GB1499822A - 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones - Google Patents

2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones

Info

Publication number
GB1499822A
GB1499822A GB8928/74A GB892874A GB1499822A GB 1499822 A GB1499822 A GB 1499822A GB 8928/74 A GB8928/74 A GB 8928/74A GB 892874 A GB892874 A GB 892874A GB 1499822 A GB1499822 A GB 1499822A
Authority
GB
United Kingdom
Prior art keywords
acyloxy
hydrocarbyl
prepared
fluoropregna
diones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8928/74A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Priority to GB8928/74A priority Critical patent/GB1499822A/en
Priority to CA219,681A priority patent/CA1064476A/en
Priority to ZA00750851A priority patent/ZA75851B/xx
Priority to FR7504616A priority patent/FR2261776B1/fr
Priority to DK61575A priority patent/DK144068C/da
Priority to YU39075A priority patent/YU39075A/xx
Priority to NZ176716A priority patent/NZ176716A/xx
Priority to AU78429/75A priority patent/AU499811B2/en
Priority to AR257732A priority patent/AR218601A1/es
Priority to CS751199A priority patent/CS197245B2/cs
Priority to IE379/75A priority patent/IE42112B1/en
Priority to AT141075A priority patent/AT359212B/de
Priority to NL7502252A priority patent/NL7502252A/xx
Priority to HU75PI448A priority patent/HU175404B/hu
Priority to DE2508136A priority patent/DE2508136C3/de
Priority to CH232575A priority patent/CH608243A5/xx
Priority to ES435067A priority patent/ES435067A1/es
Priority to LU71908A priority patent/LU71908A1/xx
Priority to NO750633A priority patent/NO144527C/no
Priority to CH1401177A priority patent/CH608244A5/fr
Priority to FI750537A priority patent/FI56188C/fi
Priority to RO7581496A priority patent/RO78881A/ro
Priority to SE7502146A priority patent/SE410736B/xx
Priority to PL19262975A priority patent/PL97346B1/pl
Priority to JP2298075A priority patent/JPS5614677B2/ja
Priority to PL1975192630A priority patent/PL101803B1/pl
Priority to PL17832675A priority patent/PL94137B1/pl
Priority to US05/553,124 priority patent/US4226862A/en
Priority to BE153787A priority patent/BE826030A/xx
Priority to BR1192/75A priority patent/BR7501192A/pt
Priority to IL46751A priority patent/IL46751A/xx
Priority to DE2533377A priority patent/DE2533377C3/de
Priority to DE2533323A priority patent/DE2533323C3/de
Priority to ES455933A priority patent/ES455933A1/es
Priority to ES455934A priority patent/ES455934A1/es
Publication of GB1499822A publication Critical patent/GB1499822A/en
Priority to US06/003,029 priority patent/US4272446A/en
Priority to DK280280A priority patent/DK280280A/da
Priority to JP55127853A priority patent/JPS5842198B2/ja
Priority to YU01083/81A priority patent/YU108381A/xx
Priority to YU01084/81A priority patent/YU108481A/xx
Priority to YU01082/81A priority patent/YU108281A/xx
Priority to JP57181239A priority patent/JPS5877898A/ja
Priority to JP57181240A priority patent/JPS5877900A/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8928/74A 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones Expired GB1499822A (en)

Priority Applications (43)

