GB1496318A - Cholesta-1,5,7-triene-3beta,25-diol and 25-hydroxy-cholesta-1,5,7-trien-3-one - Google Patents

Cholesta-1,5,7-triene-3beta,25-diol and 25-hydroxy-cholesta-1,5,7-trien-3-one

Info

Publication number
GB1496318A
GB1496318A GB6293/77A GB629377A GB1496318A GB 1496318 A GB1496318 A GB 1496318A GB 6293/77 A GB6293/77 A GB 6293/77A GB 629377 A GB629377 A GB 629377A GB 1496318 A GB1496318 A GB 1496318A
Authority
GB
United Kingdom
Prior art keywords
cholesta
trien
triene
hydroxycholesta
diol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6293/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of GB1496318A publication Critical patent/GB1496318A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1496318 Cholesta-1,5,7-triene derivatives WISCONSIN ALUMNI RESEARCH FOUNDATION 27 Feb 1976 [28 Feb 1975] 06293/77 Divided out of 1496317 Heading C2U The invention comprises cholesta-1,5,7-triene - 3#,25 - diol (I) and 25 - hydroxycholesta- 1,5,7 - trien - 3 - one (II), and their preparation by the route: cholesterol # cholesteryl acetate # 25 - hydroxycholesteryl acetate # 25 - hydroxycholesteryl (IV) # 25 - hydroxycholesta - 1,4 - dien - 3 - one # 25 - hydroxycholesta - 1,4,6 - trien - 3 - one (III) # II # I, the penultimate step being base-induced isomerization and the other steps being conventional. In variants 6#-methoxy-25-hydroxy- 3α,5-cyclo-5α-cholestane # IV; and IV # III direct. Further conversion of I is as described in parent Specifications and Specification 1,496,319.
GB6293/77A 1975-02-28 1976-02-27 Cholesta-1,5,7-triene-3beta,25-diol and 25-hydroxy-cholesta-1,5,7-trien-3-one Expired GB1496318A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50023827A JPS51100056A (en) 1975-02-28 1975-02-28 1 arufua 255 jihidorokishikorekarushifuerooruno seiho

Publications (1)

Publication Number Publication Date
GB1496318A true GB1496318A (en) 1977-12-30

Family

ID=12121191

Family Applications (3)

Application Number Title Priority Date Filing Date
GB6293/77A Expired GB1496318A (en) 1975-02-28 1976-02-27 Cholesta-1,5,7-triene-3beta,25-diol and 25-hydroxy-cholesta-1,5,7-trien-3-one
GB7890/76A Expired GB1496317A (en) 1975-02-28 1976-02-27 Previtamin derivative and process for preparing 1alpha,25-dihydroxycholecalciferol therefrom
GB6294/77A Expired GB1496319A (en) 1975-02-28 1976-02-27 Cholesta-5,7-diene-1alpha,3beta,25-triol

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB7890/76A Expired GB1496317A (en) 1975-02-28 1976-02-27 Previtamin derivative and process for preparing 1alpha,25-dihydroxycholecalciferol therefrom
GB6294/77A Expired GB1496319A (en) 1975-02-28 1976-02-27 Cholesta-5,7-diene-1alpha,3beta,25-triol

Country Status (6)

Country Link
JP (1) JPS51100056A (en)
CA (1) CA1069939A (en)
DK (1) DK85876A (en)
GB (3) GB1496318A (en)
NL (1) NL7602047A (en)
SE (3) SE409717B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54103855A (en) * 1978-01-27 1979-08-15 Chugai Pharmaceut Co Ltd 1beta, 25-dihydroxyvitamin
FR2457282A1 (en) * 1979-05-23 1980-12-19 Roussel Uclaf NEW DERIVATIVE OF 1A, 25 DIHYDROXY CHOLECALCIFEROL, ITS PREPARATION METHOD AND ITS APPLICATION AS A MEDICAMENT
JPS5626820A (en) * 1979-08-10 1981-03-16 Chugai Pharmaceut Co Ltd Immunosuppressing agent
EP0073465B1 (en) * 1981-08-28 1986-02-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cholecalciferol derivatives
JPS60163859A (en) * 1984-02-06 1985-08-26 Teijin Ltd 1-position labeled bitamin d3 derivative and its preparation
JPS61194065A (en) * 1985-02-21 1986-08-28 Taisho Pharmaceut Co Ltd Vitamin d3 derivative
DE4105503A1 (en) * 1991-02-19 1992-08-20 Jenapharm Gmbh INITIAL COMPOUNDS FOR THE PRODUCTION OF CALCITRIOL AND ITS COLLECTING MATERIALS, METHOD FOR THE PRODUCTION OF THESE OUTPUT CONNECTIONS AND INTERMEDIATE PRODUCTS FOR THIS PROCESS

Also Published As

Publication number Publication date
DK85876A (en) 1976-08-29
SE7601605L (en) 1976-08-30
SE7811147L (en) 1978-10-26
NL7602047A (en) 1976-08-31
JPS51100056A (en) 1976-09-03
GB1496317A (en) 1977-12-30
GB1496319A (en) 1977-12-30
SE7811146L (en) 1978-10-26
SE409717B (en) 1979-09-03
JPS5732055B2 (en) 1982-07-08
CA1069939A (en) 1980-01-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee