GB1235642A - A new oestratriol and a process for its manufacture - Google Patents

A new oestratriol and a process for its manufacture

Info

Publication number
GB1235642A
GB1235642A GB433970A GB433970A GB1235642A GB 1235642 A GB1235642 A GB 1235642A GB 433970 A GB433970 A GB 433970A GB 433970 A GB433970 A GB 433970A GB 1235642 A GB1235642 A GB 1235642A
Authority
GB
United Kingdom
Prior art keywords
methyl
compound
estratriene
treating
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB433970A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1235642A publication Critical patent/GB1235642A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Abstract

1,235,642. 7α - Methyl - 3,16#17α - trihydroxy- #<SP>1@10)</SP>-estratriene. CIBA GEIGY Ltd. 29 Jan., 1970 [27 Feb., 1969; 13 Jan., 1970], No. 4339/70. Heading C3U. The novel title compound is prepared by hydrolysing under acid conditions a compound of the Formula (II) or by reducing with a dilight metal hydride a compound of the Formula (III), and if necessary hydrolysing an esterified or etherified hydroxy group to a free hydroxy group (wherein OR is a free, esterified or etherified hydroxy group, and Acyl is the acyl radical of a carboxylic acid). Steroids of the Formula (II) are prepared by converting a 7α-methyl-estrone to a 17-enol acylate thereof, treating with bromine to give a 16α-bromo-17-ketone, reducing this to the bromohydrin, splitting off HBr to give the 17-unsubstituted-#<SP>16</SP>-compound, and treating this with a per acid, or treating the bromohydrin directly with a base. 3,17α- Diacetoxy - 7α - methyl - 16 - oxo - #<SP>1'3'5'(10)</SP>- estratriene is prepared by enol-acylating and then epoxidizing 3-hydroxy-7α-methyl-16-oxo- #<SP>1</SP>'<SP>3</SP>'<SP>5(10)</SP>- estratriene (prepared in known manner from 7α-methyl-estrone via the 16-oximino compound) to give 3,16 - diacetoxy - 7α- methyl - 16α,17 - oxido - #<SP>1,3,5(10)</SP> - estratriene and then treating this with ethyl acetate and perchloric acid at room temperature. The steroid of the invention has ovulationinhibiting and estrogenic activity, and it can be made up into pharmaceutical compositions with suitable carriers.
GB433970A 1969-02-27 1970-01-29 A new oestratriol and a process for its manufacture Expired GB1235642A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH296569 1969-02-27
CH42670 1970-01-13

Publications (1)

Publication Number Publication Date
GB1235642A true GB1235642A (en) 1971-06-16

Family

ID=25684546

Family Applications (1)

Application Number Title Priority Date Filing Date
GB433970A Expired GB1235642A (en) 1969-02-27 1970-01-29 A new oestratriol and a process for its manufacture

Country Status (7)

Country Link
AT (1) AT296516B (en)
AU (1) AU1180970A (en)
BE (1) BE746549A (en)
DE (1) DE2007464A1 (en)
FR (1) FR2034570A1 (en)
GB (1) GB1235642A (en)
NL (1) NL7002752A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114891169A (en) * 2021-08-05 2022-08-12 中原工学院 Method for synthesizing zinc complex COFs material in one step

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19906159A1 (en) * 1999-02-09 2000-08-10 Schering Ag 16-hydroxyestratrienes as selectively active estrogens

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114891169A (en) * 2021-08-05 2022-08-12 中原工学院 Method for synthesizing zinc complex COFs material in one step
CN114891169B (en) * 2021-08-05 2023-07-21 中原工学院 Method for synthesizing zinc complex COFs material in one step

Also Published As

Publication number Publication date
BE746549A (en) 1970-08-26
NL7002752A (en) 1970-08-31
DE2007464A1 (en) 1970-09-10
AT296516B (en) 1972-02-25
FR2034570A1 (en) 1970-12-11
AU1180970A (en) 1971-08-26

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