GB1269291A - Improvements in or relating to corticoid carbonates - Google Patents

Improvements in or relating to corticoid carbonates

Info

Publication number
GB1269291A
GB1269291A GB1644470A GB1644470A GB1269291A GB 1269291 A GB1269291 A GB 1269291A GB 1644470 A GB1644470 A GB 1644470A GB 1644470 A GB1644470 A GB 1644470A GB 1269291 A GB1269291 A GB 1269291A
Authority
GB
United Kingdom
Prior art keywords
cycloalkyl
optionally substituted
monocyclic
lower alkyl
carbonates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1644470A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of GB1269291A publication Critical patent/GB1269291A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

1,269,291. Steroid 21-carbonates. SYNTEX CORP. 7 April, 1970 [18 April, 1969], No. 16444/70. Heading C2U. Novel steroids of the formula where R<SP>1</SP> is F or Cl, R<SP>2</SP> is H, F or Cl, R<SP>3</SP> is OH or, when R<SP>2</SP> is Cl, R<SP>3</SP> can be Cl, R<SP>4</SP> is lower alkyl, C 3-10 cycloalkyl (including cycloalkyl-alkyl) or C 7-10 phenylalkyl optionally substituted, Z<SP>1</SP> is a single or double bond, and P and Q are each H, lower alkyl optionally halogenated, monocyclic C 3-10 cycloalkyl (including cycloalkyl-alkyl), monocyclic aryl optionally substituted, C 7-10 phenylalkyl optionally substituted, or monocyclic heterocyclic or heterocyclic lower alkyl optionally substituted, or >CPQ is cycloalkyl or monocyclic heterocyclic, " lower " referring to groups containing at most 6 carbon atoms, are prepared from the free 21-ols and chloroformates Cl.COOR<SP>4</SP>. The novel steroids are stated to possess anti-inflammatory, glycogenic, thymolytic, anti-estrogenic and anti-androgenic activity, and they may be made up into pharmaceutical compositions with suitable carriers.
GB1644470A 1969-04-18 1970-04-07 Improvements in or relating to corticoid carbonates Expired GB1269291A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81756469A 1969-04-18 1969-04-18

Publications (1)

Publication Number Publication Date
GB1269291A true GB1269291A (en) 1972-04-06

Family

ID=25223364

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1644470A Expired GB1269291A (en) 1969-04-18 1970-04-07 Improvements in or relating to corticoid carbonates

Country Status (5)

Country Link
CA (1) CA929933A (en)
CH (1) CH536299A (en)
FR (1) FR2042348B1 (en)
GB (1) GB1269291A (en)
NL (1) NL7005605A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070745A2 (en) * 2002-02-20 2003-08-28 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids
WO2004033478A2 (en) * 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
WO2004047845A1 (en) * 2002-11-21 2004-06-10 Sepracor Inc. CARBONATE AND CARBAMATE MODIFIED FORMS OF GLUCOCORTICOIDS IN COMBINATION WITH β2 ADRENERGIC AGONISTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3056727A (en) * 1960-10-27 1962-10-02 Roussel Uclaf Cyclohexylcarbonates of steroids

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070745A2 (en) * 2002-02-20 2003-08-28 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids
WO2003070745A3 (en) * 2002-02-20 2003-11-20 Sepracor Inc Carbonate and carbamate modified forms of glucocorticoids
US7018995B2 (en) 2002-02-20 2006-03-28 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids
US7253156B2 (en) 2002-02-20 2007-08-07 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists
US7468362B2 (en) 2002-02-20 2008-12-23 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with β2 adrenergic agonists
US8445470B2 (en) 2002-02-20 2013-05-21 Sunovion Pharmaceuticals Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists
US8710036B2 (en) 2002-02-20 2014-04-29 Sunovion Pharmaceuticals Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with β2 adrenergic agonists
WO2004033478A2 (en) * 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
WO2004033478A3 (en) * 2002-10-08 2004-09-30 Sepracor Inc Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
US7390796B2 (en) 2002-10-08 2008-06-24 Sepracor Inc. Fatty acid modified forms of glucocorticoids
WO2004047845A1 (en) * 2002-11-21 2004-06-10 Sepracor Inc. CARBONATE AND CARBAMATE MODIFIED FORMS OF GLUCOCORTICOIDS IN COMBINATION WITH β2 ADRENERGIC AGONISTS

Also Published As

Publication number Publication date
FR2042348A1 (en) 1971-02-12
DE2017533B2 (en) 1975-11-06
CA929933A (en) 1973-07-10
NL7005605A (en) 1970-10-20
FR2042348B1 (en) 1974-08-30
CH536299A (en) 1973-04-30
DE2017533A1 (en) 1970-12-10

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