CN107735398B (zh) | 2020-07-31 |
| KR20180015257A (ko) | 2018-02-12 |
| EP3109250A1 (en) | 2016-12-28 |
| JP6745823B2 (ja) | 2020-08-26 |
| EP3313853A1 (en) | 2018-05-02 |
| MX2017017022A (es) | 2018-08-15 |
| CN107735398A (zh) | 2018-02-23 |
| SI3313853T1 (sl) | 2019-10-30 |
| TWI646100B (zh) | 2019-01-01 |
| AR105091A1 (es) | 2017-09-06 |
| AU2016282816A1 (en) | 2018-01-04 |
| WO2016207205A1 (en) | 2016-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201706729SA (en) | Derivatives of sobetirome | |
| SI3687999T1 (sl) | Derivati rapamicina | |
| IL263050B (en) | History of Subtirum | |
| GB201700937D0 (en) | Synthesis method | |
| HUE045651T2 (hu) | Eljárás rapamicin-származékok szintézisére | |
| HK1252767A1 (zh) | 作為eaat3抑制劑的吡唑-吡啶衍生物 | |
| GB2564185B (en) | Process for the preparation of derivatives of benzodioxole | |
| PT3368513T (pt) | Processo para a síntese de pirfenidona | |
| HRP20181918T1 (hr) | Postupak za sintezu derivata benzazepina | |
| PL3713952T3 (pl) | Sposób syntezy pochodnych glutationu | |
| HK1256411A1 (zh) | 苯並二氮雜䓬衍生物的合成 | |
| IL262889B (en) | Process for the manufacture of 6-alkynyl-pyridine derivatives | |
| ZA201802980B (en) | Method for the selective synthesis of trialkoxysilanes | |
| EP3285875A4 (en) | PROCESS FOR SYNTHESIS OF CERAGENES | |
| IL271512B (en) | A method for the preparation of modified 4-aminoindan derivatives | |
| IL266902A (en) | Method for reduction of oxo-halogen compounds | |
| IL263091B (en) | A method for the production of heterocyclic compounds | |
| HK1208220A1 (en) | Synthesis method of 9-allylcamptothecin derivatives 9- | |
| IL253630A0 (en) | A process for the preparation of modified phenylisoxazoline derivatives | |
| PT3320102T (pt) | Processo para a síntese de pentostatina | |
| EP3288560A4 (en) | Methods for the synthesis of ceragenins | |
| GB201600050D0 (en) | lmidaclothiz pharmaceutical intermediate 2-chloro-5-methylthiazole synthesis method | |
| GB201416951D0 (en) | Method of synthesis |