Application Number Priority Date Filing Date Title
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
CA219,681A CA1064476A (en) 1974-02-27 1975-02-10 Steroids and process for preparing the same
ZA00750851A ZA75851B (en) 1974-02-27 1975-02-11 New steroids and process for preparing the same
FR7504616A FR2261776B1 (enrdf_load_stackoverflow) 1974-02-27 1975-02-14
DK61575A DK144068C (da) 1974-02-27 1975-02-19 Analogifremgangsmaade til fremstilling af 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroxypregna-1,4-dien-3,20-dion-21-monoestere eller -17alfa,21-diestere
YU39075A YU39075A (en) 1974-02-27 1975-02-19 Process for obtaining 2-bromo-6 beta-fluoro-pregna-1,4-diene-3,20-dione-17,21-alcohols,esters or orthoesters
NZ176716A NZ176716A (en) 1974-02-27 1975-02-20 2-bromo-6b-fluoropregna-1,4-diene-3,20-diones
AU78429/75A AU499811B2 (en) 1974-02-27 1975-02-21 Substituted 2-bromo-sb-fluoro-pregna 1,4-diene 3, 2o diones
AR257732A AR218601A1 (es) 1974-02-27 1975-02-24 Un procedimiento para la preparacion de 2-bromo-6 beta-fluoro-9 alfa-fluo-11 beta,17,21-trihidroxi-pregna-1,4-dieno-3,20-diona y de sus esteres 17,21,alquilortoester 17,21 y acetales o cetales ciclicos 17,21
CS751199A CS197245B2 (en) 1974-02-27 1975-02-24 Method of producing novel 2-brom-6-beta,9alpha-difluor-pregna-1,4-diene-3,20 diones or 17,21-esters,17-21-alkylorthoesters or 17,21-cyclic acetals or ketals thereof
IE379/75A IE42112B1 (en) 1974-02-27 1975-02-24 2-bromo-6-fluoropregna-1,4-diene-3,20-diones
AT141075A AT359212B (de) 1974-02-27 1975-02-25 Verfahren zur herstellung neuer pharma- zeutisch aktiver steroide
NL7502252A NL7502252A (nl) 1974-02-27 1975-02-25 Werkwijze voor het bereiden van een geneesmid- del met anti-inflammatoire werking, gevormd ge- neesmiddel verkregen volgens deze werkwijze alsmede werkwijze voor het bereiden van in het geneesmiddel gebruikte nieuwe steroiden.
HU75PI448A HU175404B (hu) 1974-02-27 1975-02-25 Sposob poluchenija novykh proizvodnykh 2-bromo-6beta,9al'fa-diftoro-pregna-1,4-dien-3,20-diona
DE2508136A DE2508136C3 (de) 1974-02-27 1975-02-25 Neue Steroide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
CH232575A CH608243A5 (en) 1974-02-27 1975-02-25 Process for the preparation of steroids
ES435067A ES435067A1 (es) 1974-02-27 1975-02-25 Procedimiento para la preparacion de nuevos esteroides.
LU71908A LU71908A1 (enrdf_load_stackoverflow) 1974-02-27 1975-02-25
NO750633A NO144527C (no) 1974-02-27 1975-02-25 Analogifremg.m. ved fremst. av anti-inflammatorisk virksomme estere av 2-brom-6beta,9alfa-difluor-11beta,16alfa,17alfa,21-tetrahydroksypregna- eller 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroksypregna-1,4-dien-3,20-dioner
CH1401177A CH608244A5 (en) 1974-02-27 1975-02-25 Process for the preparation of steroids
FI750537A FI56188C (fi) 1974-02-27 1975-02-25 Foerfarande foer framstaellning av 2-brom-6beta 9alfa-difluor-11beta-hydroxipregna-1,4-dien-3,20-dionderivat med antiinflammatorisk verkan
RO7581496A RO78881A (ro) 1974-02-27 1975-02-26 Procedeu de preparare a unor derivati de pregnan
SE7502146A SE410736B (sv) 1974-02-27 1975-02-26 Forfarande for framstellning av 2-brom-6beta-fluor-pregna-1,4-dien-3,20-dioner
PL19262975A PL97346B1 (pl) 1974-02-27 1975-02-26 Sposob wytwarzania 2-bromo-6 beta-fluoropregnadien-1,4-dionow-3,20
JP2298075A JPS5614677B2 (enrdf_load_stackoverflow) 1974-02-27 1975-02-26
PL1975192630A PL101803B1 (pl) 1974-02-27 1975-02-26 A process of producing new 2-bromo-6-beta-fluoropregnadiene-1,4-diones-3,20
PL17832675A PL94137B1 (enrdf_load_stackoverflow) 1974-02-27 1975-02-26
US05/553,124 US4226862A (en) 1974-02-27 1975-02-26 Steroids and process for preparing the same
BE153787A BE826030A (fr) 1974-02-27 1975-02-26 Nouveaux steroides et procedes pour les preparer
BR1192/75A BR7501192A (pt) 1974-02-27 1975-02-28 Esteroides e processo para preparacao dos mesmos
IL46751A IL46751A (en) 1974-02-27 1975-03-05 2-bromo-6-9difluoro-11-hydroxy-pregna-1,4-diene-3,20-diones and process for their preparation
DE2533323A DE2533323C3 (de) 1974-02-27 1975-07-25 Neue Steroide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
DE2533377A DE2533377C3 (de) 1974-02-27 1975-07-25 Neue Steroide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
ES455933A ES455933A1 (es) 1974-02-27 1977-02-15 Procedimiento para la preparacion de nuevos esteroides.
ES455934A ES455934A1 (es) 1974-02-27 1977-02-15 Procedimiento para la preparacion de nuevos esteroides.
US06/003,029 US4272446A (en) 1974-02-27 1979-01-12 Steroids and process for preparing the same
DK280280A DK280280A (da) 1974-02-27 1980-06-27 Analogifremgangsmaade til fremstilling af 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroxypregna-1,4-dien-3,20-dion-17-monoestere
JP55127853A JPS5842198B2 (ja) 1974-02-27 1980-09-13 ２−ブロム−６β，９α−ジフルオル−１１β，１７，２１−トリオキシ−１，４−プレグナジエン−３，２０−ジオン−１７，２１−アセトニドの製造方法
YU01083/81A YU108381A (en) 1974-02-27 1981-04-27 Process for obtaining 2-bromo-6-fluoro-pregna-1,4-diene-3,20-dione-21-estra-17,21-cyclic ketals and acetals
YU01082/81A YU108281A (en) 1974-02-27 1981-04-27 Process for obtaining 2-bromo-6 beta-fluoro-pregna-1,4-diene3,20-dione-21-estra-16,17-alcohols or esters
YU01084/81A YU108481A (en) 1974-02-27 1981-04-27 Process for obtaning 2-bromo-6 beta-fluoro-pregna-1,4-diene-3,20-dione-21-estra-16,17-cyclic ketals and acetals
JP57181239A JPS5877898A (ja) 1974-02-27 1982-10-15 ２−ブロム−６β−フルオル−１，４−プレグナジエン−３，２０−ジオン類の製造方法
JP57181240A JPS5877900A (ja) 1974-02-27 1982-10-15 ２−ブロム−６β−フルオル−１，４−プレグナジエン−３，２０−ジオン類の製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
GB2998474 1974-07-05
GB3294574 1974-07-25
GB4998274 1974-11-19

