IE33329B1 - 6,9,21-trihalogenosteroids - Google Patents
6,9,21-trihalogenosteroidsInfo
- Publication number
- IE33329B1 IE33329B1 IE1363/69A IE136369A IE33329B1 IE 33329 B1 IE33329 B1 IE 33329B1 IE 1363/69 A IE1363/69 A IE 1363/69A IE 136369 A IE136369 A IE 136369A IE 33329 B1 IE33329 B1 IE 33329B1
- Authority
- IE
- Ireland
- Prior art keywords
- converting
- prepared
- formula
- fluoro
- trihalogenosteroids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1286659 6,9,21-Trihalogenosteroids SCHER - ING AG 30 Sept 1969 [2 Oct 1968] 48004/69 Heading C2U Novel steroids of the formula (where X is F, Cl or Br and Y is Cl or F) are prepared by adding HOCl or HOBr to the corresponding 9,11 - unsubstituted - 9(11) - dehydrosteroids and, when the 9α-fluoro compounds are required, converting the products to 9,11)1- epoxides and splitting these with HF. Starting materials of the formula are prepared from 6α -fluoro - 21 - hydroxy - 16α- methyl - #<SP>1,4</SP>'<SP>9(11)</SP> - pregnatriene - 3,20 - dione (prepared by hydrolysis of the corresponding 21-acetoxy compound) by converting this to the 21-mesylate and then reacting this with KHF 2 or LiCl or by converting it directly to the 21- chloro compound using SOCl 2 in pyridine. The novel steroids are anti-inflammatory agents with slight diuretic activity and they may be made up into pharmaceutical compositions with suitable carriers.
[GB1286659A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681801390 DE1801390C3 (en) | 1968-10-02 | 6,9,21-trihalo steroids, processes for their preparation, medicaments containing them and 6,21-dihalo intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33329L IE33329L (en) | 1970-04-02 |
| IE33329B1 true IE33329B1 (en) | 1974-05-29 |
Family
ID=5709719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1363/69A IE33329B1 (en) | 1968-10-02 | 1969-09-30 | 6,9,21-trihalogenosteroids |
Country Status (16)
| Country | Link |
|---|---|
| AT (1) | AT290033B (en) |
| BE (1) | BE739736A (en) |
| BR (1) | BR6912959D0 (en) |
| CH (1) | CH540891A (en) |
| CS (1) | CS150285B2 (en) |
| DK (1) | DK121053B (en) |
| ES (1) | ES372061A1 (en) |
| FI (1) | FI46505C (en) |
| FR (1) | FR2019676A1 (en) |
| GB (1) | GB1286659A (en) |
| IE (1) | IE33329B1 (en) |
| IL (1) | IL33017A (en) |
| NL (1) | NL167439C (en) |
| NO (1) | NO130824C (en) |
| RO (1) | RO54664A (en) |
| SE (1) | SE352082B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2010458B2 (en) * | 1970-02-28 | 1979-04-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | New 21-Halogen Steroids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3499016A (en) * | 1958-08-04 | 1970-03-03 | Upjohn Co | 6alpha-fluoro-16alpha-methyl derivatives of the pregnane series |
-
1969
- 1969-09-15 RO RO61035A patent/RO54664A/ro unknown
- 1969-09-17 IL IL33017A patent/IL33017A/en unknown
- 1969-09-22 CH CH1427369A patent/CH540891A/en not_active IP Right Cessation
- 1969-09-30 ES ES372061A patent/ES372061A1/en not_active Expired
- 1969-09-30 IE IE1363/69A patent/IE33329B1/en unknown
- 1969-09-30 GB GB48004/69A patent/GB1286659A/en not_active Expired
- 1969-10-01 SE SE13534/69A patent/SE352082B/xx unknown
- 1969-10-01 FR FR6933482A patent/FR2019676A1/fr not_active Withdrawn
- 1969-10-01 DK DK523169AA patent/DK121053B/en not_active IP Right Cessation
- 1969-10-01 CS CS6578A patent/CS150285B2/cs unknown
