IE33329L - 6, 9, 21-trihalogenosteroids - Google Patents

6, 9, 21-trihalogenosteroids

Info

Publication number
IE33329L
IE33329L IE691363A IE136369A IE33329L IE 33329 L IE33329 L IE 33329L IE 691363 A IE691363 A IE 691363A IE 136369 A IE136369 A IE 136369A IE 33329 L IE33329 L IE 33329L
Authority
IE
Ireland
Prior art keywords
converting
prepared
formula
fluoro
trihalogenosteroids
Prior art date
Application number
IE691363A
Other versions
IE33329B1 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19681801390 external-priority patent/DE1801390C3/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of IE33329L publication Critical patent/IE33329L/en
Publication of IE33329B1 publication Critical patent/IE33329B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1286659 6,9,21-Trihalogenosteroids SCHER - ING AG 30 Sept 1969 [2 Oct 1968] 48004/69 Heading C2U Novel steroids of the formula (where X is F, Cl or Br and Y is Cl or F) are prepared by adding HOCl or HOBr to the corresponding 9,11 - unsubstituted - 9(11) - dehydrosteroids and, when the 9α-fluoro compounds are required, converting the products to 9,11)1- epoxides and splitting these with HF. Starting materials of the formula are prepared from 6α -fluoro - 21 - hydroxy - 16α- methyl - #<SP>1,4</SP>'<SP>9(11)</SP> - pregnatriene - 3,20 - dione (prepared by hydrolysis of the corresponding 21-acetoxy compound) by converting this to the 21-mesylate and then reacting this with KHF 2 or LiCl or by converting it directly to the 21- chloro compound using SOCl 2 in pyridine. The novel steroids are anti-inflammatory agents with slight diuretic activity and they may be made up into pharmaceutical compositions with suitable carriers. [GB1286659A]
IE1363/69A 1968-10-02 1969-09-30 6,9,21-trihalogenosteroids IE33329B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19681801390 DE1801390C3 (en) 1968-10-02 6,9,21-trihalo steroids, processes for their preparation, medicaments containing them and 6,21-dihalo intermediates

Publications (2)

Publication Number Publication Date
IE33329L true IE33329L (en) 1970-04-02
IE33329B1 IE33329B1 (en) 1974-05-29

Family

ID=5709719

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1363/69A IE33329B1 (en) 1968-10-02 1969-09-30 6,9,21-trihalogenosteroids

Country Status (16)

Country Link
AT (1) AT290033B (en)
BE (1) BE739736A (en)
BR (1) BR6912959D0 (en)
CH (1) CH540891A (en)
CS (1) CS150285B2 (en)
DK (1) DK121053B (en)
ES (1) ES372061A1 (en)
FI (1) FI46505C (en)
FR (1) FR2019676A1 (en)
GB (1) GB1286659A (en)
IE (1) IE33329B1 (en)
IL (1) IL33017A (en)
NL (1) NL167439C (en)
NO (1) NO130824C (en)
RO (1) RO54664A (en)
SE (1) SE352082B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2010458B2 (en) * 1970-02-28 1979-04-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen New 21-Halogen Steroids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499016A (en) * 1958-08-04 1970-03-03 Upjohn Co 6alpha-fluoro-16alpha-methyl derivatives of the pregnane series

Also Published As

Publication number Publication date
FI46505C (en) 1973-04-10
IL33017A (en) 1974-01-14
FR2019676A1 (en) 1970-07-03
NL6914942A (en) 1970-04-06
DE1801390B2 (en) 1977-02-17
DK121053B (en) 1971-08-30
AT290033B (en) 1971-05-10
RO54664A (en) 1973-03-15
NL167439B (en) 1981-07-16
NO130824B (en) 1974-11-11
CS150285B2 (en) 1973-09-04
IL33017A0 (en) 1969-11-30
BR6912959D0 (en) 1973-02-08
ES372061A1 (en) 1971-09-01
FI46505B (en) 1973-01-02
CH540891A (en) 1973-08-31
GB1286659A (en) 1972-08-23
NL167439C (en) 1981-12-16
SE352082B (en) 1972-12-18
IE33329B1 (en) 1974-05-29
NO130824C (en) 1975-02-19
DE1801390A1 (en) 1970-05-21
BE739736A (en) 1970-04-02

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