JPS5549398A - Preparation of estrone - Google Patents
Preparation of estroneInfo
- Publication number
- JPS5549398A JPS5549398A JP12179278A JP12179278A JPS5549398A JP S5549398 A JPS5549398 A JP S5549398A JP 12179278 A JP12179278 A JP 12179278A JP 12179278 A JP12179278 A JP 12179278A JP S5549398 A JPS5549398 A JP S5549398A
- Authority
- JP
- Japan
- Prior art keywords
- estrone
- sodium
- androsta
- acetal
- diene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: To prepare estrone which is a female hormone, in high yield, by reacting an androsta-1,4-diene-3,17-acetal in the presence of a specific sodium alcoholate.
CONSTITUTION: Estrone is prepared by reacting (A) an androsta-1,4-diene-3,17- dione-17-acetal of formula I (R is 1W6C lower alkyl) or II (R1 is 2W6C lower alkylene), with (B) a reaction mixture prepared from metallic sodium and a polycyclic aromatic compound (e.g. α-methylnaphthalene) which acts as a radical anion precursor, in (C) an ether slovent, in the presence of (D) sodium alcoholate of polyethylene glycol monoehter. The reaction can be carried out using a low-cost sodium metal, in high yield.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12179278A JPS5549398A (en) | 1978-10-03 | 1978-10-03 | Preparation of estrone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12179278A JPS5549398A (en) | 1978-10-03 | 1978-10-03 | Preparation of estrone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5549398A true JPS5549398A (en) | 1980-04-09 |
JPS6111237B2 JPS6111237B2 (en) | 1986-04-01 |
Family
ID=14820007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12179278A Granted JPS5549398A (en) | 1978-10-03 | 1978-10-03 | Preparation of estrone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5549398A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984003094A1 (en) * | 1983-02-02 | 1984-08-16 | Mitsubishi Chem Ind | Process for preparing estrone acetal |
JPS6050498U (en) * | 1983-09-14 | 1985-04-09 | 不二交易株式会社 | Flash discharge light emitter with lithium battery inside |
CN105001293A (en) * | 2015-06-10 | 2015-10-28 | 浙江仙居君业药业有限公司 | Preparation method of estrone |
-
1978
- 1978-10-03 JP JP12179278A patent/JPS5549398A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984003094A1 (en) * | 1983-02-02 | 1984-08-16 | Mitsubishi Chem Ind | Process for preparing estrone acetal |
US4622181A (en) * | 1983-02-02 | 1986-11-11 | Mitsubishi Chemical Industries Ltd. | Process for producing an estrone acetal |
DE3490045C2 (en) * | 1983-02-02 | 1992-10-01 | Mitsubishi Kasei Corp., Tokio/Tokyo, Jp | |
JPS6050498U (en) * | 1983-09-14 | 1985-04-09 | 不二交易株式会社 | Flash discharge light emitter with lithium battery inside |
CN105001293A (en) * | 2015-06-10 | 2015-10-28 | 浙江仙居君业药业有限公司 | Preparation method of estrone |
Also Published As
Publication number | Publication date |
---|---|
JPS6111237B2 (en) | 1986-04-01 |
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