- 1969-10-01 AT AT928069A patent/AT290033B/en not_active IP Right Cessation
- 1969-10-01 NO NO3902/69A patent/NO130824C/no unknown
- 1969-10-02 BE BE739736D patent/BE739736A/xx unknown
- 1969-10-02 FI FI692843A patent/FI46505C/en active
- 1969-10-02 BR BR212959/69A patent/BR6912959D0/en unknown
- 1969-10-02 NL NL6914942.A patent/NL167439C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CS150285B2 (en) | 1973-09-04 |
| FI46505C (en) | 1973-04-10 |
| IL33017A0 (en) | 1969-11-30 |
| AT290033B (en) | 1971-05-10 |
| NO130824C (en) | 1975-02-19 |
| DE1801390A1 (en) | 1970-05-21 |
| NL167439B (en) | 1981-07-16 |
| NO130824B (en) | 1974-11-11 |
| CH540891A (en) | 1973-08-31 |
| IE33329L (en) | 1970-04-02 |
| DK121053B (en) | 1971-08-30 |
| NL6914942A (en) | 1970-04-06 |
| RO54664A (en) | 1973-03-15 |
| GB1286659A (en) | 1972-08-23 |
| FR2019676A1 (en) | 1970-07-03 |
| IL33017A (en) | 1974-01-14 |
| FI46505B (en) | 1973-01-02 |
| BR6912959D0 (en) | 1973-02-08 |
| BE739736A (en) | 1970-04-02 |
| DE1801390B2 (en) | 1977-02-17 |
| ES372061A1 (en) | 1971-09-01 |
| SE352082B (en) | 1972-12-18 |
| NL167439C (en) | 1981-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL190871C (en) | Process for the preparation of 21-hydroxypregna-4,16-diene-3,20-dione derivatives and intermediates to be used therewith. | |
| IE33329B1 (en) | 6,9,21-trihalogenosteroids | |
| GB1440064A (en) | Delta8-9- steroids of the pregnane series | |
| ES308634A1 (en) | 17-acylates of 9alpha-fluoro-11beta, 17alpha-dihydroxy-16-methyl-1, 4-pregnadiene-3, 20-dione and corresponding-11-keto steroids and pharmaceutical compositions thereof | |
| GB1317185A (en) | Acyloxy-3alpha-hydroxy-pregnones | |
| IE35822L (en) | 6ó, 16ó-dimethylsteroids. | |
| GB1215164A (en) | 21-sulphonated pregnadienes | |
| GB1202001A (en) | 6alpha,9alpha-DIFLUOROPREDNISOLONE 17,21-DIESTERS | |
| GB1289020A (en) | ||
| GB1308673A (en) | 21-halogeno-steroids | |
| ES366737A1 (en) | Unsaturated pregna-3 20-dione-(17alph a16alpha-d)-oxazalines | |
| GB1213118A (en) | PROCESS FOR PREPARING 9alpha-FLUORO-16-METHYLENE-PREDNISOLONE OR PREDNISONE, AND 21-ESTERS THEREOF | |
| GB1174359A (en) | 6,16-Dimethyl-21-Halo-Steriods of the Pregnane Series. | |
| IE34403L (en) | Halohydrins | |
| GB1309121A (en) | Process for the manufacture of 5-bromo-6-fluoro-steroids | |
| GB1180176A (en) | Novel Steroid 21-Esters, their Preparation, and Compositions containing them | |
| AU222534B2 (en) | Improvements in or relating to metal sheathed building constructions and methods of erecting same | |
| IE42112L (en) | 2-BROMO-6ß-FLUOROPREGNA-1,4-DIENE-3,20-DIONES | |
| GR930100234A (en) | Novel steroids with pregnane skeleton pharmaceutical compositions containing them and process for preparing same | |
| AU253561A (en) | 3, 20-diketals of 17- hydroxy-16 -methyl-pregn 5-ene-3, 20-dione, their preparation and conversion to other steriods | |
| IE35208L (en) | 21-halogeneo-steroids. | |
| CA794416A (en) | Building compositions of cement, polymer and gluconic acid | |
| AU3011357A (en) | Improvements in or relating to metal sheathed building constructions and methods of erecting same | |
| AU256920B2 (en) | Improvements relating to joining prefabricated roof panels and roofs formed thereby | |
| CA608394A (en) | Acid proof concrete and structures made therefrom |