Publications (1)

Publication Number Publication Date
GB1499822A true GB1499822A (en) 1978-02-01

Family

ID=27447687

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8928/74A Expired GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones

Country Status (18)

Country Link
JP (1) JPS5614677B2 (enrdf_load_stackoverflow)
AR (1) AR218601A1 (enrdf_load_stackoverflow)
BE (1) BE826030A (enrdf_load_stackoverflow)
CA (1) CA1064476A (enrdf_load_stackoverflow)
CH (1) CH608243A5 (enrdf_load_stackoverflow)
DE (3) DE2508136C3 (enrdf_load_stackoverflow)
DK (1) DK144068C (enrdf_load_stackoverflow)
ES (3) ES435067A1 (enrdf_load_stackoverflow)
FI (1) FI56188C (enrdf_load_stackoverflow)
FR (1) FR2261776B1 (enrdf_load_stackoverflow)
GB (1) GB1499822A (enrdf_load_stackoverflow)
IE (1) IE42112B1 (enrdf_load_stackoverflow)
LU (1) LU71908A1 (enrdf_load_stackoverflow)
NO (1) NO144527C (enrdf_load_stackoverflow)
NZ (1) NZ176716A (enrdf_load_stackoverflow)
RO (1) RO78881A (enrdf_load_stackoverflow)
SE (1) SE410736B (enrdf_load_stackoverflow)
YU (3) YU108381A (enrdf_load_stackoverflow)

Also Published As

Publication number Publication date
DK61575A (enrdf_load_stackoverflow) 1975-10-27
NO750633L (enrdf_load_stackoverflow) 1975-08-28
DE2533323C3 (de) 1979-07-12
FR2261776B1 (enrdf_load_stackoverflow) 1978-07-21
ES455933A1 (es) 1978-05-01
FI56188C (fi) 1979-12-10
DE2508136C3 (de) 1979-06-21
DE2533377C3 (de) 1979-08-02
FR2261776A1 (enrdf_load_stackoverflow) 1975-09-19
IE42112L (en) 1975-08-27
NO144527B (no) 1981-06-09
NZ176716A (en) 1978-07-10
SE7502146L (enrdf_load_stackoverflow) 1975-08-28
AR218601A1 (es) 1980-06-30
SE410736B (sv) 1979-10-29
RO78881A (ro) 1982-07-06
DK144068C (da) 1982-05-03
JPS50126652A (enrdf_load_stackoverflow) 1975-10-04
JPS5614677B2 (enrdf_load_stackoverflow) 1981-04-06
YU108381A (en) 1982-02-28
FI56188B (fi) 1979-08-31
DE2533323A1 (de) 1976-02-12
DE2533377B2 (de) 1978-11-16
ES455934A1 (es) 1978-05-01
DE2533323B2 (de) 1978-11-16
BE826030A (fr) 1975-06-16
NO144527C (no) 1981-09-23
ES435067A1 (es) 1977-07-01
DK144068B (da) 1981-11-30
DE2533377A1 (de) 1976-02-05
DE2508136B2 (de) 1978-11-02
YU108281A (en) 1982-02-28
IE42112B1 (en) 1980-06-04
LU71908A1 (enrdf_load_stackoverflow) 1975-06-24
DE2508136A1 (de) 1975-10-30
CA1064476A (en) 1979-10-16
CH608243A5 (en) 1978-12-29
YU108481A (en) 1982-02-28
FI750537A7 (enrdf_load_stackoverflow) 1975-08-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
48S Specification amended (sect. 8/1949)
SP Amendment (slips) printed
PCNP Patent ceased through non-payment of renewal fee