GB1273955A - Dexamethasone-17-valerate and processes for preparing it - Google Patents
Dexamethasone-17-valerate and processes for preparing itInfo
- Publication number
- GB1273955A GB1273955A GB23992/71A GB2399271A GB1273955A GB 1273955 A GB1273955 A GB 1273955A GB 23992/71 A GB23992/71 A GB 23992/71A GB 2399271 A GB2399271 A GB 2399271A GB 1273955 A GB1273955 A GB 1273955A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dexamethasone
- methyl
- pregnadiene
- dione
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,273,955. Dexamethasone 17-valerate. INSTITUTO LUSO FARMACO D'ITALIA S.r.L. 19 April, 1971 [14 March, 1970], No. 23992/71. Heading C2U. The novel title compound, alternatively named 9α-fluoro-11#,21-dihydroxy-16α-methyl-17α-valeroyloxy-1,4-pregnadiene-3,20-dione, is prepared (1) by acid hydrolysis of 9α-fluoro-11#- hydroxy - 16α - methyl - 17α,21 - (1<SP>1</SP> - butyl - 1<SP>1</SP>- methoxy - methylenedioxy) - 1,4 - pregnadiene- 3,20-dione (prepared from dexamethasone and methyl orthovalerate); or (2) by acid hydrolysis of 9α-fluoro- 11#-hydroxy-16α-methyl-17α-valeroyloxy - 21 - acetoxy - 1,4 - pregnadiene - 3,20- dione (prepared from dexamethasone-21-acetate and valeric anhydride) followed by separation of the resulting mono-ester mixture by chromatography. The novel steroid is stated to be an antiinflammatory agent, and it may be made up into pharmaceutical compositions with suitable carriers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21992/70A IT1033042B (en) | 1970-03-14 | 1970-03-14 | DESAMETAZONE 17 VALERATO AND PROCESSES FOR ITS PREPARATION |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1273955A true GB1273955A (en) | 1972-05-10 |
Family
ID=11189894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB23992/71A Expired GB1273955A (en) | 1970-03-14 | 1971-04-19 | Dexamethasone-17-valerate and processes for preparing it |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS5129152B1 (en) |
FR (1) | FR2085709B1 (en) |
GB (1) | GB1273955A (en) |
IT (1) | IT1033042B (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1195748B (en) * | 1961-06-24 | 1965-07-01 | Vismara Francesco Spa | Process for the preparation of 1'-substituted 17alpha, 21- (1'-alkoxy) -methylenedioxysteriodes |
GB1227992A (en) * | 1968-01-23 | 1971-04-15 | Koninklijke Gist Spiritus |
-
1970
- 1970-03-14 IT IT21992/70A patent/IT1033042B/en active
-
1971
- 1971-03-12 FR FR7108759A patent/FR2085709B1/fr not_active Expired
- 1971-03-12 JP JP46013401A patent/JPS5129152B1/ja active Pending
- 1971-04-19 GB GB23992/71A patent/GB1273955A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IT1033042B (en) | 1979-07-10 |
DE2111114A1 (en) | 1971-09-30 |
FR2085709A1 (en) | 1971-12-31 |
JPS5129152B1 (en) | 1976-08-24 |
DE2111114B2 (en) | 1976-01-22 |
FR2085709B1 (en) | 1974-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PE20 | Patent expired after termination of 20 years |