JPS577499A - Improved preparation of steroid 17-ester - Google Patents

Improved preparation of steroid 17-ester

Info

Publication number
JPS577499A
JPS577499A JP7980180A JP7980180A JPS577499A JP S577499 A JPS577499 A JP S577499A JP 7980180 A JP7980180 A JP 7980180A JP 7980180 A JP7980180 A JP 7980180A JP S577499 A JPS577499 A JP S577499A
Authority
JP
Japan
Prior art keywords
steroid
ester
keto
dihydroxy
improved preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7980180A
Other languages
Japanese (ja)
Other versions
JPS6247199B2 (en
Inventor
Kazumasa Nitta
Toshio Haruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP7980180A priority Critical patent/JPS577499A/en
Publication of JPS577499A publication Critical patent/JPS577499A/en
Publication of JPS6247199B2 publication Critical patent/JPS6247199B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Steroid Compounds (AREA)

Abstract

PURPOSE: To obtain a 17-ester useful as an anti-inflammatory agent in high yield, by hydrolyzing a 17α,21-cyclic orthoester of 17α-,21-dihydroxy-20-keto-steroid under specific conditions.
CONSTITUTION: A 17α,21-cyclic orthoester of a 17α,21-dihydroxy-20-keto-steroid having the 17-position and a side chain thereof in the D ring expressed by the partial structural formula (R is 1W10C alkyl, aralkyl, cycloalkyl or aryl; R' is 1W4C lower alkyl) is hydrolyzed in the presence of a Lewis acid, e.g. aluminum chloride, in an aqueous alcoholic medium to prepare 17-monoester of 17α,21-dihydroxy-20- keto-steroid. The formation of the 21-ester and the 17α,21-diol as by-products is very slight.
COPYRIGHT: (C)1982,JPO&Japio
JP7980180A 1980-06-13 1980-06-13 Improved preparation of steroid 17-ester Granted JPS577499A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7980180A JPS577499A (en) 1980-06-13 1980-06-13 Improved preparation of steroid 17-ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7980180A JPS577499A (en) 1980-06-13 1980-06-13 Improved preparation of steroid 17-ester

Publications (2)

Publication Number Publication Date
JPS577499A true JPS577499A (en) 1982-01-14
JPS6247199B2 JPS6247199B2 (en) 1987-10-06

Family

ID=13700313

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7980180A Granted JPS577499A (en) 1980-06-13 1980-06-13 Improved preparation of steroid 17-ester

Country Status (1)

Country Link
JP (1) JPS577499A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63164296U (en) * 1987-04-15 1988-10-26
JP7095856B2 (en) 2017-07-04 2022-07-05 株式会社トンボ鉛筆 Coating film transfer tool

Also Published As

Publication number Publication date
JPS6247199B2 (en) 1987-10-06

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