GB1286659A - 6,9,21-trihalogenosteroids - Google Patents
6,9,21-trihalogenosteroidsInfo
- Publication number
- GB1286659A GB1286659A GB48004/69A GB4800469A GB1286659A GB 1286659 A GB1286659 A GB 1286659A GB 48004/69 A GB48004/69 A GB 48004/69A GB 4800469 A GB4800469 A GB 4800469A GB 1286659 A GB1286659 A GB 1286659A
- Authority
- GB
- United Kingdom
- Prior art keywords
- converting
- prepared
- formula
- fluoro
- trihalogenosteroids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1286659 6,9,21-Trihalogenosteroids SCHER - ING AG 30 Sept 1969 [2 Oct 1968] 48004/69 Heading C2U Novel steroids of the formula (where X is F, Cl or Br and Y is Cl or F) are prepared by adding HOCl or HOBr to the corresponding 9,11 - unsubstituted - 9(11) - dehydrosteroids and, when the 9α-fluoro compounds are required, converting the products to 9,11)1- epoxides and splitting these with HF. Starting materials of the formula are prepared from 6α -fluoro - 21 - hydroxy - 16α- methyl - #<SP>1,4</SP>'<SP>9(11)</SP> - pregnatriene - 3,20 - dione (prepared by hydrolysis of the corresponding 21-acetoxy compound) by converting this to the 21-mesylate and then reacting this with KHF 2 or LiCl or by converting it directly to the 21- chloro compound using SOCl 2 in pyridine. The novel steroids are anti-inflammatory agents with slight diuretic activity and they may be made up into pharmaceutical compositions with suitable carriers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681801390 DE1801390C3 (en) | 1968-10-02 | 6,9,21-trihalo steroids, processes for their preparation, medicaments containing them and 6,21-dihalo intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1286659A true GB1286659A (en) | 1972-08-23 |
Family
ID=5709719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB48004/69A Expired GB1286659A (en) | 1968-10-02 | 1969-09-30 | 6,9,21-trihalogenosteroids |
Country Status (16)
| Country | Link |
|---|---|
| AT (1) | AT290033B (en) |
| BE (1) | BE739736A (en) |
| BR (1) | BR6912959D0 (en) |
| CH (1) | CH540891A (en) |
| CS (1) | CS150285B2 (en) |
| DK (1) | DK121053B (en) |
| ES (1) | ES372061A1 (en) |
| FI (1) | FI46505C (en) |
| FR (1) | FR2019676A1 (en) |
| GB (1) | GB1286659A (en) |
| IE (1) | IE33329B1 (en) |
| IL (1) | IL33017A (en) |
| NL (1) | NL167439C (en) |
| NO (1) | NO130824C (en) |
| RO (1) | RO54664A (en) |
| SE (1) | SE352082B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2010458B2 (en) * | 1970-02-28 | 1979-04-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | New 21-Halogen Steroids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3499016A (en) * | 1958-08-04 | 1970-03-03 | Upjohn Co | 6alpha-fluoro-16alpha-methyl derivatives of the pregnane series |
-
1969
- 1969-09-15 RO RO61035A patent/RO54664A/ro unknown
- 1969-09-17 IL IL33017A patent/IL33017A/en unknown
- 1969-09-22 CH CH1427369A patent/CH540891A/en not_active IP Right Cessation
- 1969-09-30 GB GB48004/69A patent/GB1286659A/en not_active Expired
- 1969-09-30 ES ES372061A patent/ES372061A1/en not_active Expired
- 1969-09-30 IE IE1363/69A patent/IE33329B1/en unknown
- 1969-10-01 DK DK523169AA patent/DK121053B/en not_active IP Right Cessation
- 1969-10-01 CS CS6578A patent/CS150285B2/cs unknown
- 1969-10-01 AT AT928069A patent/AT290033B/en not_active IP Right Cessation
- 1969-10-01 NO NO3902/69A patent/NO130824C/no unknown
- 1969-10-01 FR FR6933482A patent/FR2019676A1/fr not_active Withdrawn
- 1969-10-01 SE SE13534/69A patent/SE352082B/xx unknown
- 1969-10-02 NL NL6914942.A patent/NL167439C/en not_active IP Right Cessation
- 1969-10-02 BE BE739736D patent/BE739736A/xx unknown
- 1969-10-02 BR BR212959/69A patent/BR6912959D0/en unknown
- 1969-10-02 FI FI692843A patent/FI46505C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| FI46505B (en) | 1973-01-02 |
| NO130824C (en) | 1975-02-19 |
| DE1801390A1 (en) | 1970-05-21 |
| IE33329L (en) | 1970-04-02 |
| CH540891A (en) | 1973-08-31 |
| CS150285B2 (en) | 1973-09-04 |
| IL33017A (en) | 1974-01-14 |
| DE1801390B2 (en) | 1977-02-17 |
| FR2019676A1 (en) | 1970-07-03 |
| AT290033B (en) | 1971-05-10 |
| NL167439B (en) | 1981-07-16 |
| NO130824B (en) | 1974-11-11 |
| RO54664A (en) | 1973-03-15 |
| IL33017A0 (en) | 1969-11-30 |
| NL167439C (en) | 1981-12-16 |
| DK121053B (en) | 1971-08-30 |
| IE33329B1 (en) | 1974-05-29 |
| BR6912959D0 (en) | 1973-02-08 |
| NL6914942A (en) | 1970-04-06 |
| ES372061A1 (en) | 1971-09-01 |
| BE739736A (en) | 1970-04-02 |
| FI46505C (en) | 1973-04-10 |
| SE352082B (en) | 1972-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |