GB1273955A - Dexamethasone-17-valerate and processes for preparing it - Google Patents

Dexamethasone-17-valerate and processes for preparing it

Info

Publication number
GB1273955A
GB1273955A GB23992/71A GB2399271A GB1273955A GB 1273955 A GB1273955 A GB 1273955A GB 23992/71 A GB23992/71 A GB 23992/71A GB 2399271 A GB2399271 A GB 2399271A GB 1273955 A GB1273955 A GB 1273955A
Authority
GB
United Kingdom
Prior art keywords
dexamethasone
methyl
pregnadiene
dione
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23992/71A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Luso Farmaco dItalia SpA
Original Assignee
Istituto Luso Farmaco dItalia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Luso Farmaco dItalia SpA filed Critical Istituto Luso Farmaco dItalia SpA
Publication of GB1273955A publication Critical patent/GB1273955A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,273,955. Dexamethasone 17-valerate. INSTITUTO LUSO FARMACO D'ITALIA S.r.L. 19 April, 1971 [14 March, 1970], No. 23992/71. Heading C2U. The novel title compound, alternatively named 9α-fluoro-11#,21-dihydroxy-16α-methyl-17α-valeroyloxy-1,4-pregnadiene-3,20-dione, is prepared (1) by acid hydrolysis of 9α-fluoro-11#- hydroxy - 16α - methyl - 17α,21 - (1<SP>1</SP> - butyl - 1<SP>1</SP>- methoxy - methylenedioxy) - 1,4 - pregnadiene- 3,20-dione (prepared from dexamethasone and methyl orthovalerate); or (2) by acid hydrolysis of 9α-fluoro- 11#-hydroxy-16α-methyl-17α-valeroyloxy - 21 - acetoxy - 1,4 - pregnadiene - 3,20- dione (prepared from dexamethasone-21-acetate and valeric anhydride) followed by separation of the resulting mono-ester mixture by chromatography. The novel steroid is stated to be an antiinflammatory agent, and it may be made up into pharmaceutical compositions with suitable carriers.
GB23992/71A 1970-03-14 1971-04-19 Dexamethasone-17-valerate and processes for preparing it Expired GB1273955A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21992/70A IT1033042B (en) 1970-03-14 1970-03-14 DESAMETAZONE 17 VALERATO AND PROCESSES FOR ITS PREPARATION

Publications (1)

Publication Number Publication Date
GB1273955A true GB1273955A (en) 1972-05-10

Family

ID=11189894

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23992/71A Expired GB1273955A (en) 1970-03-14 1971-04-19 Dexamethasone-17-valerate and processes for preparing it

Country Status (4)

Country Link
JP (1) JPS5129152B1 (en)
FR (1) FR2085709B1 (en)
GB (1) GB1273955A (en)
IT (1) IT1033042B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195748B (en) * 1961-06-24 1965-07-01 Vismara Francesco Spa Process for the preparation of 1'-substituted 17alpha, 21- (1'-alkoxy) -methylenedioxysteriodes
GB1227992A (en) * 1968-01-23 1971-04-15 Koninklijke Gist Spiritus

Also Published As

Publication number Publication date
IT1033042B (en) 1979-07-10
FR2085709B1 (en) 1974-09-27
DE2111114A1 (en) 1971-09-30
JPS5129152B1 (en) 1976-08-24
FR2085709A1 (en) 1971-12-31
DE2111114B2 (en) 1976-01-22

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years