JPS5549398A - Preparation of estrone - Google Patents

Preparation of estrone

Info

Publication number
JPS5549398A
JPS5549398A JP12179278A JP12179278A JPS5549398A JP S5549398 A JPS5549398 A JP S5549398A JP 12179278 A JP12179278 A JP 12179278A JP 12179278 A JP12179278 A JP 12179278A JP S5549398 A JPS5549398 A JP S5549398A
Authority
JP
Japan
Prior art keywords
estrone
sodium
androsta
acetal
diene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12179278A
Other languages
Japanese (ja)
Other versions
JPS6111237B2 (en
Inventor
Yoshimi Morita
Tadashi Shirasaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP12179278A priority Critical patent/JPS5549398A/en
Publication of JPS5549398A publication Critical patent/JPS5549398A/en
Publication of JPS6111237B2 publication Critical patent/JPS6111237B2/ja
Granted legal-status Critical Current

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  • Steroid Compounds (AREA)

Abstract

PURPOSE: To prepare estrone which is a female hormone, in high yield, by reacting an androsta-1,4-diene-3,17-acetal in the presence of a specific sodium alcoholate.
CONSTITUTION: Estrone is prepared by reacting (A) an androsta-1,4-diene-3,17- dione-17-acetal of formula I (R is 1W6C lower alkyl) or II (R1 is 2W6C lower alkylene), with (B) a reaction mixture prepared from metallic sodium and a polycyclic aromatic compound (e.g. α-methylnaphthalene) which acts as a radical anion precursor, in (C) an ether slovent, in the presence of (D) sodium alcoholate of polyethylene glycol monoehter. The reaction can be carried out using a low-cost sodium metal, in high yield.
COPYRIGHT: (C)1980,JPO&Japio
JP12179278A 1978-10-03 1978-10-03 Preparation of estrone Granted JPS5549398A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12179278A JPS5549398A (en) 1978-10-03 1978-10-03 Preparation of estrone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12179278A JPS5549398A (en) 1978-10-03 1978-10-03 Preparation of estrone

Publications (2)

Publication Number Publication Date
JPS5549398A true JPS5549398A (en) 1980-04-09
JPS6111237B2 JPS6111237B2 (en) 1986-04-01

Family

ID=14820007

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12179278A Granted JPS5549398A (en) 1978-10-03 1978-10-03 Preparation of estrone

Country Status (1)

Country Link
JP (1) JPS5549398A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984003094A1 (en) * 1983-02-02 1984-08-16 Mitsubishi Chem Ind Process for preparing estrone acetal
JPS6050498U (en) * 1983-09-14 1985-04-09 不二交易株式会社 Flash discharge light emitter with lithium battery inside
CN105001293A (en) * 2015-06-10 2015-10-28 浙江仙居君业药业有限公司 Preparation method of estrone

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984003094A1 (en) * 1983-02-02 1984-08-16 Mitsubishi Chem Ind Process for preparing estrone acetal
US4622181A (en) * 1983-02-02 1986-11-11 Mitsubishi Chemical Industries Ltd. Process for producing an estrone acetal
DE3490045C2 (en) * 1983-02-02 1992-10-01 Mitsubishi Kasei Corp., Tokio/Tokyo, Jp
JPS6050498U (en) * 1983-09-14 1985-04-09 不二交易株式会社 Flash discharge light emitter with lithium battery inside
CN105001293A (en) * 2015-06-10 2015-10-28 浙江仙居君业药业有限公司 Preparation method of estrone

Also Published As

Publication number Publication date
JPS6111237B2 (en) 1986-04-01

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